cilapam fn 0.5mg/10mg tablet - Uses, Price, Side Effects & Substitutes
What is cilapam fn 0.5mg/10mg tablet used for?
Avanxit-FN Tablet (Flupenthixol + Nortriptyline) is used to treat NEURO CNS. It contains Flupenthixol (0.5mg) + Nortriptyline (10mg), which Flupenthixol blocks dopamine D1/D2 receptors; Nortriptyline inhibits serotonin a. Always consult your doctor before use. Take as prescribed.
- Generic Name: Flupenthixol + Nortriptyline
- Manufacturer: Alteus Biogenics Pvt Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ cilapam fn 0.5mg/10mg tablet Uses & Benefits
Depression with anxiety, psychotic depression, chronic pain with depression
Off-label uses: Bipolar depression, anxiety disorders, neuropathic pain
๐ Drug Information
| Generic Name(s) | Flupenthixol + Nortriptyline |
| Brand Name | Avanxit-FN Tablet |
| Manufacturer | Alteus Biogenics Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Antidepressant + Antipsychotic |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC, protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Flupenthixol blocks dopamine D1/D2 receptors; Nortriptyline inhibits serotonin and norepinephrine reuptake
Mechanism Steps
๐ก How to Take cilapam fn 0.5mg/10mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cilapam fn 0.5mg/10mg tablet
โ Common Side Effects
- Dry mouth
- Constipation
- Blurred vision
- Sedation
- Dizziness
- Weight gain
- Extrapyramidal symptoms
๐จ Serious Side Effects
- QT prolongation
- Torsades de pointes
- Neuroleptic malignant syndrome
- Seizures
- Serotonin syndrome
- Agranulocytosis
โ ๏ธ Rare Side Effects
- Hepatotoxicity
- Pancreatitis
- SIADH
- Photosensitivity
- Tardive dyskinesia
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | Hypertensive crisis, serotonin syndrome |
| CYP2D6 inhibitors | Major | Increased nortriptyline levels, toxicity |
| QT-prolonging agents | Major | Increased risk of arrhythmias |
| CNS depressants | Major | Additive sedation, respiratory depression |
| Anticholinergics | Moderate | Additive anticholinergic effects |
| Antihypertensives | Moderate | Enhanced hypotensive effect |
| Lithium | Moderate | Neurotoxicity risk |
| SSRIs | Moderate | Serotonin syndrome risk |
| Cimetidine | Minor | Increased nortriptyline levels |
| Oral contraceptives | Minor | Reduced flupenthixol efficacy |
| Smoking | Minor | Reduced nortriptyline levels |
๐จ Major Interactions
- MAOIs
- CYP2D6 inhibitors
- QT-prolonging agents
- CNS depressants
โก Moderate Interactions
- Anticholinergics
- Antihypertensives
- Lithium
- SSRIs
โน๏ธ Minor Interactions
- Cimetidine
- Oral contraceptives
- Smoking
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase levels, High-fat meals may delay absorption
๐ท Alcohol Interaction
Enhanced CNS depression; avoid alcohol
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, recent MI, severe liver disease, narrow-angle glaucoma, urinary retention, concurrent MAOI use
๐ Monitoring Parameters
ECG, blood pressure, liver function, serum drug levels (nortriptyline), mental status, EPS symptoms
๐คฑ Lactation Safety
Not recommended; excreted in breast milk
๐ Overdose Management
Symptomatic and supportive; ECG monitoring; consider activated charcoal; benzodiazepines for seizures; sodium bicarbonate for QRS widening
โฐ Missed Dose
Take as soon as remembered unless near next dose; skip if close; do not double