Oflox OZ Suspension: Comprehensive Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Pain, swelling, or rupture of a tendon
- Numbness or tingling in hands or feet
- Seizures or confusion
If experiencing severe symptoms, call emergency services immediately.
What is Floxzen OZ 50mg/5ml/125mg/5ml Suspension used for?
This medicine is a combination antibiotic and antiprotozoal suspension used to treat mixed gastrointestinal infections caused by bacteria and protozoa. It contains ofloxacin and ornidazole, which work together to kill susceptible organisms. It is available by prescription only and should be taken exactly as directed by your doctor.
- Generic Name: Ofloxacin (50mg/5ml) + Ornidazole (125mg/5ml)
- Manufacturer: Moraceae Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Floxzen OZ 50mg/5ml/125mg/5ml Suspension के बारे में (Hindi Summary)
उपयोग: यह दवा ऑफ़लोक्सासिन और ओर्निडाज़ोल का संयोजन है, जिसका उपयोग बैक्टीरिया और प्रोटोज़ोआ के कारण होने वाले मिश्रित संक्रमणों के इलाज के लिए किया जाता है। यह मुख्य रूप से आंतों के संक्रमण, जैसे अमीबिक पेचिश, जियार्डिया संक्रमण, और बैक्टीरियल गैस्ट्रोएंटेराइटिस के लिए निर्धारित की जाती है। यह दवा केवल डॉक्टर के पर्चे पर ही मिलती है और इसे डॉक्टर के निर्देशानुसार ही लेना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, दस्त, पेट दर्द, सिरदर्द, चक्कर आना और मुँह में धातु जैसा स्वाद शामिल हैं। गंभीर दुष्प्रभावों में टेंडन टूटना, तंत्रिका क्षति, दौरे, गंभीर एलर्जी प्रतिक्रियाएँ और रक्त विकार शामिल हो सकते हैं। दुर्लभ दुष्प्रभावों में हेपेटाइटिस, अग्नाशयशोथ और सूर्य के प्रति संवेदनशीलता शामिल हैं।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक न छोड़ें और न ही बीच में बंद करें, भले ही आप बेहतर महसूस करें। उपयोग से पहले बोतल को अच्छी तरह हिलाएँ। खुराक मापने के लिए दी गई मापन कप का ही उपयोग करें। इस दवा के साथ शराब का सेवन बिल्कुल न करें, क्योंकि इससे गंभीर प्रतिक्रिया हो सकती है। पर्याप्त पानी पिएँ। धूप में जाने से बचें और सनस्क्रीन का उपयोग करें। यदि आपको टेंडन में दर्द, सूजन या टूटने का अनुभव हो, तो तुरंत डॉक्टर से संपर्क करें।
💊 Floxzen OZ 50mg/5ml/125mg/5ml Suspension Uses & Benefits
[{"condition":"Amoebic dysentery","description":"Treats intestinal infection caused by Entamoeba histolytica, relieving diarrhea, abdominal pain, and fever.","evidence":"Well-established"},{"condition":"Giardiasis","description":"Effective against Giardia lamblia, a protozoan that causes diarrhea and malabsorption.","evidence":"Well-established"},{"condition":"Bacterial gastroenteritis","description":"Used when mixed bacterial and protozoal infections are suspected, covering a broad range of pathogens.","evidence":"Established"},{"condition":"Intra-abdominal infections","description":"May be used as part of combination therapy for complicated intra-abdominal infections caused by susceptible organisms.","evidence":"Limited"}]
Off-label uses: [{"condition":"Traveler's diarrhea","description":"Sometimes prescribed off-label for empirical treatment of traveler's diarrhea when mixed infection is suspected.","evidence":"Limited"}]
Primary treatment for: Mixed bacterial and protozoal gastrointestinal infections
Also treats: Amoebic dysentery, Giardiasis, Bacterial gastroenteritis, Intra-abdominal infections
📋 Drug Information
| Generic Name(s) | Ofloxacin (50mg/5ml) + Ornidazole (125mg/5ml) |
| Brand Name | Floxzen OZ 50mg/5ml/125mg/5ml Suspension |
| Manufacturer | Moraceae Pharmaceuticals Pvt Ltd |
| Packaging / Form | bottle of 30 ml Suspension (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, protected from light and moisture. Do not freeze. Keep the bottle tightly closed. Shake well before each use. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, repair, and recombination, leading to bacterial cell death. Ornidazole is a nitroimidazole that diffuses into anaerobic bacteria and protozoa, where its nitro group is reduced, forming reactive intermediates that damage DNA and inhibit nucleic acid synthesis, causing cell death.
Mechanism Steps
💡 How to Take Floxzen OZ 50mg/5ml/125mg/5ml Suspension
Strength: Each 5 mL of suspension contains Ofloxacin 50 mg and Ornidazole 125 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 5-10 mL (containing 50-100 mg ofloxacin and 125-250 mg ornidazole) taken orally twice daily, or as directed by your doctor. The dose and duration depend on the type and severity of the infection, your age, weight, kidney and liver function, and other medical conditions. Always follow your doctor's prescription. Do not self-medicate. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially CNS effects and tendon rupture. Dose adjustment may be required based on renal function. Consult your doctor for appropriate dosing. |
| Renal Impairment | In patients with renal impairment, dose adjustment of ofloxacin is required. For creatinine clearance between 20-50 mL/min, the usual dose may be given once daily. For creatinine clearance less than 20 mL/min, the dose may need to be further reduced. Ornidazole does not require dose adjustment in renal impairment. Consult your doctor for specific dosing. |
| Hepatic Impairment | In patients with severe hepatic impairment, dose adjustment may be necessary. Ornidazole is metabolized in the liver, and its clearance may be reduced. Monitor liver function closely. Consult your doctor for specific dosing. |
| Maximum Daily Dose | The maximum daily dose of ofloxacin is 400 mg and ornidazole is 1000 mg, but the exact maximum for this combination depends on the prescribed regimen. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Floxzen OZ 50mg/5ml/125mg/5ml Suspension
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Antacids | Major | |
| Theophylline | Major | |
| NSAIDs | Major | |
| Corticosteroids | Major | |
| Alcohol | Major | |
| Caffeine | Moderate | |
| Cyclosporine | Moderate | |
| Oral hypoglycemics | Moderate | |
| Phenytoin | Moderate |
🚨 Major Interactions
- Warfarin
- Antacids, iron, zinc, sucralfate
- Theophylline
- NSAIDs
- Corticosteroids
- Alcohol
⚡ Moderate Interactions
- Caffeine
- Cyclosporine
- Oral hypoglycemics
- Phenytoin
- Probenecid
🍷 Alcohol Interaction
Alcohol must be strictly avoided while taking this medicine and for at least 48 hours after the last dose. Ornidazole can cause a disulfiram-like reaction characterized by severe nausea, vomiting, flushing, headache, and rapid heart rate. Additionally, alcohol may worsen dizziness and drowsiness caused by ofloxacin.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to ofloxacin, ornidazole, or any other fluoroquinolone or nitroimidazole","History of tendon disorders associated with fluoroquinolone use","Myasthenia gravis (may exacerbate muscle weakness)","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["Fluoroquinolones, including ofloxacin, have been associated with disabling and potentially irreversible serious adverse reactions, including tendinitis, tendon rupture, peripheral neuropathy, and CNS effects. Reserve use for patients with no alternative treatment options.","Avoid use in patients with a history of tendon disorders or those receiving corticosteroids.","May cause dizziness and lightheadedness; avoid driving or operating machinery until you know how it affects you.","Avoid excessive sunlight and use sunscreen due to photosensitivity risk.","May worsen symptoms of myasthenia gravis.","Ornidazole may cause a disulfiram-like reaction with alcohol; avoid alcohol during and for 48 hours after treatment.","Use with caution in patients with hepatic impairment; monitor liver function.","Dose adjustment required in renal impairment.","May cause blood dyscrasias; monitor CBC if symptoms occur.","Prolonged use may lead to superinfection with resistant organisms."]
🤱 Lactation Safety
Ofloxacin and ornidazole are excreted in breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Consult your doctor.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. In case of overdose, discontinue the drug and provide symptomatic and supportive care. Monitor vital signs, renal function, and electrolyte balance. Activated charcoal may be considered if ingestion is recent. Hemodialysis may be considered for ofloxacin overdose but is not effective for ornidazole. Contact a poison control center or emergency department immediately.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop early, even if you feel better. Shake the bottle well before each use to ensure the medicine is evenly mixed. Measure the dose with the provided measuring cup or spoon, not a household spoon. Avoid alcohol while taking this medicine, as it can cause severe nausea and vomiting. Stay well hydrated. Avoid excessive sunlight and use sunscreen, as this medicine can make your skin more sensitive to sunlight. Inform your doctor if you have kidney or liver problems, diabetes, or a history of seizures. Do not take antacids, iron, or zinc supplements within 2 hours before or after this medicine, as they can reduce its absorption. If you experience pain, swelling, or rupture of a tendon, stop taking this medicine and seek medical attention immediately. This medicine may cause dizziness; avoid driving or operating machinery until you know how it affects you.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at increased risk of tendon rupture, peripheral neuropathy, and CNS effects. Dose adjustment may be needed based on renal function. Monitor closely for any adverse effects.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It is not recommended during pregnancy unless clearly needed. Discuss alternative treatments if you are pregnant or planning to conceive.
🏥 Post-Surgery Considerations
If you have recently undergone surgery, inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with other medications and affect recovery. Consult your doctor for specific guidance.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may interact with other medications used during dental work. Your dentist may recommend postponing elective procedures until you complete the course.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while taking this medicine, as it may increase the risk of tendon rupture. If you experience joint or tendon pain, stop exercising and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, headache, or fatigue. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to take rest and stay hydrated. If your work involves physical exertion, consult your doctor about temporary modifications.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor, even if you feel better. Complete the full course as prescribed. If you experience serious side effects such as tendon pain, severe diarrhea, or allergic reactions, stop the medicine and seek immediate medical attention.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance, superinfection with resistant organisms, and rare but serious effects such as tendon rupture, peripheral neuropathy, and liver or kidney damage. It should only be used for the prescribed duration. Regular monitoring of liver and kidney function may be required if used for prolonged periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Essential for managing dehydration caused by diarrhea.
Evidence: Well-establishedMay help restore gut flora and reduce antibiotic-associated diarrhea.
Evidence: ModerateCan reduce the duration and severity of diarrhea in children.
Evidence: Well-established for children💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the effectiveness of live bacterial vaccines such as typhoid vaccine. Avoid vaccination with live bacterial vaccines during treatment and for several days after. Consult your doctor for specific advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Shake well before each use
❌ DON'T
Do not use if the suspension has changed color or consistency
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription or a letter from your doctor, especially for international travel. Store it at room temperature and protect it from extreme heat or cold. If crossing time zones, adjust dosing times gradually, but maintain the prescribed interval between doses. Keep it in your carry-on luggage to avoid loss or temperature extremes. Check customs regulations for restricted medicines before traveling.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 1-2 days, but it is important to complete the full course as prescribed, usually 5-7 days.
A: Yes, you can take it with or without food. Taking it with food may help reduce stomach upset.
A: Avoid alcohol, antacids, iron, and zinc supplements within 2 hours of taking this medicine. Also avoid excessive sunlight.
A: This medicine is not recommended for children unless specifically prescribed by a pediatrician. Consult your doctor.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
🤔 Common Patient Concerns
🔄 Substitutes for Floxzen OZ 50mg/5ml/125mg/5ml Suspension
View AllAlternative brands with exact same active ingredient:
-
oflobest oz syrupBestoChem Formulations India Ltd ₹11.48 62.3% CHEAPER
-
owin o 50mg/5ml/125mg/5ml suspensionAlembic Pharmaceuticals Ltd ₹12.08 60.4% CHEAPER
-
ofpil o suspensionPsychotropics India Ltd ₹12.67 58.4% CHEAPER
-
alfox oz 50mg/5ml/125mg/5ml syrupAlliaance Biotech ₹12.89 57.7% CHEAPER
-
oflofine oz suspensionGlenmark Pharmaceuticals Ltd ₹14.06 53.9% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of diarrhea.
Fact: This medicine is only effective against specific bacterial and protozoal infections. It does not work for viral diarrhea or other causes. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full course as prescribed, even if symptoms improve, to prevent recurrence and resistance. - Myth: This medicine is safe to take with alcohol.
Fact: Alcohol must be strictly avoided as it can cause a severe disulfiram-like reaction with ornidazole. - Myth: This medicine can be taken with antacids without any issues.
Fact: Antacids, iron, and zinc can reduce the absorption of ofloxacin. They should be taken at least 2 hours apart.
🔄 Alternative Options
Generic Alternatives
- Ofloxacin + Ornidazole suspension (generic)
Brand Alternatives
- Oflox OZ Suspension
- O2 Suspension
- Ofloxacin Ornidazole Suspension