alfox oz 50mg/5ml/125mg/5ml syrup - Ofloxacin (50mg/5ml) + Ornidazole (125mg/5ml) medicine

Azoflox OZ Syrup: Complete Medicine Guide

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🏭 Alliaance Biotech 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 22, 2026
🤰 Pregnancy Category Not established from the available information. Use only if clearly needed and prescribed by a doctor. Fluoroquinolones and nitroimidazoles are generally avoided in pregnancy unless the benefit outweighs the risk. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Oct 22, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
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When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Numbness or tingling in hands or feet
  • Pain or swelling in a joint

If experiencing severe symptoms, call emergency services immediately.

What is alfox oz 50mg/5ml/125mg/5ml syrup used for?

This medicine is a combination antibiotic and antiprotozoal syrup used to treat intestinal infections like amoebic dysentery and giardiasis. It contains ofloxacin and ornidazole, which work together to kill bacteria and protozoa. It is available by prescription only and should be taken exactly as directed.

  • Generic Name: Ofloxacin + Ornidazole
  • Manufacturer: Alliaance Biotech
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 alfox oz 50mg/5ml/125mg/5ml syrup के बारे में (Hindi Summary)

उपयोग: यह दवा ओफ्लोक्सासिन और ओर्निडाजोल का संयोजन है, जिसका उपयोग आंतों के संक्रमण जैसे अमीबिक पेचिश, जियार्डिया और बैक्टीरियल दस्त के इलाज के लिए किया जाता है। यह बैक्टीरिया और प्रोटोजोआ को मारकर काम करती है। इसे डॉक्टर के निर्देशानुसार ही लें।

साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, सिरदर्द, चक्कर आना और मुंह में धातु जैसा स्वाद शामिल हैं। गंभीर दुष्प्रभावों में टेंडन टूटना, तंत्रिका क्षति, दौरे और एलर्जी प्रतिक्रियाएं शामिल हो सकती हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक न छोड़ें और न ही समय से पहले बंद करें। उपयोग से पहले बोतल को अच्छी तरह हिलाएं। सही मापने वाले कप या चम्मच का उपयोग करें। दवा लेते समय शराब न पिएं। एंटासिड, आयरन या जिंक सप्लीमेंट के साथ 2 घंटे का अंतराल रखें। गुर्दे या यकृत की समस्या हो तो डॉक्टर को बताएं।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 alfox oz 50mg/5ml/125mg/5ml syrup Uses & Benefits

[{"condition":"Amoebic dysentery","description":"This medicine is used to treat intestinal infections caused by Entamoeba histolytica, relieving symptoms like bloody diarrhea and abdominal pain.","evidence":"Well-established"},{"condition":"Giardiasis","description":"It is effective against Giardia lamblia, a protozoan that causes diarrhea and malabsorption.","evidence":"Well-established"},{"condition":"Bacterial gastroenteritis","description":"The combination targets a broad range of bacteria that cause infectious diarrhea.","evidence":"Well-established"},{"condition":"Mixed infections","description":"It is used when both bacterial and protozoal pathogens are suspected or confirmed.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Pelvic inflammatory disease","description":"Sometimes used off-label as part of a regimen for PID, but not a first-line choice.","evidence":"Limited"},{"condition":"Bacterial vaginosis","description":"May be used off-label, but other treatments are preferred.","evidence":"Limited"}]

Primary treatment for: Amoebic dysentery

Also treats: Giardiasis, Bacterial gastroenteritis, Mixed intestinal infections

📋 Drug Information

Generic Name(s)Ofloxacin + Ornidazole
Brand NameAssault Novo 200 mg/500 mg Tablet
ManufacturerAlliaance Biotech
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action ClassAntibiotic + Antiprotozoal
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Do not freeze. Keep the bottle tightly closed. Shake well before use.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always prescribe this medicine only when there is a confirmed or strongly suspected bacterial/protozoal infection.
2
Advise patients to take the syrup with food to minimize gastrointestinal upset.
3
Warn patients about the risk of tendon rupture and to report any joint pain immediately.
4
Instruct patients to avoid antacids, iron, and zinc within 2 hours of dosing.
5
Monitor renal function before and during therapy, especially in elderly patients.
6
Caution patients about driving or operating machinery until they know how the medicine affects them.
7
Emphasize completing the full course even if symptoms improve.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Bloody diarrhea
This medicine is commonly prescribed for amoebic dysentery.
Likely Use
✅
Watery diarrhea with bloating
May be used for giardiasis or bacterial gastroenteritis.
Likely Use
❌
Fever
This medicine is not a primary fever reducer; it treats the underlying infection.
Not Primary
❌
Common cold
This medicine is not effective against viral infections.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionOfloxacin is rapidly and well absorbed from the gastrointestinal tract after oral administration. Ornidazole is also well absorbed orally. The syrup formulation is designed for pediatric and adult patients who have difficulty swallowing tablets.
DistributionOfloxacin distributes widely into body tissues and fluids, including lung, kidney, prostate, and bile. Ornidazole also distributes widely, including into the cerebrospinal fluid and brain tissue.
Protein BindingOfloxacin is approximately 20-30% bound to plasma proteins. Ornidazole is less than 15% bound to plasma proteins.
MetabolismOfloxacin undergoes limited metabolism in the liver, with a small percentage metabolized to desmethyl and N-oxide metabolites. Ornidazole is metabolized in the liver primarily by conjugation and oxidation.
Half-LifeThe elimination half-life of ofloxacin is approximately 4-5 hours in adults with normal renal function. The elimination half-life of ornidazole is approximately 12-14 hours.
ExcretionOfloxacin is primarily excreted unchanged in the urine (70-80%) and to a lesser extent in feces. Ornidazole is excreted mainly in the urine as metabolites and in feces.
BioavailabilityThe oral bioavailability of ofloxacin is approximately 95-100%. The oral bioavailability of ornidazole is approximately 90%.
Onset of ActionThe onset of action for ofloxacin is typically within 1-2 hours after oral administration. For ornidazole, the onset is also within 1-2 hours.
Peak Plasma TimePeak plasma concentrations of ofloxacin are reached within 1-2 hours after oral administration. For ornidazole, peak plasma concentrations are reached within 2-3 hours.
Duration of ActionThe duration of action for ofloxacin is approximately 12 hours, allowing for twice-daily dosing. For ornidazole, the duration is approximately 24 hours, allowing for once-daily dosing.

How It Works

This medicine combines two antimicrobial agents with distinct mechanisms. Ofloxacin, a fluoroquinolone, inhibits bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication, transcription, repair, and recombination. This leads to bacterial cell death. Ornidazole, a nitroimidazole, enters susceptible microorganisms and undergoes reductive activation of its nitro group, producing reactive intermediates that damage DNA and inhibit nucleic acid synthesis, leading to cell death. The combination provides broad-spectrum coverage against aerobic bacteria (ofloxacin) and anaerobic bacteria and protozoa (ornidazole).

Mechanism Steps

1
Ofloxacin entry and target binding: Ofloxacin enters bacterial cells and binds to DNA gyrase and topoisomerase IV, inhibiting their activity.
2
Inhibition of DNA replication: This prevents the supercoiling of DNA necessary for replication and transcription, leading to bacterial death.
3
Ornidazole activation: Ornidazole diffuses into anaerobic organisms and protozoa, where its nitro group is reduced by ferredoxin-like electron transport proteins.
4
DNA damage by reactive intermediates: The reduced intermediates cause DNA strand breaks and inhibit DNA synthesis, resulting in cell death.

💡 How to Take alfox oz 50mg/5ml/125mg/5ml syrup

Strength: Each 5 ml of syrup contains 50 mg ofloxacin and 125 mg ornidazole.

1Shake the bottle well before each use.
2Use a calibrated measuring cup or spoon to measure the dose accurately.
3Take with food to reduce stomach upset.
4Swallow the syrup directly; do not mix with other liquids unless instructed.
5Take at evenly spaced intervals as prescribed.
6Complete the full course even if you feel better.
7Do not take antacids, iron, or zinc within 2 hours of this medicine.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 10 ml (2 teaspoons) twice daily, or as prescribed by your doctor. The dose may vary depending on the severity of the infection and your kidney function. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician. This medicine is generally not recommended for children under 18 years due to the risk of cartilage and tendon effects from fluoroquinolones.
Elderly DosageElderly patients may require dose adjustment based on renal function. Ofloxacin clearance decreases with age. Monitor for side effects such as tendon rupture and CNS effects. Dose must be individualized by a qualified clinician.
Renal ImpairmentDose adjustment is required for ofloxacin in patients with renal impairment. For creatinine clearance 20-50 ml/min, the usual dose may be reduced. For creatinine clearance <20 ml/min, the dose may need further reduction. Ornidazole does not require adjustment. Consult your doctor for specific dosing.
Hepatic ImpairmentNo specific dose adjustment is established for mild to moderate hepatic impairment. In severe hepatic impairment, use with caution and monitor liver function. Consult your doctor.
Maximum Daily DoseThe maximum daily dose is 20 ml (100 mg ofloxacin and 500 mg ornidazole) for adults, but this may vary based on indication and renal function. Do not exceed the prescribed dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Dairy products
Separate by 2 hours
Calcium reduces absorption of ofloxacin.
Iron-fortified cereals
Separate by 2 hours
Iron reduces absorption of ofloxacin.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of alfox oz 50mg/5ml/125mg/5ml syrup

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food to reduce nausea. If it persists, consult your doctor.
Vomiting (Common (5-10%))
Stay hydrated. If vomiting is severe or persistent, contact your doctor.
Abdominal pain (Common (5-10%))
Usually resolves. If severe, seek medical advice.
Diarrhea (Common (5-10%))
Monitor for dehydration. If bloody or persistent, seek medical attention.
Headache (Common (5-10%))
Rest and hydrate. If severe, consult your doctor.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you.
Metallic taste (Common (5-10%))
Usually temporary. Chewing sugar-free gum may help.

🚨 Serious Side Effects

Tendinitis or tendon rupture (Rare (<0.1%))
Stop the medicine and seek immediate medical attention if you experience pain, swelling, or inability to move a joint.
Peripheral neuropathy (Rare (<0.1%))
Report numbness, tingling, or burning in hands or feet to your doctor immediately.
Central nervous system effects (seizures, confusion) (Rare (<0.1%))
Seek immediate medical attention if you experience seizures, confusion, or hallucinations.
Severe allergic reactions (anaphylaxis) (Rare (<0.1%))
Call emergency services if you have difficulty breathing, swelling of face or throat, or a severe rash.
Blood dyscrasias (Rare (<0.1%))
Report unusual bruising, bleeding, or signs of infection to your doctor.

⚠️ Rare Side Effects

Hepatitis
Seek medical attention if you notice yellowing of skin or eyes, dark urine, or severe fatigue.
Pancreatitis
Seek immediate care for severe abdominal pain radiating to the back.
Photosensitivity
Avoid prolonged sun exposure and use sunscreen.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Antacids Major
Theophylline Major
NSAIDs Major
Caffeine Moderate
Oral hypoglycemics Moderate
Phenytoin Moderate
Probenecid Minor
Cimetidine Minor
Alcohol Moderate

🚨 Major Interactions

  • Warfarin
  • Antacids, iron, zinc, sucralfate
  • Theophylline
  • NSAIDs

⚡ Moderate Interactions

  • Caffeine
  • Oral hypoglycemics
  • Phenytoin

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol can increase the risk of stomach upset, dizziness, and liver problems. It may also worsen the central nervous system side effects of ofloxacin.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to ofloxacin, ornidazole, or other fluoroquinolones or nitroimidazoles.","History of tendon disorders related to fluoroquinolone use.","Myasthenia gravis (may worsen muscle weakness).","Severe renal impairment (for ofloxacin component, unless dose adjusted).","Pregnancy and lactation (unless clearly needed).","Children under 18 years (fluoroquinolones may affect cartilage development)."]

⚠️ Warnings & Precautions

["Fluoroquinolones can cause tendon inflammation and rupture, especially in older adults and those on corticosteroids.","May cause peripheral neuropathy; discontinue if symptoms occur.","Can exacerbate myasthenia gravis.","May cause CNS effects including seizures; use caution in patients with CNS disorders.","Avoid excessive sunlight due to photosensitivity risk.","May cause blood sugar disturbances; monitor diabetics closely.","Do not use for viral infections.","Complete the full course to prevent resistance."]

🤱 Lactation Safety

Not established from the available information. Ofloxacin and ornidazole are excreted in breast milk. Consult your doctor before breastfeeding while taking this medicine.

💊 Overdose Management

There is no specific antidote for overdose. Treatment should be symptomatic and supportive. Gastric lavage may be considered if ingestion is recent. Monitor vital signs and provide supportive care. Contact a poison control center or emergency department immediately.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop early, even if you feel better. Shake the bottle well before each use to ensure the medicine is evenly mixed. Use a proper measuring device to get the correct dose. Avoid alcohol while taking this medicine, as it can increase the risk of stomach upset and liver problems. Do not take antacids, iron, or zinc supplements within 2 hours of this medicine, as they can reduce its absorption. If you have kidney or liver problems, your doctor may adjust your dose. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Avoid driving or operating heavy machinery if you feel dizzy. Store at room temperature and keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of tendon rupture, peripheral neuropathy, and CNS effects. Renal function declines with age, so dose adjustment may be necessary. Monitor closely for side effects and consider alternative antibiotics if possible.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before taking this medicine. Fluoroquinolones and nitroimidazoles are generally avoided during pregnancy unless clearly needed. Use effective contraception while taking this medicine and for a few days after.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist if you are taking this medicine before surgery. It may interact with other medications and affect wound healing. Your doctor may advise stopping it before elective surgery.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure. It may interact with antibiotics prescribed by the dentist. No specific precautions are otherwise required.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated to help flush out the infection.
🥗
Eat a bland diet to reduce stomach irritation.
😴
Avoid alcohol and caffeine while taking this medicine.
💧
Get plenty of rest to support your immune system.
🧘
Practice good hand hygiene to prevent spreading infections.
🌞
Complete the full course even if you feel better.

🏋️ Exercise Considerations

Avoid strenuous exercise or heavy lifting while taking this medicine, as it may increase the risk of tendon rupture. If you experience joint pain, stop exercising and consult your doctor.

🥗 Diet Recommendations

Include probiotics like yogurt to restore gut flora.
Eat easily digestible foods like rice, bananas, and toast.
Avoid spicy, oily, and processed foods.
Stay well hydrated with water and oral rehydration solutions.
Limit caffeine and alcohol.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or fatigue. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to take rest if you have severe diarrhea or fever. Most people can continue light work, but listen to your body.

🛑 When to Stop This Medicine

Stop taking this medicine only after completing the full prescribed course, unless your doctor advises otherwise. If you experience serious side effects like tendon pain, numbness, or severe allergic reactions, stop immediately and seek medical attention. Do not stop early even if symptoms improve, as this can lead to relapse and resistance.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of bacterial resistance, tendon damage, peripheral neuropathy, and liver or kidney problems. It should only be used for the prescribed duration. Regular monitoring of renal and hepatic function may be required if used for prolonged periods. Do not use for longer than prescribed without medical supervision.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Oral rehydration therapy

Essential for managing dehydration from diarrhea.

Evidence: Well-established
Probiotics

May help restore gut flora and reduce diarrhea duration.

Evidence: Moderate
Zinc supplementation

Recommended for children with diarrhea in some guidelines.

Evidence: Well-established for children

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific interactions with vaccines are established. However, if you are scheduled for a live vaccine, inform your doctor as antibiotics may affect the immune response. Generally, this medicine does not require postponing vaccinations.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✅ DO

Shake well before each use

❌ DON'T

Do not use if the syrup appears discolored or has particles

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with the prescription label. Bring a copy of your prescription in case of customs checks. Store at room temperature and protect from extreme heat or cold. If crossing time zones, adjust dosing times gradually to maintain even intervals. Keep the bottle upright to prevent leakage. Do not pack in checked luggage if refrigeration is not required; keep in carry-on for easy access.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with amoebic dysentery
He was prescribed this medicine for bloody diarrhea and abdominal cramps. After 3 days, his symptoms improved significantly. He completed the 7-day course as directed and recovered fully. He was advised to avoid alcohol and take the medicine with food.
💡 Lesson: Completing the full course and following dietary advice leads to successful treatment.
👤 A 28-year-old woman with giardiasis
She had persistent diarrhea and bloating. This medicine was prescribed twice daily for 5 days. She experienced mild nausea initially, which subsided when she took it with meals. Her symptoms resolved completely.
💡 Lesson: Taking the medicine with food can reduce side effects and improve adherence.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: You may start feeling better within 1-2 days, but it is important to complete the full course as prescribed, usually 5-7 days.

Q: Can I take this medicine with food?

A: Yes, taking it with food can reduce stomach upset. However, avoid dairy products, antacids, iron, or zinc within 2 hours of taking this medicine.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Q: Is this medicine safe for children?

A: This medicine is generally not recommended for children under 18 years due to the risk of cartilage and tendon effects from fluoroquinolones. Consult a pediatrician for alternatives.

Q: Can I drink alcohol while taking this medicine?

A: No, avoid alcohol as it can increase the risk of stomach upset, dizziness, and liver problems.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is it safe for my child?
  • Can I take it with other antibiotics?

🔄 Substitutes for alfox oz 50mg/5ml/125mg/5ml syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure any type of diarrhea.
    Fact: It only works for specific bacterial and protozoal infections. Viral diarrhea will not respond.
  • Myth: You can stop taking it once you feel better.
    Fact: You must complete the full course to prevent resistance and relapse.
  • Myth: It is safe to take with antacids.
    Fact: Antacids reduce absorption. Separate by at least 2 hours.

🔄 Alternative Options

Generic Alternatives

  • Ofloxacin + Ornidazole suspension (generic)

Brand Alternatives

  • O2 Syrup
  • Oflox OZ Syrup
  • Zanocin OZ Syrup

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Ofloxacin 50mg/5ml + Ornidazole 125mg/5ml","route":"Oral","frequency":"Twice daily"},{"medicine":"Metronidazole + Ofloxacin","composition":"Ofloxacin 50mg/5ml + Metronidazole 100mg/5ml","route":"Oral","frequency":"Twice daily"},{"medicine":"Ciprofloxacin + Tinidazole","composition":"Ciprofloxacin 100mg/5ml + Tinidazole 150mg/5ml","route":"Oral","frequency":"Twice daily"}]

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