Floxisure OT Cream: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe burning, blistering, or peeling at the application site
- Signs of allergic reaction such as rash, swelling of face, lips, or throat, or difficulty breathing
- Worsening of the fungal infection or spread to new areas
- Signs of systemic steroid effects like weight gain, moon face, easy bruising, or fatigue
- Symptoms of adrenal insufficiency such as weakness, dizziness, or low blood pressure
- New or worsening skin infection (bacterial or fungal) at the application site
- Yellowing of skin or eyes, or dark urine
If experiencing severe symptoms, call emergency services immediately.
What is Floxisure OT Cream used for?
This medicine is a topical cream combining terbinafine (an antifungal) and clobetasol (a potent steroid). It is used short-term to treat inflamed fungal skin infections like ringworm. Apply a thin film as prescribed, usually for no more than 2 weeks. Do not use on the face or groin unless directed. Consult a doctor if symptoms worsen.
- Generic Name: Terbinafine (1% w/v) + Clobetasol (0.05% w/v)
- Manufacturer: Metamorf Lifesciences
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Floxisure OT Cream के बारे में (Hindi Summary)
उपयोग: यह दवा एक टॉपिकल क्रीम है जिसमें टर्बिनाफाइन (एक एंटीफंगल) और क्लोबेटासोल (एक शक्तिशाली स्टेरॉयड) होता है। इसका उपयोग सूजन वाले फंगल त्वचा संक्रमण जैसे दाद, खुजली और पैरों के फंगस के इलाज के लिए किया जाता है। यह खुजली, लालिमा और सूजन को कम करता है और फंगस को मारता है। इसे डॉक्टर के निर्देशानुसार ही लगाएं, आमतौर पर 1-2 सप्ताह से ज्यादा नहीं। चेहरे, जांघों या बगलों पर बिना डॉक्टर की सलाह के न लगाएं।
साइड इफेक्ट्स: आम दुष्प्रभावों में लगाने की जगह पर हल्की जलन, खुजली, सूखापन या लालिमा शामिल हैं। ये आमतौर पर अस्थायी होते हैं। लंबे समय तक उपयोग से त्वचा पतली हो सकती है, खिंचाव के निशान पड़ सकते हैं और शरीर में स्टेरॉयड के दुष्प्रभाव हो सकते हैं। अगर त्वचा पर गंभीर लालिमा, सूजन या छाले पड़ें तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को सिर्फ बाहरी त्वचा पर लगाएं। आंखों, मुंह और श्लेष्मा झिल्ली के संपर्क में न आने दें। डॉक्टर के बताए समय से ज्यादा इस्तेमाल न करें, आमतौर पर 2 सप्ताह से अधिक नहीं। बिना डॉक्टर की सलाह के चेहरे, जांघों या बगलों पर न लगाएं। अगर आप गर्भवती हैं, स्तनपान करा रही हैं या गर्भधारण की योजना बना रही हैं तो डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें।
💊 Floxisure OT Cream Uses & Benefits
[{"condition":"Inflammatory tinea corporis (ringworm of the body)","description":"Used short-term to treat fungal infection of the body skin when significant inflammation, itching, or redness is present.","evidence":"Well-established for short-term use under medical supervision"},{"condition":"Inflammatory tinea cruris (jock itch)","description":"Applied to the groin area for a limited period to reduce fungal infection and associated inflammation.","evidence":"Well-established but caution needed due to sensitive skin area"},{"condition":"Inflammatory tinea pedis (athlete's foot)","description":"Used to treat fungal infection of the feet with marked inflammation or itching.","evidence":"Well-established for short-term use"}]
Off-label uses: [{"condition":"Inflammatory dermatophytosis with secondary eczema","description":"Sometimes prescribed when fungal infection is accompanied by eczematous changes, but only for a short duration.","evidence":"Limited; specialist supervision required"}]
Primary treatment for: Inflammatory fungal skin infections (dermatophytosis)
Also treats: Tinea corporis, Tinea cruris, Tinea pedis
📋 Drug Information
| Generic Name(s) | Terbinafine (1% w/v) + Clobetasol (0.05% w/v) |
| Brand Name | Floxisure OT Cream |
| Manufacturer | Metamorf Lifesciences |
| Packaging / Form | tube of 15 gm Cream (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Topical |
| Storage | Store at room temperature (15-30°C). Protect from light and moisture. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise specified on the packaging. |
| WHO Guideline | Not established from the available information. Topical antifungal-corticosteroid combinations are generally not recommended as first-line therapy by WHO for uncomplicated fungal infections due to risk of steroid side effects and masking of infection. |
| ICMR Guideline | Not established from the available information. ICMR guidelines generally advise against routine use of topical corticosteroid-antifungal combinations for superficial fungal infections due to concerns of steroid-modified tinea and relapse. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Terbinafine is an allylamine antifungal that selectively inhibits fungal squalene epoxidase, an enzyme essential for ergosterol synthesis in the fungal cell membrane. This inhibition leads to squalene accumulation and ergosterol deficiency, causing fungal cell membrane disruption and cell death. Clobetasol propionate is a very potent synthetic corticosteroid that binds to glucocorticoid receptors in the skin, leading to suppression of inflammatory mediators, reduced migration of inflammatory cells, and stabilization of lysosomal membranes. Together, terbinafine kills the fungus while clobetasol rapidly reduces inflammation, itching, and redness.
Mechanism Steps
💡 How to Take Floxisure OT Cream
Strength: Cream containing terbinafine 1% w/v and clobetasol 0.05% w/v.
Dosage Information
| Adult Dosage | Apply a thin film of this medicine to the affected skin area once or twice daily, or as directed by your doctor. The duration of treatment is typically limited to 1-2 weeks because it contains a very potent corticosteroid. Do not use for longer than prescribed. Dose must be individualized by a qualified clinician based on the indication, severity, and response to treatment. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine is generally not recommended for children under 12 years due to the potent corticosteroid component. |
| Elderly Dosage | Elderly patients may be more susceptible to the effects of topical corticosteroids, including skin thinning and systemic absorption. Use with caution and for the shortest duration possible. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No specific dose adjustment is established for topical use in renal impairment. Systemic absorption is minimal. Use with caution if applying to large areas or if renal function is severely impaired. |
| Hepatic Impairment | No specific dose adjustment is established for topical use in hepatic impairment. Systemic absorption is minimal. Use with caution if applying to large areas or if hepatic function is severely impaired. |
| Maximum Daily Dose | Not established from the available information. Use only as prescribed by your doctor, typically for a maximum of 2 weeks. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Floxisure OT Cream
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Other topical corticosteroids | Major | |
| CYP3A4 inhibitors | Major | |
| CYP2C9 inhibitors | Moderate | |
| CYP1A2 inhibitors | Moderate | |
| Other topical products | Minor |
🚨 Major Interactions
- Other topical corticosteroids
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, clarithromycin)
⚡ Moderate Interactions
- CYP2C9 inhibitors (e.g., fluconazole)
- CYP1A2 inhibitors (e.g., ciprofloxacin)
🍷 Alcohol Interaction
No known interaction between this topical medicine and alcohol. However, alcohol may worsen certain skin conditions or interact with other medicines you are taking. Consult your doctor for personalized advice.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to terbinafine, clobetasol, or any component of the formulation","Untreated bacterial or viral skin infections (e.g., impetigo, herpes simplex, chickenpox)","Acne vulgaris, rosacea, perioral dermatitis","Use on the face, groin, or underarms unless specifically directed by a doctor","Use in children under 12 years unless prescribed by a doctor","Ophthalmic use"]
⚠️ Warnings & Precautions
["For external use only. Do not swallow.","Avoid contact with eyes, mouth, and mucous membranes.","Do not use on open wounds or broken skin.","Do not cover with airtight dressings unless instructed.","Do not use for longer than prescribed, typically not more than 2 weeks.","Prolonged use can cause skin thinning, stretch marks, and systemic steroid effects.","Corticosteroids can mask or worsen fungal infections; if infection worsens, consult your doctor.","Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Keep out of reach of children.","Do not share this medicine with others."]
🤱 Lactation Safety
It is not known whether topical terbinafine or clobetasol is excreted in breast milk in significant amounts. To minimize infant exposure, avoid applying to the breast area and do not apply to large areas. Consult your doctor before use while breastfeeding.
💊 Overdose Management
Overdose from topical application is unlikely. If accidental ingestion occurs, seek immediate medical attention. Symptoms of systemic corticosteroid overdose may include weakness, fatigue, nausea, and low blood pressure. Treatment is supportive and symptomatic.
⏰ Missed Dose
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.
Additional Safety Advice
Apply this medicine exactly as prescribed by your doctor, usually a thin film to the affected area once or twice daily. Do not cover the area with airtight dressings unless instructed, as this increases absorption and side effects. Avoid contact with eyes, mouth, and other mucous membranes. Wash your hands thoroughly after applying unless your hands are the treated area. Do not use this medicine for longer than the prescribed duration, typically not more than two weeks, because prolonged use of potent topical steroids can cause skin damage and systemic effects. Do not use on the face, groin, or underarms unless your doctor specifically tells you to. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before using this medicine. Keep out of reach of children. Do not share this medicine with others, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more susceptible to the side effects of topical corticosteroids, including skin thinning, easy bruising, and systemic absorption. Use the smallest effective amount for the shortest duration. Monitor for signs of adrenal suppression if used extensively.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. Topical corticosteroids should be used during pregnancy only if clearly needed. Limit use to the smallest area and shortest duration. Terbinafine topical use is generally considered low risk, but consult your doctor.
🏥 Post-Surgery Considerations
Consult your doctor before using this medicine on surgical wounds or near incision sites. It should not be applied to open wounds or broken skin. If you have a fungal infection after surgery, your doctor will advise on appropriate treatment.
🦷 Dental Procedures
No specific considerations for dental procedures. This medicine is for topical skin use and does not interact with dental anesthetics or procedures. Inform your dentist about all medicines you are using.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
No specific exercise restrictions while using this medicine. However, if you have athlete's foot, avoid barefoot walking in public areas and keep feet dry during exercise. If the treated area is irritated, avoid activities that cause excessive sweating or friction.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is applied topically and is unlikely to affect your ability to drive or operate machinery. However, if you experience any dizziness or allergic reaction, avoid these activities until you feel better. It does not generally interfere with work or daily activities.
🛑 When to Stop This Medicine
Stop using this medicine after the prescribed duration, usually not more than 2 weeks, unless your doctor advises otherwise. If the infection worsens, spreads, or if you develop signs of skin thinning or systemic steroid effects, stop and consult your doctor immediately. Do not stop abruptly if you have been using it for a long time without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to skin atrophy, stretch marks, telangiectasia, and systemic absorption of clobetasol, which may cause adrenal suppression, Cushing's syndrome, and hyperglycemia. It can also mask or worsen fungal infections. Regular monitoring of skin condition and signs of systemic steroid effects is advised if used for more than 2 weeks.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For uncomplicated fungal infections without significant inflammation, a plain antifungal cream is preferred to avoid steroid side effects.
Evidence: Well-establishedFor extensive or resistant fungal infections, oral antifungals may be prescribed by a doctor.
Evidence: Well-establishedKeeping skin clean and dry, avoiding sharing personal items, and wearing breathable clothing can help prevent recurrence.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interaction between this topical medicine and vaccines. However, if you are using it over a large area for a prolonged period, systemic steroid absorption could theoretically affect immune response. Consult your doctor before vaccination if you have concerns.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case you need to show it at customs. Store at room temperature and protect from extreme heat or cold. If traveling across time zones, continue applying as per your usual schedule; topical application does not require strict time zone adjustment. Keep it in your carry-on luggage if you need it during the flight, but ensure it complies with liquid regulations for creams.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Itching and redness may start to improve within a few days. The fungal infection itself may take 1-2 weeks to clear. Complete the full course as prescribed.
A: No, stopping too early may allow the infection to return. Complete the prescribed duration unless your doctor advises otherwise.
A: It is generally not recommended for children under 12 years due to the potent steroid. Consult a pediatrician.
A: Consult your doctor before use. Topical use should be limited to the smallest area and shortest duration.
A: Seek immediate medical attention. Overdose from ingestion can cause systemic steroid effects.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This cream can be used for any skin rash.
Fact: It is only for specific fungal infections with inflammation. Using it for other rashes can worsen the condition. - Myth: The more you apply, the faster it works.
Fact: Applying more than prescribed increases the risk of side effects without speeding up recovery. - Myth: It is safe to use for months.
Fact: Prolonged use of potent steroids can cause skin thinning and other serious effects. Use only for the prescribed duration. - Myth: Once symptoms improve, you can stop the cream.
Fact: Stopping too early may allow the fungal infection to return. Complete the full course as prescribed.
🔄 Alternative Options
Generic Alternatives
- Terbinafine 1% + Clobetasol 0.05% cream
Brand Alternatives
- Floxisure OT Cream