Mifepristone 25mg Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Heavy vaginal bleeding that soaks more than one pad per hour for several hours
- Severe or worsening abdominal pain
- Fever, chills, or foul-smelling vaginal discharge
- Yellowing of the skin or eyes, dark urine, or right upper abdominal pain
- Swelling of the face, lips, tongue, or throat, or difficulty breathing
- Severe headache with visual changes
- Decreased urine output or swelling in the legs
If experiencing severe symptoms, call emergency services immediately.
What is fibromif 25mg tablet used for?
This medicine contains Mifepristone 25mg, an antiprogestin used primarily to treat uterine fibroids by reducing their size and relieving symptoms like heavy bleeding and pelvic pain. It works by blocking progesterone receptors. It must be taken under medical supervision and is not suitable during pregnancy.
- Generic Name: Mifepristone (25mg)
- Manufacturer: Jay Ell Healthcare Pvt. Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 fibromif 25mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मिफेप्रिस्टोन 25mg टैबलेट है, जिसका उपयोग मुख्य रूप से गर्भाशय के फाइब्रॉएड के इलाज में किया जाता है। यह फाइब्रॉएड का आकार कम करने और भारी मासिक धर्म, पेल्विक दर्द और दबाव जैसे लक्षणों को कम करने में मदद करती है। यह प्रोजेस्टेरोन हार्मोन के प्रभाव को रोककर काम करती है। इस दवा को डॉक्टर की देखरेख में ही लेना चाहिए। गर्भावस्था में इसका सेवन नहीं करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट में ऐंठन, सिरदर्द, चक्कर आना और थकान शामिल हैं। कुछ लोगों को योनि से रक्तस्राव या स्पॉटिंग भी हो सकती है। गंभीर दुष्प्रभावों में भारी रक्तस्राव, तेज पेट दर्द, बुखार या एलर्जी की प्रतिक्रिया शामिल हो सकती है। अगर आपको कोई भी असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को केवल डॉक्टर के बताए अनुसार ही लें। अपनी मर्जी से खुराक न बदलें और न ही दवा लेना बंद करें। गर्भावस्था से बचने के लिए इलाज के दौरान प्रभावी गर्भनिरोधक तरीके अपनाएं। शराब का सेवन न करें क्योंकि इससे चक्कर और पेट की समस्या बढ़ सकती है। नियमित फॉलो-अप के लिए डॉक्टर के पास जाएं। दवा को बच्चों की पहुंच से दूर रखें।
💊 fibromif 25mg tablet Uses & Benefits
- [{"condition":"Uterine fibroids","description":"This medicine is used to reduce the size of uterine fibroids and to relieve symptoms such as heavy menstrual bleeding, pelvic pain, and pressure.
- It is often prescribed for a limited duration before surgery or as part of a longer-term management plan.","evidence":"Well-established"},{"condition":"Preoperative preparation for fibroid surgery","description":"In some cases, this medicine is used before surgery to shrink fibroids, which may make the procedure easier and reduce blood loss.","evidence":"Established"},{"condition":"Cushing's syndrome","description":"At higher doses, Mifepristone is approved in some countries for the treatment of endogenous Cushing's syndrome in adults who are not suitable for surgery.
- This use is not the same as the 25mg tablet and requires specialist supervision.","evidence":"Established for specific high-dose formulations"}]
Off-label uses: [{"condition":"Endometriosis","description":"Sometimes prescribed off-label to help manage pain associated with endometriosis, though evidence is still evolving.","evidence":"Limited"},{"condition":"Emergency contraception","description":"Mifepristone has been studied for emergency contraception, but this is not the standard use of the 25mg tablet and should not be self-administered for this purpose.","evidence":"Limited for this formulation"}]
Primary treatment for: Uterine fibroids
Also treats: Heavy menstrual bleeding associated with fibroids, Pelvic pain and pressure due to fibroids
📋 Drug Information
| Generic Name(s) | Mifepristone (25mg) |
| Brand Name | fibromif 25mg tablet |
| Manufacturer | Jay Ell Healthcare Pvt. Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | Anti-progesterone |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Keep the tablets in their original packaging, away from moisture and direct sunlight. Do not refrigerate unless specifically instructed. |
| Shelf Life | Refer to the expiry date printed on the packaging. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by blocking progesterone receptors in the body. Progesterone is a hormone that helps maintain the lining of the uterus and supports the growth of certain tissues, including uterine fibroids. By binding to these receptors, Mifepristone prevents progesterone from exerting its effects, which can lead to a reduction in fibroid size and a decrease in associated symptoms such as heavy bleeding and pelvic pressure. It may also affect the lining of the uterus directly, contributing to its therapeutic effects.
Mechanism Steps
💡 How to Take fibromif 25mg tablet
Strength: Mifepristone 25mg immediate-release tablet
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the condition being treated, the patient's age, weight, liver and kidney function, and other factors. For uterine fibroids, a common regimen is one 25mg tablet taken orally once daily, but the exact dose and duration must be determined by your doctor. Do not adjust the dose without medical advice. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Dose selection should be cautious, and liver and kidney function should be considered. Follow your doctor's instructions carefully. |
| Renal Impairment | Dose adjustment may be necessary in patients with kidney impairment. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Dose adjustment may be necessary in patients with liver impairment. Mifepristone is metabolized in the liver, so caution is advised. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose depends on the indication and must be determined by a qualified clinician. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of fibromif 25mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Rifampicin | Major | |
| Warfarin | Moderate | |
| Ibuprofen | Moderate | |
| Dexamethasone | Major | |
| St. John's wort | Major | |
| Clarithromycin | Major | |
| Carbamazepine | Major | |
| Phenytoin | Major | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir)
- CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin, St. John's wort)
- Corticosteroids (e.g., dexamethasone, prednisolone)
⚡ Moderate Interactions
- NSAIDs (e.g., ibuprofen, diclofenac)
- Anticoagulants (e.g., warfarin)
🍷 Alcohol Interaction
Alcohol may worsen side effects such as dizziness, drowsiness, and stomach upset. It is advisable to avoid alcohol while taking this medicine, especially if you are also taking other medicines that affect the liver.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to Mifepristone or any component of the tablet","Pregnancy intended to be continued","Breastfeeding","Adrenal insufficiency","Severe liver disease","Use of certain medicines that strongly affect CYP3A4 enzymes without medical supervision","Undiagnosed vaginal bleeding"]
⚠️ Warnings & Precautions
["This medicine must only be used under the supervision of a qualified healthcare professional.","Do not use this medicine if you are pregnant and wish to continue the pregnancy.","Use effective contraception during treatment to avoid pregnancy.","Inform your doctor if you have liver or kidney problems before starting this medicine.","Avoid alcohol while taking this medicine.","Do not drive or operate machinery if you feel dizzy or fatigued.","Keep all follow-up appointments for monitoring.","Do not share this medicine with others."]
🤱 Lactation Safety
It is not known whether Mifepristone passes into breast milk. Because of the potential for serious adverse effects in a nursing infant, breastfeeding is not recommended while taking this medicine. Discuss with your doctor about alternative feeding options.
💊 Overdose Management
There is no specific antidote for Mifepristone overdose. In case of suspected overdose, seek immediate medical attention. Treatment is supportive and symptomatic. Contact a poison control centre or emergency department for guidance.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
This medicine must only be taken exactly as prescribed by your doctor. Do not share it with anyone else, and do not change the dose on your own. Because Mifepristone can affect hormone-sensitive tissues, it is essential to tell your doctor if you are pregnant, planning pregnancy, or breastfeeding. Avoid alcohol while taking this medicine, as it can worsen dizziness and stomach upset. Use reliable contraception during treatment unless your doctor has advised otherwise. Keep all follow-up appointments so your doctor can check your response and monitor for any complications. Store the tablets in their original packaging, away from moisture and direct sunlight, and keep them out of reach of children. If you experience heavy bleeding, severe pain, or feel unwell, seek medical help immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine, especially regarding liver and kidney function. Dose adjustments may be necessary. Regular monitoring is advised.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated if you are trying to conceive or are pregnant. Use effective contraception during treatment. If you plan to become pregnant, discuss with your doctor and stop the medicine as advised. Wait for your doctor's guidance before attempting conception.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon and anaesthesiologist that you are taking this medicine. It may affect bleeding and healing. Your doctor may advise you to stop the medicine before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may affect bleeding and healing. Your dentist may consult with your doctor before proceeding.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience fatigue or dizziness. Avoid strenuous exercise if you feel unwell. Light to moderate exercise is generally safe, but consult your doctor before starting any new exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. Most people can continue their daily activities with some adjustments. Inform your employer if you need flexible hours for medical appointments.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Your doctor will determine the appropriate duration of treatment based on your condition and response. If you experience severe side effects, contact your doctor immediately for advice.
📅 Long-Term Use Effects
Long-term use of this medicine may be associated with effects on liver function, bone density, and hormonal balance. Regular monitoring of liver enzymes and symptoms is recommended. The duration of treatment should be determined by your doctor based on your condition and response. Do not use for longer than prescribed without medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another oral medicine for uterine fibroids that works by a similar mechanism.
Evidence: Well-establishedInjectable medicines that shrink fibroids by reducing oestrogen levels.
Evidence: Well-establishedSurgical removal of fibroids or the uterus for definitive treatment.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, always inform your healthcare provider about all medicines you are taking before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your hand luggage to avoid loss or exposure to extreme temperatures. Store at room temperature and away from direct sunlight. If crossing time zones, continue taking your dose at the same interval as prescribed, but consult your doctor for specific advice. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may notice reduced bleeding within a few weeks, but changes in fibroid size may take several months. Follow your doctor's advice for monitoring.
A: Yes, you can take it with or without food as advised by your doctor. Taking it with food may help reduce nausea.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, this medicine is contraindicated during pregnancy when the intention is to continue the pregnancy. It can cause termination of pregnancy. Consult your doctor immediately if you become pregnant.
🤔 Common Patient Concerns
🔄 Substitutes for fibromif 25mg tablet
View AllAlternative brands with exact same active ingredient:
-
fibrograce tabletSignorah Healthcare ₹328.13 24.4% CHEAPER
-
fibisafe 25mg tabletRhine Biogenics Pvt Ltd ₹360.94 16.8% CHEAPER
-
mifistar 25 tabletMedgrow Health Care ₹365.63 15.8% CHEAPER
-
fibrocede 25 tabletBlisson Medica Private Limited ₹398.44 8.2% CHEAPER
-
mifescan 25 tabletVhl Pharmaceuticals Private Limited ₹468.75 8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a painkiller.
Fact: This medicine is not a painkiller. It is an antiprogestin used for specific hormonal conditions such as uterine fibroids. - Myth: This medicine can be taken without a doctor's supervision.
Fact: This medicine must only be taken under the supervision of a qualified healthcare professional due to its potent effects and potential risks. - Myth: This medicine is safe to take during pregnancy.
Fact: This medicine is contraindicated in pregnancy when the intention is to continue the pregnancy. It can cause termination of pregnancy.
🔄 Alternative Options
Generic Alternatives
- Mifepristone 25mg tablet
Brand Alternatives
- Fibroease 25mg tablet