friptal tablet - Ulipristal acetate (5mg) medicine

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🏭 Jay Ell Healthcare Pvt. Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 21, 2026
⚠️ Hepatotoxicity Risk 🤰 Pregnancy Category This medicine is contraindicated in pregnancy. It may cause harm to the developing fetus. Women of childbearing potential should use effective contraception during treatment and for a period after stopping, as advised by their doctor. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for the treatment of uterine fibroids.
Reviewed by
SaathiMed Expert Panel | Oct 21, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Yellowing of skin or eyes (jaundice)
  • Dark urine or pale stools
  • Severe abdominal pain, especially in the upper right area
  • Swelling of face, lips, or throat
  • Difficulty breathing or swallowing
  • Unusual tiredness or weakness
  • Severe headache with visual changes
  • Heavy or prolonged vaginal bleeding

If experiencing severe symptoms, call emergency services immediately.

What is friptal tablet used for?

This medicine contains Ulipristal acetate 5mg, a selective progesterone receptor modulator used to treat uterine fibroids. It reduces heavy menstrual bleeding and shrinks fibroids. It is taken orally once daily for up to 3 months under medical supervision.

  • Generic Name: Ulipristal acetate (5mg)
  • Manufacturer: Jay Ell Healthcare Pvt. Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 friptal tablet के बारे में (Hindi Summary)

उपयोग: यह दवा यूटेराइन फाइब्रॉएड (गर्भाशय के ट्यूमर) के इलाज के लिए इस्तेमाल की जाती है। यह भारी मासिक धर्म को कम करने और फाइब्रॉएड का आकार घटाने में मदद करती है। यह दवा केवल डॉक्टर के पर्चे पर ही मिलती है और इसे डॉक्टर की सलाह के अनुसार ही लेना चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, मतली, पेट दर्द, थकान और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें लिवर की समस्या, एलर्जी प्रतिक्रिया आदि हो सकते हैं। यदि आपको पीलिया, गहरे रंग का पेशाब, या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं और दवाओं के बारे में बताएं। गर्भवती महिलाओं को यह दवा नहीं लेनी चाहिए। इस दवा को लेते समय शराब का सेवन न करें। नियमित रूप से डॉक्टर से जांच कराते रहें। दवा को बच्चों की पहुंच से दूर रखें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 friptal tablet Uses & Benefits

[{"condition":"Uterine fibroids (leiomyomas)","description":"This medicine is used to treat moderate to severe symptoms of uterine fibroids in women of reproductive age, including heavy menstrual bleeding and pelvic pressure.","evidence":"Well-established"},{"condition":"Preoperative treatment for uterine fibroids","description":"It may be used before surgery to reduce fibroid size and correct anemia, making surgery easier and safer.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Emergency contraception","description":"Ulipristal acetate at a higher dose (30 mg) is approved for emergency contraception, but the 5 mg dose is not intended for this use.","evidence":"Not established for this strength"}]

Primary treatment for: Uterine fibroids

Also treats: Heavy menstrual bleeding, Anemia due to heavy bleeding, Pelvic pain

📋 Drug Information

Generic Name(s)Ulipristal acetate (5mg)
Brand Namefriptal tablet
ManufacturerJay Ell Healthcare Pvt. Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGYNAECOLOGICAL
Action ClassSelective Progesterone receptor modulators(SPRM)
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at the same time each day to maintain consistent levels.
2
Use effective non-hormonal contraception while taking this medicine and for a period after stopping, as advised by your doctor.
3
Avoid alcohol completely during treatment to reduce the risk of liver problems.
4
Report any signs of liver injury such as yellowing of eyes or skin, dark urine, or severe abdominal pain immediately.
5
Do not stop taking this medicine without consulting your doctor, even if you feel better.
6
Keep all scheduled follow-up appointments for monitoring liver function and treatment response.
7
Inform your doctor if you are planning to become pregnant or if you suspect you might be pregnant.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Heavy menstrual bleeding
This medicine is commonly prescribed for this.
Likely Use
✅
Pelvic pain or pressure
This medicine may help reduce fibroid-related pelvic pressure.
Likely Use
❌
Fever
This medicine is not a fever reducer.
Not Primary
❌
Headache
This medicine is not used for headache relief; it may cause headache as a side effect.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionFollowing oral administration, ulipristal acetate is rapidly absorbed. The absolute bioavailability is not well established but is thought to be moderate. Food does not significantly affect the absorption of this medicine.
DistributionUlipristal acetate is highly protein-bound and distributes widely into tissues. It is not known to what extent it crosses the placenta or enters breast milk.
Protein BindingUlipristal acetate is approximately 97% bound to plasma proteins, including albumin and alpha-1-acid glycoprotein.
MetabolismUlipristal acetate is extensively metabolized in the liver, primarily by the cytochrome P450 enzyme CYP3A4. It undergoes oxidative metabolism to form several metabolites, some of which may be active.
Half-LifeThe terminal elimination half-life of ulipristal acetate is approximately 38 hours.
ExcretionUlipristal acetate and its metabolites are excreted mainly in the feces, with a smaller amount excreted in the urine.
BioavailabilityThe absolute bioavailability of ulipristal acetate is not well established from the available information.
Onset of ActionThe onset of action for symptom relief (such as reduction in bleeding) may take several days to weeks. For fibroid size reduction, it may take several months.
Peak Plasma TimePeak plasma concentrations are reached approximately 1 to 2 hours after oral administration.
Duration of ActionThe duration of action depends on the indication and treatment duration. For fibroid treatment, courses are typically 3 months, with effects lasting during treatment.

How It Works

This medicine works by selectively binding to progesterone receptors and modulating their activity. It acts as a selective progesterone receptor modulator, which means it can have both agonist and antagonist effects depending on the tissue. In uterine fibroids, it primarily acts as an antagonist, reducing progesterone-driven cell proliferation and inducing apoptosis (cell death) in fibroid cells. This leads to a reduction in fibroid size and associated symptoms such as heavy bleeding.

Mechanism Steps

1
Binding to progesterone receptors: This medicine binds with high affinity to progesterone receptors in target tissues such as the uterus and fibroids.
2
Modulation of receptor activity: It acts as an antagonist in fibroid tissue, blocking the effects of progesterone that promote fibroid growth.
3
Reduction in fibroid cell proliferation: By blocking progesterone, it reduces cell division and induces programmed cell death in fibroid cells.
4
Decreased bleeding and fibroid size: The overall effect is a reduction in fibroid size and a significant decrease in heavy menstrual bleeding.

💡 How to Take friptal tablet

Strength: Capsule, 5 mg

1Take this medicine exactly as prescribed by your doctor.
2Swallow the capsule whole with a glass of water.
3You can take it with or without food.
4Take it at the same time each day to maintain consistent levels.
5Do not crush, chew, or open the capsule.
6If you miss a dose, follow the missed dose instructions.
7Do not stop taking this medicine without consulting your doctor.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 5 mg taken orally once daily for up to 3 months. The dose and duration must be individualized by a qualified clinician based on the indication, severity of symptoms, and patient response. Treatment courses may be repeated, but only under medical supervision. Do not exceed the prescribed dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageThere is limited information on the use of this medicine in elderly patients. It is not typically indicated for use in postmenopausal women. Dose must be individualized by a qualified clinician.
Renal ImpairmentNo specific dose adjustment is recommended for renal impairment. However, use with caution in patients with severe renal impairment. Dose must be individualized by a qualified clinician.
Hepatic ImpairmentThis medicine is contraindicated in patients with severe liver disease. In patients with mild to moderate hepatic impairment, no dose adjustment is recommended, but caution is advised. Dose must be individualized by a qualified clinician.
Maximum Daily Dose5 mg once daily.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With or without food
Take at the same time each day
Food does not significantly affect absorption.
Grapefruit
Avoid
May increase drug levels and risk of side effects.
Alcohol
Avoid
May increase risk of liver problems.

⏰ What to Do If You Miss a Dose

📌 Less than 12 hours have passed since the missed dose
→ Take the missed dose as soon as you remember.
💡 Continue with your regular schedule.
📌 More than 12 hours have passed since the missed dose
→ Skip the missed dose.
💡 Do not double dose to catch up. Take your next dose at the regular time.

⚠️ Side Effects of friptal tablet

✅ Common Side Effects

Headache (Common (5-10%))
Usually resolves on its own. Consult doctor if persistent or severe.
Nausea (Common (5-10%))
Take with food to reduce nausea. Consult doctor if it continues.
Abdominal pain (Common (5-10%))
Use a heating pad and rest. If pain is severe, contact your doctor.
Fatigue (Common (5-10%))
Ensure adequate rest. If fatigue interferes with daily activities, consult your doctor.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how this medicine affects you.

🚨 Serious Side Effects

Liver injury (Rare (<0.1%))
Seek immediate medical attention if you notice yellowing of skin or eyes, dark urine, or severe abdominal pain.
Severe allergic reaction (Rare (<0.1%))
Seek emergency help if you experience swelling of face, lips, throat, or difficulty breathing.
Endometrial changes (Uncommon (0.1-1%))
Report any abnormal vaginal bleeding to your doctor. Regular monitoring may be required.

⚠️ Rare Side Effects

Palpitations
Consult your doctor if you experience a racing or irregular heartbeat.
Anxiety
Discuss with your doctor if anxiety becomes bothersome.
Acne
Maintain good skin hygiene. Consult a dermatologist if severe.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major
Rifampicin Major
Grapefruit juice Moderate
Hormonal contraceptives Moderate
Antacids Minor

🚨 Major Interactions

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, clarithromycin)
  • Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin)

⚡ Moderate Interactions

  • Moderate CYP3A4 inhibitors (e.g., grapefruit juice, fluconazole)
  • Hormonal contraceptives

🍷 Alcohol Interaction

Alcohol may increase the risk of liver problems when taken with this medicine. It is advisable to avoid alcohol during treatment.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Pregnancy","Known hypersensitivity to ulipristal acetate or any component of the formulation","Breastfeeding","Severe liver disease","Undiagnosed vaginal bleeding"]

⚠️ Warnings & Precautions

["This medicine is not a contraceptive and should not be used as one.","Use effective non-hormonal contraception during treatment and for a period after stopping.","Avoid alcohol during treatment due to increased risk of liver problems.","Report any signs of liver injury immediately.","Regular monitoring of liver function is recommended.","Do not use if you are pregnant or planning to become pregnant.","Caution in patients with renal impairment.","May cause dizziness; avoid driving or operating machinery until you know how it affects you."]

🤱 Lactation Safety

It is not known whether ulipristal acetate is excreted in human breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother.

💊 Overdose Management

There is no specific antidote for overdose with this medicine. In case of suspected overdose, seek immediate medical attention. Treatment should be symptomatic and supportive. Monitor liver function and vital signs.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Before taking this medicine, inform your doctor if you have any liver problems, kidney disease, or a history of allergic reactions to similar medicines. This medicine is not recommended during pregnancy. Women of childbearing potential should use effective non-hormonal contraception while taking this medicine and for a period after stopping, as advised by the doctor. Avoid alcohol while taking this medicine as it may increase the risk of liver problems. Do not take this medicine if you are breastfeeding, as it may pass into breast milk and affect the baby. Regular follow-up visits and blood tests may be necessary to monitor liver function and other parameters. Do not share this medicine with others, even if they have similar symptoms. Keep this medicine out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

This medicine is not typically indicated for use in postmenopausal women. Safety and efficacy in elderly patients have not been established. Consult your doctor for individualized advice.

🤰 Pregnancy Planning (TTC)

This medicine is contraindicated during pregnancy. Women planning to become pregnant should stop this medicine and consult their doctor. Use effective contraception during treatment and for a period after stopping, as advised by your doctor.

🏥 Post-Surgery Considerations

If you are scheduled for surgery, inform your surgeon that you are taking this medicine. It may need to be stopped before surgery as advised by your doctor.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine before any dental procedure. No specific precautions are usually needed, but your dentist may consult your doctor.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce pressure on the uterus.
🥗
Eat a balanced diet rich in iron to prevent anemia from heavy bleeding.
😴
Stay hydrated by drinking plenty of water.
💧
Avoid alcohol and limit caffeine intake.
🧘
Practice stress-reducing activities like yoga or meditation.
🌞
Get regular exercise, but consult your doctor before starting any new routine.
🚭
Keep track of your menstrual bleeding patterns and report any changes to your doctor.

🏋️ Exercise Considerations

Moderate exercise is generally safe while taking this medicine. However, if you experience dizziness or fatigue, avoid strenuous activities. Consult your doctor before starting any new exercise regimen.

🥗 Diet Recommendations

Include iron-rich foods like leafy greens, beans, and lean meats to prevent anemia.
Eat plenty of fruits and vegetables for antioxidants.
Avoid grapefruit and grapefruit juice.
Limit processed foods and added sugars.
Stay well hydrated.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or fatigue in some people. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal daily activities with caution.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as signs of liver injury, seek immediate medical attention and your doctor will advise whether to stop the medicine.

📅 Long-Term Use Effects

Long-term use of this medicine may be associated with changes in the endometrium (lining of the uterus), which are usually reversible after stopping treatment. Regular monitoring of liver function is recommended. The safety and efficacy of treatment beyond 3 months have not been established. Repeated courses may be considered under medical supervision.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Surgical removal of fibroids (myomectomy)

A surgical option to remove fibroids while preserving the uterus.

Evidence: Well-established
Hormonal contraceptives

May help control heavy bleeding but do not shrink fibroids.

Evidence: Well-established
Uterine artery embolization

A minimally invasive procedure to shrink fibroids by blocking blood supply.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while on this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✅ DO

Keep out of reach of children

❌ DON'T

Do not use after expiry date

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, continue taking your dose at the same time each day as close as possible. Check local customs regulations for carrying prescription medicines. Always carry enough supply for your entire trip.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 38-year-old woman with heavy menstrual bleeding due to uterine fibroids
She was prescribed this medicine for 3 months. Within the first month, her bleeding reduced significantly, and her energy levels improved. She experienced mild headaches initially, which resolved. She emphasized the importance of taking the medicine at the same time daily and avoiding alcohol.
💡 Lesson: Consistent daily dosing and avoiding alcohol can improve treatment outcomes and reduce side effects.
👤 A 42-year-old woman scheduled for fibroid surgery
She took this medicine for 3 months before surgery to shrink her fibroids and correct anemia. Her fibroids reduced in size, and her hemoglobin improved, making surgery safer. She reported mild nausea, which was managed by taking the medicine with food.
💡 Lesson: Preoperative treatment with this medicine can reduce fibroid size and improve surgical outcomes.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: You may notice a reduction in bleeding within the first few weeks. Shrinkage of fibroids may take several months of treatment.

Q: Can I take this medicine with food?

A: Yes, you can take it with or without food. However, avoid grapefruit and alcohol.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Q: Is this medicine safe during pregnancy?

A: No, this medicine is contraindicated during pregnancy as it may harm the developing baby. Use effective contraception during treatment.

Q: Can I stop taking this medicine on my own?

A: No, do not stop taking this medicine without consulting your doctor. Stopping abruptly may cause symptoms to return.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my liver?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Does this medicine affect my fertility?
  • Can I take this medicine if I have diabetes?

🔄 Substitutes for friptal tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is a contraceptive.
    Fact: This medicine is not a contraceptive and should not be used as one. It is used to treat uterine fibroids.
  • Myth: This medicine can be taken without a prescription.
    Fact: This medicine is a prescription-only medicine and must be taken under medical supervision.
  • Myth: This medicine is safe during pregnancy.
    Fact: This medicine is contraindicated during pregnancy as it may harm the developing baby.

🔄 Alternative Options

Generic Alternatives

  • Ulipristal acetate 5mg capsule

Brand Alternatives

  • Blata 5mg capsule

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","class":"Selective progesterone receptor modulator","route":"Oral","main_use":"Uterine fibroids","key_side_effect":"Liver injury (rare)"},{"medicine":"Leuprolide acetate","class":"GnRH agonist","route":"Injection","main_use":"Uterine fibroids","key_side_effect":"Menopausal symptoms"}]

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