Mesacol OD 1200 mg Tablet PR: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in your stool or vomit
- Severe or worsening abdominal pain
- Decreased urine output or swelling in your legs
- Yellowing of your skin or eyes
- Unusual bruising or bleeding
- Fever with sore throat or mouth ulcers
- Chest pain, shortness of breath, or palpitations
- Swelling of your face, lips, or throat
If experiencing severe symptoms, call emergency services immediately.
What is fibrimin-od tablet used for?
This medicine is a prolonged-release tablet of mesalazine 1200 mg used to treat and prevent flare-ups of ulcerative colitis. It works by reducing inflammation in the colon and is usually taken once daily. It is not a painkiller and should be swallowed whole.
- Generic Name: Mesalazine (1200mg)
- Manufacturer: Fibrica Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 fibrimin-od tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मेसलाज़ीन 1200 मिलीग्राम का प्रोलॉन्ग्ड-रिलीज़ टैबलेट है, जिसका उपयोग अल्सरेटिव कोलाइटिस और क्रोहन रोग जैसी सूजन आंत्र रोगों के इलाज और रोकथाम के लिए किया जाता है। यह आंतों की सूजन को कम करती है और दस्त, खून आना, पेट दर्द जैसे लक्षणों में राहत देती है। यह दर्द निवारक दवा नहीं है। इसे डॉक्टर के बताए अनुसार ही लें और टैबलेट को चबाएं या तोड़ें नहीं।
साइड इफेक्ट्स: आमतौर पर यह दवा सहन की जाती है, लेकिन कुछ लोगों को सिरदर्द, जी मिचलाना, पेट दर्द, दस्त या गैस की शिकायत हो सकती है। ये आमतौर पर हल्के होते हैं और अपने आप ठीक हो जाते हैं। दुर्लभ मामलों में गुर्दे या लीवर की समस्या, एलर्जी, या खून की बीमारी हो सकती है। अगर आपको गंभीर पेट दर्द, मल में खून, पेशाब कम आना, आंखों या त्वचा का पीला पड़ना, या चेहरे पर सूजन हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। टैबलेट को पानी के साथ पूरा निगलें, चबाएं या तोड़ें नहीं। इसे भोजन के साथ या बिना भोजन के लिया जा सकता है, लेकिन भोजन के साथ लेने से पेट की जलन कम हो सकती है। डॉक्टर की सलाह के बिना दवा बंद न करें। नियमित रूप से गुर्दे और लीवर की जांच कराते रहें। गर्भावस्था या स्तनपान के दौरान डॉक्टर को बताएं। शराब से बचें। दवा को ठंडी और सूखी जगह पर, बच्चों से दूर रखें।
💊 fibrimin-od tablet Uses & Benefits
[{"condition":"Ulcerative colitis (maintenance of remission)","description":"This medicine helps prevent flare-ups and keeps the disease inactive in adults with ulcerative colitis.","evidence":"Well-established"},{"condition":"Ulcerative colitis (active mild-to-moderate disease)","description":"It reduces inflammation in the colon and helps control symptoms such as diarrhoea, rectal bleeding, and urgency.","evidence":"Well-established"},{"condition":"Crohn's disease","description":"Sometimes used to treat mild-to-moderate Crohn's disease affecting the colon, though evidence is less strong than for ulcerative colitis.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Diverticular disease","description":"Occasionally prescribed to reduce inflammation in diverticular disease, but this is not a standard approved use.","evidence":"Limited"},{"condition":"Radiation proctitis","description":"May be used to manage rectal inflammation after radiation therapy, but evidence is limited.","evidence":"Limited"}]
Primary treatment for: Ulcerative colitis
Also treats: Crohn's disease, Inflammatory bowel disease
📋 Drug Information
| Generic Name(s) | Mesalazine (1200mg) |
| Brand Name | fibrimin-od tablet |
| Manufacturer | Fibrica Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | 5- Aminosalicylic acid (5-ASA) |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep the tablets in their original container and out of reach of children. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the pack. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by delivering mesalazine directly to the colon, where it acts locally on the inflamed lining. Mesalazine is an aminosalicylate that reduces the production of inflammatory chemicals called prostaglandins and leukotrienes. It also scavenges free radicals and inhibits the activation of nuclear factor kappa-B, a key switch for inflammation. By calming the immune response in the gut wall, it helps heal ulcers and reduces symptoms of ulcerative colitis.
Mechanism Steps
💡 How to Take fibrimin-od tablet
Strength: Prolonged-release tablet containing 1200 mg of mesalazine.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one 1200 mg prolonged-release tablet taken once daily, preferably in the morning. For active ulcerative colitis, your doctor may prescribe a higher dose initially, such as 2.4 g to 4.8 g daily in divided doses, depending on the severity. For maintenance of remission, 1.2 g to 2.4 g daily is typical. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Always follow your doctor's prescription exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially kidney-related side effects. Dose should be individualized by a clinician, and kidney function should be monitored regularly. |
| Renal Impairment | In patients with mild to moderate kidney impairment, this medicine should be used with caution and kidney function monitored closely. It is contraindicated in severe kidney impairment. Dose adjustment may be necessary based on creatinine clearance; consult your doctor. |
| Hepatic Impairment | In patients with mild to moderate liver impairment, this medicine should be used with caution and liver function monitored. It is contraindicated in severe liver impairment. Dose adjustment may be required; consult your doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is 4.8 g of mesalazine, but this must be determined by a qualified clinician based on the individual patient's condition and response. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of fibrimin-od tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| NSAIDs | Moderate | |
| Azathioprine | Moderate | |
| 6-Mercaptopurine | Moderate | |
| Antacids | Minor | |
| Iron supplements | Minor |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Nephrotoxic drugs (e.g., NSAIDs, aminoglycosides, cyclosporine)
⚡ Moderate Interactions
- Azathioprine
- 6-Mercaptopurine
- NSAIDs (e.g., ibuprofen, naproxen)
🍷 Alcohol Interaction
Alcohol may increase the risk of stomach irritation and liver problems while taking this medicine. It is advisable to avoid alcohol or limit intake to occasional small amounts. If you have liver disease, avoid alcohol completely.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to mesalazine, other salicylates, or any component of the tablet","Severe kidney disease (e.g., severe renal impairment)","Severe liver disease","Active peptic ulcer or bleeding disorders","Children under 18 years (safety and efficacy not established for this formulation)"]
⚠️ Warnings & Precautions
["Regular monitoring of kidney and liver function is essential during treatment.","Do not crush, chew, or break the tablet; swallow it whole.","If you have a history of kidney or liver problems, inform your doctor before starting this medicine.","Stop the medicine and seek medical advice if you develop severe abdominal pain, blood in stool, or signs of an allergic reaction.","This medicine may cause dizziness in some people; avoid driving or operating machinery until you know how it affects you.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Keep all follow-up appointments and laboratory tests as scheduled."]
🤱 Lactation Safety
Mesalazine passes into breast milk in small amounts. It is generally considered compatible with breastfeeding, but some infants may develop diarrhoea. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose with mesalazine may cause nausea, vomiting, abdominal pain, and diarrhoea. In severe cases, it can lead to kidney or liver damage. If you suspect an overdose, contact your doctor or a poison control centre immediately. Treatment is supportive and symptomatic, with monitoring of kidney and liver function.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Swallow the tablet whole with a full glass of water; do not break, crush, or chew it. You may take it with or without food, but taking it with food may reduce stomach upset. Do not stop or change the dose without consulting your doctor. Keep all follow-up appointments for blood tests to monitor kidney and liver function. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Avoid alcohol while taking this medicine as it may worsen stomach irritation. Store the tablets in their original container at room temperature, away from moisture and direct sunlight. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to kidney-related side effects. Kidney function should be monitored more frequently. The dose may need to be adjusted based on kidney function. Elderly patients should also be cautious about dizziness and falls.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before conception. This medicine is generally considered safe during pregnancy, but your doctor may adjust your dose or monitor you more closely. Continue taking your medicine unless your doctor advises otherwise.
🏥 Post-Surgery Considerations
After surgery, inform your surgeon and anaesthesiologist that you are taking this medicine. It may need to be temporarily stopped before surgery if there is a risk of bleeding or kidney problems. Follow your doctor's instructions regarding when to resume.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. There is no specific contraindication, but if you have a bleeding disorder or are on blood thinners, your dentist may take extra precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe and beneficial while taking this medicine. However, during active flare-ups with severe diarrhoea, abdominal pain, or fatigue, you should rest and avoid strenuous activities. Listen to your body and consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness in some people. If you experience dizziness, avoid driving or operating heavy machinery until you know how it affects you. Otherwise, it should not significantly impact your daily work or activities. However, during flare-ups, you may need to take time off work or adjust your schedule due to symptoms like frequent bowel movements and fatigue.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as kidney problems, liver problems, severe allergic reactions, or blood disorders, your doctor may advise you to stop. If you are planning to become pregnant or are breastfeeding, discuss with your doctor before stopping. Always follow your doctor's guidance.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe and effective for maintaining remission in ulcerative colitis. However, it can rarely cause kidney or liver problems, so regular monitoring of kidney and liver function is recommended. Some patients may experience reduced kidney function over time, especially if they have pre-existing kidney disease or take other nephrotoxic drugs. Long-term use has not been shown to increase the risk of cancer. Regular follow-up with your doctor is important to assess the ongoing benefit and safety of treatment.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Avoiding trigger foods and following a low-residue diet during flare-ups can help manage symptoms.
Evidence: ModerateCertain probiotic strains may help maintain remission in ulcerative colitis, but evidence is mixed.
Evidence: LimitedYoga, meditation, and counselling can help reduce stress, which may trigger flare-ups.
Evidence: ModerateFor severe cases not responding to medicine, surgery to remove the colon may be considered.
Evidence: Well-established for refractory disease💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, if you are taking other immunosuppressive medicines for inflammatory bowel disease, live vaccines may be contraindicated. Consult your doctor before receiving any live vaccines.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When travelling, carry your medicine in its original packaging along with a copy of your prescription. Keep it in your hand luggage to avoid loss or exposure to extreme temperatures. Store it at room temperature and away from direct sunlight. If you are crossing time zones, continue taking your dose at the same local time as usual, or consult your doctor for specific advice. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start to notice improvement in symptoms within a few days to weeks, but it may take several weeks for the full effect, especially for maintaining remission.
A: Yes, you can take it with or without food. Taking it with food may help reduce stomach upset.
A: If you remember within 12 hours, take the missed dose. If more than 12 hours have passed, skip it and take your next dose at the usual time. Do not double dose.
A: Yes, it is often used long-term to maintain remission. However, regular monitoring of kidney and liver function is important.
A: It is best to avoid alcohol as it may increase stomach irritation and liver risk.
A: There is no strong evidence that mesalazine affects fertility. However, consult your doctor if you are planning pregnancy.
🤔 Common Patient Concerns
🔄 Substitutes for fibrimin-od tablet
View AllAlternative brands with exact same active ingredient:
-
mosart tablet drCadila Pharmaceuticals Ltd ₹58.60 78.8% CHEAPER
-
davaindia mesalazine 1200mg tablet prDavaindia Generic Pharmacy ₹90.00 67.4% CHEAPER
-
mesavin 1200mg tabletAlniche Life Sciences Pvt Ltd ₹179.13 35.1% CHEAPER
-
procol od 1200mg tabletDelvin Formulations Pvt Ltd ₹189.30 31.4% CHEAPER
-
zemakool od 1200mg tabletAlembic Pharmaceuticals Ltd ₹199.00 27.9% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a painkiller.
Fact: This medicine is an anti-inflammatory drug for inflammatory bowel disease, not a general painkiller. - Myth: You can stop taking this medicine once symptoms improve.
Fact: This medicine is often used long-term to maintain remission. Stopping without doctor's advice can lead to flare-ups. - Myth: This medicine is a steroid.
Fact: This medicine is an aminosalicylate, not a steroid. It has a different mechanism and side effect profile. - Myth: It is safe to crush or chew the tablet.
Fact: The tablet must be swallowed whole to ensure the medicine is released in the colon. Crushing or chewing can affect how it works.
🔄 Alternative Options
Generic Alternatives
- Mesalazine 1200 mg prolonged-release tablet
Brand Alternatives
- Mesacol OD 1200 mg Tablet PR