davaindia mesalazine 1200mg tablet pr

4.4 (16 reviews)

Mesalazine (1200mg)

🏭 Davaindia Generic Pharmacy 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 21, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 21, 2026

What is davaindia mesalazine 1200mg tablet pr used for?

Asacus Sachet (Mesalazine) is used to treat GASTRO INTESTINAL. It contains Mesalazine (1200mg), which Mesalazine inhibits cyclooxygenase and lipoxygenase pathways, reducing prostagla. Always consult your doctor before use. Take as prescribed.

Generic Name: Mesalazine
Manufacturer: Davaindia Generic Pharmacy
Form: Allopathy
Pregnancy Category: B
Prescription Required: Yes

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 davaindia mesalazine 1200mg tablet pr Uses & Benefits

Treatment of mild to moderate ulcerative colitis, maintenance of remission in ulcerative colitis.

Off-label uses: Crohn's disease, diverticulitis, radiation proctitis.

📋 Drug Information

Generic Name(s)	Mesalazine
Brand Name	Asacus Sachet
Manufacturer	Davaindia Generic Pharmacy
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	GASTRO INTESTINAL
Action Class	5- Aminosalicylic acid (5-ASA)
Route of Administration	Oral
Storage	Store at room temperature (20-25°C) in a dry place, protect from moisture.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionMesalazine is released in the colon where it is absorbed. Approximately 20-30% of the dose is absorbed systemically.

DistributionDistributes into tissues, crosses placenta, and enters breast milk in small amounts.

Protein BindingApproximately 40-50% bound to plasma proteins.

MetabolismMetabolized in the intestinal mucosa and liver to N-acetyl-5-aminosalicylic acid (Ac-5-ASA) via N-acetyltransferase.

Half-Life0.5-2 hours for mesalazine; 5-10 hours for its metabolite.

ExcretionPrimarily excreted in urine (as metabolites) and feces (unabsorbed drug).

Bioavailability20-30% after oral administration.

Onset of ActionWithin 3-7 days for symptomatic improvement.

Peak Plasma Time4-6 hours after oral administration.

Duration of ActionUp to 24 hours.

How It Works

Mesalazine inhibits cyclooxygenase and lipoxygenase pathways, reducing prostaglandin and leukotriene synthesis. It also scavenges reactive oxygen species and inhibits nuclear factor-kappa B (NF-κB), leading to decreased inflammatory cytokine production.

Mechanism Steps

1Inhibition of cyclooxygenase (COX) and lipoxygenase pathways

2Reduction of prostaglandin and leukotriene synthesis

3Scavenging of reactive oxygen species

💡 How to Take davaindia mesalazine 1200mg tablet pr

Follow your doctor's prescription exactly.

⚠️ Side Effects of davaindia mesalazine 1200mg tablet pr

✅ Common Side Effects

Nausea
Diarrhea
Headache
Abdominal pain
Flatulence

🚨 Serious Side Effects

Interstitial nephritis
Pancreatitis
Hepatotoxicity
Blood dyscrasias (agranulocytosis, aplastic anemia)
Pericarditis

⚠️ Rare Side Effects

Alopecia
Stevens-Johnson syndrome
Lupus-like syndrome
Pulmonary fibrosis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased bleeding risk
Azathioprine	Major	Increased risk of myelosuppression
Mercaptopurine	Major	Increased risk of myelosuppression
Methotrexate	Major	Increased risk of hepatotoxicity
NSAIDs	Moderate	Increased risk of renal toxicity
Corticosteroids	Moderate	Increased gastrointestinal side effects
Anticoagulants	Moderate	Increased bleeding risk
Digoxin	Minor	Possible reduced digoxin absorption
Furosemide	Minor	Possible reduced diuretic effect
Spironolactone	Minor	Possible reduced diuretic effect

🚨 Major Interactions

Warfarin
Azathioprine
Mercaptopurine
Methotrexate

⚡ Moderate Interactions

NSAIDs
Corticosteroids
Anticoagulants

ℹ️ Minor Interactions

Digoxin
Furosemide
Spironolactone

🍽️ Food Interactions

Food may delay absorption but does not significantly affect efficacy.

🍷 Alcohol Interaction

Alcohol may increase gastrointestinal irritation and worsen side effects.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to mesalazine or salicylates, severe renal impairment (eGFR <30 mL/min/1.73m²), severe hepatic impairment.

📊 Monitoring Parameters

Renal function (serum creatinine, BUN), liver function tests, complete blood count, urinalysis.

🤱 Lactation Safety

Caution advised; small amounts excreted in breast milk.

💊 Overdose Management

Gastric lavage, activated charcoal, supportive care; monitor renal function.

⏰ Missed Dose

Take as soon as remembered unless close to next dose; skip missed dose if near next dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

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🔄 Substitutes for davaindia mesalazine 1200mg tablet pr

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Alternative brands with exact same active ingredient (Mesalazine (1200mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Happy Patient Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Verified User Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Trusted Reviewer Jul 10, 2026