Esium-HP Kit: Complete Guide to Uses, Dosage, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Severe or persistent diarrhea
If experiencing severe symptoms, call emergency services immediately.
What is esomac hp combo kit used for?
This medicine is a combination antibiotic kit containing Amoxycillin 750 mg and Clarithromycin 500 mg, used to treat Helicobacter pylori infection in the stomach. It is taken twice daily with food for 7-14 days as part of a multi-drug regimen.
- Generic Name: Amoxycillin (750mg) + Clarithromycin (500mg)
- Manufacturer: Cipla Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 esomac hp combo kit के बारे में (Hindi Summary)
उपयोग: यह दवा एमोक्सिसिलिन 750 मिलीग्राम और क्लैरिथ्रोमाइसिन 500 मिलीग्राम का संयोजन है, जिसका उपयोग पेट में हेलिकोबैक्टर पाइलोरी संक्रमण के इलाज के लिए किया जाता है। यह पेप्टिक अल्सर और गैस्ट्रिटिस के इलाज में मदद करती है। इसे डॉक्टर के निर्देशानुसार भोजन के साथ दिन में दो बार लेना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, दस्त, पेट दर्द, धातु जैसा स्वाद, सिरदर्द और त्वचा पर चकत्ते शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, लीवर की समस्या, और दिल की धड़कन में गड़बड़ी हो सकती है। किसी भी गंभीर लक्षण पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक न छोड़ें और पूरा कोर्स पूरा करें। भोजन के साथ लें ताकि पेट की परेशानी कम हो। शराब का सेवन न करें। गुर्दे या लीवर की बीमारी, दिल की धड़कन की समस्या हो तो डॉक्टर को बताएं।
💊 esomac hp combo kit Uses & Benefits
- [{"condition":"Helicobacter pylori eradication","description":"Used as part of combination therapy to eradicate H.
- pylori infection in patients with peptic ulcer disease or gastric mucosa-associated lymphoid tissue (MALT) lymphoma.","evidence":"Well-established"},{"condition":"Duodenal ulcer associated with H.
- pylori","description":"Helps heal ulcers by eliminating the underlying H.
- pylori infection when combined with acid suppression.","evidence":"Well-established"},{"condition":"Gastric ulcer associated with H.
- pylori","description":"Eradicates H.
- pylori to promote ulcer healing and reduce recurrence.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Chronic gastritis with H. pylori","description":"Sometimes used to treat chronic gastritis when H. pylori is detected, though primarily indicated for ulcer disease.","evidence":"Limited"}]
Primary treatment for: Helicobacter pylori infection
Also treats: Peptic ulcer disease, Gastric MALT lymphoma, Chronic gastritis
📋 Drug Information
| Generic Name(s) | Amoxycillin (750mg) + Clarithromycin (500mg) |
| Brand Name | esomac hp combo kit |
| Manufacturer | Cipla Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original packaging. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | WHO recommends H. pylori eradication in patients with peptic ulcer disease. Combination therapy including amoxycillin and clarithromycin is among the recommended regimens. |
| ICMR Guideline | ICMR guidelines recommend triple therapy with a proton pump inhibitor, amoxycillin, and clarithromycin for 14 days in areas with low clarithromycin resistance. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Amoxycillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to bacterial lysis. Clarithromycin binds to the 50S ribosomal subunit, inhibiting protein synthesis and bacterial growth. The combination provides synergistic killing of Helicobacter pylori.
Mechanism Steps
💡 How to Take esomac hp combo kit
Strength: Amoxycillin 750 mg and Clarithromycin 500 mg immediate-release tablets in a kit.
Dosage Information
| Adult Dosage | The typical adult dose is one kit containing Amoxycillin 750 mg and Clarithromycin 500 mg, taken twice daily (every 12 hours) for 7 to 14 days as part of a triple or quadruple therapy regimen that includes a proton pump inhibitor. The exact dose and duration must be individualized by a qualified clinician based on the indication, patient's age, weight, renal and hepatic function, and local resistance patterns. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function; dose adjustment may be necessary. Monitor renal function and for signs of toxicity. Consult a doctor for individualized dosing. |
| Renal Impairment | In patients with creatinine clearance less than 30 mL/min, dose reduction of clarithromycin is recommended. Amoxycillin dose may also need adjustment. Consult a doctor for specific dosing. |
| Hepatic Impairment | In patients with severe hepatic impairment, clarithromycin should be used with caution; dose reduction may be considered. Monitor liver function. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is Amoxycillin 1500 mg and Clarithromycin 1000 mg, divided into two doses. Do not exceed without medical supervision. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of esomac hp combo kit
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ergot alkaloids | Major | |
| Statins | Major | |
| Amiodarone | Major | |
| Carbamazepine | Moderate | |
| Theophylline | Moderate | |
| Oral contraceptives | Moderate | |
| Antacids | Minor | |
| Rifampicin | Minor | |
| Digoxin | Moderate |
🚨 Major Interactions
- Warfarin
- Ergot alkaloids
- Statins (e.g., simvastatin, atorvastatin)
- QT-prolonging drugs (e.g., amiodarone, sotalol)
⚡ Moderate Interactions
- Carbamazepine
- Theophylline
- Oral contraceptives
🍷 Alcohol Interaction
Alcohol may worsen gastrointestinal side effects such as nausea and abdominal pain, and may reduce treatment adherence. It is advisable to avoid alcohol during the course of this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to penicillins or macrolides","History of severe allergic reaction to beta-lactams","Concomitant use with ergot alkaloids","Severe hepatic impairment","History of QT prolongation or ventricular arrhythmias","Concomitant use with certain QT-prolonging drugs"]
⚠️ Warnings & Precautions
["Use with caution in patients with renal impairment; dose adjustment may be needed.","Use with caution in patients with liver disease; monitor liver function.","May cause Clostridioides difficile-associated diarrhea; report severe diarrhea.","May prolong QT interval; caution in patients with cardiac disease.","May reduce efficacy of oral contraceptives; use backup contraception.","Do not use for viral infections; inappropriate use promotes resistance."]
🤱 Lactation Safety
Amoxycillin is excreted in breast milk in small amounts and is generally considered safe. Clarithromycin is also excreted in breast milk; caution is advised. Consult your doctor before breastfeeding while on this medicine.
💊 Overdose Management
Overdose may cause severe nausea, vomiting, diarrhea, and abdominal pain. In case of overdose, seek immediate medical attention. Treatment is symptomatic and supportive. Hemodialysis may be considered for amoxycillin but is not effective for clarithromycin.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop early, even if you feel better, to prevent antibiotic resistance. Swallow the tablets whole with water; do not crush or chew. Take with food to reduce stomach upset. Avoid alcohol during treatment as it may worsen side effects and reduce effectiveness. Inform your doctor if you have kidney or liver problems, heart rhythm disorders, or myasthenia gravis. Do not share this medicine with others. Complete the full course as directed.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced renal function and are at higher risk of side effects. Dose adjustment may be needed. Monitor renal and liver function.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. Clarithromycin is not recommended during pregnancy unless clearly needed.
🏥 Post-Surgery Considerations
Inform your surgeon if you are taking this medicine before surgery. It may interact with anesthetics and other medications.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It may interact with antibiotics prescribed for dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but if you experience dizziness or fatigue, avoid strenuous activities until you feel better.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some people. Avoid driving or operating heavy machinery if you experience these effects. Otherwise, normal activities can continue.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Complete the full prescribed course even if you feel better. If you experience severe side effects, contact your doctor immediately for guidance.
📅 Long-Term Use Effects
Long-term use of this combination is not recommended. Prolonged use may lead to antibiotic resistance, gut flora imbalance, and rare liver or heart effects. Regular monitoring may be needed if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
May help reduce antibiotic-associated diarrhea when taken alongside.
Evidence: ModerateAn alternative regimen for H. pylori eradication in case of resistance or allergy.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, antibiotics may reduce the efficacy of live bacterial vaccines like typhoid vaccine. Consult your doctor for timing.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid temperature extremes. If traveling across time zones, adjust dosing times gradually to maintain 12-hour intervals. Store at room temperature and avoid direct sunlight. Check customs regulations for carrying prescription antibiotics.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 2-3 days, but you must complete the full course (usually 7-14 days) to ensure eradication.
A: Yes, take it with food to reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it's almost time for the next dose, skip it and continue your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for esomac hp combo kit
View AllAlternative brands with exact same active ingredient:
-
esorim hp 750mg/500mg/40mg kitUmbrella Biotech ₹186.56 18.5% COSTLIER
-
pylokit-ac kitCipla Ltd ₹196.50 24.8% COSTLIER
-
esium-hp kitTas Med India Pvt Ltd ₹203.40 29.1% COSTLIER
-
sompraz hp combipackSun Pharmaceutical Industries Ltd ₹232.50 47.6% COSTLIER
-
nexpro hp combipackTorrent Pharmaceuticals Ltd ₹242.85 54.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Antibiotics can cure the common cold.
Fact: This medicine is effective only against bacterial infections like H. pylori, not viruses. - Myth: You can stop antibiotics once you feel better.
Fact: You must complete the full course to prevent resistance and ensure eradication. - Myth: Taking antibiotics with alcohol is safe.
Fact: Alcohol can worsen side effects and reduce treatment effectiveness.
🔄 Alternative Options
Generic Alternatives
- Amoxycillin 750 mg + Clarithromycin 500 mg generic kit
Brand Alternatives
- Esium-HP kit