Apregen 150mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of face, lips, or throat
- Difficulty breathing or wheezing
- Severe rash or blistering skin
- Yellowing of skin or eyes
- Severe abdominal pain
- Dark urine or pale stools
- Chest pain or irregular heartbeat
- Severe dizziness or fainting
If experiencing severe symptoms, call emergency services immediately.
What is es pitant 150mg injection used for?
This medicine is a prescription injection containing fosaprepitant, used to prevent nausea and vomiting caused by chemotherapy. It works by blocking NK1 receptors in the brain and is given intravenously by a healthcare professional before chemotherapy.
- Generic Name: Fosaprepitant (150mg)
- Manufacturer: Esperer Bioresearch Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 es pitant 150mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा मुख्य रूप से कीमोथेरेपी के कारण होने वाली मतली और उल्टी को रोकने के लिए दी जाती है। इसे आमतौर पर कीमोथेरेपी से लगभग 30 मिनट पहले नस के माध्यम से ड्रिप के रूप में दिया जाता है। यह दवा मस्तिष्क में उन रिसेप्टर्स को ब्लॉक करती है जो उल्टी की भावना पैदा करते हैं, जिससे मरीज को कीमोथेरेपी के दौरान और उसके बाद होने वाली मतली और उल्टी से राहत मिलती है। यह दवा केवल डॉक्टर की देखरेख में ही दी जानी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में थकान, सिरदर्द, कब्ज, दस्त, भूख न लगना और हिचकी शामिल हैं। कुछ लोगों को ड्रिप के दौरान चक्कर आ सकते हैं या ब्लड प्रेशर कम हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी की प्रतिक्रिया, सांस लेने में कठिनाई, चेहरे या गले में सूजन, या त्वचा पर गंभीर दाने हो सकते हैं। अगर आपको कोई भी असामान्य लक्षण महसूस हो, तो तुरंत अपने डॉक्टर या नर्स को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल या क्लिनिक में डॉक्टर या नर्स द्वारा ही दी जानी चाहिए। अगर आपको फोसाप्रेपिटेंट या किसी भी दवा से एलर्जी है, तो अपने डॉक्टर को बताएं। अपने डॉक्टर को अपनी सभी दवाओं के बारे में जानकारी दें, खासकर वारफेरिन जैसी खून पतला करने वाली दवाएं। अगर आप गर्भवती हैं या गर्भधारण की योजना बना रही हैं, तो अपने डॉक्टर से सलाह लें। इस दवा के साथ शराब न पिएं। अगर आपको चक्कर आते हैं या थकान महसूस होती है, तो वाहन न चलाएं।
💊 es pitant 150mg injection Uses & Benefits
[{"condition":"Prevention of chemotherapy-induced nausea and vomiting (CINV)","description":"This medicine is used to prevent acute and delayed nausea and vomiting caused by highly emetogenic chemotherapy and moderately emetogenic chemotherapy in adults.","evidence":"Well-established"},{"condition":"Prevention of postoperative nausea and vomiting (PONV)","description":"In some settings, this medicine may be used to prevent nausea and vomiting after surgery, but this is not its primary approved use.","evidence":"Limited"}]
Off-label uses: [{"condition":"Refractory nausea and vomiting not related to chemotherapy","description":"Rarely, this medicine may be tried for severe nausea and vomiting from other causes when standard treatments fail, but evidence is limited.","evidence":"Limited"}]
Primary treatment for: Chemotherapy-induced nausea and vomiting
Also treats: Postoperative nausea and vomiting
📋 Drug Information
| Generic Name(s) | Fosaprepitant (150mg) |
| Brand Name | es pitant 150mg injection |
| Manufacturer | Esperer Bioresearch Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | NK1 Antagonists |
| Route of Administration | Parenteral (intravenous infusion) |
| Storage | Store this medicine in its original packaging in a refrigerator at 2°C to 8°C. Do not freeze. Protect from light. Once reconstituted, use immediately or store as directed by the pharmacist. |
| Shelf Life | Refer to the expiry date on the packaging. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by blocking the neurokinin-1 (NK1) receptor, which is the target for substance P, a chemical in the body that triggers nausea and vomiting. By blocking this receptor in the brain and gastrointestinal tract, this medicine reduces the vomiting reflex caused by chemotherapy medicines. This effect helps prevent both acute nausea and vomiting that occur within the first 24 hours after chemotherapy and delayed nausea and vomiting that can occur for several days afterward.
Mechanism Steps
💡 How to Take es pitant 150mg injection
Strength: Injection: 150 mg
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 150 mg given as an intravenous infusion over 20 to 30 minutes on the day of chemotherapy, approximately 30 minutes before the start of chemotherapy. It is often given as part of a regimen that includes a 5-HT3 receptor antagonist and dexamethasone. Dose must be individualized by a qualified clinician based on the chemotherapy regimen, age, liver function, and other medicines being taken. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No dose adjustment is needed for elderly patients based on age alone. However, dose must be individualized by a qualified clinician based on liver function and other medicines being taken. |
| Renal Impairment | No dose adjustment is needed for patients with kidney problems. Consult your doctor if you have severe kidney disease. |
| Hepatic Impairment | No dose adjustment is needed for mild to moderate liver disease. This medicine should not be used in patients with severe liver disease. Consult your doctor for guidance. |
| Maximum Daily Dose | The maximum recommended dose is 150 mg per day as a single intravenous infusion. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of es pitant 150mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Hormonal contraceptives | Major | |
| Ketoconazole | Moderate | |
| Rifampin | Moderate | |
| Dexamethasone | Moderate | |
| Midazolam | Moderate | |
| Paracetamol | Minor | |
| Antacids | Minor | |
| Grapefruit juice | Moderate | |
| Alcohol | Moderate |
🚨 Major Interactions
- Warfarin
- Hormonal contraceptives
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
- CYP3A4 inducers (e.g., rifampin, carbamazepine)
⚡ Moderate Interactions
- Dexamethasone
- Methylprednisolone
- Midazolam
🍷 Alcohol Interaction
Alcohol may increase dizziness and drowsiness caused by this medicine. It is best to avoid alcohol during treatment and for at least 24 hours after receiving this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Allergy to fosaprepitant, aprepitant, or any ingredient of this medicine","Severe liver disease","Use with caution in patients taking certain medicines that interact with CYP3A4"]
⚠️ Warnings & Precautions
["This medicine must be given only by a healthcare professional.","Tell your doctor about all medicines you take, especially warfarin and hormonal contraceptives.","Use an additional non-hormonal method of birth control during treatment and for one month after the last dose.","Avoid alcohol during treatment.","Do not drive or operate machinery if you feel dizzy or tired.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Report any signs of allergic reaction or liver problems immediately."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Breastfeeding is not recommended during treatment and for at least 1 week after the last dose. Consult your doctor for guidance.
💊 Overdose Management
Overdose with this medicine is unlikely because it is given by a healthcare professional. If an overdose is suspected, seek immediate medical attention. Treatment is supportive and symptomatic.
⏰ Missed Dose
This medicine is given as a single dose or as part of a chemotherapy regimen. If you miss a scheduled dose, contact your healthcare provider as soon as possible to reschedule.
Additional Safety Advice
This medicine must be given only by a healthcare professional in a clinic or hospital setting. Tell your doctor if you are allergic to fosaprepitant, aprepitant, or any other medicine. Inform your doctor about all medicines you take, especially blood thinners such as warfarin, because this medicine can change their effect. If you have severe liver disease, this medicine should not be used. This medicine may interact with hormonal contraceptives, so use an additional non-hormonal method of birth control during treatment and for one month after the last dose. Avoid driving or operating heavy machinery if you feel dizzy or tired after receiving this medicine. Do not receive this medicine if you are pregnant or planning pregnancy without discussing the risks and benefits with your doctor. If you miss a scheduled dose, contact your healthcare provider as soon as possible.
👴 Special Considerations for Elderly
💡 For Patients Above 65
No dose adjustment is needed for elderly patients based on age alone. However, elderly patients may be more sensitive to side effects like dizziness and low blood pressure. Monitor closely during infusion.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss with your doctor before receiving this medicine. Use effective contraception during treatment and for one month after the last dose. This medicine may harm the fetus.
🏥 Post-Surgery Considerations
This medicine is sometimes used to prevent postoperative nausea and vomiting. Follow your doctor's instructions for use after surgery.
🦷 Dental Procedures
Inform your dentist if you have received this medicine recently. No specific precautions are established, but it is important to share your medical history.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise immediately after receiving this medicine, especially if you feel dizzy or tired. Light activity like walking may be helpful if you feel up to it. Consult your doctor before starting any exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause tiredness or dizziness, which can affect your ability to drive or operate machinery. It is best to rest after receiving this medicine. Discuss with your doctor when you can resume normal activities.
🛑 When to Stop This Medicine
This medicine is given as a single dose or short course. Do not stop or change the regimen without consulting your doctor. If you experience severe side effects, seek medical attention immediately.
📅 Long-Term Use Effects
This medicine is usually given as a single dose or for a short duration as part of a chemotherapy regimen. Long-term effects are not well established because it is not used for long-term therapy. Monitoring of liver function may be needed if used repeatedly. Consult your doctor for any concerns.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
5-HT3 receptor antagonists like ondansetron and corticosteroids like dexamethasone are often used in combination.
Evidence: Well-establishedAn oral NK1 receptor antagonist that can be used instead of the intravenous form in some regimens.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions known with this medicine. However, chemotherapy may affect your immune response to vaccines. Consult your doctor about vaccination timing.
📦 Storage Guide
✅ DO
Store in a refrigerator at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep in original packaging
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store at room temperature for long periods
✈️ Traveling with This Medicine
This medicine is given in a healthcare setting, so travel advice is limited. If you are traveling for treatment, carry a copy of your prescription and medical records. Store the medicine in its original packaging in a refrigerator at 2°C to 8°C. Do not freeze. If traveling by air, check with the airline about carrying medical injections. Always inform your healthcare provider about your travel plans.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within about 30 minutes to 1 hour after the infusion begins.
A: It is given as an intravenous infusion by a healthcare professional, usually over 20 to 30 minutes.
A: This medicine should be used during pregnancy only if the potential benefit justifies the potential risk. Consult your doctor.
A: Common side effects include tiredness, headache, constipation, diarrhea, and hiccups.
A: Yes, it may reduce the effectiveness of hormonal contraceptives. Use an additional non-hormonal method during treatment and for one month after.
🤔 Common Patient Concerns
🔄 Substitutes for es pitant 150mg injection
View AllAlternative brands with exact same active ingredient:
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fosa 150mg injectionMylan Pharmaceuticals Pvt Ltd ₹1,540.00 40.8% CHEAPER
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fosapretero injectionHetero Drugs Ltd ₹2,226.00 14.5% CHEAPER
-
fosup injectionZydus Cadila ₹2,250.00 13.6% CHEAPER
-
fosaprepit 150mg injectionCipla Ltd ₹2,250.00 13.6% CHEAPER
-
fosaran 150mg injectionSun Pharmaceutical Industries Ltd ₹2,299.00 11.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken at home.
Fact: This medicine must be given by a healthcare professional in a clinic or hospital setting. - Myth: This medicine can be used to treat nausea after it starts.
Fact: This medicine is used to prevent nausea and vomiting, not to treat it once it has started. - Myth: This medicine is safe in severe liver disease.
Fact: This medicine should not be used in patients with severe liver disease.
🔄 Alternative Options
Generic Alternatives
- Fosaprepitant
Brand Alternatives
- Apregen 150mg Injection