Biovorin 50mg Injection (Calcium Leucovorin): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Seizures or convulsions
- Severe abdominal pain or bloody diarrhea
- Unusual bleeding or bruising
- Fever, chills, or sore throat
- Yellowing of the skin or eyes
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is es lc injection used for?
This medicine is a folate analog used to rescue normal cells after high-dose methotrexate therapy and to enhance the effects of fluorouracil in colorectal cancer. It is given by injection under medical supervision.
- Generic Name: Calcium Leucovorin (50mg)
- Manufacturer: Esperer Bioresearch Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 es lc injection के बारे में (Hindi Summary)
उपयोग: यह दवा कैल्शियम ल्यूकोवोरिन का इंजेक्शन है, जिसका उपयोग मेथोट्रेक्सेट के उच्च खुराक के बाद होने वाले विषाक्तता से बचाने के लिए किया जाता है। यह कोलोरेक्टल कैंसर में फ्लोरोयूरासिल की प्रभावशीलता बढ़ाने के लिए भी दी जाती है। यह फोलेट की कमी के इलाज में भी उपयोगी है जब मुंह से दवा नहीं ली जा सकती। यह दवा डॉक्टर द्वारा इंजेक्शन के रूप में दी जाती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त और थकान शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, दौरे, और रक्त कोशिकाओं की कमी हो सकती है। किसी भी असामान्य लक्षण पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल डॉक्टर की देखरेख में दी जानी चाहिए। अपने डॉक्टर को सभी दवाओं के बारे में बताएं, खासकर मेथोट्रेक्सेट और फ्लोरोयूरासिल। इलाज के दौरान शराब से बचें। नियमित रूप से रक्त की जांच कराएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।
💊 es lc injection Uses & Benefits
[{"condition":"Methotrexate rescue","description":"Used after high-dose methotrexate therapy to prevent toxicity to normal cells, especially in bone marrow and gastrointestinal tract.","evidence":"Well-established"},{"condition":"Colorectal cancer","description":"Used in combination with fluorouracil to enhance its anticancer effect in advanced colorectal cancer.","evidence":"Well-established"},{"condition":"Folate deficiency","description":"Treats folate deficiency when oral administration is not feasible, such as in severe malabsorption.","evidence":"Well-established"},{"condition":"Toxicity from folate antagonists","description":"May be used to rescue from toxicity caused by other folate antagonists like trimethoprim or pyrimethamine.","evidence":"Limited"}]
Off-label uses: [{"condition":"Cerebral folate deficiency","description":"Sometimes used off-label to treat cerebral folate deficiency syndromes, though evidence is limited.","evidence":"Limited"},{"condition":"Autism spectrum disorder","description":"Investigational use for autism with cerebral folate deficiency, but not standard.","evidence":"Limited"}]
Primary treatment for: Methotrexate toxicity
Also treats: Colorectal cancer, Folate deficiency
📋 Drug Information
| Generic Name(s) | Calcium Leucovorin (50mg) |
| Brand Name | es lc injection |
| Manufacturer | Esperer Bioresearch Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | BLOOD RELATED |
| Action Class | Cytoprotective agents- methotrexate |
| Route of Administration | Parenteral (intramuscular or intravenous) |
| Storage | Store at 20°C to 25°C (68°F to 77°F). Protect from light. Do not freeze. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Calcium leucovorin is a reduced form of folate that enters cells via the reduced folate carrier and is converted to other active folate cofactors. It bypasses the dihydrofolate reductase step that is blocked by methotrexate, thereby replenishing tetrahydrofolate pools needed for thymidylate and purine synthesis. This rescues normal cells from methotrexate-induced toxicity. In combination with fluorouracil, leucovorin stabilizes the ternary complex of thymidylate synthase and fluorodeoxyuridylate, enhancing inhibition of DNA synthesis in cancer cells.
Mechanism Steps
💡 How to Take es lc injection
Strength: 50 mg injection
Dosage Information
| Adult Dosage | The dose of this medicine is highly individualized and depends on the indication, patient's condition, and response to therapy. For methotrexate rescue, typical doses range from 10 to 25 mg per square meter of body surface area, given every 6 hours for several doses. For colorectal cancer, doses vary widely. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function; dose should be adjusted accordingly. Use with caution and monitor renal function. |
| Renal Impairment | Dose adjustment may be necessary in patients with renal impairment. Consult a clinician for specific guidance. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment. Use with caution and monitor liver function. |
| Maximum Daily Dose | Not established from the available information. Doses are individualized based on indication and patient factors. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of es lc injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Methotrexate | Major | |
| Fluorouracil | Major | |
| Phenytoin | Moderate | |
| Trimethoprim | Moderate | |
| Pyrimethamine | Moderate | |
| Sulfasalazine | Moderate | |
| Anticonvulsants | Moderate | |
| Folic acid | Minor |
🚨 Major Interactions
- Methotrexate
- Fluorouracil
- Phenytoin
- Trimethoprim
- Pyrimethamine
⚡ Moderate Interactions
- Sulfasalazine
- Anticonvulsants
🍷 Alcohol Interaction
Alcohol may exacerbate the side effects of this medicine and increase the risk of liver toxicity. It is advisable to avoid alcohol during treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to leucovorin or any component of the formulation","Pernicious anemia or other megaloblastic anemias due to vitamin B12 deficiency (leucovorin may mask hematologic signs)","Concurrent use with methotrexate for cancer treatment without proper protocol"]
⚠️ Warnings & Precautions
["Administer only under medical supervision.","Do not use for anemia unless folate deficiency is confirmed.","May interact with methotrexate and fluorouracil; use with caution.","Monitor for allergic reactions.","Use with caution in patients with seizure disorders.","Renal impairment may require dose adjustment.","Safety and effectiveness in children have not been fully established for all indications."]
🤱 Lactation Safety
It is not known whether leucovorin is excreted in human breast milk. Consult your doctor before breastfeeding.
💊 Overdose Management
There is no specific antidote for leucovorin overdose. Treatment should be symptomatic and supportive. In case of overdose, contact a poison control center or emergency room immediately.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional, missed doses are unlikely. If you miss an appointment for your injection, contact your doctor to reschedule as soon as possible.
Additional Safety Advice
This medicine must be administered by a healthcare professional. Do not attempt to self-administer. Inform your doctor about all medications you are taking, especially methotrexate, fluorouracil, and other chemotherapy agents. Your doctor will monitor your blood counts, kidney function, and liver function regularly. Avoid alcohol during treatment as it may increase the risk of liver problems. If you are pregnant or planning to become pregnant, discuss the risks and benefits with your doctor. This medicine may interact with certain seizure medications, so inform your neurologist if you are on such drugs. Keep all appointments for monitoring and follow-up.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced renal function; dose adjustment may be necessary. Monitor renal function closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor. Leucovorin is generally considered safe when used as indicated, but the underlying condition and other medications may affect fertility and pregnancy.
🏥 Post-Surgery Considerations
No specific considerations. Follow your doctor's instructions regarding resumption of medications after surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, especially if you are on chemotherapy, as you may be at increased risk of bleeding or infection.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
No specific exercise restrictions, but if you feel fatigued or unwell, avoid strenuous activities until you feel better.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue or dizziness in some patients. Avoid driving or operating heavy machinery if you experience these effects.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. The duration of treatment is determined by your condition and response to therapy.
📅 Long-Term Use Effects
Long-term effects are not well established for leucovorin itself, as it is typically used for short courses. However, in patients receiving repeated doses, monitoring of blood counts, renal and hepatic function is advised. There is no known risk of cumulative toxicity.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
May be used when oral administration is feasible, but bioavailability may vary.
Evidence: Well-establishedUsed for folate deficiency but not for methotrexate rescue.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are established. However, live vaccines should be avoided during chemotherapy due to immunosuppression.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription label. Bring a copy of your prescription and a letter from your doctor explaining the medical need. Keep it in a cool, dry place, and avoid extreme temperatures. If traveling across time zones, consult your doctor about adjusting the dosing schedule. Check customs regulations for carrying injectable medications.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine acts rapidly after injection, within minutes to hours, to provide reduced folates to cells.
A: Avoid alcohol and inform your doctor about all other medications, especially methotrexate and fluorouracil.
A: Consult your doctor. It is used only if clearly needed.
🤔 Common Patient Concerns
🔄 Substitutes for es lc injection
View AllAlternative brands with exact same active ingredient:
-
neovorin injectionNeon Laboratories Ltd ₹68.00 79.1% CHEAPER
-
leucovorin injectionDabur India Ltd ₹234.38 27.9% CHEAPER
-
nyrin 50mg injectionVhb Life Sciences Inc ₹240.00 26.2% CHEAPER
-
adcov 50mg injectionAdley Formulations ₹250.00 23.1% CHEAPER
-
cevoric c 50mg injectionHealth Biotech Limited ₹250.00 23.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Leucovorin is the same as folic acid.
Fact: Leucovorin is a reduced form of folate and is not the same as folic acid. It is used for specific medical indications and not as a routine supplement. - Myth: Leucovorin can be taken orally for all conditions.
Fact: This medicine is given by injection for certain conditions. Oral forms exist but are used differently.
🔄 Alternative Options
Generic Alternatives
- Calcium leucovorin injection
Brand Alternatives
- Biovorin 50mg injection