Adcov 50mg Injection (Calcium Leucovorin): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Severe diarrhea or bloody stools
- Unusual bleeding or bruising
- Seizures or confusion
- Decreased urine output
- Persistent vomiting or inability to keep fluids down
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is cevoric c 50mg injection used for?
Calcium leucovorin injection is used to rescue normal cells from methotrexate toxicity and to enhance fluorouracil chemotherapy in colorectal cancer. It is given intravenously by a healthcare professional.
- Generic Name: Calcium Leucovorin
- Manufacturer: Health Biotech Limited
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cevoric c 50mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा कैल्शियम ल्यूकोवोरिन का इंजेक्शन है, जिसका उपयोग मुख्य रूप से कीमोथेरेपी में किया जाता है। यह मेथोट्रेक्सेट के जहरीले प्रभावों से सामान्य कोशिकाओं को बचाने के लिए दी जाती है। इसके अलावा, कोलोरेक्टल कैंसर में फ्लोरोयूरासिल की प्रभावशीलता बढ़ाने के लिए भी इसका उपयोग होता है। यह दवा फोलेट की कमी को पूरा करने में भी मदद करती है। यह केवल डॉक्टर की देखरेख में अस्पताल में ही दी जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त और पेट में परेशानी शामिल हैं। कुछ रोगियों को मुँह के छाले, थकान या दाने हो सकते हैं। गंभीर एलर्जी प्रतिक्रियाएँ दुर्लभ हैं लेकिन ध्यान देने योग्य हैं। यदि आपको साँस लेने में कठिनाई, चेहरे पर सूजन, या गंभीर दस्त हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्यकर्मी द्वारा अस्पताल या क्लिनिक में ही दी जानी चाहिए। इसे स्वयं न लगाएं। अपने डॉक्टर को सभी दवाओं के बारे में बताएं जो आप ले रहे हैं। उपचार के दौरान खूब पानी पिएं। शराब से बचें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें। किसी भी असामान्य लक्षण की तुरंत रिपोर्ट करें।
💊 cevoric c 50mg injection Uses & Benefits
[{"condition":"Methotrexate rescue therapy","description":"Used after high-dose methotrexate administration to prevent or reduce toxicity to normal tissues by providing reduced folate.","evidence":"Well-established"},{"condition":"Colorectal cancer (with fluorouracil)","description":"Enhances the antitumor effect of fluorouracil in palliative treatment of advanced colorectal cancer.","evidence":"Well-established"},{"condition":"Folate deficiency due to certain drugs","description":"Treats or prevents folate deficiency caused by drugs like methotrexate, trimethoprim, or pyrimethamine.","evidence":"Well-established"},{"condition":"Methotrexate overdose","description":"Used as an antidote to reduce methotrexate toxicity after accidental or intentional overdose.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Elderly depression","description":"Sometimes used off-label to enhance the effect of antidepressants, but evidence is limited.","evidence":"Limited"},{"condition":"Autism spectrum disorder","description":"Investigated for improving communication and behavior, but not proven and not recommended.","evidence":"Insufficient"}]
Primary treatment for: Methotrexate toxicity
Also treats: Colorectal cancer, Folate deficiency
📋 Drug Information
| Generic Name(s) | Calcium Leucovorin |
| Brand Name | Adcov 50mg Injection |
| Manufacturer | Health Biotech Limited |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | BLOOD RELATED |
| Action Class | Cytoprotective agents- methotrexate |
| Route of Administration | Intravenous |
| Storage | Store at room temperature (15-30°C). Protect from light. Do not freeze. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Calcium leucovorin is a reduced folate that enters cells and is converted to tetrahydrofolate, bypassing the dihydrofolate reductase (DHFR) enzyme. This provides the active cofactor needed for thymidylate and purine synthesis, thereby rescuing normal cells from the toxic effects of methotrexate, which inhibits DHFR. In fluorouracil therapy, leucovorin stabilizes the ternary complex between fluorodeoxyuridylate (FdUMP) and thymidylate synthase, enhancing the inhibition of DNA synthesis in cancer cells.
Mechanism Steps
💡 How to Take cevoric c 50mg injection
Strength: 50 mg injection
Dosage Information
| Adult Dosage | The dose of this medicine is highly individualized and depends on the indication, patient's renal function, and the specific treatment protocol. For methotrexate rescue, typical doses range from 10-15 mg/m² every 6 hours for several doses, but must be guided by methotrexate levels. For colorectal cancer with fluorouracil, doses are determined by the oncologist. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function; dose should be adjusted accordingly. Use with caution and monitor renal function. |
| Renal Impairment | Dose adjustment may be necessary in patients with renal impairment. Consult a clinician for individualized dosing. |
| Hepatic Impairment | No specific dose adjustment established for hepatic impairment. Use with caution. |
| Maximum Daily Dose | Not established from the available information. Dosing is individualized. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cevoric c 50mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Methotrexate | Major | |
| Fluorouracil | Major | |
| Phenytoin | Moderate | |
| Trimethoprim-sulfamethoxazole | Moderate | |
| Sulfasalazine | Moderate |
🚨 Major Interactions
- Methotrexate
- Fluorouracil
- Phenytoin
- Trimethoprim-sulfamethoxazole
⚡ Moderate Interactions
- Sulfasalazine
- Antacids
🍷 Alcohol Interaction
Alcohol may worsen side effects such as nausea, vomiting, and diarrhea. It is advisable to avoid alcohol during treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to calcium leucovorin or any component of the formulation","Pernicious anemia or other megaloblastic anemias due to vitamin B12 deficiency (unless B12 is also given)","Concurrent use with methotrexate for cancer treatment without proper protocol"]
⚠️ Warnings & Precautions
["Administer only under medical supervision.","Do not use for anemia without confirming folate deficiency.","May increase risk of fluorouracil toxicity; monitor closely.","Use with caution in patients with renal impairment.","May precipitate seizures in susceptible patients.","Not a substitute for folic acid in routine supplementation."]
🤱 Lactation Safety
It is not known whether calcium leucovorin is excreted in human breast milk. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose of calcium leucovorin is unlikely to cause serious effects due to its low toxicity. However, in case of accidental overdose, seek medical attention. Treatment is symptomatic and supportive.
⏰ Missed Dose
This medicine is given by a healthcare professional in a clinical setting. If you miss an appointment for your dose, contact your doctor or clinic immediately to reschedule. Do not attempt to self-administer.
Additional Safety Advice
This medicine must be given only by a qualified healthcare professional in a hospital or clinic setting. Do not attempt to self-administer. Inform your doctor about all medicines you are taking, especially methotrexate, fluorouracil, phenytoin, or sulfa drugs. Your doctor will monitor your blood counts, kidney function, and liver function regularly. Stay well hydrated during treatment. Avoid alcohol as it may worsen side effects. If you are pregnant or planning pregnancy, discuss the risks and benefits with your doctor. Do not breastfeed while on this medicine without medical advice. Report any signs of allergic reaction, severe diarrhea, or unusual bleeding immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced renal function and are at higher risk of methotrexate toxicity. Dose adjustments and close monitoring are recommended.
🤰 Pregnancy Planning (TTC)
Discuss with your doctor if you are planning pregnancy. This medicine is used only when clearly needed, and the risks and benefits must be weighed.
🏥 Post-Surgery Considerations
This medicine may be used after surgery if methotrexate or fluorouracil therapy is part of the treatment plan. Follow your surgeon's and oncologist's instructions.
🦷 Dental Procedures
Inform your dentist that you are receiving this medicine. It may affect healing or increase bleeding risk if you have low blood counts.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Mild exercise is generally safe, but avoid strenuous activity if you feel fatigued or dizzy. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a clinical setting and may cause fatigue or dizziness. Avoid driving or operating heavy machinery until you know how it affects you. You may need to take time off work for treatment sessions.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. The duration of treatment is determined by your healthcare provider based on your condition and response.
📅 Long-Term Use Effects
Long-term effects of calcium leucovorin are generally not a concern when used as directed for short-term rescue or chemotherapy enhancement. However, repeated use may require monitoring of kidney function and blood counts. There is no known cumulative toxicity.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
An alternative reduced folate that may be used instead of calcium leucovorin.
Evidence: Well-establishedUsed for routine folate deficiency but not for methotrexate rescue.
Evidence: Well-established for deficiency, not for rescue💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during chemotherapy. Consult your doctor about vaccination timing.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not freeze
✅ DO
Protect from light
❌ DON'T
Do not use if solution is discolored or contains particles
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✈️ Traveling with This Medicine
This medicine is administered in a healthcare setting, so travel is not typically applicable. If you are traveling between treatment sessions, carry a copy of your prescription and medical records. Store the injection as directed by your healthcare provider. For international travel, check customs regulations regarding injectable medicines and carry a doctor's letter.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine acts rapidly after intravenous administration, usually within minutes to hours. Its effects in rescuing normal cells from methotrexate begin soon after injection.
A: No, this medicine must be given by a healthcare professional in a hospital or clinic setting.
A: Avoid alcohol and inform your doctor about all other medicines you are taking. Stay well hydrated.
🤔 Common Patient Concerns
🔄 Substitutes for cevoric c 50mg injection
View AllAlternative brands with exact same active ingredient:
-
neovorin injectionNeon Laboratories Ltd ₹68.00 72.8% CHEAPER
-
leucovorin injectionDabur India Ltd ₹234.38 6.2% CHEAPER
-
nyrin 50mg injectionVhb Life Sciences Inc ₹240.00 4% CHEAPER
-
adcov 50mg injectionAdley Formulations ₹250.00 SAME PRICE
-
leutero 50mg injectionHetero Drugs Ltd ₹250.00 SAME PRICE
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Leucovorin is a chemotherapy drug.
Fact: Leucovorin is not a chemotherapy drug; it is a rescue agent and modulator that protects normal cells and enhances certain chemotherapy effects. - Myth: Leucovorin can be taken as a vitamin supplement.
Fact: Leucovorin is a prescription medicine used for specific medical conditions, not a routine vitamin supplement.
🔄 Alternative Options
Generic Alternatives
- Calcium leucovorin injection (generic)
Brand Alternatives
- Adcov 50mg injection