Emispas 40mg/10mg/250mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
- Severe dizziness or fainting
If experiencing severe symptoms, call emergency services immediately.
What is emispas 40mg/10mg/250mg tablet used for?
This medicine is a combination of dicyclomine (an antispasmodic) and mefenamic acid (an NSAID) used to relieve abdominal cramps and pain associated with irritable bowel syndrome and menstrual cramps. It works by relaxing gastrointestinal smooth muscles and reducing inflammation. It is taken orally with food, usually 2 to 4 times daily as needed. It should not be used for more than 7 days without medical advice.
- Generic Name: Dicyclomine (40mg) + Mefenamic Acid (10mg)
- Manufacturer: Empire Drugs
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 emispas 40mg/10mg/250mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डाइसाइक्लोमिन और मेफेनैमिक एसिड का संयोजन है, जिसका उपयोग पेट की ऐंठन, चिड़चिड़ा आंत्र सिंड्रोम (IBS) और मासिक धर्म के दर्द को कम करने के लिए किया जाता है। यह पेट की मांसपेशियों को आराम देकर और सूजन को कम करके दर्द से राहत देती है। इसे भोजन के साथ लेना चाहिए और डॉक्टर की सलाह के बिना 7 दिनों से अधिक नहीं लेना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में मुँह सूखना, चक्कर आना, नींद आना, जी मिचलाना, उल्टी, पेट दर्द और कब्ज शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट में रक्तस्राव, अल्सर, गुर्दे की समस्या, गंभीर एलर्जी प्रतिक्रिया और रक्त विकार शामिल हो सकते हैं। यदि आपको काला या खूनी मल, खून की उल्टी, गंभीर पेट दर्द, पेशाब में कमी, चेहरे या गले में सूजन, या असामान्य रक्तस्राव या चोट लगने पर तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। अनुशंसित खुराक या अवधि से अधिक न लें। पेट की परेशानी कम करने के लिए इसे भोजन या दूध के साथ लें। इस दवा के साथ शराब का सेवन न करें क्योंकि इससे पेट में रक्तस्राव का खतरा बढ़ सकता है। यदि आपको चक्कर या नींद आती है तो वाहन चलाने या भारी मशीनरी चलाने से बचें। यदि आपको अल्सर, गुर्दे या यकृत की बीमारी, अस्थमा या रक्तस्राव विकार का इतिहास है तो अपने डॉक्टर को बताएं। बिना चिकित्सकीय सलाह के 7 दिनों से अधिक इस दवा का उपयोग न करें। बच्चों की पहुंच से दूर रखें।
💊 emispas 40mg/10mg/250mg tablet Uses & Benefits
[{"condition":"Irritable bowel syndrome (IBS)","description":"Relieves abdominal cramps and pain associated with IBS by reducing smooth muscle spasms and inflammation.","evidence":"Well-established"},{"condition":"Primary dysmenorrhea","description":"Reduces menstrual cramps and associated pain by inhibiting prostaglandin production and relaxing uterine muscles.","evidence":"Well-established"},{"condition":"Gastrointestinal spasms","description":"Used to treat spasms of the gastrointestinal tract that cause pain and discomfort.","evidence":"Established"},{"condition":"Biliary colic","description":"May help relieve pain from gallbladder spasms, though definitive evidence is limited.","evidence":"Limited"}]
Off-label uses: [{"condition":"Urinary tract spasms","description":"Sometimes prescribed off-label to relieve bladder spasms, but evidence is limited.","evidence":"Limited"},{"condition":"Pelvic pain","description":"Occasionally used for chronic pelvic pain, but not a standard indication.","evidence":"Limited"}]
Primary treatment for: Irritable bowel syndrome (IBS) and primary dysmenorrhea
Also treats: Gastrointestinal spasms, Biliary colic, Urinary tract spasms
📋 Drug Information
| Generic Name(s) | Dicyclomine (40mg) + Mefenamic Acid (10mg) |
| Brand Name | emispas 40mg/10mg/250mg tablet |
| Manufacturer | Empire Drugs |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Dicyclomine is an anticholinergic and antispasmodic agent that blocks muscarinic acetylcholine receptors on smooth muscle cells, reducing contractions and spasms in the gastrointestinal tract. Mefenamic acid is a nonsteroidal anti-inflammatory drug that reversibly inhibits cyclooxygenase enzymes (COX-1 and COX-2), decreasing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. The combined effect provides relief from both spasm and inflammation, addressing abdominal pain more comprehensively.
Mechanism Steps
💡 How to Take emispas 40mg/10mg/250mg tablet
Strength: Tablet containing Dicyclomine 40mg and Mefenamic Acid 10mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally 2 to 4 times daily as needed for pain and spasms. The maximum recommended daily dose is 4 tablets in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose or duration. Take with food or milk to reduce stomach upset. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the anticholinergic effects of dicyclomine and the renal effects of mefenamic acid. Use with caution and lower doses may be appropriate. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be necessary. Avoid in severe renal impairment. Consult a clinician for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose adjustment may be necessary. Avoid in severe hepatic impairment. Consult a clinician for individualized dosing. |
| Maximum Daily Dose | Maximum daily dose is 4 tablets (each containing dicyclomine 40mg and mefenamic acid 10mg) in 24 hours. Do not exceed the recommended dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of emispas 40mg/10mg/250mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Anticholinergics | Major | |
| Lithium | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., aspirin, ibuprofen)
- Anticholinergic drugs (e.g., atropine, antihistamines)
- Lithium
- Methotrexate
⚡ Moderate Interactions
- ACE inhibitors and ARBs
- Diuretics
- Corticosteroids
- SSRIs
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase the risk of gastrointestinal bleeding and may worsen drowsiness and dizziness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to dicyclomine, mefenamic acid, or any component of the formulation","Active peptic ulcer disease or history of recurrent ulcers","Severe renal impairment","Severe hepatic impairment","Third trimester of pregnancy","Patients with glaucoma (dicyclomine may increase intraocular pressure)","Myasthenia gravis","Paralytic ileus or intestinal obstruction","Children below 12 years of age (safety not established)"]
⚠️ Warnings & Precautions
["Use with caution in elderly patients due to increased risk of anticholinergic effects and renal impairment.","Avoid in patients with cardiovascular disease due to increased risk of thrombotic events.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Do not use for more than 7 days without medical advice.","May mask signs of infection (NSAIDs can reduce fever).","Use with caution in patients with asthma, as NSAIDs may precipitate bronchospasm.","May cause fluid retention and edema; use with caution in heart failure.","Avoid concurrent use with other NSAIDs or anticoagulants."]
🤱 Lactation Safety
Dicyclomine and mefenamic acid may pass into breast milk. Consult your doctor before breastfeeding. Dicyclomine may cause anticholinergic effects in the infant. Mefenamic acid may cause gastrointestinal upset. Use with caution and monitor the infant for any adverse effects.
💊 Overdose Management
Overdose may cause severe anticholinergic symptoms (e.g., dry mouth, blurred vision, tachycardia, urinary retention, confusion) and NSAID toxicity (e.g., nausea, vomiting, gastrointestinal bleeding, kidney failure). Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor vital signs, electrolytes, and renal function.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of gastrointestinal bleeding. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Inform your doctor if you have a history of ulcers, kidney or liver disease, asthma, or bleeding disorders. Do not use this medicine for more than 7 days without medical advice. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the anticholinergic effects of dicyclomine (e.g., confusion, dry mouth, constipation, urinary retention) and the renal effects of mefenamic acid. Use with caution, lower doses may be appropriate, and monitor kidney function regularly.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It is not recommended during pregnancy, especially in the third trimester, due to the risk of premature closure of the ductus arteriosus. Discuss alternative treatments with your doctor.
🏥 Post-Surgery Considerations
After surgery, consult your doctor before taking this medicine. NSAIDs may increase the risk of bleeding and interfere with wound healing. Dicyclomine may cause urinary retention, which can be problematic after certain surgeries.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. NSAIDs can increase bleeding risk, and dicyclomine can cause dry mouth, which may affect dental health. Your dentist may recommend adjusting your medication or taking precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you experience dizziness or drowsiness. Listen to your body and rest if you feel unwell. Gentle activities like walking or yoga are generally safe.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause dry mouth, which can be managed by sipping water. Inform your employer if your work requires alertness.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any serious side effects such as black stools, severe abdominal pain, or allergic reactions. Do not stop abruptly if you have been on long-term therapy without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of gastrointestinal bleeding, ulcers, kidney problems, and liver toxicity. It is not recommended for prolonged use without medical supervision. Regular monitoring of kidney and liver function may be required. Consult your doctor if you need to use it for more than 7 days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Avoiding trigger foods and eating a balanced diet can help manage IBS and cramps.
Evidence: Well-establishedYoga, meditation, and counseling can reduce stress-related gastrointestinal symptoms.
Evidence: ModerateApplying a heating pad to the abdomen can relieve menstrual cramps.
Evidence: Well-establishedMay help restore gut flora and reduce IBS symptoms.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, continue your regular dosing schedule as prescribed; consult your doctor if adjustments are needed. Declare the medicine at customs if required. Keep it in your carry-on luggage to avoid loss.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain and cramps within 1 to 2 hours after taking it orally.
A: It is best taken with food or milk to reduce the risk of stomach upset and bleeding.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: This medicine is not recommended during pregnancy, especially in the third trimester, unless clearly needed and prescribed by a doctor. Consult your doctor for advice.
A: No, avoid alcohol while taking this medicine as it increases the risk of gastrointestinal bleeding and drowsiness.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can cure irritable bowel syndrome.
Fact: This medicine provides symptomatic relief but does not cure IBS. Lifestyle and dietary changes are also important. - Myth: It is safe to take this medicine for any stomach pain.
Fact: This medicine is specific for spasmodic pain and should not be used for all types of stomach pain. Consult a doctor for proper diagnosis. - Myth: You can take this medicine on an empty stomach.
Fact: It should be taken with food or milk to reduce the risk of stomach upset and bleeding.
🔄 Alternative Options
Generic Alternatives
- Dicyclomine + Mefenamic Acid combination tablets (various manufacturers)
Brand Alternatives
- Emispas 40mg/10mg/250mg Tablet