dromef 80 mg/250 mg tablet
What is dromef 80 mg/250 mg tablet used for?
Almefkem-D Tablet (Drotaverine + Mefenamic Acid) is used to treat GASTRO INTESTINAL. It contains Drotaverine (80mg) + Mefenamic Acid (250mg), which Drotaverine inhibits phosphodiesterase IV, causing smooth muscle relaxation; Mef. Always consult your doctor before use. Take as prescribed.
- Generic Name: Drotaverine + Mefenamic Acid
- Manufacturer: Numed
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ dromef 80 mg/250 mg tablet Uses & Benefits
Smooth muscle spasms associated with GI, biliary, or urinary tract disorders; dysmenorrhea
Off-label uses: Renal colic, biliary colic, migraine (limited evidence)
๐ Drug Information
| Generic Name(s) | Drotaverine + Mefenamic Acid |
| Brand Name | Almefkem-D Tablet |
| Manufacturer | Numed |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Antispasmodic + NSAID |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture and light |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Drotaverine inhibits phosphodiesterase IV, causing smooth muscle relaxation; Mefenamic acid inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis.
Mechanism Steps
๐ก How to Take dromef 80 mg/250 mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of dromef 80 mg/250 mg tablet
โ Common Side Effects
- Nausea
- Vomiting
- Dizziness
- Headache
- Drowsiness
- Dry mouth
- Diarrhea
- Constipation
๐จ Serious Side Effects
- GI bleeding
- Peptic ulcer
- Renal failure
- Hepatotoxicity
- Anaphylaxis
- Stevens-Johnson syndrome
- Bone marrow suppression
โ ๏ธ Rare Side Effects
- Pancreatitis
- Hepatic necrosis
- Agranulocytosis
- Thrombocytopenia
- Aplastic anemia
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Aspirin | Major | Increased risk of GI ulceration and bleeding |
| Lithium | Major | Increased lithium toxicity |
| Methotrexate | Major | Increased methotrexate toxicity |
| ACE inhibitors | Major | Reduced antihypertensive effect |
| Diuretics | Major | Reduced diuretic effect |
| Anticoagulants | Moderate | Increased bleeding risk |
| Antiplatelets | Moderate | Increased bleeding risk |
| Corticosteroids | Moderate | Increased GI ulceration risk |
| SSRIs | Moderate | Increased bleeding risk |
| Alcohol | Moderate | Increased GI bleeding and hepatotoxicity |
| Antacids | Minor | Reduced absorption of mefenamic acid |
| Digoxin | Minor | Possible increased digoxin levels |
| Phenytoin | Minor | Possible increased phenytoin levels |
๐จ Major Interactions
- Warfarin
- Aspirin
- Lithium
- Methotrexate
- ACE inhibitors
- Diuretics
โก Moderate Interactions
- Anticoagulants
- Antiplatelets
- Corticosteroids
- SSRIs
- Alcohol
โน๏ธ Minor Interactions
- Antacids
- Digoxin
- Phenytoin
๐ฝ๏ธ Food Interactions
Food may delay absorption; avoid high-fat meals.
๐ท Alcohol Interaction
Increased risk of GI bleeding and hepatotoxicity
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, active GI bleeding, severe hepatic/renal impairment, asthma, history of NSAID-induced reactions, third trimester pregnancy
๐ Monitoring Parameters
Renal function, hepatic function, CBC, blood pressure, signs of GI bleeding
๐คฑ Lactation Safety
Not recommended; excreted in breast milk
๐ Overdose Management
Symptomatic and supportive; gastric lavage, activated charcoal; monitor for CNS depression, seizures, renal failure
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose; do not double dose
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
Effective and reliable. Worked as expected.
Effective and reliable. Worked as expected.
This medicine was effective for me. I followed the doctor's advice.
Good quality medicine. Satisfied with the outcome.
Helpful and effective medicine as per my experience. Always consult a doctor.