doran-o 4mg/50mg injection - Ondansetron (4mg) + Ranitidine (50mg) medicine

doran-o 4mg/50mg injection - Uses, Price, Side Effects & Substitutes

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๐Ÿญ BestoChem Formulations India Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 30, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 30, 2026

What is doran-o 4mg/50mg injection used for?

Anset OR 4mg/150mg Tablet (Ondansetron + Ranitidine) is used to treat GASTRO INTESTINAL. It contains Ondansetron (4mg) + Ranitidine (50mg), which Ondansetron: Selective 5-HT3 receptor antagonist; Ranitidine: Competitive H2 rec. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Ondansetron + Ranitidine
  • Manufacturer: BestoChem Formulations India Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š doran-o 4mg/50mg injection Uses & Benefits

Prevention of nausea and vomiting associated with chemotherapy, radiotherapy, and surgery; treatment of gastroesophageal reflux disease and peptic ulcer disease

Off-label uses: Ondansetron: Hyperemesis gravidarum; Ranitidine: Urticaria (off-label)

๐Ÿ“‹ Drug Information

Generic Name(s)Ondansetron + Ranitidine
Brand NameAnset OR 4mg/150mg Tablet
ManufacturerBestoChem Formulations India Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action ClassAntiemetic + H2 Receptor Antagonist
Route of AdministrationOral
StorageStore at room temperature (20-25ยฐC), protect from light and moisture
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionOndansetron: Well absorbed orally, bioavailability ~60%; Ranitidine: Rapidly absorbed, bioavailability ~50%
DistributionOndansetron: Vd ~2.2 L/kg; Ranitidine: Vd ~1.4 L/kg
Protein BindingOndansetron: 70-76%; Ranitidine: 15%
MetabolismOndansetron: Hepatic via CYP1A2, CYP2D6, CYP3A4; Ranitidine: Hepatic (minor) and renal
Half-LifeOndansetron: 3-6 h; Ranitidine: 2-3 h
ExcretionOndansetron: Urine (50% unchanged) and feces; Ranitidine: Urine (30% unchanged) and feces
BioavailabilityOndansetron: ~60%; Ranitidine: ~50%
Onset of ActionOndansetron: 30-60 min; Ranitidine: 1-2 h
Peak Plasma TimeOndansetron: 1-2 h; Ranitidine: 1-3 h
Duration of ActionOndansetron: 4-8 h; Ranitidine: 8-12 h

How It Works

Ondansetron: Selective 5-HT3 receptor antagonist; Ranitidine: Competitive H2 receptor antagonist

Mechanism Steps

1Ondansetron blocks 5-HT3 receptors in the chemoreceptor trigger zone and gastrointestinal tract, preventing serotonin-mediated emesis.
2Ranitidine competitively blocks H2 receptors on gastric parietal cells, reducing basal and stimulated gastric acid secretion.

๐Ÿ’ก How to Take doran-o 4mg/50mg injection

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of doran-o 4mg/50mg injection

โœ… Common Side Effects

  • Headache
  • Constipation
  • Diarrhea
  • Dizziness
  • Fatigue

๐Ÿšจ Serious Side Effects

  • QT prolongation
  • Torsades de pointes
  • Severe hypotension
  • Bronchospasm

โš ๏ธ Rare Side Effects

  • Hepatotoxicity
  • Pancreatitis
  • Agranulocytosis
  • Anaphylaxis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Apomorphine Major Increased risk of hypotension and loss of consciousness
Warfarin Moderate Possible altered anticoagulation effect
Antacids Minor Reduced absorption of ranitidine; separate by 1-2 hours

๐Ÿšจ Major Interactions

  • Apomorphine
  • Thioridazine
  • Pimozide

โšก Moderate Interactions

  • Warfarin
  • CYP1A2 substrates
  • CYP2D6 substrates

โ„น๏ธ Minor Interactions

  • Antacids
  • Sucralfate

๐Ÿฝ๏ธ Food Interactions

Food may delay absorption of ranitidine; no significant effect on ondansetron

๐Ÿท Alcohol Interaction

Alcohol may increase gastric irritation; avoid concurrent use

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to components, concomitant apomorphine, severe hepatic impairment

๐Ÿ“Š Monitoring Parameters

ECG for QT interval, liver function tests, renal function

๐Ÿคฑ Lactation Safety

Ondansetron: Excreted in milk, use caution; Ranitidine: Excreted in milk, use caution

๐Ÿ’Š Overdose Management

Symptomatic and supportive; monitor ECG for QT prolongation; no specific antidote

โฐ Missed Dose

Take as soon as remembered; if near next dose, skip missed dose; do not double dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 30, 2026

๐Ÿ”— View Profile

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