dobutam injection - Dobutamine (50mg) medicine

dobutam injection

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🏭 Varenyam Healthcare Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 21, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 21, 2026

What is dobutam injection used for?

This medicine contains Dobutamine (50mg) and is used to treat CARDIAC. Stimulates beta-1 adrenergic receptors in the heart, increasing myocardial contractility and stroke . Always consult your doctor before use.

  • Generic Name: Dobutamine
  • Manufacturer: Varenyam Healthcare Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category C
  • Prescription Required: Yes
💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 dobutam injection Uses & Benefits

Short-term management of cardiac decompensation due to depressed contractility (e.g., acute heart failure, cardiogenic shock).

Off-label uses: Stress echocardiography (dobutamine stress test).

📋 Drug Information

Generic Name(s)Dobutamine
Brand NameButim 250mg Injection
ManufacturerVarenyam Healthcare Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassSympathomimetics agonist-Inotropes
Route of AdministrationIntravenous infusion only
StorageStore at 20-25°C; protect from light; do not freeze.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionIntravenous administration results in complete bioavailability.
DistributionDistributes widely into tissues; volume of distribution approximately 0.2 L/kg.
Protein BindingApproximately 25% bound to plasma proteins.
MetabolismPrimarily metabolized in the liver by catechol-O-methyltransferase (COMT) to inactive metabolites.
Half-LifeApproximately 2 minutes.
ExcretionExcreted mainly in urine as metabolites and unchanged drug.
Bioavailability100% (intravenous).
Onset of Action1-2 minutes after intravenous administration.
Peak Plasma TimeWithin 10 minutes after start of infusion.
Duration of ActionShort duration; effects cease shortly after infusion stops.

How It Works

Stimulates beta-1 adrenergic receptors in the heart, increasing myocardial contractility and stroke volume.

Mechanism Steps

1Dobutamine binds to beta-1 adrenergic receptors on cardiac myocytes.
2Activation of Gs protein stimulates adenylate cyclase.
3Increased cyclic AMP (cAMP) levels activate protein kinase A.
4Phosphorylation of calcium channels increases calcium influx.
5Enhanced calcium release from sarcoplasmic reticulum increases contractility.
6Increased stroke volume and cardiac output.

💡 How to Take dobutam injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of dobutam injection

✅ Common Side Effects

Increased heart rate
Increased blood pressure
Ventricular ectopic activity
Nausea
Headache
Angina
Palpitations

🚨 Serious Side Effects

Arrhythmias (e.g., ventricular tachycardia, fibrillation)
Myocardial ischemia
Hypotension
Cardiac arrest

⚠️ Rare Side Effects

Hypersensitivity reactions
Thrombocytopenia
Seizures

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
MAOIs Major Increased risk of hypertensive crisis
Linezolid Major Increased pressor response
Tricyclic antidepressants Major Enhanced cardiovascular effects
Halogenated anesthetics Major Increased risk of arrhythmias
Beta-blockers Major Reduced inotropic effect; unopposed alpha activity
Digoxin Moderate Increased risk of arrhythmias
Diuretics Moderate Hypokalemia may increase arrhythmia risk
Insulin Moderate May alter glucose levels
Antidiabetic agents Moderate May alter glucose levels
Theophylline Minor Additive chronotropic effects
Thyroid hormones Minor Increased cardiovascular effects

🚨 Major Interactions

  • MAOIs
  • Linezolid
  • Tricyclic antidepressants
  • Halogenated anesthetics
  • Beta-blockers

⚡ Moderate Interactions

  • Digoxin
  • Diuretics
  • Insulin
  • Antidiabetic agents

🍷 Alcohol Interaction

Avoid alcohol; may increase cardiovascular side effects.

🛡️ Safety & Warnings

🚫 Contraindications

Idiopathic hypertrophic subaortic stenosis, hypersensitivity to dobutamine or sulfites, uncorrected hypovolemia.

🤱 Lactation Safety

Not recommended; unknown if excreted in breast milk.

💊 Overdose Management

Discontinue infusion; supportive measures; beta-blockers may be used for excessive tachycardia or hypertension.

⏰ Missed Dose

Continuous infusion; do not double dose. Adjust infusion rate as prescribed.

🔄 Substitutes for dobutam injection

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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