Dobucin 50mg Injection: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Chest pain or pressure that does not resolve
- Severe shortness of breath or difficulty breathing
- Palpitations or irregular heartbeat
- Dizziness or fainting
- Cold, clammy skin or decreased urine output
- Pain, swelling, or redness at the infusion site
- Severe headache or visual changes
If experiencing severe symptoms, call emergency services immediately.
What is dobutrop 50mg injection used for?
This medicine is a prescription injection used in hospitals to increase heart contraction and improve blood flow in patients with acute heart failure or cardiogenic shock. It is given intravenously under continuous monitoring.
- Generic Name: Dobutamine (50mg)
- Manufacturer: Geo Pharma Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 dobutrop 50mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा डोबुटामाइन का इंजेक्शन है, जिसका उपयोग अस्पताल में हृदय की मांसपेशियों की संकुचन शक्ति बढ़ाने और रक्त प्रवाह में सुधार करने के लिए किया जाता है। यह तीव्र हृदय विफलता, कार्डियोजेनिक शॉक और कम हृदय उत्पादन वाली स्थितियों में दी जाती है। यह दवा केवल डॉक्टर की देखरेख में नस के माध्यम से दी जाती है और इसके दौरान हृदय गति और रक्तचाप की लगातार निगरानी की जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में हृदय गति बढ़ना, धड़कन महसूस होना, सीने में दर्द, सिरदर्द, मतली, उल्टी और सांस लेने में कठिनाई शामिल हैं। गंभीर दुष्प्रभावों में वेंट्रिकुलर टैचीकार्डिया, एट्रियल फाइब्रिलेशन, दिल का दौरा और गंभीर उच्च या निम्न रक्तचाप हो सकते हैं। इन्हें तुरंत डॉक्टर को बताना चाहिए।
सुरक्षा सलाह: यह दवा केवल अस्पताल में डॉक्टर या नर्स द्वारा दी जाती है। इसे घर पर स्वयं न लें। उपचार के दौरान हृदय गति, रक्तचाप और हृदय की लय की लगातार निगरानी की जाती है। यदि सीने में दर्द, धड़कन तेज होना, सांस लेने में तकलीफ या चक्कर आना महसूस हो तो तुरंत चिकित्सक को सूचित करें। गर्भावस्था और स्तनपान के दौरान इस दवा का उपयोग डॉक्टर की सलाह के बिना न करें।
💊 dobutrop 50mg injection Uses & Benefits
[{"condition":"Acute decompensated heart failure","description":"This medicine is used to increase cardiac contractility and improve cardiac output in patients hospitalized with acute heart failure and low cardiac output.","evidence":"Well-established"},{"condition":"Cardiogenic shock","description":"It helps support blood pressure and organ perfusion in patients with cardiogenic shock, often in combination with other vasoactive agents.","evidence":"Well-established"},{"condition":"Low cardiac output syndrome after cardiac surgery","description":"This medicine is commonly used to improve heart function after coronary artery bypass grafting or other cardiac surgeries.","evidence":"Well-established"},{"condition":"Stress echocardiography","description":"It is used as a pharmacological stress agent to detect coronary artery disease in patients who cannot exercise adequately.","evidence":"Well-established"},{"condition":"Septic shock with myocardial depression","description":"In selected patients with septic shock and evidence of myocardial dysfunction, this medicine may be added to improve cardiac output.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Perioperative low cardiac output in non-cardiac surgery","description":"Occasionally used to support cardiac output during high-risk non-cardiac surgery, though evidence is limited.","evidence":"Limited"},{"condition":"Bridge to heart transplantation","description":"May be used temporarily to maintain cardiac output in patients awaiting heart transplant, but not as a standard therapy.","evidence":"Limited"}]
Primary treatment for: Acute decompensated heart failure
Also treats: Cardiogenic shock, Low cardiac output syndrome, Septic shock with myocardial depression, Coronary artery disease (for stress testing)
📋 Drug Information
| Generic Name(s) | Dobutamine (50mg) |
| Brand Name | dobutrop 50mg injection |
| Manufacturer | Geo Pharma Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Sympathomimetics agonist-Inotropes |
| Route of Administration | Parenteral (intravenous infusion only) |
| Storage | Store at 20°C to 25°C (68°F to 77°F). Do not freeze. Protect from light. Keep in the original carton until use. Once diluted, the solution should be used within 24 hours if stored at room temperature or 48 hours if refrigerated at 2°C to 8°C. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by directly stimulating beta-1 adrenergic receptors on the heart muscle, which increases the force of cardiac contraction (positive inotropy) and slightly increases heart rate (positive chronotropy). It also has mild beta-2 and alpha-1 agonist activity, which can cause peripheral vasodilation and mild vasoconstriction, respectively. The overall effect is an increase in cardiac output and improved tissue perfusion. Unlike some other inotropes, this medicine does not rely on the release of endogenous norepinephrine, so it remains effective in patients with depleted catecholamine stores.
Mechanism Steps
💡 How to Take dobutrop 50mg injection
Strength: Injection: 50 mg per vial (as dobutamine hydrochloride).
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the patient's clinical condition, hemodynamic response, and other factors. A typical starting infusion rate is 2.5 to 5 micrograms per kilogram per minute, which may be titrated up to 20 micrograms per kilogram per minute based on response. For stress echocardiography, a different protocol is used. Continuous monitoring is essential. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially to increases in heart rate and blood pressure. Doses should be titrated carefully, starting at the lower end of the recommended range. Close monitoring is required. |
| Renal Impairment | No specific dose adjustment is provided in the labeling for renal impairment. However, since this medicine is primarily excreted in urine, caution is advised in patients with severe renal impairment. Dose should be individualized based on clinical response. |
| Hepatic Impairment | No specific dose adjustment is provided in the labeling for hepatic impairment. Since this medicine is metabolized in the liver, caution is advised in patients with severe hepatic impairment. Dose should be individualized based on clinical response. |
| Maximum Daily Dose | The maximum recommended dose is 20 micrograms per kilogram per minute, but this may be exceeded in some clinical situations under close supervision. The total daily dose depends on the duration of infusion. Dose must be individualized by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of dobutrop 50mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Beta-blockers | Major | |
| MAOIs | Major | |
| Tricyclic antidepressants | Major | |
| General anesthetics | Major | |
| Oxytocin | Major | |
| Nitrates | Moderate | |
| Diuretics | Moderate | |
| Insulin | Moderate | |
| Thyroid hormones | Moderate | |
| Caffeine | Minor |
🚨 Major Interactions
- Beta-blockers (e.g., propranolol, metoprolol)
- Monoamine oxidase inhibitors (MAOIs)
- Tricyclic antidepressants
- General anesthetics (e.g., halothane, cyclopropane)
- Oxytocin
⚡ Moderate Interactions
- Nitrates (e.g., nitroglycerin)
- Diuretics
- Insulin and oral hypoglycemics
- Thyroid hormones
🍷 Alcohol Interaction
Alcohol may enhance the vasodilatory effects of this medicine and increase the risk of hypotension. It is advisable to avoid alcohol during treatment with this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to dobutamine or any component of the formulation","Idiopathic hypertrophic subaortic stenosis (IHSS)","Severe aortic stenosis","Atrial fibrillation without rate control","Ventricular arrhythmias","Hypovolemia (must be corrected before use)"]
⚠️ Warnings & Precautions
["This medicine should be used only in a monitored setting with continuous cardiac and blood pressure monitoring.","It can increase myocardial oxygen demand and may precipitate angina or myocardial infarction in patients with coronary artery disease.","It may cause tachyarrhythmias, including ventricular tachycardia and atrial fibrillation.","Prolonged use may lead to tolerance and decreased effectiveness.","It should not be mixed with alkaline solutions such as sodium bicarbonate.","Extravasation can cause local tissue necrosis; monitor infusion site closely.","Use with caution in patients with hypertension, hyperthyroidism, or a history of arrhythmias.","It may increase blood glucose levels; monitor in diabetic patients.","Safety and effectiveness in pediatric patients have not been well established for all indications."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
💊 Overdose Management
Overdose of this medicine can cause severe hypertension, tachycardia, arrhythmias, and myocardial ischemia. There is no specific antidote. Treatment is symptomatic and supportive. The infusion should be stopped immediately. If necessary, a short-acting beta-blocker such as esmolol may be used to counteract excessive beta-adrenergic stimulation, but caution is advised as it may worsen heart failure. Monitor vital signs and cardiac rhythm until stable.
⏰ Missed Dose
This medicine is given as a continuous intravenous infusion in a hospital setting. Missed doses are not applicable because the infusion is controlled by healthcare professionals. If the infusion is interrupted, the healthcare team will restart it as soon as clinically appropriate.
Additional Safety Advice
This medicine is for hospital use only and must be administered by a trained healthcare professional using an infusion pump. Never attempt to self-administer this medicine. Before starting the infusion, inform your doctor about all your medical conditions, especially heart rhythm problems, high blood pressure, asthma, or allergies to sulfites. During the infusion, your heart rate, blood pressure, and heart rhythm will be monitored closely. Report any chest pain, palpitations, difficulty breathing, or dizziness immediately to the nursing staff. This medicine should not be mixed with alkaline solutions such as sodium bicarbonate, as it may become inactive. Do not use if the solution is discolored or contains particles. The infusion site should be checked regularly for signs of extravasation, such as pain, swelling, or redness. If extravasation occurs, the infusion must be stopped and the area treated as per hospital protocol. This medicine is not recommended during pregnancy unless the potential benefit justifies the potential risk to the fetus. It may pass into breast milk, so breastfeeding should be avoided during treatment.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine, especially increases in heart rate and blood pressure. Doses should be titrated carefully, starting at the lower end of the recommended range. Close monitoring is required.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss with your doctor. This medicine is used only in acute hospital settings, and its use during pregnancy should be based on a careful risk-benefit assessment.
🏥 Post-Surgery Considerations
This medicine is often used after cardiac surgery to support heart function. It is administered in the ICU with continuous monitoring. After stabilization, it is gradually weaned off.
🦷 Dental Procedures
This medicine is not typically relevant to dental procedures. However, inform your dentist if you have a history of heart failure or are taking any heart medications.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, patients are in a hospital setting and should not engage in any physical exercise. After discharge, follow your doctor's advice regarding gradual return to activity.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital setting, so it does not directly impact work or daily life. After treatment, patients may need time to recover and should follow their doctor's advice regarding return to work and driving.
🛑 When to Stop This Medicine
This medicine is stopped by the healthcare team when the patient's hemodynamic status improves or when the risks outweigh the benefits. Patients should never stop or adjust the infusion themselves. After discharge, follow your doctor's instructions regarding other medications.
📅 Long-Term Use Effects
This medicine is intended for short-term use in acute settings. Prolonged infusion may lead to tolerance, requiring higher doses for the same effect. Long-term use is not recommended. Patients who receive this medicine should be monitored for cardiac arrhythmias, ischemia, and changes in blood pressure. After discontinuation, a gradual transition to oral therapy is typically planned.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
An alternative inotrope that may be used in patients who do not respond to this medicine.
Evidence: Well-establishedDevices such as intra-aortic balloon pump or ventricular assist devices may be used in severe cases.
Evidence: Well-establishedFor eligible patients with end-stage heart failure.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, patients with heart failure should receive appropriate vaccinations such as influenza and pneumococcal vaccines as per guidelines.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original carton to protect from light
❌ DON'T
Do not use if solution is discolored or contains particles
✅ DO
Use diluted solution within 24 hours at room temperature or 48 hours if refrigerated
❌ DON'T
Do not store diluted solution for longer than recommended
✈️ Traveling with This Medicine
This medicine is for hospital use only and is not typically carried by patients during travel. If you are a healthcare professional traveling with this medicine, carry it in its original packaging with the prescription and documentation. Store it at room temperature, protect it from light, and do not freeze. Check with customs regarding regulations for carrying injectable medications across borders.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 1 to 2 minutes after the infusion begins, but its effects wear off quickly once the infusion is stopped.
A: No, this medicine is for hospital use only and must be given by a healthcare professional with continuous monitoring.
A: Serious side effects include dangerous heart rhythm problems, heart attack, and severe blood pressure changes. Report any chest pain, palpitations, or difficulty breathing immediately.
A: It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor.
A: Store at room temperature, protect from light, and do not freeze. Once diluted, use within the recommended time.
🤔 Common Patient Concerns
🔄 Substitutes for dobutrop 50mg injection
View AllAlternative brands with exact same active ingredient:
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cardiject 50mg injectionSun Pharmaceutical Industries Ltd ₹81.80 67.3% CHEAPER
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dobutam injectionVarenyam Healthcare Pvt Ltd ₹218.16 12.7% CHEAPER
-
dobucard 50mg injectionSPM Drugs Pvt Ltd ₹250.00 SAME PRICE
-
dobucin 50mg injectionTroikaa Pharmaceuticals Ltd ₹320.00 28% COSTLIER
-
dobier s 50mg injectionChandra Bhagat Pharma Pvt Ltd ₹1,111.21 344.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken at home for heart failure.
Fact: This medicine is for hospital use only and must be given intravenously under continuous monitoring. - Myth: This medicine is a cure for heart failure.
Fact: This medicine is a short-term supportive treatment to improve heart function; it does not cure the underlying condition. - Myth: This medicine is safe for everyone with low blood pressure.
Fact: This medicine is contraindicated in certain conditions like idiopathic hypertrophic subaortic stenosis and severe aortic stenosis.
🔄 Alternative Options
Generic Alternatives
- Dobutamine injection
Brand Alternatives
- Dobutrex
- Dobutamine Injection