Atrabloc Injection (Atracurium 10mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Sudden swelling of the face, lips, or throat
- Severe difficulty breathing or wheezing
- A sudden, severe drop in blood pressure
- A widespread rash or hives
- High fever with muscle rigidity and fast heartbeat
- Prolonged muscle weakness that does not improve
- Seizures or unusual movements
- Chest pain or irregular heartbeat
If experiencing severe symptoms, call emergency services immediately.
What is atrabloc injection used for?
This medicine is a hospital-only injectable muscle relaxant containing atracurium. It is used by anesthesiologists to relax muscles during surgery, help insert a breathing tube, and support patients on a breathing machine. It works by blocking nerve signals to muscles and must only be given under close medical supervision.
- Generic Name: Atracurium besilate
- Manufacturer: Varenyam Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 atrabloc injection के बारे में (Hindi Summary)
उपयोग: यह दवा अस्पताल में विशेषज्ञों द्वारा दी जाने वाली इंजेक्शन है जिसमें एट्राक्यूरियम नामक सक्रिय तत्व होता है। इसका उपयोग सर्जरी के दौरान मांसपेशियों को ढीला करने, सांस की नली डालने और वेंटिलेटर पर मरीज को आराम देने के लिए किया जाता है। यह दवा मांसपेशियों तक नसों के संकेत पहुंचने को रोकती है, जिससे मांसपेशियां सिकुड़ नहीं पातीं। यह दवा केवल बेहोश मरीज को ही दी जाती है और इसके साथ सांस देने वाली मशीन का होना जरूरी है। इसे घर पर या खुद से कभी नहीं लगाया जा सकता।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में चेहरे पर लालिमा, रक्तचाप में हल्की कमी, दिल की धड़कन तेज होना और इंजेक्शन वाली जगह पर हल्की सूजन शामिल हैं। कभी-कभी मांसपेशियों में कमजोरी कुछ समय तक बनी रह सकती है। बहुत कम मामलों में गंभीर एलर्जी, सांस लेने में तकलीफ, या शरीर का तापमान अचानक बढ़ना जैसी गंभीर समस्याएं हो सकती हैं। ऐसा होने पर तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल में विशेषज्ञ डॉक्टर द्वारा ही दी जानी चाहिए। मरीज को बेहोश होना चाहिए और सांस की नली लगी होनी चाहिए। अगर आपको पहले कभी किसी मसल रिलैक्सेंट से एलर्जी हुई है, या आपको मायस्थेनिया ग्रेविस, किडनी या लीवर की बीमारी है, तो डॉक्टर को जरूर बताएं। इस दवा के बाद मरीज को तब तक निगरानी में रखा जाता है जब तक उसकी मांसपेशियां और सांस पूरी तरह सामान्य न हो जाएं।
💊 atrabloc injection Uses & Benefits
[{"condition":"Endotracheal intubation during general anesthesia","description":"This medicine relaxes the jaw, throat, and vocal cord muscles so that a breathing tube can be inserted smoothly and safely during surgery.","evidence":"Well-established"},{"condition":"Skeletal muscle relaxation during surgery","description":"It provides controlled muscle paralysis during abdominal, orthopedic, cardiac, and other surgical procedures where muscle movement must be prevented.","evidence":"Well-established"},{"condition":"Mechanical ventilation in intensive care","description":"It helps patients in the intensive care unit tolerate a breathing machine by preventing coughing, straining, and fighting against the ventilator.","evidence":"Well-established"},{"condition":"Facilitation of procedures such as endoscopy or bronchoscopy","description":"It may be used to relax muscles during certain diagnostic or therapeutic procedures that require complete stillness.","evidence":"Established"},{"condition":"Control of muscle spasms in tetanus or similar conditions","description":"In selected critical care situations, it can help control severe muscle spasms that do not respond to other treatments.","evidence":"Limited"}]
Off-label uses: [{"condition":"Rapid sequence intubation in emergency departments","description":"Sometimes used off-label in emergency settings when rapid paralysis is needed, though other agents are often preferred.","evidence":"Limited"},{"condition":"Adjunct in therapeutic hypothermia protocols","description":"Occasionally used to prevent shivering in patients undergoing targeted temperature management.","evidence":"Limited"}]
Primary treatment for: Surgical muscle relaxation and intubation
Also treats: Mechanical ventilation in intensive care, Tetanus with severe muscle spasms, Diagnostic procedures requiring muscle relaxation
📋 Drug Information
| Generic Name(s) | Atracurium besilate |
| Brand Name | Atracurium Besilate Injection |
| Manufacturer | Varenyam Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Skeletal muscle relaxant- Peripherally acting |
| Route of Administration | Intravenous (into a vein) only, by a trained healthcare professional |
| Storage | Store this medicine in its original container at a controlled room temperature between 2°C and 8°C (refrigerated) as per the manufacturer's instructions. Do not freeze. Protect from light. Once diluted for infusion, use as directed by the hospital pharmacy and discard any unused portion. |
| Shelf Life | The shelf life is typically 24 months from the date of manufacture when stored under the recommended conditions. Always check the expiry date on the vial before use. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by blocking the action of acetylcholine at the neuromuscular junction, which is the special connection point between a nerve ending and a muscle fibre. Acetylcholine is the natural chemical messenger that carries the signal from the nerve to the muscle to make it contract. Atracurium binds to the same receptor sites on the muscle that acetylcholine would normally activate, but it does not activate them. By occupying these receptors without stimulating them, it prevents acetylcholine from delivering its signal, so the muscle cannot contract. This results in a gradual and reversible paralysis of skeletal muscles. The medicine is broken down in the body by a process called Hofmann elimination, which does not depend on the liver or kidneys, making its effect more predictable in patients with organ problems. The paralysis begins within a few minutes after injection, reaches its maximum effect shortly after, and wears off as the medicine is eliminated from the body.
Mechanism Steps
💡 How to Take atrabloc injection
Strength: Atracurium 10 mg per mL injection, supplied in single-use vials.
Dosage Information
| Adult Dosage | The dose of this medicine is always individualized by a qualified anesthesiologist or critical care specialist based on the patient's weight, age, medical condition, and the procedure being performed. A typical intubating dose for adults is in the range of 0.4 to 0.5 mg per kg of body weight given intravenously, but this may vary. For continuous infusion during surgery or in intensive care, the rate is adjusted according to the measured muscle relaxation using a nerve stimulator. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and body temperature. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician or pediatric anesthesiologist for appropriate use. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, and the effect may last longer. The dose should be reduced and adjusted carefully by the anesthesiologist based on the patient's condition and response. |
| Renal Impairment | This medicine is broken down independently of the kidneys, so dose adjustment is usually not required for kidney disease alone. However, the dose should still be individualized by the clinician based on the patient's overall condition and response. |
| Hepatic Impairment | This medicine is broken down independently of the liver, so dose adjustment is usually not required for liver disease alone. However, the dose should still be individualized by the clinician based on the patient's overall condition and response. |
| Maximum Daily Dose | The maximum daily dose is not fixed and depends on the clinical situation. It is determined by the anesthesiologist or critical care specialist based on the patient's needs, monitoring, and response. Doses should be kept as low as possible for the shortest duration needed. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of atrabloc injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Gentamicin | Major | |
| Magnesium sulfate | Major | |
| Isoflurane | Major | |
| Lidocaine | Major | |
| Furosemide | Moderate | |
| Corticosteroids | Moderate | |
| Calcium channel blockers | Moderate | |
| Lithium | Moderate | |
| Neostigmine | Minor | |
| Theophylline | Minor |
🚨 Major Interactions
- Aminoglycoside antibiotics (e.g., gentamicin, amikacin)
- Magnesium sulfate
- Inhaled anesthetics (e.g., isoflurane, sevoflurane)
- Local anesthetics (e.g., lidocaine)
- Other neuromuscular blocking agents
⚡ Moderate Interactions
- Diuretics (e.g., furosemide)
- Corticosteroids
- Calcium channel blockers
- Lithium
🍷 Alcohol Interaction
Alcohol is not directly relevant to this medicine because it is given in a hospital setting under controlled conditions. However, alcohol can affect liver function, electrolyte balance, and the response to anesthesia. Patients should inform their anesthesiologist about any recent alcohol use, as it may influence the dose and effects of this medicine and other anesthetic drugs.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy or hypersensitivity to atracurium or any component of the injection","Patients who are awake or not on a breathing machine","Known history of malignant hyperthermia","Severe neuromuscular disease such as myasthenia gravis without proper monitoring","Use without appropriate resuscitation equipment and trained personnel"]
⚠️ Warnings & Precautions
["This medicine must only be given by trained anesthesia or critical care professionals.","Patients must be unconscious and have a secure airway before administration.","Use with caution in patients with neuromuscular disorders, electrolyte imbalances, or acid-base disturbances.","The dose should be reduced in elderly patients and in those with low body temperature.","Prolonged use in intensive care can lead to muscle weakness and should be monitored.","Laudanosine, a breakdown product, can accumulate with high doses or long infusions and may rarely cause seizures.","Always have resuscitation equipment and medicines for allergic reactions ready.","Inform the medical team if you have ever had a reaction to any muscle relaxant."]
🤱 Lactation Safety
This medicine is given as a single dose during surgery and is broken down rapidly in the body. It is not expected to pass into breast milk in significant amounts. However, because it is used only in hospital settings, breastfeeding mothers should discuss the timing of breastfeeding with their doctor after the procedure.
💊 Overdose Management
Overdose of this medicine can cause prolonged and excessive muscle paralysis, including the muscles used for breathing. There is no specific antidote that works instantly, but the effect can be reversed with medicines called anticholinesterases such as neostigmine, given by a qualified doctor. The patient must be kept on a breathing machine and monitored closely until muscle power returns. Supportive care includes maintaining blood pressure, heart rate, and oxygen levels. In case of accidental overdose, seek emergency medical help immediately.
⏰ Missed Dose
This medicine is given only in a hospital setting by a healthcare professional. There is no home dosing schedule, so missed doses are not applicable. If you have questions about your treatment, speak to your anesthesiologist or critical care doctor.
Additional Safety Advice
This medicine is a powerful hospital medicine and must never be used outside a properly equipped medical facility. It should only be given by an anesthesiologist or a trained critical care specialist who can monitor breathing, heart rate, blood pressure, and oxygen levels continuously. Patients must be unconscious and have a secure airway with a breathing tube in place before this medicine is injected, because it paralyses the muscles used for breathing. The medical team should always have resuscitation equipment, oxygen, and medicines for allergic reactions ready at the bedside. Tell your doctor if you have ever had a reaction to any muscle relaxant, if you have a neuromuscular disease such as myasthenia gravis, if you have kidney or liver problems, or if you have a history of malignant hyperthermia. This medicine should not be given to patients who are awake or who are not on a breathing machine. Do not attempt to move or reposition a patient who has received this medicine without professional help, because the muscles are completely relaxed. After the procedure, the medical team will monitor you until the muscle relaxant effect has fully worn off and you can breathe on your own.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine, and the paralysis may last longer. The dose should be reduced and adjusted carefully. Elderly patients should be monitored closely for prolonged weakness and breathing difficulties after the procedure.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy or are pregnant, tell your doctor before any procedure. This medicine may be used during surgery in pregnancy when medically necessary, but the decision will be made by a specialist who will weigh the benefits and risks for both mother and baby.
🏥 Post-Surgery Considerations
After surgery, you will be monitored in the recovery area until the effect of this medicine has worn off and you can breathe on your own. You may feel weak or tired for a few hours. Follow your doctor's instructions on when to eat, drink, and resume activities. Report any difficulty breathing, persistent weakness, or allergic symptoms immediately.
🦷 Dental Procedures
This medicine is not used in routine dental procedures. If you are having dental surgery under general anesthesia, inform your dentist and anesthesiologist about any allergies or medical conditions. The same precautions apply as for any other surgery.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
After receiving this medicine, you may feel weak or tired for some time. Do not drive, operate machinery, or perform strenuous activities until your doctor says it is safe. Start with gentle movements and follow your physiotherapy plan if provided.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital setting, so it does not directly affect your daily work. However, after the procedure, you may need time to recover. Do not drive or operate heavy machinery until you are fully alert and your doctor has cleared you. Most people can return to normal activities within a few days, depending on the type of surgery.
🛑 When to Stop This Medicine
This medicine is stopped by the medical team when the procedure is finished or when the patient no longer needs muscle relaxation. You should never stop or adjust this medicine yourself. If you have concerns about its effects, speak to your doctor.
📅 Long-Term Use Effects
This medicine is usually given for short periods during surgery or for a limited time in intensive care. Long-term effects are mainly seen when it is used as a continuous infusion for many days. In such cases, patients may develop prolonged muscle weakness, which can delay recovery and require physiotherapy. Monitoring muscle function and keeping the dose as low as possible for the shortest duration helps reduce this risk. There are no known long-term effects on the liver or kidneys.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Medicines such as cisatracurium, vecuronium, or rocuronium may be used depending on the clinical situation.
Evidence: Well-establishedIn some procedures, deeper anesthesia may be used instead of a muscle relaxant, but this is not suitable for all cases.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for surgery, tell your doctor about any recent vaccinations. Routine vaccinations should not be given during an acute illness or immediately after surgery without medical advice.
📦 Storage Guide
✅ DO
Store in the refrigerator between 2°C and 8°C as per manufacturer instructions.
❌ DON'T
Do not freeze the vial.
✅ DO
Keep the vial in its original carton to protect from light.
❌ DON'T
Do not use if the solution is discolored or contains particles.
✅ DO
Use immediately after opening or as directed by the hospital pharmacy.
❌ DON'T
Do not store diluted solution for later use without proper guidance.
✈️ Traveling with This Medicine
This medicine is given only in a hospital setting and is not carried by patients. If you are traveling after a procedure that used this medicine, carry a copy of your discharge summary and inform your doctor about the procedure. Do not attempt to self-administer this medicine during travel. If you need medical care while traveling, tell the treating team that you received a muscle relaxant during a recent surgery.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: No. This medicine is only given after you are unconscious from anesthesia. It does not cause sleep, so it is always used with anesthetics or sedatives.
A: A standard dose usually lasts about 20 to 35 minutes. The effect can be reversed with another medicine, or it wears off naturally.
A: No. You will be monitored in the recovery area until the muscle relaxant effect has fully worn off and you can breathe normally.
A: This medicine is broken down independently of the kidneys, so it is often preferred in patients with kidney problems. However, your doctor will still monitor you closely.
A: Tell your doctor about any allergies, muscle disorders, kidney or liver problems, and all medicines you take, including herbal products.
🤔 Common Patient Concerns
🔄 Substitutes for atrabloc injection
View AllAlternative brands with exact same active ingredient:
-
cisblok 10mg injectionAbbott ₹395.00 22.1% COSTLIER
-
cisartacil 10mg injectionNeon Laboratories Ltd ₹450.00 39.1% COSTLIER
-
atrabloc 10mg injectionVarenyam Healthcare Pvt Ltd ₹648.00 100.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a painkiller.
Fact: This medicine does not relieve pain. It only relaxes muscles and must be used with anesthetics or sedatives. - Myth: This medicine can be taken at home for muscle spasms.
Fact: This medicine is strictly for hospital use and must only be given by trained professionals with breathing support available. - Myth: This medicine makes you sleep.
Fact: This medicine does not cause sleep or unconsciousness. It only paralyses muscles, so it is always used with anesthesia. - Myth: Once given, the effect cannot be reversed.
Fact: The effect can be reversed with medicines such as neostigmine, and it also wears off naturally over time.
🔄 Alternative Options
Generic Alternatives
- Atracurium besylate injection
Brand Alternatives
- Atrabloc Injection