Dasatinib 50mg Tablet: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or chest pain
- Sudden weight gain or swelling of face, lips, or throat
- Unusual bleeding or bruising
- Blood in vomit or black stools
- Severe headache with visual changes
- Fever with chills or signs of infection
- Yellowing of skin or eyes
- Decreased urine output
- Palpitations or fainting
If experiencing severe symptoms, call emergency services immediately.
What is dastila 50 tablet used for?
This medicine is a targeted cancer medicine used to treat chronic myeloid leukemia and Philadelphia chromosome positive acute lymphoblastic leukemia. It works by blocking specific proteins that drive cancer cell growth.
- Generic Name: Dasatinib (50mg)
- Manufacturer: Sun Pharmaceutical Industries Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 dastila 50 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डैसैटिनिब 50 मिलीग्राम की गोली है, जिसका उपयोग क्रोनिक मायलॉइड ल्यूकेमिया (सीएमएल) और फिलाडेल्फिया क्रोमोसोम पॉजिटिव एक्यूट लिम्फोब्लास्टिक ल्यूकेमिया (पीएच+ एएलएल) के इलाज के लिए किया जाता है। यह एक टार्गेटेड कैंसर दवा है जो कैंसर कोशिकाओं में विशिष्ट प्रोटीन को रोककर उनकी वृद्धि को नियंत्रित करती है। यह दवा केवल कैंसर रोग विशेषज्ञ की देखरेख में ही लेनी चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में शरीर में पानी जमा होना, दस्त, सिरदर्द, थकान, मतली और रक्त कोशिकाओं की कमी शामिल हैं। गंभीर दुष्प्रभावों में फेफड़ों या हृदय के आसपास तरल पदार्थ जमा होना, रक्तस्राव, संक्रमण और हृदय की लय में गड़बड़ी शामिल हैं। यदि आपको सांस लेने में कठिनाई, अचानक वजन बढ़ना, या असामान्य रक्तस्राव हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को अपने डॉक्टर के निर्देशानुसार ही लें। गोली को पूरा निगलें, चबाएं या तोड़ें नहीं। अंगूर और अंगूर के रस से बचें क्योंकि इससे दवा का स्तर बढ़ सकता है। अपने डॉक्टर को अन्य सभी दवाओं, सप्लीमेंट्स और हर्बल उत्पादों के बारे में बताएं। उपचार के दौरान और अंतिम खुराक के कम से कम 30 दिन बाद तक प्रभावी गर्भनिरोधक का उपयोग करें। इस दवा को लेते समय स्तनपान न करें। सभी निर्धारित रक्त परीक्षण और फॉलो-अप अपॉइंटमेंट रखें। डॉक्टर से सलाह लिए बिना यह दवा बंद न करें।
💊 dastila 50 tablet Uses & Benefits
[{"condition":"Chronic myeloid leukemia (CML) in chronic phase","description":"Used as first-line or subsequent therapy for newly diagnosed Philadelphia chromosome positive CML in chronic phase.","evidence":"Well-established"},{"condition":"Chronic myeloid leukemia in accelerated or blast phase","description":"Used in patients with resistance or intolerance to prior therapy including imatinib.","evidence":"Well-established"},{"condition":"Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL)","description":"Used in combination with chemotherapy in adults and children with Ph+ ALL.","evidence":"Well-established"},{"condition":"Lymphoid blast crisis of CML","description":"Used in patients with lymphoid blast crisis who are resistant or intolerant to other therapies.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Gastrointestinal stromal tumor (GIST)","description":"Sometimes used off-label in imatinib-resistant GIST with specific mutations.","evidence":"Limited"},{"condition":"Systemic mastocytosis","description":"Rarely used off-label in advanced systemic mastocytosis with certain mutations.","evidence":"Limited"}]
Primary treatment for: Chronic myeloid leukemia (CML)
Also treats: Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL), Lymphoid blast crisis of CML
📋 Drug Information
| Generic Name(s) | Dasatinib (50mg) |
| Brand Name | dastila 50 tablet |
| Manufacturer | Sun Pharmaceutical Industries Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Tyrosine kinase inhibitors |
| Route of Administration | Oral |
| Storage | Store at room temperature between 20°C and 25°C (68°F to 77°F). Keep in the original container. Protect from moisture and light. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a potent inhibitor of multiple tyrosine kinases including BCR-ABL, SRC family kinases, c-KIT, and PDGFR. By binding to the ATP-binding site of these enzymes, it blocks the phosphorylation of downstream proteins that drive cancer cell proliferation and survival. In CML and Ph+ ALL, the BCR-ABL fusion protein is the primary target. This medicine is active against both the unmutated and many mutated forms of BCR-ABL, except the T315I mutation.
Mechanism Steps
💡 How to Take dastila 50 tablet
Strength: 50 mg immediate-release tablet
Dosage Information
| Adult Dosage | The recommended adult dose for chronic phase CML is 100 mg once daily. For accelerated or blast phase CML or Ph+ ALL, the recommended dose is 140 mg once daily. For pediatric patients, dosing is based on body weight. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to therapy. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist for dosing in children. |
| Elderly Dosage | No specific dose adjustment is recommended for elderly patients, but they may be more susceptible to fluid retention and cardiac effects. Monitor closely. |
| Renal Impairment | No dose adjustment is required for patients with renal impairment. However, monitor for fluid retention and adjust as needed. |
| Hepatic Impairment | For patients with moderate hepatic impairment, a reduced dose is recommended. For severe hepatic impairment, this medicine is contraindicated. |
| Maximum Daily Dose | The maximum recommended daily dose is 140 mg for adults. For pediatric patients, the maximum dose is 100 mg once daily or 70 mg twice daily based on weight. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of dastila 50 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Rifampin | Major | |
| Warfarin | Moderate | |
| Omeprazole | Moderate | |
| Famotidine | Moderate | |
| Aluminum hydroxide | Moderate | |
| St. John's wort | Minor | |
| Grapefruit juice | Minor | |
| NSAIDs | Moderate | |
| Corticosteroids | Moderate |
🚨 Major Interactions
- Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
- Strong CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin)
- Antacids (aluminum/magnesium hydroxide)
- H2 blockers (e.g., famotidine)
- Proton pump inhibitors (e.g., omeprazole)
⚡ Moderate Interactions
- Warfarin
- NSAIDs
- Corticosteroids
🍷 Alcohol Interaction
Alcohol may increase the risk of liver problems and drowsiness. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to dasatinib or any component of the formulation","Pregnancy","Breastfeeding","Severe hepatic impairment"]
⚠️ Warnings & Precautions
["Myelosuppression: May require dose reduction or interruption.","Fluid retention: Can be severe. Monitor weight and symptoms.","Bleeding: May cause serious bleeding. Monitor closely.","QT prolongation: Use with caution in patients with cardiac disease.","Pulmonary arterial hypertension: Rare but serious. Monitor for symptoms.","Tumor lysis syndrome: Risk in patients with high tumor burden.","Hepatitis B reactivation: Screen patients before starting therapy.","Use in pediatric patients: Safety and efficacy established in some age groups."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants, breastfeeding is not recommended during treatment and for at least 30 days after the last dose.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. In case of overdose, provide supportive care and monitor vital signs and blood counts. Gastric lavage may be considered if ingestion is recent. Contact a poison control center immediately.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your oncologist. Do not crush or split the tablet unless instructed. Swallow it whole with water. Avoid grapefruit and grapefruit juice because they can increase the level of this medicine in your body. Inform your doctor about all other medicines, supplements, and herbal products you are taking. Use effective contraception during treatment and for at least 30 days after the last dose. Do not breastfeed while taking this medicine. Keep all scheduled blood tests and follow-up appointments. Do not stop this medicine without consulting your doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to fluid retention, cardiac effects, and myelosuppression. Close monitoring is recommended. Dose adjustments may be needed based on tolerability.
🤰 Pregnancy Planning (TTC)
This medicine can cause fetal harm. Women of childbearing potential should use effective contraception during treatment and for at least 30 days after the last dose. If you are planning pregnancy, consult your doctor to discuss alternative treatment options.
🏥 Post-Surgery Considerations
This medicine may increase the risk of bleeding and impair wound healing. Inform your surgeon that you are taking this medicine. Your doctor may advise temporary interruption before surgery.
🦷 Dental Procedures
This medicine can increase the risk of bleeding during dental procedures. Inform your dentist that you are taking this medicine. Your dentist may recommend precautions or temporary interruption.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Consult your doctor before starting any exercise program. If you have fluid retention, heart problems, or low blood counts, you may need to modify your exercise routine. Avoid contact sports due to bleeding risk.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, dizziness, or fluid retention, which can affect your ability to drive or operate machinery. Use caution until you know how this medicine affects you. You may need to adjust your work schedule for medical appointments and monitoring.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your oncologist. If you experience severe side effects, your doctor may reduce the dose or temporarily interrupt treatment. Stopping suddenly can lead to relapse of leukemia.
📅 Long-Term Use Effects
Long-term use of this medicine may be associated with an increased risk of pulmonary arterial hypertension, chronic fluid retention, and cardiac toxicity. Regular monitoring of heart and lung function is recommended. Patients may also experience persistent fatigue and low blood counts. Adherence to follow-up appointments is crucial to detect and manage these effects early.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another tyrosine kinase inhibitor used for CML. May be used if dasatinib is not tolerated.
Evidence: Well-establishedA second-generation tyrosine kinase inhibitor for CML.
Evidence: Well-establishedA potential curative option for some patients with CML or Ph+ ALL.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with this medicine because of the risk of infection. Inactivated vaccines may be given, but their effectiveness may be reduced. Consult your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature between 20°C and 25°C
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in the original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from moisture. If traveling across time zones, consult your doctor about adjusting the dosing schedule. Check customs regulations for carrying prescription medicines. Carry enough supply for the entire trip and a little extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Clinical response in CML usually becomes evident within weeks to months of starting therapy. Regular blood tests will monitor your response.
A: You may take this medicine with or without food, but avoid grapefruit and grapefruit juice. Take it at the same time each day.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: This medicine can cause fetal harm. It is not recommended during pregnancy. Use effective contraception during treatment and for at least 30 days after the last dose.
A: No, do not stop taking this medicine without consulting your doctor. Stopping suddenly can lead to relapse.
🤔 Common Patient Concerns
🔄 Substitutes for dastila 50 tablet
View AllAlternative brands with exact same active ingredient:
-
nextki 50mg tabletEmcure Pharmaceuticals Ltd ₹3,281.25 46% COSTLIER
-
daslemia 50mg tabletIntas Pharmaceuticals Ltd ₹3,510.94 56.2% COSTLIER
-
dasamyl 50mg tabletMylan Pharmaceuticals Pvt Ltd ₹3,557.00 58.2% COSTLIER
-
dasamed 50mg tabletMedicamen Biotech Ltd ₹5,062.50 125.2% COSTLIER
-
dasacine 50mg tabletArechar Healthcare ₹6,051.56 169.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure leukemia completely.
Fact: This medicine can control the disease and induce remission, but it is not a guaranteed cure. Long-term treatment and monitoring are often required. - Myth: This medicine has no serious side effects.
Fact: This medicine can cause serious side effects including fluid retention, bleeding, and heart problems. Regular monitoring is essential. - Myth: You can stop taking this medicine once you feel better.
Fact: Stopping this medicine without medical advice can lead to relapse. Always consult your doctor before making any changes.
🔄 Alternative Options
Generic Alternatives
- Dasatinib 50 mg tablet (generic)
Brand Alternatives
- Sprycel 50 mg tablet