dasatrue 70mg tablet

4.8 (12 reviews)

Dasatinib (70mg)

🏭 Cipla Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 21, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 21, 2026

What is dasatrue 70mg tablet used for?

Alsatinib (Dasatinib) is used to treat ANTI NEOPLASTICS. It contains Dasatinib (70mg), which Inhibits BCR-ABL tyrosine kinase, SRC family kinases, and other oncogenic kinase. Always consult your doctor before use. Take as prescribed.

Generic Name: Dasatinib
Manufacturer: Cipla Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 dasatrue 70mg tablet Uses & Benefits

Chronic myeloid leukemia (CML) in chronic, accelerated, or blast phase; Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).

Off-label uses: GIST (gastrointestinal stromal tumor) with specific mutations; other solid tumors with SRC activation.

📋 Drug Information

Generic Name(s)	Dasatinib
Brand Name	Alsatinib
Manufacturer	Cipla Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI NEOPLASTICS
Action Class	Tyrosine kinase inhibitors
Route of Administration	Oral
Storage	Store at 20-25°C (68-77°F); protect from moisture.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after oral administration; peak plasma concentrations achieved within 0.5-6 hours.

DistributionWidely distributed; highly bound to plasma proteins (approximately 96%).

Protein Binding96%

MetabolismExtensively metabolized by CYP3A4, with minor contributions from flavin-containing monooxygenase 3 (FMO3) and UGT.

Half-Life3-5 hours

ExcretionPrimarily in feces (85%) and to a lesser extent in urine (4%).

Bioavailability14-34% (oral)

Onset of ActionWithin 2 hours

Peak Plasma Time0.5-6 hours

Duration of Action12-24 hours

How It Works

Inhibits BCR-ABL tyrosine kinase, SRC family kinases, and other oncogenic kinases.

Mechanism Steps

1Dasatinib binds to the ATP-binding site of BCR-ABL tyrosine kinase.

2Inhibits phosphorylation of downstream signaling proteins (e.g., STAT5, CRKL).

3Blocks cell proliferation and induces apoptosis in BCR-ABL-positive cells.

💡 How to Take dasatrue 70mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of dasatrue 70mg tablet

✅ Common Side Effects

Myelosuppression (neutropenia, thrombocytopenia, anemia)
Fluid retention (pleural effusion, peripheral edema)
Diarrhea
Headache
Fatigue
Nausea

🚨 Serious Side Effects

Pleural effusion
Pulmonary arterial hypertension
QT prolongation
Severe hemorrhage
Hepatotoxicity

⚠️ Rare Side Effects

Pancreatitis
Colitis
Severe skin reactions (Stevens-Johnson syndrome)
Tumor lysis syndrome

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Ketoconazole	Major	Increased dasatinib exposure (AUC increased 5-fold)
Rifampin	Major	Decreased dasatinib exposure (AUC decreased 82%)
Antacids	Major	Reduced absorption; separate by at least 2 hours
Grapefruit juice	Moderate	Increased dasatinib levels
Warfarin	Minor	Potential increased INR; monitor

🚨 Major Interactions

CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
CYP3A4 inducers (e.g., rifampin, phenytoin)
Antacids
H2 antagonists
Proton pump inhibitors

⚡ Moderate Interactions

Grapefruit juice
St. John's wort
Calcium channel blockers
Statins

ℹ️ Minor Interactions

Acetaminophen
Warfarin (monitor INR)

🍽️ Food Interactions

Avoid grapefruit juice; take with or without food.

🍷 Alcohol Interaction

May increase risk of liver toxicity; avoid excessive alcohol.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to dasatinib or any excipients; pregnancy; severe hepatic impairment.

📊 Monitoring Parameters

Complete blood count (CBC), liver function tests, renal function, ECG for QT interval, pleural effusion symptoms.

🤱 Lactation Safety

Not recommended; excreted in animal milk, unknown in humans.

💊 Overdose Management

No specific antidote; supportive care, monitor for myelosuppression and bleeding.

⏰ Missed Dose

Take as soon as remembered unless within 12 hours of next dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

🔗 View Profile

🔄 Substitutes for dasatrue 70mg tablet

View All

Alternative brands with exact same active ingredient (Dasatinib (70mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Happy Patient Jul 10, 2026

Effective and reliable. Worked as expected.

Verified User Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Trusted Reviewer Jul 10, 2026