Dasatrue 70mg Tablet (Dasatinib): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Sudden weight gain or swelling of the face, hands, or feet
- Difficulty breathing or chest pain
- Unusual bleeding or bruising, such as blood in vomit or stool
- Severe headache with vision changes
- Yellowing of the skin or eyes
- Decreased urine output or dark urine
- Fainting or palpitations
If experiencing severe symptoms, call emergency services immediately.
What is dasatrue 70mg tablet used for?
This medicine is a targeted cancer drug used to treat Philadelphia chromosome-positive chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). It works by blocking abnormal proteins that drive cancer cell growth. It is taken orally once daily, and regular monitoring is essential.
- Generic Name: Dasatinib
- Manufacturer: Cipla Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 dasatrue 70mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डैसाटिनिब 70 मिलीग्राम टैबलेट के रूप में उपलब्ध है और मुख्य रूप से फिलाडेल्फिया क्रोमोसोम-पॉजिटिव क्रोनिक मायलॉइड ल्यूकेमिया (सीएमएल) और फिलाडेल्फिया क्रोमोसोम-पॉजिटिव एक्यूट लिम्फोब्लास्टिक ल्यूकेमिया (एएलएल) के इलाज के लिए इस्तेमाल की जाती है। यह एक टार्गेटेड कैंसर दवा है जो ल्यूकेमिया कोशिकाओं के असामान्य प्रोटीन को रोककर उनकी वृद्धि को धीमा करती है। यह दवा मुंह से ली जाती है और इसका सेवन डॉक्टर के निर्देशानुसार ही करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में शरीर में सूजन (पैरों, चेहरे या हाथों में), दस्त, सिरदर्द, थकान, मतली, उल्टी, मांसपेशियों में दर्द और त्वचा पर दाने शामिल हैं। गंभीर दुष्प्रभावों में फेफड़ों के आसपास तरल पदार्थ जमा होना, गंभीर रक्तस्राव, हृदय की धड़कन में गड़बड़ी और लीवर की समस्या शामिल हो सकती है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। गोली को पानी के साथ पूरा निगलें, चबाएं या तोड़ें नहीं। इसे भोजन के साथ या बिना भोजन के लिया जा सकता है, लेकिन अंगूर और अंगूर के रस से बचें क्योंकि इससे दवा का स्तर बढ़ सकता है। बिना डॉक्टर की सलाह के दवा बंद न करें। नियमित रक्त जांच और लीवर फंक्शन टेस्ट कराते रहें। गर्भवती महिलाओं को इस दवा से बचना चाहिए।
💊 dasatrue 70mg tablet Uses & Benefits
- [{"condition":"Philadelphia chromosome-positive chronic myeloid leukemia (CML) in chronic phase","description":"Used in adults with newly diagnosed Philadelphia chromosome-positive CML in chronic phase.
- It helps control the disease by inhibiting the abnormal BCR-ABL protein.","evidence":"Well-established"},{"condition":"Philadelphia chromosome-positive CML in accelerated or blast phase","description":"Indicated for adults with Philadelphia chromosome-positive CML in accelerated phase, myeloid blast crisis, or lymphoid blast crisis who are resistant or intolerant to prior therapy including imatinib.","evidence":"Well-established"},{"condition":"Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL)","description":"Used in adults with Philadelphia chromosome-positive ALL who are resistant or intolerant to other therapies.","evidence":"Well-established"},{"condition":"Pediatric Philadelphia chromosome-positive CML","description":"Used in children with Philadelphia chromosome-positive CML in chronic phase who are resistant or intolerant to imatinib.","evidence":"Established in pediatric studies"}]
Off-label uses: [{"condition":"Gastrointestinal stromal tumors (GIST)","description":"Sometimes used off-label in patients with GIST who have specific mutations, but evidence is limited.","evidence":"Limited"},{"condition":"Systemic mastocytosis","description":"Rarely used off-label for advanced systemic mastocytosis, but not standard.","evidence":"Limited"}]
Primary treatment for: Philadelphia chromosome-positive chronic myeloid leukemia (CML)
Also treats: Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL), Accelerated phase CML, Blast crisis CML
📋 Drug Information
| Generic Name(s) | Dasatinib |
| Brand Name | Alsatinib |
| Manufacturer | Cipla Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Tyrosine kinase inhibitors |
| Route of Administration | Oral |
| Storage | Store at room temperature between 20°C and 25°C (68°F to 77°F). Keep the tablets in their original container, tightly closed, and protect from moisture and light. Do not store in the bathroom. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization does not issue specific treatment guidelines for individual medicines. Treatment guidelines for CML and ALL are typically developed by professional organizations such as the National Comprehensive Cancer Network (NCCN) and the European Society for Medical Oncology (ESMO). |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) has not published specific guidelines for this medicine. Treatment should follow institutional protocols and international guidelines adapted to the Indian context. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a potent inhibitor of multiple tyrosine kinases, including BCR-ABL, SRC family kinases, c-KIT, and PDGFR. By binding to the ATP-binding site of these enzymes, it blocks the phosphorylation of downstream signaling proteins that drive the proliferation and survival of leukemia cells. In Philadelphia chromosome-positive leukemias, the abnormal BCR-ABL fusion protein is the primary target. Inhibition of BCR-ABL leads to growth arrest and apoptosis of leukemic cells. This medicine is active against many imatinib-resistant BCR-ABL mutants, except the T315I mutation.
Mechanism Steps
💡 How to Take dasatrue 70mg tablet
Strength: Immediate-release tablet, 70 mg
Dosage Information
| Adult Dosage | The recommended dose of this medicine for adults with chronic phase CML is 100 mg once daily, but for accelerated or blast phase CML or Ph+ ALL, the recommended dose is 140 mg once daily. For newly diagnosed chronic phase CML, the dose is 100 mg once daily. The 70 mg tablet strength is used as part of a dosing regimen, often in combination with other strengths to achieve the required dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to therapy. Dose adjustments may be necessary for toxicity. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist for dosing in children. |
| Elderly Dosage | No specific dose adjustment is recommended for elderly patients based on age alone. However, elderly patients may be more susceptible to fluid retention and cardiac toxicity. Monitor closely and adjust dose based on tolerability. |
| Renal Impairment | No dose adjustment is required for patients with mild to moderate renal impairment. There is limited experience in patients with severe renal impairment; use with caution and monitor closely. |
| Hepatic Impairment | For patients with mild, moderate, or severe hepatic impairment, dose reduction is recommended. The recommended dose for patients with moderate hepatic impairment is 70 mg once daily for chronic phase CML and 100 mg once daily for accelerated or blast phase CML or Ph+ ALL. For severe hepatic impairment, the dose should be further reduced. Consult a hepatologist or clinical pharmacist for individualized dosing. |
| Maximum Daily Dose | The maximum recommended dose is 140 mg once daily for accelerated or blast phase CML or Ph+ ALL. For chronic phase CML, the maximum is 100 mg once daily. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of dasatrue 70mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Rifampin | Major | |
| Warfarin | Major | |
| Omeprazole | Moderate | |
| Amiodarone | Moderate | |
| Grapefruit juice | Moderate | |
| St. John's wort | Major | |
| Aspirin | Moderate | |
| Cimetidine | Minor | |
| Dexamethasone | Minor |
🚨 Major Interactions
- Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir)
- Strong CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin, St. John's wort)
- Antacids (aluminum/magnesium hydroxide)
- H2 blockers (e.g., famotidine) and proton pump inhibitors (e.g., omeprazole)
- Anticoagulants (e.g., warfarin) and antiplatelet agents (e.g., aspirin, clopidogrel)
⚡ Moderate Interactions
- CYP3A4 substrates with narrow therapeutic index (e.g., cyclosporine, fentanyl, sirolimus)
- QT-prolonging drugs (e.g., amiodarone, sotalol, haloperidol)
- Grapefruit juice
🍷 Alcohol Interaction
Alcohol may increase the risk of liver problems and drowsiness when taken with this medicine. It is advisable to avoid alcohol or limit intake while on treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to dasatinib or any component of the formulation.","Concomitant use with strong CYP3A4 inhibitors or inducers is not recommended.","Pregnancy: This medicine can cause fetal harm.","Lactation: Potential for serious adverse reactions in nursing infants.","Severe hepatic impairment: Use with caution and dose adjustment may be needed."]
⚠️ Warnings & Precautions
["Myelosuppression: This medicine can cause severe thrombocytopenia, neutropenia, and anemia. Monitor blood counts regularly and interrupt or reduce dose as needed.","Bleeding: This medicine can cause serious bleeding, including gastrointestinal and intracranial hemorrhage. Monitor for signs of bleeding and use with caution in patients on anticoagulants or antiplatelet agents.","Fluid retention: This medicine can cause pleural effusion, pericardial effusion, and peripheral edema. Monitor weight and symptoms; manage with diuretics or dose interruption as needed.","Pulmonary arterial hypertension: This medicine can cause PAH, which may be reversible upon discontinuation. Evaluate for PAH if symptoms occur.","QT prolongation: This medicine can prolong the QT interval. Use with caution in patients with a history of QT prolongation, electrolyte abnormalities, or on other QT-prolonging drugs.","Tumor lysis syndrome: This medicine can cause tumor lysis syndrome. Monitor electrolytes and renal function, and provide supportive care.","Hepatotoxicity: This medicine can cause liver injury. Monitor liver function tests.","Embryo-fetal toxicity: This medicine can cause fetal harm. Advise women of childbearing potential to use effective contraception."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. In case of overdose, monitor the patient closely for signs of toxicity, including myelosuppression, fluid retention, and QT prolongation. Provide supportive care and symptomatic treatment. Gastric lavage may be considered if the overdose is recent and the patient is stable. Hemodialysis is not expected to be effective because this medicine is highly protein-bound.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. If it is almost time for your next dose (less than 12 hours away), skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your oncologist. Swallow the tablet whole with a glass of water; do not crush or chew it. You may take it with or without food, but avoid grapefruit and grapefruit juice because they can increase the levels of this medicine in your body. Do not stop taking this medicine without consulting your doctor, as sudden discontinuation can worsen your condition. Regular blood tests, including complete blood counts and liver function tests, are necessary to monitor your response and detect side effects early. Inform your doctor if you have a history of heart problems, liver disease, or bleeding disorders. Use effective contraception during treatment and for at least 30 days after the last dose if you are of childbearing potential. Avoid close contact with people who have infections, and practice good hand hygiene. Do not drive or operate heavy machinery if you feel dizzy or fatigued.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients (above 65 years) may be more susceptible to fluid retention, cardiac toxicity, and myelosuppression. Close monitoring of blood counts, liver function, and cardiac function is recommended. Dose adjustments may be necessary based on tolerability.
🤰 Pregnancy Planning (TTC)
This medicine can cause fetal harm. Women of childbearing potential should use effective contraception during treatment and for at least 30 days after the last dose. If you are planning to become pregnant, consult your doctor to discuss alternative treatment options. Men taking this medicine should also use contraception, as it may affect sperm and cause harm to a fetus.
🏥 Post-Surgery Considerations
This medicine can increase the risk of bleeding and impair wound healing. Inform your surgeon that you are taking this medicine before any surgery. Your doctor may advise you to temporarily stop the medicine before and after surgery. Do not stop without medical advice.
🦷 Dental Procedures
This medicine can increase the risk of bleeding during dental procedures. Inform your dentist that you are taking this medicine. Your dentist may recommend postponing elective dental work or taking precautions to control bleeding. Maintain good oral hygiene to prevent dental problems.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause fatigue and fluid retention, which may limit your ability to exercise. Start with light activities and gradually increase as tolerated. Avoid strenuous exercise if you have swelling or shortness of breath. Consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, dizziness, or fluid retention, which can affect your ability to drive or operate heavy machinery. Avoid driving if you feel tired or dizzy. Most patients can continue their normal activities, but listen to your body and rest when needed. Discuss any work-related concerns with your doctor.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your oncologist. Stopping suddenly can cause the leukemia to relapse or worsen. Your doctor may decide to stop treatment if the disease is in deep remission for a prolonged period, or if you experience severe side effects. Always follow your doctor's guidance.
📅 Long-Term Use Effects
Long-term use of this medicine may be associated with an increased risk of certain side effects, including fluid retention, pulmonary arterial hypertension, and cardiac toxicity. Regular monitoring of blood counts, liver function, and heart function is essential. Some patients may develop resistance to this medicine over time, requiring a change in therapy. Long-term treatment is often necessary to keep the disease under control.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A potential curative option for some patients with CML or Ph+ ALL, especially those who do not respond adequately to tyrosine kinase inhibitors.
Evidence: Well-establishedParticipation in clinical trials may offer access to new therapies for resistant or intolerant disease.
Evidence: VariesManagement of symptoms and side effects to improve quality of life during treatment.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided while taking this medicine because it can suppress the immune system. Inactivated vaccines are generally safe, but their effectiveness may be reduced. Consult your doctor before receiving any vaccination.
📦 Storage Guide
✅ DO
Store at room temperature between 20°C and 25°C (68°F to 77°F).
❌ DON'T
Do not refrigerate or freeze.
✅ DO
Keep in the original container, tightly closed.
❌ DON'T
Do not transfer to unmarked containers.
✅ DO
Protect from moisture and light.
❌ DON'T
Do not store in the bathroom.
✅ DO
Keep out of reach of children and pets.
❌ DON'T
Do not use after the expiry date.
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label clearly visible. Bring a copy of your prescription and a doctor's letter explaining that you need this medicine for a serious medical condition. Keep the medicine in your carry-on luggage to avoid loss or temperature extremes. Store at room temperature and protect from moisture. If crossing time zones, continue taking your dose at the same time each day according to your home schedule, or consult your doctor for adjustments. Check customs regulations for controlled substances in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within days, but it may take several weeks to months to see significant improvement in blood counts and disease control. Your doctor will monitor your response with regular blood tests.
A: You can take this medicine with or without food, but avoid grapefruit and grapefruit juice. Take it at the same time each day.
A: If you miss a dose, take it as soon as you remember if less than 12 hours have passed. If more than 12 hours have passed, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, do not stop taking this medicine without consulting your doctor. Stopping suddenly can cause the disease to worsen. Your doctor will decide when and how to stop treatment.
A: Seek immediate medical attention if you experience difficulty breathing, chest pain, sudden weight gain, swelling, unusual bleeding, or yellowing of the skin or eyes.
🤔 Common Patient Concerns
🔄 Substitutes for dasatrue 70mg tablet
View AllAlternative brands with exact same active ingredient:
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dasamyl 70mg tabletMylan Pharmaceuticals Pvt Ltd ₹4,589.00 47.6% CHEAPER
-
daslemia 70 tabletIntas Pharmaceuticals Ltd ₹4,682.81 46.6% CHEAPER
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nextki 70mg tabletEmcure Pharmaceuticals Ltd ₹5,000.00 43% CHEAPER
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dasamed 70mg tabletMedicamen Biotech Ltd ₹6,750.00 23% CHEAPER
-
dasakast 70mg tabletAprazer Healthcare Pvt Ltd ₹7,968.75 9.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure leukemia completely.
Fact: This medicine can control the disease and lead to remission, but it is not a guaranteed cure. Long-term treatment and monitoring are often required. - Myth: Once you start this medicine, you can stop it whenever you feel better.
Fact: Stopping this medicine without medical advice can cause the disease to worsen. Always consult your doctor before making any changes. - Myth: This medicine has no serious side effects.
Fact: This medicine can cause serious side effects such as fluid retention, bleeding, and heart rhythm problems. Regular monitoring is necessary.
🔄 Alternative Options
Generic Alternatives
- Dasatinib 70 mg tablet
Brand Alternatives
- Dasatrue 70mg Tablet