Cididap M 10mg/1000mg Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or rapid breathing
- Severe muscle pain or weakness
- Extreme fatigue or unusual sleepiness
- Stomach pain with nausea and vomiting
- Swelling, redness, or pain in the genital area with fever
- Decreased urine output or swelling in legs
- Yellowing of skin or eyes
- Severe dizziness or fainting
If experiencing severe symptoms, call emergency services immediately.
What is dapnat-m 10/1000 tablet er used for?
This medicine is a combination of dapagliflozin and metformin used to treat type 2 diabetes. It helps control blood sugar by increasing glucose excretion in urine and reducing glucose production in the liver. It is taken orally with meals, usually once or twice daily, as prescribed by a doctor.
- Generic Name: Dapagliflozin + Metformin
- Manufacturer: Natco Pharma Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 dapnat-m 10/1000 tablet er के बारे में (Hindi Summary)
उपयोग: यह दवा टाइप 2 डायबिटीज (मधुमेह) के इलाज के लिए इस्तेमाल की जाती है। इसमें डैपाग्लिफ्लोज़िन और मेटफॉर्मिन दो सक्रिय तत्व हैं जो मिलकर ब्लड शुगर को कंट्रोल करते हैं। डैपाग्लिफ्लोज़िन किडनी के जरिए यूरिन में शुगर निकालने में मदद करता है, जबकि मेटफॉर्मिन लिवर में शुगर बनने को कम करता है और शरीर की इंसुलिन के प्रति संवेदनशीलता बढ़ाता है। यह दवा उन वयस्कों के लिए है जिनका डायबिटीज सिर्फ मेटफॉर्मिन से कंट्रोल नहीं हो पा रहा है। इसे डॉक्टर की सलाह से ही लें, खुद से नहीं।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में जी मिचलाना, उल्टी, दस्त, पेट में परेशानी, सिरदर्द और जननांगों में फंगल इन्फेक्शन शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन लैक्टिक एसिडोसिस (मांसपेशियों में दर्द, सांस लेने में तकलीफ, पेट दर्द, अत्यधिक थकान), डिहाइड्रेशन, किडनी की समस्या और जननांगों में गंभीर संक्रमण हो सकते हैं। अगर आपको सांस लेने में दिक्कत, अत्यधिक कमजोरी, या जननांग क्षेत्र में दर्द और सूजन हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक खुद से न बदलें और न ही बंद करें। टैबलेट को पानी के साथ पूरा निगलें, खाने के साथ लें ताकि पेट की परेशानी कम हो। खूब पानी पिएं, खासकर गर्मी में या व्यायाम के दौरान। शराब का सेवन न करें क्योंकि इससे लैक्टिक एसिडोसिस का खतरा बढ़ता है। नियमित रूप से ब्लड शुगर और किडनी फंक्शन की जांच कराएं। अगर आप गर्भवती हैं या गर्भधारण की योजना बना रही हैं, तो डॉक्टर को बताएं। इसे बच्चों की पहुंच से दूर रखें।
💊 dapnat-m 10/1000 tablet er Uses & Benefits
[{"condition":"Type 2 Diabetes Mellitus","description":"Improves glycemic control in adults when used along with diet and exercise, particularly when Metformin alone is insufficient.","evidence":"Well-established"},{"condition":"Cardiovascular risk reduction","description":"Dapagliflozin component may reduce the risk of cardiovascular death and hospitalization for heart failure in patients with type 2 diabetes and established cardiovascular disease.","evidence":"Well-established"},{"condition":"Chronic kidney disease","description":"Dapagliflozin component slows progression of kidney disease in patients with type 2 diabetes and diabetic nephropathy.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Weight management","description":"Dapagliflozin can cause modest weight loss, but this is not a primary indication.","evidence":"Limited"},{"condition":"Non-alcoholic fatty liver disease","description":"Some studies suggest benefit, but not an approved use.","evidence":"Limited"}]
Primary treatment for: Type 2 Diabetes Mellitus
Also treats: Cardiovascular disease, Chronic kidney disease, Heart failure
📋 Drug Information
| Generic Name(s) | Dapagliflozin + Metformin |
| Brand Name | Cididap M 10mg/500mg Tablet |
| Manufacturer | Natco Pharma Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | SGLT2 Inhibitor + Biguanide |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in a dry place, away from direct sunlight and moisture. Do not refrigerate unless specified. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization recommends metformin as first-line therapy for type 2 diabetes. SGLT2 inhibitors, including dapagliflozin, are recommended as second-line or add-on therapy in patients with cardiovascular or renal disease. This combination is in line with WHO recommendations for individualized treatment. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) guidelines for type 2 diabetes recommend metformin as initial therapy. Dapagliflozin may be added for better glycemic control and cardiovascular/renal benefits. This fixed-dose combination is acceptable when both agents are indicated. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antidiabetic agents with distinct mechanisms. Dapagliflozin selectively inhibits sodium-glucose co-transporter 2 (SGLT2) in the proximal renal tubules, reducing glucose reabsorption and increasing urinary glucose excretion, which lowers blood glucose independently of insulin. Metformin decreases hepatic glucose production, reduces intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Together, they provide complementary glycemic control.
Mechanism Steps
💡 How to Take dapnat-m 10/1000 tablet er
Strength: Tablet containing Dapagliflozin 10 mg and Metformin 1000 mg (immediate release).
Dosage Information
| Adult Dosage | The usual starting dose is one tablet taken orally once daily with a meal. The dose may be adjusted by your doctor based on your blood sugar levels, kidney function, and overall health. The maximum recommended dose is one tablet of dapagliflozin 10 mg and metformin 1000 mg twice daily, but the exact dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially regarding kidney function and risk of lactic acidosis. Dose selection should be cautious, and renal function should be monitored regularly. Individualized by a qualified clinician. |
| Renal Impairment | Dapagliflozin: No dose adjustment is needed for mild to moderate renal impairment. Not recommended if eGFR <45 mL/min/1.73 m2 for glycemic control; for other indications, may be used with caution. Metformin: Contraindicated if eGFR <30 mL/min/1.73 m2. Dose adjustment may be needed for eGFR 30-45 mL/min/1.73 m2. Consult your doctor for personalized dosing. |
| Hepatic Impairment | Dapagliflozin: No dose adjustment for mild to moderate hepatic impairment. Not recommended in severe hepatic impairment. Metformin: Contraindicated in severe hepatic impairment. Use with caution in mild to moderate. Individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is dapagliflozin 10 mg and metformin 2000 mg (as two tablets of this combination). Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of dapnat-m 10/1000 tablet er
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Iodinated contrast media | Major | |
| Alcohol | Major | |
| Diuretics | Major | |
| Insulin | Moderate | |
| Sulfonylureas | Moderate | |
| Cationic drugs | Moderate | |
| Carbonic anhydrase inhibitors | Moderate | |
| NSAIDs | Minor | |
| Corticosteroids | Minor |
🚨 Major Interactions
- Iodinated contrast media
- Alcohol
- Diuretics
⚡ Moderate Interactions
- Insulin or sulfonylureas
- Cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin)
- Carbonic anhydrase inhibitors (e.g., topiramate, zonisamide)
🍷 Alcohol Interaction
Avoid excessive alcohol consumption while taking this medicine. Alcohol increases the risk of lactic acidosis, a rare but serious complication, and can also cause hypoglycemia. If you drink alcohol, do so in moderation and only after consulting your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe renal impairment (eGFR
⚠️ Warnings & Precautions
["Lactic acidosis: Rare but serious. Discontinue and seek medical help if symptoms occur.","Dehydration: May cause volume depletion. Maintain adequate fluid intake.","Genital mycotic infections: Monitor and treat as needed.","Urinary tract infections: Report symptoms promptly.","Hypoglycemia: Risk increases when used with insulin or sulfonylureas.","Vitamin B12 deficiency: Long-term metformin use may reduce B12 levels. Monitor.","Surgery: Discontinue temporarily before surgery as advised by your doctor.","Alcohol: Avoid excessive intake due to lactic acidosis risk.","Pregnancy and lactation: Use only if clearly needed. Consult your doctor.","Elderly: Increased risk of renal impairment and lactic acidosis. Monitor closely."]
🤱 Lactation Safety
Not established from the available information. Dapagliflozin and metformin are excreted in human milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
💊 Overdose Management
In case of overdose, seek immediate medical attention. Symptoms may include severe hypoglycemia, lactic acidosis, and dehydration. Treatment is supportive and symptomatic. Hemodialysis may be considered for metformin overdose. Contact a poison control center or emergency room right away.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice. Swallow the tablet whole with a glass of water, with meals to reduce stomach upset. Stay well hydrated, especially in hot weather or during exercise, to prevent dehydration. Avoid excessive alcohol, as it increases the risk of lactic acidosis. Check your blood sugar regularly as advised. Tell your doctor if you have kidney or liver problems, are scheduled for surgery, or are pregnant or planning pregnancy. This medicine is not for type 1 diabetes or diabetic ketoacidosis. Keep all appointments for monitoring of kidney function, blood sugar, and vitamin B12 levels. Store at room temperature away from moisture and heat. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at increased risk of renal impairment, dehydration, and lactic acidosis. Regular monitoring of kidney function and blood sugar is essential. Dose adjustments may be needed based on renal function. Falls risk may increase if dizziness occurs.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before conceiving. This medicine is not recommended during pregnancy. Insulin is the preferred treatment for diabetes in pregnancy. Your doctor will adjust your treatment plan.
🏥 Post-Surgery Considerations
This medicine may need to be temporarily discontinued before surgery due to the risk of lactic acidosis and dehydration. Inform your surgeon and anesthesiologist about all medicines you take. Follow your doctor's instructions regarding when to resume.
🦷 Dental Procedures
Inform your dentist about this medicine before any dental procedure. Maintain good oral hygiene as diabetes can increase the risk of gum disease. If you need to fast before a procedure, consult your doctor about adjusting your diabetes medication.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is encouraged as part of diabetes management, but be cautious about dehydration. Drink plenty of water before, during, and after exercise. If you experience dizziness, weakness, or signs of low blood sugar, stop and seek medical advice. Adjust exercise intensity based on your overall health and doctor's recommendations.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or low blood sugar, especially when combined with other diabetes medications. Avoid driving or operating heavy machinery if you feel dizzy or unwell. Take regular breaks if you have a sedentary job, and stay hydrated. Inform your employer about your condition in case of emergencies.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as lactic acidosis, severe dehydration, or kidney problems, your doctor may advise temporary or permanent discontinuation. Always seek medical advice before stopping.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to vitamin B12 deficiency due to metformin, requiring periodic monitoring. Dapagliflozin may provide sustained cardiovascular and renal benefits. Regular monitoring of kidney function, blood sugar, and HbA1c is essential. Do not stop the medicine without consulting your doctor, as blood sugar may rise.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise are cornerstone therapies for type 2 diabetes and can complement medicine.
Evidence: Well-establishedDPP-4 inhibitors, sulfonylureas, or other SGLT2 inhibitors may be alternatives based on individual needs.
Evidence: Well-establishedMay be required if oral agents fail to control blood sugar.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, patients with diabetes are at higher risk of infections, so ensure routine vaccinations such as influenza and pneumococcal vaccines are up to date. Consult your doctor before any vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, adjust dosing times gradually in consultation with your doctor. Carry enough supply for the entire trip plus extra in case of delays. Check local customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood sugar within a few days, but the full effect may take 2-4 weeks. Your doctor will monitor your HbA1c every 3-6 months.
A: It depends on your kidney function. Dapagliflozin may be used with caution, but metformin is contraindicated if eGFR is below 30 mL/min/1.73 m2. Your doctor will adjust the dose based on your kidney function.
A: Mild side effects like nausea or diarrhea often improve with time. If you experience severe symptoms like difficulty breathing, muscle pain, or genital swelling, seek immediate medical attention.
🤔 Common Patient Concerns
🔄 Substitutes for dapnat-m 10/1000 tablet er
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dapabest m 10mg/1000mg tabletPanacea Biotec Ltd ₹116.23 4.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps manage blood sugar but does not cure diabetes. Lifestyle changes and ongoing treatment are essential. - Myth: You can stop taking this medicine once your sugar levels are normal.
Fact: Stopping without medical advice can cause blood sugar to rise again. Always consult your doctor before stopping. - Myth: This medicine causes weight gain.
Fact: Dapagliflozin may cause modest weight loss, and metformin is weight-neutral. This combination does not typically cause weight gain. - Myth: It is safe to take extra doses if you eat more sugar.
Fact: Never adjust your dose without medical advice. Extra doses can cause dangerous low blood sugar or other side effects.
🔄 Alternative Options
Generic Alternatives
- Dapagliflozin 10 mg + Metformin 1000 mg tablet (various manufacturers)
Brand Alternatives
- Cididap M 10mg/1000mg Tablet