alphalan 5mg tablet - Melphalan (5mg) medicine

alphalan 5mg tablet

4.4 (16 reviews)
๐Ÿญ Natco Pharma Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 21, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 21, 2026

What is alphalan 5mg tablet used for?

Alphalan (Melphalan) is used to treat ANTI NEOPLASTICS. It contains Melphalan (5mg), which Alkylating agent; cross-links DNA, inhibiting DNA replication and transcription.. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Melphalan
  • Manufacturer: Natco Pharma Ltd
  • Form: Allopathy
  • Pregnancy Category: D
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

๐Ÿ’Š alphalan 5mg tablet Uses & Benefits

Multiple myeloma, ovarian cancer, breast cancer, malignant melanoma, soft tissue sarcoma.

Off-label uses: Amyloidosis, conditioning for stem cell transplant.

๐Ÿ“‹ Drug Information

Generic Name(s)Melphalan
Brand NameAlphalan
ManufacturerNatco Pharma Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI NEOPLASTICS
Action ClassAlkylating agent
Route of AdministrationOral, intravenous.
StorageStore at 20-25ยฐC (68-77ยฐF); protect from light.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionIncompletely absorbed from the gastrointestinal tract; bioavailability is variable (25-89%).
DistributionWidely distributed; crosses blood-brain barrier poorly.
Protein Binding60-90% bound to plasma proteins, primarily albumin.
MetabolismHepatic; primarily hydrolyzed to monohydroxymelphalan and dihydroxymelphalan.
Half-Life1.5-2 hours (terminal half-life).
ExcretionRenal (10-30% unchanged) and fecal.
Bioavailability25-89% (oral).
Onset of ActionRapid; within 1-2 hours.
Peak Plasma Time1-2 hours (oral).
Duration of ActionVariable; depends on dose and regimen.

How It Works

Alkylating agent; cross-links DNA, inhibiting DNA replication and transcription.

Mechanism Steps

1Melphalan enters cells via active transport.
2Undergoes hydrolysis to form reactive alkylating species.
3Alkylates DNA at guanine N7 position.

๐Ÿ’ก How to Take alphalan 5mg tablet

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of alphalan 5mg tablet

โœ… Common Side Effects

  • Nausea
  • Vomiting
  • Myelosuppression
  • Alopecia
  • Mucositis

๐Ÿšจ Serious Side Effects

  • Severe myelosuppression
  • Secondary malignancies
  • Pulmonary fibrosis
  • Venocclusive disease

โš ๏ธ Rare Side Effects

  • Anaphylaxis
  • Hemolytic anemia
  • Interstitial pneumonitis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Cyclosporine Major Increased risk of nephrotoxicity and myelosuppression
Warfarin Moderate Increased bleeding risk
Live vaccines Major Risk of disseminated infection

๐Ÿšจ Major Interactions

  • Cyclosporine
  • Tacrolimus
  • Other alkylating agents
  • Radiation therapy

โšก Moderate Interactions

  • NSAIDs
  • Anticoagulants
  • Live vaccines
  • Phenytoin

โ„น๏ธ Minor Interactions

  • Cimetidine
  • Allopurinol

๐Ÿฝ๏ธ Food Interactions

Food may reduce absorption; take on empty stomach.

๐Ÿท Alcohol Interaction

Avoid alcohol; may increase hepatotoxicity risk.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to melphalan, severe myelosuppression, pregnancy, breastfeeding.

๐Ÿ“Š Monitoring Parameters

Complete blood count, renal function, hepatic function, serum uric acid.

๐Ÿคฑ Lactation Safety

Contraindicated; excreted in breast milk.

๐Ÿ’Š Overdose Management

Supportive care; monitor blood counts; consider hematopoietic growth factors.

โฐ Missed Dose

Take as soon as remembered; if near next dose, skip missed dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for alphalan 5mg tablet

View All

Alternative brands with exact same active ingredient (Melphalan (5mg)):

Medical Note: Always consult your doctor before switching medications.

โญ User Reviews

Happy Patient Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Happy Patient Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Happy Patient Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Regular Customer Jul 10, 2026

Found this to be a helpful product. Good results.

Certified Buyer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

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