dacotin 50 injection - Uses, Price, Side Effects & Substitutes
What is dacotin 50 injection used for?
Acoxal 50 Injection (Oxaliplatin) is used to treat ANTI NEOPLASTICS. It contains Oxaliplatin (50mg), which Forms platinum-DNA adducts, inhibiting DNA replication and transcription, leadin. Always consult your doctor before use. Take as prescribed.
- Generic Name: Oxaliplatin
- Manufacturer: Dr Reddy's Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ dacotin 50 injection Uses & Benefits
Metastatic colorectal cancer (adjuvant and advanced), Adjuvant treatment of stage III colon cancer
Off-label uses: Pancreatic cancer, Gastric cancer, Hepatocellular carcinoma
๐ Drug Information
| Generic Name(s) | Oxaliplatin |
| Brand Name | Acoxal 50 Injection |
| Manufacturer | Dr Reddy's Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Platinum compounds-Anticancer |
| Route of Administration | Intravenous infusion (over 2-6 hours). |
| Storage | Store at 20-25ยฐC; protect from light; do not freeze. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Forms platinum-DNA adducts, inhibiting DNA replication and transcription, leading to cell death.
Mechanism Steps
๐ก How to Take dacotin 50 injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of dacotin 50 injection
โ Common Side Effects
- Peripheral neuropathy
- Nausea/vomiting
- Diarrhea
- Myelosuppression (neutropenia, thrombocytopenia)
- Fatigue
๐จ Serious Side Effects
- Severe neurotoxicity (ataxia, dysarthria)
- Anaphylaxis
- Acute renal failure
- Interstitial lung disease
โ ๏ธ Rare Side Effects
- Hemolytic uremic syndrome
- Pancreatitis
- Hepatic veno-occlusive disease
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased INR and bleeding risk. |
| Aminoglycosides | Major | Increased nephrotoxicity. |
| Cisplatin | Major | Additive neurotoxicity. |
| NSAIDs | Moderate | Increased risk of bleeding. |
| Loop diuretics | Moderate | Increased nephrotoxicity. |
๐จ Major Interactions
- Warfarin
- Nephrotoxic drugs (e.g., aminoglycosides)
- Neurotoxic drugs (e.g., cisplatin)
โก Moderate Interactions
- Anticoagulants
- NSAIDs
- Loop diuretics
โน๏ธ Minor Interactions
- Antacids
- Cimetidine
๐ฝ๏ธ Food Interactions
No significant food interactions (IV administration).
๐ท Alcohol Interaction
No known interaction.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to oxaliplatin, Severe renal impairment (CrCl <30 mL/min), Pregnancy, Lactation
๐ Monitoring Parameters
CBC with differential, Liver function tests, Renal function (creatinine, BUN), Neurologic exam for peripheral neuropathy
๐คฑ Lactation Safety
Contraindicated; excreted in breast milk.
๐ Overdose Management
Supportive care; no specific antidote; monitor for myelosuppression and neurotoxicity.
โฐ Missed Dose
Do not double dose; consult physician for rescheduling.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for dacotin 50 injection
View AllAlternative brands with exact same active ingredient (Oxaliplatin (50mg)):
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oxyrea 50 injectionNeon Laboratories Ltd โน824.00 75.6% CHEAPER
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oxichemo 50mg injectionLupin Ltd โน937.50 72.2% CHEAPER
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metaplatin 50mg injectionParenteral Drugs India Ltd โน1,190.47 64.7% CHEAPER
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oxoplan 50mg injectionSamarth Life Sciences Pvt Ltd โน1,239.00 63.3% CHEAPER
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oxaltor 50mg injectionTorrent Pharmaceuticals Ltd โน1,369.04 59.4% CHEAPER
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celdach 50mg injectionCelon Laboratories Ltd โน1,740.00 48.5% CHEAPER
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oxpla 50mg injectionZydus Cadila โน1,784.06 47.1% CHEAPER
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platoxin 50mg injectionShantha Biotech โน1,807.47 46.5% CHEAPER
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xtide 50mg injectionBiocon โน1,870.74 44.6% CHEAPER
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oxalispera 50mg injectionIndoco Remedies Ltd โน1,875.00 44.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.