cvroz-gold 10/75 capsule - Uses, Price, Side Effects & Substitutes
What is cvroz-gold 10/75 capsule used for?
Azuva 20-Gold Capsule (Aspirin + Rosuvastatin) is used to treat CARDIAC. It contains Aspirin (75mg) + Rosuvastatin (10mg), which Aspirin: Irreversibly acetylates cyclooxygenase-1 (COX-1) inhibiting thromboxane. Always consult your doctor before use. Take as prescribed.
- Generic Name: Aspirin + Rosuvastatin
- Manufacturer: Holymed Pharma
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ cvroz-gold 10/75 capsule Uses & Benefits
Secondary prevention of cardiovascular events (MI, stroke), stable angina, post-PCI, hyperlipidemia.
Off-label uses: Primary prevention in high-risk patients, preeclampsia prevention (low-dose aspirin), Kawasaki disease.
๐ Drug Information
| Generic Name(s) | Aspirin + Rosuvastatin |
| Brand Name | Azuva 20-Gold Capsule |
| Manufacturer | Holymed Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Antiplatelet + HMG-CoA Reductase Inhibitor |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture and light. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Aspirin: Irreversibly acetylates cyclooxygenase-1 (COX-1) inhibiting thromboxane A2 synthesis, reducing platelet aggregation. Rosuvastatin: Competitive inhibitor of HMG-CoA reductase, reducing cholesterol synthesis and increasing LDL receptor expression.
Mechanism Steps
๐ก How to Take cvroz-gold 10/75 capsule
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cvroz-gold 10/75 capsule
โ Common Side Effects
- Dyspepsia
- Nausea
- Abdominal pain
- Headache
- Myalgia
- Increased liver enzymes
๐จ Serious Side Effects
- GI bleeding
- Hemorrhagic stroke
- Rhabdomyolysis
- Hepatotoxicity
- Stevens-Johnson syndrome
โ ๏ธ Rare Side Effects
- Anaphylaxis
- Thrombocytopenia
- Pancreatitis
- Interstitial nephritis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Methotrexate | Major | Increased methotrexate toxicity |
| Clopidogrel | Major | Increased bleeding risk |
| NSAIDs | Major | Increased GI bleeding risk |
| Anticoagulants | Major | Increased bleeding risk |
| ACE inhibitors | Moderate | Reduced antihypertensive effect |
| Diuretics | Moderate | Reduced diuretic effect |
| Corticosteroids | Moderate | Increased GI bleeding risk |
| Cyclosporine | Moderate | Increased statin levels |
| Gemfibrozil | Moderate | Increased risk of myopathy |
| Antacids | Minor | Reduced aspirin absorption |
| Alcohol | Minor | Increased GI bleeding risk |
| Caffeine | Minor | Increased aspirin absorption |
| Digoxin | Minor | Minimal interaction |
๐จ Major Interactions
- Warfarin
- Methotrexate
- Clopidogrel
- NSAIDs
- Anticoagulants
โก Moderate Interactions
- ACE inhibitors
- Diuretics
- Corticosteroids
- Cyclosporine
- Gemfibrozil
โน๏ธ Minor Interactions
- Antacids
- Alcohol
- Caffeine
- Digoxin
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase rosuvastatin levels; food delays absorption but not extent.
๐ท Alcohol Interaction
Increased risk of gastrointestinal bleeding with aspirin; alcohol may increase statin hepatotoxicity.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Active peptic ulcer, bleeding disorders, hypersensitivity to aspirin or statins, severe hepatic impairment, pregnancy (third trimester for aspirin; rosuvastatin contraindicated in pregnancy), lactation.
๐ Monitoring Parameters
Lipid profile, liver function tests, renal function, INR if on anticoagulants, signs of bleeding.
๐คฑ Lactation Safety
Aspirin excreted in breast milk; rosuvastatin present in low levels; avoid or use with caution.
๐ Overdose Management
Aspirin overdose: gastric lavage, activated charcoal, sodium bicarbonate, hemodialysis. Rosuvastatin overdose: supportive care, monitor liver function.
โฐ Missed Dose
Take as soon as remembered unless near next dose; skip if almost time for next dose; do not double.