Bisowin-AM Tablet - Uses, Price, Side Effects, and More
What is bisowin-am tablet used for?
Bisowin-AM Tablet is a combination of Amlodipine (a calcium channel blocker) and Bisoprolol (a beta-blocker) used to treat high blood pressure and angina. It works by relaxing blood vessels and reducing heart rate, improving blood flow and reducing oxygen demand.
- Generic Name: Amlodipine + Bisoprolol
- Manufacturer: Holymed Pharma
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ bisowin-am tablet Uses & Benefits
Hypertension, angina pectoris, stable chronic heart failure (bisoprolol component).
Off-label uses: Migraine prophylaxis (bisoprolol), Raynaud's phenomenon (amlodipine).
๐ Drug Information
| Generic Name(s) | Amlodipine + Bisoprolol |
| Brand Name | Bisonext AM 2.5 Tablet |
| Manufacturer | Holymed Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Antihypertensive combination (Calcium channel blocker + Beta blocker) |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Amlodipine inhibits calcium influx across cell membranes, causing vasodilation and reduced peripheral resistance; Bisoprolol selectively blocks beta-1 adrenergic receptors, reducing heart rate and contractility.
Mechanism Steps
๐ก How to Take bisowin-am tablet
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of bisowin-am tablet
โ Common Side Effects
- Edema (ankle/foot)
- Headache
- Dizziness
- Fatigue
- Nausea
- Bradycardia
- Hypotension
๐จ Serious Side Effects
- Severe bradycardia
- Heart block
- Heart failure exacerbation
- Bronchospasm
- Hepatotoxicity
- Stevens-Johnson syndrome
โ ๏ธ Rare Side Effects
- Gingival hyperplasia
- Leukopenia
- Thrombocytopenia
- Pancreatitis
- Depression
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Moderate | Increased risk of bleeding |
| NSAIDs | Moderate | Reduced antihypertensive effect |
| Beta-blockers | Major | Additive bradycardia and hypotension |
| Calcium channel blockers | Major | Increased risk of heart block and hypotension |
| Digoxin | Moderate | Increased risk of bradycardia |
๐จ Major Interactions
- Verapamil
- Diltiazem
- Beta-blockers (other)
- Clonidine
- Digoxin
- Lithium
โก Moderate Interactions
- CYP3A4 inhibitors (e.g., ketoconazole)
- CYP3A4 inducers (e.g., rifampin)
- NSAIDs
- Antidiabetic agents
- Theophylline
โน๏ธ Minor Interactions
- Grapefruit juice
- Cimetidine
- Sildenafil
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase amlodipine levels; avoid high-fat meals with bisoprolol.
๐ท Alcohol Interaction
Alcohol may enhance hypotensive effect; avoid excessive consumption.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, cardiogenic shock, severe bradycardia, sick sinus syndrome, second/third-degree AV block, decompensated heart failure, severe hypotension, asthma/COPD (bisoprolol).
๐ Monitoring Parameters
Blood pressure, heart rate, ECG, renal function, hepatic function, blood glucose (diabetics).
๐คฑ Lactation Safety
Not recommended; both drugs excreted in breast milk.
๐ Overdose Management
Supportive care; atropine for bradycardia, calcium gluconate for amlodipine overdose, glucagon or catecholamines for bisoprolol overdose.
โฐ Missed Dose
Take as soon as remembered unless near next dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
Effective and reliable. Worked as expected.
Effective and reliable. Worked as expected.
Found this to be a helpful product. Good results.
Found this to be a helpful product. Good results.
This medicine was effective for me. I followed the doctor's advice.