cvroz-gold 20/75 capsule

4.7 (9 reviews)

Aspirin (75mg) Rosuvastatin (20mg)

🏭 Holymed Pharma 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is cvroz-gold 20/75 capsule used for?

Azuva 20-Gold Capsule (Aspirin + Rosuvastatin) is used to treat CARDIAC. It contains Aspirin (75mg) + Rosuvastatin (20mg), which Aspirin: Irreversibly acetylates cyclooxygenase-1 (COX-1) inhibiting thromboxane. Always consult your doctor before use. Take as prescribed.

Generic Name: Aspirin + Rosuvastatin
Manufacturer: Holymed Pharma
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 cvroz-gold 20/75 capsule Uses & Benefits

Secondary prevention of cardiovascular events (MI, stroke), stable angina, post-PCI, hyperlipidemia.

Off-label uses: Primary prevention in high-risk patients, preeclampsia prevention (low-dose aspirin), Kawasaki disease.

📋 Drug Information

Generic Name(s)	Aspirin + Rosuvastatin
Brand Name	Azuva 20-Gold Capsule
Manufacturer	Holymed Pharma
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	CARDIAC
Action Class	Antiplatelet + HMG-CoA Reductase Inhibitor
Route of Administration	Oral
Storage	Store at room temperature (20-25°C), protect from moisture and light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionAspirin: Rapidly absorbed from stomach and small intestine; Rosuvastatin: Absorbed with peak plasma concentration at 3-5 hours, food reduces rate but not extent.

DistributionAspirin: Widely distributed, crosses placenta and blood-brain barrier; Rosuvastatin: Extensive distribution to tissues, high uptake by liver.

Protein BindingAspirin: 80-90% bound to albumin; Rosuvastatin: 88% bound to albumin.

MetabolismAspirin: Hydrolyzed to salicylic acid by esterases; Rosuvastatin: Minimal metabolism (CYP2C9 and 2C19), mostly unchanged.

Half-LifeAspirin: 15-20 minutes (salicylic acid: 2-3 hours); Rosuvastatin: 19 hours.

ExcretionAspirin: Renal excretion of salicylic acid and metabolites; Rosuvastatin: 90% in feces, 10% in urine.

BioavailabilityAspirin: 40-50% (oral); Rosuvastatin: 20%.

Onset of ActionAspirin: 30-60 minutes; Rosuvastatin: 1 week for lipid effects.

Peak Plasma TimeAspirin: 1-2 hours; Rosuvastatin: 3-5 hours.

Duration of ActionAspirin: 4-6 hours (antiplatelet effect lasts 7-10 days); Rosuvastatin: 24 hours.

How It Works

Aspirin: Irreversibly acetylates cyclooxygenase-1 (COX-1) inhibiting thromboxane A2 synthesis, reducing platelet aggregation. Rosuvastatin: Competitive inhibitor of HMG-CoA reductase, reducing cholesterol synthesis and increasing LDL receptor expression.

Mechanism Steps

1Aspirin irreversibly acetylates COX-1, inhibiting thromboxane A2 synthesis.

2Reduced thromboxane A2 decreases platelet aggregation.

3Rosuvastatin competitively inhibits HMG-CoA reductase.

💡 How to Take cvroz-gold 20/75 capsule

Follow your doctor's prescription exactly.

⚠️ Side Effects of cvroz-gold 20/75 capsule

✅ Common Side Effects

Dyspepsia
Nausea
Abdominal pain
Headache
Myalgia
Increased liver enzymes

🚨 Serious Side Effects

GI bleeding
Hemorrhagic stroke
Rhabdomyolysis
Hepatotoxicity
Stevens-Johnson syndrome

⚠️ Rare Side Effects

Anaphylaxis
Thrombocytopenia
Pancreatitis
Interstitial nephritis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased bleeding risk
Methotrexate	Major	Increased methotrexate toxicity
Clopidogrel	Major	Increased bleeding risk
NSAIDs	Major	Increased GI bleeding risk
Anticoagulants	Major	Increased bleeding risk
ACE inhibitors	Moderate	Reduced antihypertensive effect
Diuretics	Moderate	Reduced diuretic effect
Corticosteroids	Moderate	Increased GI bleeding risk
Cyclosporine	Moderate	Increased statin levels
Gemfibrozil	Moderate	Increased risk of myopathy
Antacids	Minor	Reduced aspirin absorption
Alcohol	Minor	Increased GI bleeding risk
Caffeine	Minor	Increased aspirin absorption
Digoxin	Minor	Minimal interaction

🚨 Major Interactions

Warfarin
Methotrexate
Clopidogrel
NSAIDs
Anticoagulants

⚡ Moderate Interactions

ACE inhibitors
Diuretics
Corticosteroids
Cyclosporine
Gemfibrozil

ℹ️ Minor Interactions

Antacids
Alcohol
Caffeine
Digoxin

🍽️ Food Interactions

Grapefruit juice may increase rosuvastatin levels; food delays absorption but not extent.

🍷 Alcohol Interaction

Increased risk of gastrointestinal bleeding with aspirin; alcohol may increase statin hepatotoxicity.

🛡️ Safety & Warnings

🚫 Contraindications

Active peptic ulcer, bleeding disorders, hypersensitivity to aspirin or statins, severe hepatic impairment, pregnancy (third trimester for aspirin; rosuvastatin contraindicated in pregnancy), lactation.

📊 Monitoring Parameters

Lipid profile, liver function tests, renal function, INR if on anticoagulants, signs of bleeding.

🤱 Lactation Safety

Aspirin excreted in breast milk; rosuvastatin present in low levels; avoid or use with caution.

💊 Overdose Management

Aspirin overdose: gastric lavage, activated charcoal, sodium bicarbonate, hemodialysis. Rosuvastatin overdose: supportive care, monitor liver function.

⏰ Missed Dose

Take as soon as remembered unless near next dose; skip if almost time for next dose; do not double.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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⭐ User Reviews

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.

Happy Patient Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Verified User Jul 10, 2026

Good quality medicine. Satisfied with the outcome.