Azuvas 20-Gold Capsule: A Comprehensive Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unexplained muscle pain or weakness
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is cvroz-gold 20/75 capsule used for?
This medicine is a combination of Aspirin 75 mg and Rosuvastatin 20 mg used to prevent heart attacks and strokes by reducing blood clot formation and lowering cholesterol levels. It is taken orally once daily with food.
- Generic Name: Aspirin + Rosuvastatin
- Manufacturer: Holymed Pharma
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cvroz-gold 20/75 capsule के बारे में (Hindi Summary)
उपयोग: यह दवा एस्पिरिन 75 मिलीग्राम और रोसुवास्टेटिन 20 मिलीग्राम का संयोजन है, जिसका उपयोग हृदयाघात और स्ट्रोक को रोकने के लिए किया जाता है। यह रक्त के थक्के बनने को कम करती है और कोलेस्ट्रॉल के स्तर को नियंत्रित करती है। यह उन रोगियों के लिए दी जाती है जिन्हें हृदय रोग का खतरा अधिक होता है या जिन्हें पहले से हृदय रोग है। यह दवा रक्त वाहिकाओं में प्लाक के निर्माण को धीमा करती है और हृदय की रक्षा करती है। इसे डॉक्टर की सलाह के अनुसार ही लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में पेट में जलन, अपच, मतली, सिरदर्द, मांसपेशियों में दर्द और लीवर एंजाइम में मामूली वृद्धि शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें पेट या आंतों से रक्तस्राव, गंभीर मांसपेशियों की समस्या, और लीवर की क्षति शामिल हो सकती है। यदि आपको असामान्य रक्तस्राव, काला मल, गंभीर मांसपेशियों में दर्द, या आंखों या त्वचा का पीलापन दिखे, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ लें ताकि पेट में जलन न हो। शराब का सेवन न करें क्योंकि इससे पेट में रक्तस्राव और लीवर की समस्या का खतरा बढ़ सकता है। यदि आप गर्भवती हैं, स्तनपान करा रही हैं, या गर्भधारण की योजना बना रही हैं, तो इस दवा का सेवन न करें। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएं। नियमित रूप से लीवर, किडनी और कोलेस्ट्रॉल की जांच कराएं। किसी भी असामान्य लक्षण को नजरअंदाज न करें।
💊 cvroz-gold 20/75 capsule Uses & Benefits
[{"condition":"Secondary prevention of cardiovascular events","description":"Reduces the risk of heart attack, stroke, and death in patients with established cardiovascular disease.","evidence":"Well-established"},{"condition":"Primary prevention in high-risk individuals","description":"Used in patients with multiple risk factors such as diabetes, hypertension, and dyslipidemia to prevent first cardiovascular events.","evidence":"Established"},{"condition":"Hypercholesterolemia","description":"Lowers elevated LDL cholesterol and total cholesterol levels when diet and exercise alone are insufficient.","evidence":"Well-established"},{"condition":"Acute coronary syndrome","description":"Part of long-term management after acute coronary syndrome to prevent recurrent events.","evidence":"Well-established"},{"condition":"Peripheral arterial disease","description":"Helps reduce the risk of cardiovascular events in patients with peripheral arterial disease.","evidence":"Established"}]
Off-label uses: [{"condition":"Prevention of preeclampsia","description":"Low-dose aspirin is sometimes used off-label in pregnancy to reduce the risk of preeclampsia in high-risk women, but rosuvastatin is contraindicated in pregnancy.","evidence":"Limited"},{"condition":"Cancer prevention","description":"Aspirin has been studied for chemoprevention in colorectal cancer, but this combination is not approved for this use.","evidence":"Limited"}]
Primary treatment for: Cardiovascular disease prevention
Also treats: Hypercholesterolemia, Atherosclerosis, Coronary artery disease, Stroke prevention, Peripheral arterial disease
📋 Drug Information
| Generic Name(s) | Aspirin + Rosuvastatin |
| Brand Name | Azuva 20-Gold Capsule |
| Manufacturer | Holymed Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Antiplatelet + HMG-CoA Reductase Inhibitor |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and light. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization recommends statins for secondary prevention of cardiovascular disease and for primary prevention in high-risk individuals. Aspirin is recommended for secondary prevention in patients with established cardiovascular disease. This combination is in line with WHO recommendations for cardiovascular risk reduction. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) guidelines recommend statins for patients with dyslipidemia and high cardiovascular risk. Aspirin is recommended for secondary prevention of cardiovascular events. The combination may be used as per individual risk assessment. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Aspirin irreversibly acetylates cyclooxygenase-1 (COX-1) in platelets, preventing the formation of thromboxane A2, a potent platelet aggregator and vasoconstrictor. This effect lasts for the lifespan of the platelet (7-10 days). Rosuvastatin is a competitive inhibitor of HMG-CoA reductase, the enzyme that converts HMG-CoA to mevalonate, a rate-limiting step in cholesterol biosynthesis. By inhibiting this enzyme in the liver, rosuvastatin upregulates LDL receptors on hepatocytes, increasing the clearance of LDL cholesterol from the bloodstream and reducing plasma LDL levels. Together, these actions reduce thrombotic risk and slow the progression of atherosclerosis.
Mechanism Steps
💡 How to Take cvroz-gold 20/75 capsule
Strength: Capsule containing Aspirin 75 mg and Rosuvastatin 20 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one capsule taken orally once daily, preferably with food. The dose may be adjusted by the doctor based on the patient's lipid levels, cardiovascular risk, and tolerability. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the effects of this medicine. The dose should be individualized by a clinician, and renal and hepatic function should be monitored. No specific dose adjustment is generally required, but caution is advised. |
| Renal Impairment | In patients with mild to moderate renal impairment, no dose adjustment is usually needed. In severe renal impairment (creatinine clearance <30 mL/min), rosuvastatin should be used with caution and the dose should be individualized by a clinician. Aspirin should be avoided in severe renal impairment due to increased risk of bleeding and worsening renal function. |
| Hepatic Impairment | This medicine is contraindicated in patients with active liver disease or unexplained persistent elevations of serum transaminases. In patients with mild to moderate hepatic impairment, rosuvastatin should be used with caution and the dose should be individualized by a clinician. Aspirin should be used with caution in patients with hepatic impairment due to increased risk of bleeding. |
| Maximum Daily Dose | The maximum recommended daily dose is one capsule containing Aspirin 75 mg and Rosuvastatin 20 mg. Do not exceed this dose unless specifically instructed by a doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cvroz-gold 20/75 capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Cyclosporine | Major | |
| Gemfibrozil | Major | |
| NSAIDs | Moderate | |
| Corticosteroids | Moderate | |
| Fenofibrate | Moderate | |
| Antacids | Moderate | |
| Digoxin | Minor | |
| ACE inhibitors | Minor | |
| Oral hypoglycemics | Minor |
🚨 Major Interactions
- Warfarin
- Other anticoagulants (e.g., apixaban, rivaroxaban)
- Cyclosporine
- Gemfibrozil
⚡ Moderate Interactions
- NSAIDs (e.g., ibuprofen)
- Corticosteroids
- Fibrates (e.g., fenofibrate)
- Antacids (aluminum/magnesium hydroxide)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding due to aspirin and can worsen liver toxicity from rosuvastatin. It may also increase the risk of muscle-related side effects. If you consume alcohol, discuss safe limits with your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to aspirin, rosuvastatin, or any component of the formulation","Active peptic ulcer or history of recurrent peptic ulcer","Active bleeding or bleeding disorders (e.g., hemophilia, thrombocytopenia)","Severe liver disease or unexplained persistent elevations of serum transaminases","Pregnancy and breastfeeding","Severe kidney disease (creatinine clearance
⚠️ Warnings & Precautions
["This medicine increases the risk of gastrointestinal bleeding. Use with caution in patients with a history of ulcers or bleeding.","Rosuvastatin can cause myopathy and rarely rhabdomyolysis. Advise patients to report unexplained muscle pain, tenderness, or weakness.","Liver function should be monitored. Discontinue if serious liver injury occurs.","Increases in blood sugar may occur. Monitor glucose in diabetic patients.","Avoid alcohol consumption as it increases the risk of liver and stomach problems.","Use with caution in elderly patients due to increased risk of side effects.","Do not use in pregnancy or breastfeeding.","Inform patients about the signs of bleeding and the need to seek immediate medical attention."]
🤱 Lactation Safety
This medicine is contraindicated during breastfeeding. Both aspirin and rosuvastatin may pass into breast milk and could cause serious adverse reactions in the nursing infant. A decision should be made to discontinue nursing or the medicine, taking into account the importance of the drug to the mother.
💊 Overdose Management
Overdose of this medicine may cause salicylate toxicity (tinnitus, hyperventilation, metabolic acidosis, seizures) and statin-related muscle toxicity. If overdose is suspected, seek immediate medical attention. Treatment is supportive and symptomatic. Activated charcoal may be administered if ingestion is recent. Hemodialysis may be considered for severe salicylate toxicity. There is no specific antidote for rosuvastatin; manage symptoms and monitor liver and muscle enzymes.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice. Swallow the capsule whole with a glass of water, preferably with food to reduce stomach irritation. Avoid alcohol while taking this medicine because it can increase the risk of stomach bleeding and liver problems. Inform your doctor if you have a history of ulcers, bleeding disorders, liver or kidney disease, or muscle disorders. Tell your doctor about all other medicines you take, especially blood thinners, other statins, and certain antibiotics. Do not take this medicine if you are pregnant, planning to become pregnant, or breastfeeding. Regular blood tests may be needed to check your liver, kidney, and cholesterol levels. Report any unusual bleeding, bruising, muscle pain, or weakness immediately. Keep this medicine out of reach of children and store it in a cool, dry place.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients (above 65 years) are at higher risk of gastrointestinal bleeding, muscle toxicity, and liver or kidney impairment. The dose should be individualized, and regular monitoring of renal and hepatic function is advised. Falls and bleeding risk should be assessed.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated during pregnancy and in women planning to become pregnant. Rosuvastatin may cause fetal harm. Women of childbearing potential should use effective contraception while taking this medicine. If you are planning pregnancy, consult your doctor to switch to a safer alternative.
🏥 Post-Surgery Considerations
This medicine may need to be stopped before surgery due to the antiplatelet effect of aspirin, which increases bleeding risk. Your surgeon will advise you on when to stop and when to restart. Do not stop on your own. After surgery, your doctor will determine the appropriate time to resume.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, as aspirin increases the risk of bleeding during dental procedures. Your dentist may recommend stopping the medicine temporarily or taking precautions. Do not stop without consulting your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Regular exercise is encouraged while taking this medicine, but avoid activities that carry a high risk of injury or bleeding, such as contact sports, due to the antiplatelet effect of aspirin. If you experience muscle pain or weakness during exercise, stop and consult your doctor, as it may be a sign of statin-related muscle injury.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is unlikely to affect your ability to drive or operate machinery. However, if you experience dizziness, muscle pain, or unusual bleeding, avoid driving or operating heavy machinery until you feel better. Inform your employer if your job involves a risk of injury, as the antiplatelet effect may increase bleeding risk.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as severe bleeding, muscle breakdown, or liver injury, your doctor may advise stopping the medicine. In some cases, it may be temporarily stopped before surgery or dental procedures. Always follow your doctor's guidance.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe and beneficial for cardiovascular risk reduction. However, it requires regular monitoring of liver function, kidney function, and lipid levels. Prolonged use of aspirin can increase the risk of gastrointestinal bleeding, and rosuvastatin can rarely cause muscle or liver problems. Patients should have periodic check-ups and report any new symptoms. The benefits of preventing heart attack and stroke generally outweigh the risks in appropriately selected patients.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, and smoking cessation can help manage cholesterol and cardiovascular risk.
Evidence: Well-establishedAtorvastatin or simvastatin may be used if rosuvastatin is not tolerated.
Evidence: Well-establishedClopidogrel may be used if aspirin is not tolerated.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, patients on aspirin may have an increased risk of bleeding at injection sites. Inform your healthcare provider before receiving any vaccine. Annual influenza vaccination is recommended for patients with cardiovascular disease.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, continue taking your dose at the same local time as usual. Check customs regulations for carrying prescription medicines. Carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The antiplatelet effect of aspirin starts within 30-60 minutes, while the cholesterol-lowering effect of rosuvastatin begins within 1 week and reaches maximum effect in 2-4 weeks.
A: No, you should not stop taking this medicine without consulting your doctor. It is a long-term preventive medicine, and stopping it can increase your risk of heart attack or stroke.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, this medicine is contraindicated during pregnancy as it may harm the fetus. Consult your doctor for alternative treatments.
A: Always inform your doctor about all other medicines you are taking, as this medicine can interact with several drugs, including blood thinners and certain antibiotics.
🤔 Common Patient Concerns
🔄 Substitutes for cvroz-gold 20/75 capsule
View AllAlternative brands with exact same active ingredient:
-
davaindia rosuvastatin+aspirin 20mg/75mg capsuleDavaindia Generic Pharmacy ₹35.00 76.7% CHEAPER
-
rosuvotin asp 20mg/75mg tabletLividus Pharmaceuticals Pvt Ltd ₹61.88 58.7% CHEAPER
-
rosze gold 20 capsuleZeelab Pharmacy Pvt Ltd ₹70.00 53.3% CHEAPER
-
unizuva a 20mg/75mg capsuleUniza Healthcare LLP ₹70.00 53.3% CHEAPER
-
rosumac asp 20mg/75mg capsuleMacleods Pharmaceuticals Pvt Ltd ₹75.40 49.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken without a prescription.
Fact: This medicine is a prescription drug and should only be taken under medical supervision. - Myth: Once cholesterol is normal, the medicine can be stopped.
Fact: Cholesterol levels may normalize due to the medicine, but stopping it can cause levels to rise again and increase cardiovascular risk. Always consult your doctor before stopping. - Myth: This medicine causes immediate weight loss.
Fact: This medicine does not cause weight loss. It lowers cholesterol and reduces clot risk. Weight management requires diet and exercise.
🔄 Alternative Options
Generic Alternatives
- Aspirin 75 mg + Rosuvastatin 20 mg capsule (generic)
Brand Alternatives
- Azuvas 20 Gold
- Rosuvas 20 Gold
- Aspirin 75 mg + Rosuvastatin 20 mg (various brands)