Cugest 400 Soft Gelatin Capsule: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Sudden severe headache or vision changes
- Chest pain, shortness of breath, or coughing up blood
- Swelling, pain, or redness in one leg
- Severe abdominal pain or yellowing of skin/eyes
- Unusual vaginal bleeding or spotting
- Signs of allergic reaction: rash, itching, swelling of face/lips/tongue
If experiencing severe symptoms, call emergency services immediately.
What is cugest 400 soft gelatin capsule used for?
This medicine is a natural micronized progesterone supplement used to treat progesterone deficiency, support pregnancy, and regulate menstrual cycles. It works by binding to progesterone receptors and is taken orally with food.
- Generic Name: Progesterone (Natural Micronized)
- Manufacturer: Cureill Pharma Pvt. Ltd.
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cugest 400 soft gelatin capsule के बारे में (Hindi Summary)
उपयोग: यह दवा प्राकृतिक माइक्रोनाइज्ड प्रोजेस्टेरोन का एक रूप है, जिसका उपयोग प्रोजेस्टेरोन की कमी से होने वाली समस्याओं जैसे कि गर्भधारण में सहायता, बार-बार गर्भपात को रोकने, और अनियमित मासिक धर्म के इलाज के लिए किया जाता है। यह दवा गर्भाशय में प्रोजेस्टेरोन रिसेप्टर्स से जुड़कर काम करती है और गर्भावस्था को बनाए रखने में मदद करती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में सिरदर्द, स्तनों में कोमलता, मतली और नींद आना शामिल हैं। गंभीर दुष्प्रभावों में रक्त के थक्के, एलर्जी प्रतिक्रियाएं और यकृत की समस्याएं हो सकती हैं। दुर्लभ दुष्प्रभावों में अवसाद और तरल पदार्थ का बढ़ना शामिल है।
सुरक्षा सलाह: इस दवा को अपने डॉक्टर के निर्देशानुसार ही लें। अनुशंसित खुराक से अधिक न लें। यदि आपको नींद आती है तो वाहन चलाने या मशीनरी चलाने से बचें। यदि आप गर्भवती हैं, गर्भवती होने की योजना बना रही हैं, या स्तनपान करा रही हैं तो अपने डॉक्टर को सूचित करें। यदि आपको रक्त के थक्के, यकृत रोग, या अस्पष्ट योनि रक्तस्राव का इतिहास है तो यह दवा न लें।
💊 cugest 400 soft gelatin capsule Uses & Benefits
[{"condition":"Luteal phase support in assisted reproduction","description":"Used to support the luteal phase in women undergoing in vitro fertilization (IVF) or other assisted reproductive technologies.","evidence":"Well-established"},{"condition":"Threatened miscarriage","description":"Prescribed to support early pregnancy in women with a history of recurrent miscarriage or threatened miscarriage due to progesterone deficiency.","evidence":"Well-established"},{"condition":"Abnormal uterine bleeding","description":"Used to regulate menstrual bleeding in women with hormonal imbalances.","evidence":"Well-established"},{"condition":"Secondary amenorrhea","description":"Used to induce menstruation in women who have missed periods due to progesterone deficiency.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Preterm birth prevention","description":"Sometimes prescribed off-label to prevent preterm birth in women with a short cervix or history of preterm delivery.","evidence":"Limited"},{"condition":"Menopausal hormone therapy","description":"Occasionally used off-label to manage menopausal symptoms when combined with estrogen.","evidence":"Limited"}]
Primary treatment for: Progesterone deficiency
Also treats: Infertility, Threatened miscarriage, Abnormal uterine bleeding, Secondary amenorrhea
📋 Drug Information
| Generic Name(s) | Progesterone (Natural Micronized) |
| Brand Name | Aqsusten 25 Solution for Injection |
| Manufacturer | Cureill Pharma Pvt. Ltd. |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | Natural Progesterone |
| Route of Administration | Intramuscular |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by binding to progesterone receptors in the nucleus of target cells, leading to changes in gene expression that promote endometrial maturation, inhibit uterine contractions, and support pregnancy. It also has anti-estrogenic effects on the endometrium.
Mechanism Steps
💡 How to Take cugest 400 soft gelatin capsule
Strength: Soft gelatin capsule containing 400 mg of natural micronized progesterone.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 200-400 mg once daily or as directed by your doctor. The dose may be adjusted based on the indication and your response to treatment. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dosage adjustments are recommended for elderly patients, but use with caution due to potential for increased sensitivity. |
| Renal Impairment | No specific dosage adjustments are recommended for patients with renal impairment, but use with caution. |
| Hepatic Impairment | Dose reduction may be necessary in patients with hepatic impairment. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose is 400 mg, but may vary based on the indication. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cugest 400 soft gelatin capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ketoconazole | Major | |
| Rifampicin | Moderate | |
| St. John's Wort | Moderate | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Warfarin
- Ketoconazole
⚡ Moderate Interactions
- Rifampicin
- St. John's Wort
🍷 Alcohol Interaction
Alcohol may increase the sedative effects of this medicine. Avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to progesterone","Undiagnosed vaginal bleeding","History of blood clots or thromboembolic disorders","Severe liver disease","Known or suspected breast cancer"]
⚠️ Warnings & Precautions
["Use with caution in patients with a history of depression.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Inform your doctor if you have a history of blood clots, liver disease, or migraines.","Do not use if you are allergic to progesterone or any of the ingredients.","Progesterone may affect laboratory test results; inform your doctor before any tests."]
🤱 Lactation Safety
Progesterone is excreted in breast milk. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose may cause nausea, vomiting, drowsiness, and dizziness. Seek immediate medical attention if overdose is suspected. Treatment is symptomatic and supportive.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Avoid driving or operating heavy machinery if you experience drowsiness. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not use this medicine if you have a history of blood clots, liver disease, or undiagnosed vaginal bleeding. Regular monitoring may be required during treatment.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine. Use with caution and monitor for side effects such as drowsiness and fluid retention.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before starting or continuing this medicine. It is often used to support early pregnancy under medical supervision.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may affect blood clotting and interact with anesthetic agents.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may increase the risk of bleeding during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness or dizziness. Avoid strenuous exercise or activities requiring alertness until you know how it affects you.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness, which can affect your ability to drive or operate machinery. Plan your tasks accordingly and avoid hazardous activities until you know how it affects you.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Abrupt discontinuation may cause withdrawal symptoms or recurrence of symptoms. Your doctor will advise you on the appropriate duration of treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may be associated with an increased risk of blood clots, breast tenderness, and mood changes. Regular monitoring of liver function and clinical assessment is recommended. Consult your doctor for periodic reviews.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Regular exercise, balanced diet, and stress management can support hormonal balance.
Evidence: Well-establishedAlternative routes such as vaginal or oral formulations may be considered based on your condition.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust the timing of your dose gradually as advised by your doctor. Keep enough supply for the entire trip and carry it in your hand luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The onset of action varies; for luteal support, effects may be seen within days. For menstrual regulation, it may take a few weeks.
A: It is best taken with food to improve absorption and reduce nausea.
A: Yes, when prescribed by a doctor. It is commonly used to support early pregnancy.
🤔 Common Patient Concerns
🔄 Substitutes for cugest 400 soft gelatin capsule
View AllAlternative brands with exact same active ingredient:
-
ets 400 mg capsuleEmcure Pharmaceuticals Ltd ₹327.56 22.4% CHEAPER
-
prepgest-ron 400 soft gelatin capsuleSinag Healthcare Pvt Ltd ₹365.53 13.4% CHEAPER
-
gesterol 400mg tablet srNeon Laboratories Ltd ₹369.14 12.5% CHEAPER
-
sugest 400 mg capsuleSanzyme Ltd ₹394.93 6.4% CHEAPER
-
uterone 400 capsuleJagsonpal Pharmaceuticals Ltd ₹412.50 2.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a contraceptive.
Fact: This medicine is not a contraceptive; it is used for progesterone supplementation. - Myth: This medicine can be taken without a prescription.
Fact: This medicine requires a prescription and should only be used under medical supervision.
🔄 Alternative Options
Generic Alternatives
- Natural micronized progesterone 400 mg soft gelatin capsules
Brand Alternatives
- Cugest 400
- Susten 400
- Naturogest 400
- Gestofit 400