cufmol syrup - Bromhexine (4mg/5ml) + Guaifenesin (50mg/5ml) medicine

Amcuff Syrup: Complete Guide to Uses, Dosage, and Safety

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🏭 Glounce Pharmaceuticals 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 24, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for symptomatic relief of productive cough.
Reviewed by
SaathiMed Expert Panel | Oct 24, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in sputum or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • High fever with rash

If experiencing severe symptoms, call emergency services immediately.

What is cufmol syrup used for?

This medicine is a combination cough syrup containing bromhexine (a mucolytic) and guaifenesin (an expectorant). It helps thin and loosen mucus in the airways, making it easier to cough up. It is used for productive coughs due to colds, bronchitis, and other respiratory infections. The usual adult dose is 10 ml three times a day, but follow your doctor's advice.

  • Generic Name: Bromhexine + Guaifenesin
  • Manufacturer: Glounce Pharmaceuticals
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 cufmol syrup के बारे में (Hindi Summary)

उपयोग: यह दवा ब्रोमहेक्सिन और गुआइफेनेसिन का संयोजन है, जिसका उपयोग बलगम वाली खांसी (कफ वाली खांसी) के इलाज के लिए किया जाता है। यह बलगम को पतला करके उसे बाहर निकालने में मदद करती है, जिससे सांस लेने में आराम मिलता है। यह सर्दी, ब्रोंकाइटिस और अन्य श्वसन संक्रमणों में लाभकारी है।

साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, दस्त, पेट में परेशानी और सिरदर्द शामिल हैं। ये आमतौर पर हल्के होते हैं और दवा बंद करने पर ठीक हो जाते हैं। कभी-कभी चक्कर आना या नींद आना भी हो सकता है। गंभीर एलर्जी प्रतिक्रिया दुर्लभ है, लेकिन अगर सांस लेने में कठिनाई, चेहरे या गले में सूजन हो, तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को बताएं कि आप गर्भवती हैं, गर्भधारण की योजना बना रही हैं या स्तनपान करा रही हैं। अपनी अन्य दवाओं के बारे में भी जानकारी दें। खांसी 7 दिनों से अधिक रहने पर डॉक्टर से सलाह लें। दवा को बच्चों की पहुंच से दूर रखें। समाप्ति तिथि के बाद दवा का उपयोग न करें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 cufmol syrup Uses & Benefits

[{"condition":"Productive cough (wet cough)","description":"Helps loosen and thin mucus in the airways, making it easier to cough up and clear the chest.","evidence":"Well-established"},{"condition":"Bronchitis","description":"Used to relieve cough and mucus congestion associated with acute or chronic bronchitis.","evidence":"Well-established"},{"condition":"Upper respiratory tract infections","description":"Provides symptomatic relief of cough and mucus in common cold and other respiratory infections.","evidence":"Well-established"}]

Off-label uses: []

Primary treatment for: Productive cough

Also treats: Bronchitis, Upper respiratory tract infections

📋 Drug Information

Generic Name(s)Bromhexine + Guaifenesin
Brand NameAscoril Plus Expectorant
ManufacturerGlounce Pharmaceuticals
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassMucolytic and Expectorant
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a cool, dry place, away from direct sunlight. Keep the bottle tightly closed.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Stay well hydrated throughout the day to help thin mucus.
3
Avoid alcohol while taking this medicine as it may increase drowsiness.
4
Do not take more than the prescribed dose.
5
Consult your doctor if symptoms persist beyond 7 days.
6
Report any unusual bleeding or bruising immediately.
7
Do not use this medicine for a dry cough.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Productive cough
This medicine is commonly prescribed for this.
Likely Use
❌
Dry cough
This medicine is not effective for dry cough.
Not Primary
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionBromhexine and guaifenesin are absorbed from the gastrointestinal tract after oral administration. Bromhexine undergoes extensive first-pass metabolism, with bioavailability around 20-30%. Guaifenesin is rapidly absorbed and metabolized.
DistributionBoth ingredients are distributed to body tissues, including the respiratory tract. Bromhexine is highly protein-bound (about 95%), while guaifenesin has a lower protein binding. Both cross the placenta and are excreted in breast milk.
Protein BindingBromhexine: approximately 95%. Guaifenesin: Not established from the available information.
MetabolismBromhexine is metabolized in the liver to several metabolites, including ambroxol, which is also active. Guaifenesin is metabolized in the liver via oxidation and conjugation.
Half-LifeBromhexine: approximately 1 hour. Guaifenesin: approximately 1 hour.
ExcretionBoth bromhexine and its metabolites, and guaifenesin and its metabolites, are primarily excreted in the urine.
BioavailabilityBromhexine: approximately 20-30% due to first-pass metabolism. Guaifenesin: Not established from the available information.
Onset of ActionWithin 30 minutes to 1 hour after oral administration.
Peak Plasma TimeBromhexine: about 1 hour. Guaifenesin: about 1 hour.
Duration of ActionApproximately 4 to 6 hours.

How It Works

This medicine works through two complementary mechanisms. Bromhexine is a mucolytic that breaks down the structure of mucus by depolymerizing mucopolysaccharide fibers, reducing mucus viscosity. Guaifenesin is an expectorant that increases the volume and reduces the viscosity of respiratory tract secretions by increasing hydration, thereby facilitating the removal of mucus by ciliary action and coughing.

Mechanism Steps

1
Bromhexine: Mucolysis: Bromhexine breaks down the acidic mucopolysaccharide fibers in mucus, reducing its viscosity and making it less sticky.
2
Guaifenesin: Expectoration: Guaifenesin increases the water content of mucus, further thinning it and increasing the volume of secretions, which stimulates the cough reflex and helps clear the airways.
3
Ciliary action: The thinned mucus is more easily moved by the cilia (tiny hair-like structures) lining the respiratory tract, aiding in its expulsion.

💡 How to Take cufmol syrup

Strength: Each 5 ml contains Bromhexine 4 mg and Guaifenesin 50 mg.

1Shake the bottle well before each use.
2Use a measuring cup or spoon to measure the correct dose.
3Take the medicine orally, with or without food.
4Swallow the medicine; do not chew or crush.
5Drink a glass of water after taking the medicine.
6Wash the measuring cup after each use.

Dosage Information

Adult DosageThe usual adult dose is 10 ml (2 teaspoons) three times a day, or as directed by your doctor. Dose may vary based on the severity of the condition and your response to treatment. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageNo specific dose adjustment is recommended for elderly patients, but use with caution due to potential reduced hepatic and renal function. Consult your doctor for appropriate dosing.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be necessary. Consult your doctor.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose adjustment may be necessary. Consult your doctor.
Maximum Daily DoseThe maximum recommended dose is 30 ml per day for adults, unless otherwise directed by a doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Water
Drink plenty
Helps thin mucus and soothe the throat.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of cufmol syrup

✅ Common Side Effects

Nausea (Common (1-10%))
Take with food to reduce nausea. If it persists, consult your doctor.
Vomiting (Common (1-10%))
Stay hydrated. If vomiting is severe or persistent, seek medical advice.
Diarrhea (Common (1-10%))
Drink plenty of fluids. Consult doctor if diarrhea is severe or lasts more than a few days.
Headache (Common (1-10%))
Rest and stay hydrated. If headache is severe or persistent, consult your doctor.
Stomach discomfort (Common (1-10%))
Take with meals. If discomfort continues, talk to your doctor.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience difficulty breathing, swelling of face, lips, or throat, or a severe rash.
Severe skin reactions (e.g., Stevens-Johnson syndrome) (Very rare (<0.01%))
Stop the medicine and seek immediate medical help if you notice blistering, peeling skin, or sores in the mouth.

⚠️ Rare Side Effects

Dizziness
Avoid driving or operating machinery until you know how this medicine affects you.
Drowsiness
Avoid activities requiring alertness if you feel drowsy.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Antitussives Moderate
Anticholinergics Moderate
Antibiotics Minor

⚡ Moderate Interactions

  • Antitussives (cough suppressants)
  • Anticholinergic drugs

🍷 Alcohol Interaction

Alcohol may increase the sedative effects of this medicine and worsen dizziness or drowsiness. It is advisable to avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to bromhexine, guaifenesin, or any component of the formulation.","Peptic ulcer disease (due to risk of gastric irritation).","Severe hepatic or renal impairment (use with caution)."]

⚠️ Warnings & Precautions

["Do not use for a dry, non-productive cough.","Consult a doctor if cough persists for more than 7 days or is accompanied by fever, rash, or persistent headache.","Use with caution in patients with a history of peptic ulcer.","Use with caution in patients with asthma or other respiratory conditions.","Avoid concurrent use with other cough suppressants unless directed by a doctor.","Keep out of reach of children."]

🤱 Lactation Safety

Not established from the available information. Consult your doctor before use.

💊 Overdose Management

Overdose may cause nausea, vomiting, and diarrhea. Seek immediate medical attention if you suspect an overdose. Treatment is symptomatic and supportive.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Before taking this medicine, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Also, tell your doctor about any other medicines you are taking, especially other cough and cold products, as they may contain similar ingredients. Do not take this medicine for more than the recommended duration without consulting a doctor. If your cough persists for more than 7 days, or if it is accompanied by fever, rash, or persistent headache, seek medical advice. Keep this medicine out of reach of children. Do not use this medicine after the expiry date. Store it in a cool, dry place, away from direct sunlight.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the side effects of this medicine, especially dizziness and drowsiness. Use with caution and consult a doctor for appropriate dosing.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this medicine during pregnancy is not well established.

🏥 Post-Surgery Considerations

If you have recently had surgery, consult your doctor before taking this medicine, as it may affect cough reflex and mucus clearance.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure. It may cause dry mouth, which can affect dental health.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated to help thin mucus.
🥗
Use a humidifier to add moisture to the air.
😴
Avoid smoking and exposure to secondhand smoke.
💧
Get plenty of rest to help your body recover.
🧘
Gargle with warm salt water to soothe your throat.

🏋️ Exercise Considerations

Avoid strenuous exercise if you have a cough or fever. Rest is important for recovery. Light activity like walking may be okay if you feel up to it.

🥗 Diet Recommendations

Drink warm fluids like herbal tea and soup.
Include honey and ginger in your diet.
Avoid cold and processed foods.
Eat plenty of fruits and vegetables rich in vitamin C.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to work if you feel well.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your cough persists for more than 7 days, or if you experience any severe side effects. Do not stop abruptly if you have been on it for a long time without medical advice.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended without medical supervision. Prolonged use may mask underlying conditions. If your cough persists beyond 7 days, consult a doctor for further evaluation.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Steam inhalation

Helps loosen mucus and relieve congestion.

Evidence: Well-established
Saltwater gargle

Soothes throat irritation and reduces cough.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your doctor about all medicines you are taking.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If traveling across time zones, adjust dosing times gradually. Check customs regulations for carrying medicines. Keep it in your carry-on luggage if flying.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with chronic bronchitis
Started this medicine as prescribed for a productive cough. Within 2 days noticed significant improvement in chest congestion and easier coughing. Emphasized taking with food to prevent stomach upset.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 30-year-old mother with acute bronchitis
Was prescribed this medicine for a wet cough. She took it three times a day after meals and drank plenty of water. Her cough improved in 5 days. She advises others to complete the course as directed.
💡 Lesson: Staying hydrated and completing the course as prescribed helps in faster recovery.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30 minutes to 1 hour after taking a dose. You may notice easier coughing and reduced chest congestion.

Q: Can I take this medicine with other cough syrups?

A: It is not advisable to combine with other cough syrups without consulting a doctor, as it may lead to harmful interactions.

Q: Is this medicine safe for children?

A: Pediatric dosing is not established. Consult a pediatrician for appropriate use in children.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for cufmol syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure any type of cough.
    Fact: This medicine is only for productive coughs with phlegm. It is not effective for dry coughs.
  • Myth: More medicine means faster relief.
    Fact: Taking more than the recommended dose can increase side effects without providing extra benefit.
  • Myth: It is safe to take with other cough medicines.
    Fact: Combining with other cough suppressants can be harmful. Always consult a doctor before combining.

🔄 Alternative Options

Generic Alternatives

  • Bromhexine + Guaifenesin syrup (generic)

Brand Alternatives

  • Amcuff Syrup

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Bromhexine 4mg/5ml + Guaifenesin 50mg/5ml","uses":"Productive cough","notes":"Combination mucolytic and expectorant."},{"medicine":"Ambroxol + Guaifenesin","composition":"Ambroxol + Guaifenesin","uses":"Productive cough","notes":"Ambroxol is a metabolite of bromhexine."},{"medicine":"Guaifenesin alone","composition":"Guaifenesin","uses":"Productive cough","notes":"Expectorant only."}]

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