ascodex plus syrup - Guaifenesin (50mg/5ml) + Bromhexine (4mg/5ml) medicine

Ascodex Plus Syrup: Complete Medicine Guide

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🏭 Glenmark Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Evidence: Moderate for symptomatic relief of productive cough.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is ascodex plus syrup used for?

This medicine is a combination of guaifenesin and bromhexine used to treat productive cough by thinning mucus and making it easier to cough up.

  • Generic Name: Guaifenesin + Bromhexine
  • Manufacturer: Glenmark Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 ascodex plus syrup के बारे में (Hindi Summary)

उपयोग: यह दवा गुआइफेनेसिन और ब्रोमहेक्सिन का संयोजन है, जिसका उपयोग बलगम वाली खांसी के इलाज के लिए किया जाता है। यह बलगम को पतला करके उसे बाहर निकालने में मदद करती है। यह तीव्र और दीर्घकालिक ब्रोंकाइटिस, और श्वसन पथ के संक्रमण में उपयोगी है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट में परेशानी, दस्त, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, त्वचा पर चकत्ते, सांस लेने में कठिनाई हो सकती है।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक से अधिक न लें। उपयोग से पहले बोतल को अच्छी तरह हिलाएं। सही मापने वाले कप या चम्मच का उपयोग करें। यदि आपको नींद या चक्कर आते हैं तो वाहन न चलाएं। 7 दिनों से अधिक उपयोग करने से पहले डॉक्टर से सलाह लें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 ascodex plus syrup Uses & Benefits

[{"condition":"Productive cough","description":"Helps loosen and thin mucus, making it easier to cough up.","evidence":"Well-established"},{"condition":"Acute bronchitis","description":"Provides symptomatic relief of cough and mucus congestion.","evidence":"Moderate"},{"condition":"Chronic bronchitis","description":"Used to manage chronic mucus hypersecretion and facilitate clearance.","evidence":"Moderate"},{"condition":"Respiratory tract infections with thick mucus","description":"Adjunctive therapy to help clear secretions.","evidence":"Limited"}]

Off-label uses: []

Primary treatment for: Productive cough

Also treats: Acute bronchitis, Chronic bronchitis, Respiratory tract infections

📋 Drug Information

Generic Name(s)Guaifenesin + Bromhexine
Brand NameAlkof Cofgel Tablet
ManufacturerGlenmark Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassExpectorant and Mucolytic
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a cool, dry place, away from direct sunlight. Do not freeze. Keep the bottle tightly closed.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Stay well hydrated throughout the day to help thin mucus.
3
Avoid alcohol while taking this medicine as it may increase drowsiness.
4
Do not take more than the prescribed dose.
5
Consult your doctor if symptoms persist beyond 7 days.
6
Report any unusual bleeding or bruising immediately.
7
Do not combine with other cough suppressants without medical advice.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Productive cough
This medicine is commonly prescribed for this.
Likely Use
❌
Dry cough
This medicine is not effective for dry cough.
Not Primary
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionGuaifenesin is rapidly absorbed from the gastrointestinal tract after oral administration. Bromhexine is also well absorbed orally. However, specific absorption data for this combination syrup are not established from the available information.
DistributionBoth guaifenesin and bromhexine are distributed to body tissues, including the lungs. Guaifenesin crosses the placenta and is excreted in breast milk. Bromhexine also crosses the placenta and is excreted in breast milk. Protein binding data are not established from the available information.
Protein BindingNot established from the available information.
MetabolismGuaifenesin is metabolized in the liver, primarily by oxidation and conjugation. Bromhexine undergoes extensive first-pass metabolism in the liver, converted to active metabolites including ambroxol. Specific metabolic pathways for this combination are not fully established from the available information.
Half-LifeThe elimination half-life of guaifenesin is approximately 1 hour. The elimination half-life of bromhexine is approximately 6.5 hours for the parent drug and up to 22 hours for its metabolites. These values may vary.
ExcretionGuaifenesin and its metabolites are excreted primarily in the urine. Bromhexine and its metabolites are also excreted mainly in the urine. Specific excretion data for this combination syrup are not established from the available information.
BioavailabilityThe oral bioavailability of guaifenesin is approximately 60%. The oral bioavailability of bromhexine is approximately 75-80% due to first-pass metabolism. These values may vary.
Onset of ActionThe onset of action for guaifenesin is typically within 30 minutes to 1 hour. For bromhexine, the onset may be within 1-2 hours. The exact onset for this combination syrup is not established from the available information.
Peak Plasma TimePeak plasma concentrations for guaifenesin are reached within 1-2 hours. For bromhexine, peak levels are reached within 1-2 hours. Specific data for this combination are not established from the available information.
Duration of ActionThe duration of action for guaifenesin is approximately 4-6 hours. For bromhexine, the effect may last up to 6-8 hours. The exact duration for this combination syrup is not established from the available information.

How It Works

This medicine combines two active ingredients with complementary actions. Guaifenesin is an expectorant that increases the volume and reduces the viscosity of bronchial secretions by stimulating gastric mucosal receptors and reflexly increasing respiratory tract fluid output. Bromhexine is a mucolytic that depolymerizes mucoprotein and mucopolysaccharide fibers in mucus, reducing its viscosity and making it easier to expel. Together, they enhance mucus clearance from the airways.

Mechanism Steps

1
Guaifenesin stimulates gastric mucosa: Guaifenesin acts on gastric mucosal receptors, triggering a reflex that increases respiratory tract fluid secretion.
2
Increased respiratory fluid: This reflex increases the volume of bronchial secretions, thinning the mucus.
3
Bromhexine depolymerizes mucus: Bromhexine breaks down the long chains of mucoproteins and mucopolysaccharides, reducing mucus viscosity.
4
Enhanced mucus clearance: The combined effect makes the mucus less sticky and easier to cough up, improving airway clearance.

💡 How to Take ascodex plus syrup

Strength: Each 5 ml contains Guaifenesin 50 mg and Bromhexine 4 mg.

1Shake the bottle well before each use.
2Measure the dose using the measuring cup or spoon provided.
3Take the medicine orally with or without food.
4Follow the prescribed schedule.
5Do not exceed the recommended dose.
6If you miss a dose, follow the missed dose instructions.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 10 ml (two teaspoons) three times a day, or as directed by your physician. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. Shake well before use.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageNo specific dose adjustment is established. Use with caution and follow your doctor's advice.
Renal ImpairmentDose adjustment may be needed in patients with kidney disease. Consult your doctor.
Hepatic ImpairmentDose adjustment may be needed in patients with liver disease. Consult your doctor.
Maximum Daily DoseThe maximum daily dose is not established from the available information. Do not exceed the dose prescribed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of ascodex plus syrup

✅ Common Side Effects

Nausea (Common (1-10%))
Take with food or milk to reduce stomach upset. If persists, consult doctor.
Vomiting (Common (1-10%))
Stay hydrated. If severe or persistent, consult doctor.
Stomach discomfort (Common (1-10%))
Take with meals. Avoid spicy foods.
Diarrhea (Common (1-10%))
Drink plenty of fluids. If persists, consult doctor.
Headache (Common (1-10%))
Rest and stay hydrated. If severe, consult doctor.
Dizziness (Common (1-10%))
Avoid driving or operating machinery until you know how it affects you.
Drowsiness (Common (1-10%))
Avoid alcohol and activities requiring alertness.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience rash, itching, swelling of face/lips/throat, difficulty breathing.
Severe skin reactions (e.g., Stevens-Johnson syndrome) (Rare (<0.1%))
Stop medicine and seek immediate medical help if you develop painful rash, blisters, or peeling skin.
Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black, tarry stools or vomit blood.

⚠️ Rare Side Effects

Bronchospasm
Seek immediate medical attention if you experience wheezing or difficulty breathing.
Liver enzyme elevation
Consult doctor if you notice yellowing of skin or eyes, dark urine, or abdominal pain.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Codeine Major
Dextromethorphan Major
Amoxicillin Moderate
Tetracycline Moderate
Atropine Moderate
Diuretics Moderate

🚨 Major Interactions

  • Cough suppressants (e.g., codeine, dextromethorphan)
  • Antibiotics (e.g., amoxicillin, tetracycline)

⚡ Moderate Interactions

  • Anticholinergic drugs (e.g., atropine)
  • Diuretics

🍷 Alcohol Interaction

Alcohol may increase drowsiness and dizziness caused by this medicine. It is advisable to avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to guaifenesin or bromhexine","Children under 12 years (unless prescribed)","Severe liver disease","Severe kidney disease","Gastric ulcer"]

⚠️ Warnings & Precautions

["Do not exceed recommended dose.","Avoid in patients with a history of peptic ulcer.","Use with caution in patients with asthma or COPD.","May cause drowsiness; avoid driving.","Consult doctor if cough persists more than 7 days.","Not for chronic cough without medical advice."]

🤱 Lactation Safety

Guaifenesin and bromhexine are excreted in breast milk. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

Overdose may cause nausea, vomiting, diarrhea, and abdominal pain. Seek immediate medical attention. Treatment is symptomatic and supportive. There is no specific antidote.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Shake the bottle well before each use. Use a proper measuring cup or spoon to ensure accurate dosing. Avoid driving or operating heavy machinery if you feel drowsy or dizzy after taking this medicine. Do not use this medicine for more than 7 days without consulting your doctor. If your cough persists or worsens, or if you develop fever, rash, or difficulty breathing, seek medical attention. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Keep this medicine out of reach of children. Do not use this medicine after the expiry date. Store in a cool, dry place, away from direct sunlight.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness and dizziness. Use with caution and monitor for any adverse effects.

🤰 Pregnancy Planning (TTC)

Consult your doctor if you are planning to become pregnant or are pregnant. The safety of this medicine during pregnancy is not well established.

🏥 Post-Surgery Considerations

Consult your doctor before using this medicine after surgery, as it may affect cough reflex and mucus clearance.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may affect saliva production and oral health.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce respiratory strain.
🥗
Regular low-impact exercise like walking or swimming.
😴
Practice good posture to aid breathing.
💧
Include anti-inflammatory foods in your diet.
🧘
Get adequate sleep to support immune function.
🌞
Avoid smoking and exposure to secondhand smoke.

🏋️ Exercise Considerations

If you experience dizziness or drowsiness after taking this medicine, avoid strenuous exercise or operating machinery. Light activity is generally safe.

🥗 Diet Recommendations

Include omega-3 rich foods
Reduce processed food intake
Stay well hydrated
Consume warm fluids like soups and teas

💼 Impact on Daily Work & Life

This medicine may cause drowsiness or dizziness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is generally safe for office work.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your cough persists for more than 7 days, or if you experience any severe side effects. Do not stop abruptly if you have been on long-term therapy without medical advice.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended without medical supervision. Prolonged use may lead to gastrointestinal disturbances. Monitor for any signs of liver or kidney impairment. Regular review by a doctor is advised if used for more than 7 days.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Steam inhalation

Can help loosen mucus and ease breathing.

Evidence: Limited
Saline nasal irrigation

May help clear nasal congestion.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific interactions with vaccines are established. However, consult your doctor before vaccination if you are unwell.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing times gradually. Check customs regulations for carrying medicines. Keep it in your carry-on luggage if flying.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with acute bronchitis
Started this medicine as prescribed for productive cough. Within 2 days noticed significant improvement in mucus clearance. Emphasized taking with food to prevent stomach upset.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 60-year-old with chronic bronchitis
Used this medicine as part of a management plan. Found it helpful in reducing chest congestion and making cough more productive. Noted that it should not be used for more than 7 days without medical review.
💡 Lesson: Short-term use under medical supervision is key; long-term use requires monitoring.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30 minutes to 1 hour, but noticeable relief may take a few doses.

Q: Can I take it with antibiotics?

A: Yes, but consult your doctor as bromhexine may increase antibiotic levels in the lungs.

Q: Is it safe for children?

A: It is not recommended for children under 12 years without medical advice.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for ascodex plus syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure any type of cough.
    Fact: It is only for productive cough with mucus; it is not effective for dry cough.
  • Myth: It is safe to take with other cough medicines.
    Fact: Combining with cough suppressants may be harmful; consult a doctor.

🔄 Alternative Options

Generic Alternatives

  • Guaifenesin + Bromhexine syrup

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Guaifenesin 50mg/5ml + Bromhexine 4mg/5ml","use":"Productive cough"},{"medicine":"Ambroxol + Guaifenesin","composition":"Ambroxol 30mg/5ml + Guaifenesin 50mg/5ml","use":"Productive cough"}]

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