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crolimus 1mg capsule

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Tacrolimus (1mg)

🏭 Aubade Healthcare Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Jul 4, 2026

⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Jul 04, 2026

What is crolimus 1mg capsule used for?

Advagraf (Tacrolimus) is used to treat ANTI NEOPLASTICS. It contains Tacrolimus (1mg), which Inhibits calcineurin, thereby preventing dephosphorylation and nuclear transloca. Always consult your doctor before use. Take as prescribed.

Generic Name: Tacrolimus
Manufacturer: Aubade Healthcare Pvt Ltd
Form: Allopathy
Pregnancy Category: C
Prescription Required: Yes

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 crolimus 1mg capsule Uses & Benefits

Prophylaxis of organ rejection in kidney, liver, and heart transplant recipients.

Off-label uses: Autoimmune hepatitis, Ulcerative colitis, Atopic dermatitis, Nephrotic syndrome

📋 Drug Information

Generic Name(s)	Tacrolimus
Brand Name	Advagraf
Manufacturer	Aubade Healthcare Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI NEOPLASTICS
Action Class	Immunosuppressant- Calcineurin inhibitors
Route of Administration	Oral
Storage	Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F). Protect from light and moisture.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionAbsorbed from the gastrointestinal tract; absorption is variable and incomplete.

DistributionExtensively distributed; high concentration in erythrocytes.

Protein BindingApproximately 99% bound to plasma proteins, mainly albumin and alpha-1-acid glycoprotein.

MetabolismMetabolized primarily in the liver via CYP3A4 and CYP3A5.

Half-LifeApproximately 8.7 hours in healthy volunteers; longer in patients with hepatic impairment.

ExcretionPrimarily excreted in bile and feces; less than 1% excreted unchanged in urine.

BioavailabilityVariable; approximately 17-23% after oral administration.

Onset of ActionRapid; immunosuppressive effects occur within hours.

Peak Plasma Time1-3 hours for immediate-release; prolonged for extended-release (Advagraf).

Duration of Action12-24 hours; dosing interval depends on formulation.

How It Works

Inhibits calcineurin, thereby preventing dephosphorylation and nuclear translocation of nuclear factor of activated T-cells (NF-AT), leading to reduced transcription of interleukin-2 and other cytokines.

Mechanism Steps

1Tacrolimus binds to FKBP12 in T-cells.

2Tacrolimus-FKBP12 complex binds to calcineurin.

3Inhibits calcineurin's phosphatase activity.

💡 How to Take crolimus 1mg capsule

Follow your doctor's prescription exactly.

⚠️ Side Effects of crolimus 1mg capsule

✅ Common Side Effects

Tremor
Headache
Diarrhea
Hypertension
Nausea
Renal impairment
Hyperglycemia
Hyperkalemia
Insomnia
Paresthesia

🚨 Serious Side Effects

Nephrotoxicity
Neurotoxicity (e.g., seizures, encephalopathy)
Posterior reversible encephalopathy syndrome (PRES)
Thrombotic microangiopathy
Anaphylaxis
Lymphoma
Skin malignancies

⚠️ Rare Side Effects

Hemolytic uremic syndrome
Cardiomyopathy
Leukoencephalopathy
Pure red cell aplasia
Interstitial lung disease

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Ciclosporin	Major	Increased nephrotoxicity risk
Sirolimus	Major	Increased risk of thrombotic microangiopathy
Potassium-sparing diuretics	Major	Hyperkalemia
ACE inhibitors	Major	Hyperkalemia
NSAIDs	Major	Increased nephrotoxicity
Ketoconazole	Moderate	Increased tacrolimus levels
Rifampin	Moderate	Decreased tacrolimus levels
Grapefruit juice	Minor	Increased tacrolimus levels

🚨 Major Interactions

Ciclosporin
Sirolimus
Potassium-sparing diuretics
ACE inhibitors
NSAIDs

⚡ Moderate Interactions

CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
CYP3A4 inducers (e.g., rifampin, phenytoin)
Antacids

ℹ️ Minor Interactions

Grapefruit juice
Magnesium-containing antacids

🍽️ Food Interactions

Grapefruit juice increases tacrolimus levels, High-fat meals decrease absorption

🍷 Alcohol Interaction

Alcohol may increase hepatotoxicity risk; avoid excessive consumption.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to tacrolimus or any excipients; concomitant use with cyclosporine.

📊 Monitoring Parameters

Tacrolimus trough levels, renal function, liver function, blood pressure, blood glucose, electrolytes (especially potassium), and signs of infection.

🤱 Lactation Safety

Not recommended; excreted in breast milk.

💊 Overdose Management

Supportive care; no specific antidote. Hemodialysis not effective.

⏰ Missed Dose

Take as soon as remembered unless close to next dose; skip missed dose if near next dose. Do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Jul 04, 2026

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🔄 Substitutes for crolimus 1mg capsule

View All

Alternative brands with exact same active ingredient (Tacrolimus (1mg)):

Medical Note: Always consult your doctor before switching medications.

😊 Was this information helpful?

📌 Quick Facts

Storage	Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F). Protect from light and moisture.
Route	Oral
Pregnancy	Category C
Breastfeeding	Not recommended; excreted in breast milk.
Alcohol	Alcohol may increase hepatotoxicity risk; avoid excessive consumption.
Onset of Action	Rapid; immunosuppressive effects occur within hours.
Half-Life	Approximately 8.7 hours in healthy volunteers; longer in patients with hepatic impairment.
Prescription	✅ Required

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