Amigraf 1.0 Capsule - Uses, Price, Side Effects, and More
What is amigraf 1.0 capsule used for?
Amigraf 1.0 Capsule contains Tacrolimus 1mg, an immunosuppressant that prevents organ rejection in transplant patients. It works by suppressing the immune system to stop it from attacking the transplanted organ. It is used in combination with other medications and requires regular monitoring of blood levels and kidney function.
- Generic Name: Tacrolimus
- Manufacturer: Biokindle Lifesciences Pvt Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ amigraf 1.0 capsule Uses & Benefits
Prophylaxis of organ rejection in kidney, liver, and heart transplant recipients.
Off-label uses: Autoimmune hepatitis, Ulcerative colitis, Atopic dermatitis, Nephrotic syndrome
๐ Drug Information
| Generic Name(s) | Tacrolimus |
| Brand Name | Advagraf |
| Manufacturer | Biokindle Lifesciences Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Immunosuppressant- Calcineurin inhibitors |
| Route of Administration | Oral |
| Storage | Store at 25ยฐC (77ยฐF); excursions permitted to 15-30ยฐC (59-86ยฐF). Protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Inhibits calcineurin, thereby preventing dephosphorylation and nuclear translocation of nuclear factor of activated T-cells (NF-AT), leading to reduced transcription of interleukin-2 and other cytokines.
Mechanism Steps
๐ก How to Take amigraf 1.0 capsule
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of amigraf 1.0 capsule
โ Common Side Effects
- Tremor
- Headache
- Diarrhea
- Hypertension
- Nausea
- Renal impairment
- Hyperglycemia
- Hyperkalemia
- Insomnia
- Paresthesia
๐จ Serious Side Effects
- Nephrotoxicity
- Neurotoxicity (e.g., seizures, encephalopathy)
- Posterior reversible encephalopathy syndrome (PRES)
- Thrombotic microangiopathy
- Anaphylaxis
- Lymphoma
- Skin malignancies
โ ๏ธ Rare Side Effects
- Hemolytic uremic syndrome
- Cardiomyopathy
- Leukoencephalopathy
- Pure red cell aplasia
- Interstitial lung disease
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Cyclosporine | Major | Increased nephrotoxicity and risk of infection |
| Potassium-sparing diuretics | Moderate | Increased risk of hyperkalemia |
| Live vaccines | Major | Risk of disseminated infection |
๐จ Major Interactions
- Ciclosporin
- Sirolimus
- Potassium-sparing diuretics
- ACE inhibitors
- NSAIDs
โก Moderate Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
- CYP3A4 inducers (e.g., rifampin, phenytoin)
- Antacids
โน๏ธ Minor Interactions
- Grapefruit juice
- Magnesium-containing antacids
๐ฝ๏ธ Food Interactions
Grapefruit juice increases tacrolimus levels, High-fat meals decrease absorption
๐ท Alcohol Interaction
Alcohol may increase hepatotoxicity risk; avoid excessive consumption.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to tacrolimus or any excipients; concomitant use with cyclosporine.
๐ Monitoring Parameters
Tacrolimus trough levels, renal function, liver function, blood pressure, blood glucose, electrolytes (especially potassium), and signs of infection.
๐คฑ Lactation Safety
Not recommended; excreted in breast milk.
๐ Overdose Management
Supportive care; no specific antidote. Hemodialysis not effective.
โฐ Missed Dose
Take as soon as remembered unless close to next dose; skip missed dose if near next dose. Do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for amigraf 1.0 capsule
View AllAlternative brands with exact same active ingredient (Tacrolimus (1mg)):
-
limicort ointmentCatholicon Pharmaceuticals Pvt Ltd โน267.19 11.2% CHEAPER
-
tacrolim 1mg capsuleDr Reddy's Laboratories Ltd โน300.00 0.3% CHEAPER
-
nefrograf 1mg capsuleRenauxe Pharma India Pvt Ltd โน320.00 6.3% COSTLIER
-
Tacimun 1mg CapsuleBharat Serums & Vaccines Ltd โน332.16 10.4% COSTLIER
-
procept 1mg capsuleEntero Healthcare Solutions Pvt Ltd โน340.00 13% COSTLIER
-
rolitrans 1mg capsuleCipla Ltd โน343.47 14.1% COSTLIER
-
emgraf 1mg capsuleEmcure Pharmaceuticals Ltd โน351.52 16.8% COSTLIER
-
tacloran 1 capsuleWockhardt Ltd โน352.10 17% COSTLIER
-
grafnos 1 capsuleAkognos Life Sciences โน355.00 18% COSTLIER
-
Tacrotreat 1 TabletGenix Lifescience Pvt Ltd โน357.19 18.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
โญ User Reviews
This medicine was effective for me. I followed the doctor's advice.
Found this to be a helpful product. Good results.
This medicine was effective for me. I followed the doctor's advice.
Helpful and effective medicine as per my experience. Always consult a doctor.
Good quality medicine. Satisfied with the outcome.