crolimus 0.5mg capsule - Tacrolimus (0.5mg) medicine

crolimus 0.5mg capsule

4.9 (10 reviews)
Tacrolimus (0.5mg)
๐Ÿญ Aubade Healthcare Pvt Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 22, 2026
โš ๏ธ Hepatotoxicity Risk โš ๏ธ Nephrotoxicity Risk ๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 22, 2026

What is crolimus 0.5mg capsule used for?

Advagraf (Tacrolimus) is used to treat ANTI NEOPLASTICS. It contains Tacrolimus (0.5mg), which Inhibits calcineurin, thereby preventing dephosphorylation and nuclear transloca. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Tacrolimus
  • Manufacturer: Aubade Healthcare Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

๐Ÿ’Š crolimus 0.5mg capsule Uses & Benefits

Prophylaxis of organ rejection in kidney, liver, and heart transplant recipients.

Off-label uses: Autoimmune hepatitis, Ulcerative colitis, Atopic dermatitis, Nephrotic syndrome

๐Ÿ“‹ Drug Information

Generic Name(s)Tacrolimus
Brand NameAdvagraf
ManufacturerAubade Healthcare Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI NEOPLASTICS
Action ClassImmunosuppressant- Calcineurin inhibitors
Route of AdministrationOral
StorageStore at 25ยฐC (77ยฐF); excursions permitted to 15-30ยฐC (59-86ยฐF). Protect from light and moisture.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionAbsorbed from the gastrointestinal tract; absorption is variable and incomplete.
DistributionExtensively distributed; high concentration in erythrocytes.
Protein BindingApproximately 99% bound to plasma proteins, mainly albumin and alpha-1-acid glycoprotein.
MetabolismMetabolized primarily in the liver via CYP3A4 and CYP3A5.
Half-LifeApproximately 8.7 hours in healthy volunteers; longer in patients with hepatic impairment.
ExcretionPrimarily excreted in bile and feces; less than 1% excreted unchanged in urine.
BioavailabilityVariable; approximately 17-23% after oral administration.
Onset of ActionRapid; immunosuppressive effects occur within hours.
Peak Plasma Time1-3 hours for immediate-release; prolonged for extended-release (Advagraf).
Duration of Action12-24 hours; dosing interval depends on formulation.

How It Works

Inhibits calcineurin, thereby preventing dephosphorylation and nuclear translocation of nuclear factor of activated T-cells (NF-AT), leading to reduced transcription of interleukin-2 and other cytokines.

Mechanism Steps

1Tacrolimus binds to FKBP12 in T-cells.
2Tacrolimus-FKBP12 complex binds to calcineurin.
3Inhibits calcineurin's phosphatase activity.

๐Ÿ’ก How to Take crolimus 0.5mg capsule

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of crolimus 0.5mg capsule

โœ… Common Side Effects

  • Tremor
  • Headache
  • Diarrhea
  • Hypertension
  • Nausea
  • Renal impairment
  • Hyperglycemia
  • Hyperkalemia
  • Insomnia
  • Paresthesia

๐Ÿšจ Serious Side Effects

  • Nephrotoxicity
  • Neurotoxicity (e.g., seizures, encephalopathy)
  • Posterior reversible encephalopathy syndrome (PRES)
  • Thrombotic microangiopathy
  • Anaphylaxis
  • Lymphoma
  • Skin malignancies

โš ๏ธ Rare Side Effects

  • Hemolytic uremic syndrome
  • Cardiomyopathy
  • Leukoencephalopathy
  • Pure red cell aplasia
  • Interstitial lung disease

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Ciclosporin Major Increased nephrotoxicity risk
Sirolimus Major Increased risk of thrombotic microangiopathy
Potassium-sparing diuretics Major Hyperkalemia
ACE inhibitors Major Hyperkalemia
NSAIDs Major Increased nephrotoxicity
Ketoconazole Moderate Increased tacrolimus levels
Rifampin Moderate Decreased tacrolimus levels
Grapefruit juice Minor Increased tacrolimus levels

๐Ÿšจ Major Interactions

  • Ciclosporin
  • Sirolimus
  • Potassium-sparing diuretics
  • ACE inhibitors
  • NSAIDs

โšก Moderate Interactions

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
  • CYP3A4 inducers (e.g., rifampin, phenytoin)
  • Antacids

โ„น๏ธ Minor Interactions

  • Grapefruit juice
  • Magnesium-containing antacids

๐Ÿฝ๏ธ Food Interactions

Grapefruit juice increases tacrolimus levels, High-fat meals decrease absorption

๐Ÿท Alcohol Interaction

Alcohol may increase hepatotoxicity risk; avoid excessive consumption.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to tacrolimus or any excipients; concomitant use with cyclosporine.

๐Ÿ“Š Monitoring Parameters

Tacrolimus trough levels, renal function, liver function, blood pressure, blood glucose, electrolytes (especially potassium), and signs of infection.

๐Ÿคฑ Lactation Safety

Not recommended; excreted in breast milk.

๐Ÿ’Š Overdose Management

Supportive care; no specific antidote. Hemodialysis not effective.

โฐ Missed Dose

Take as soon as remembered unless close to next dose; skip missed dose if near next dose. Do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for crolimus 0.5mg capsule

View All

Alternative brands with exact same active ingredient (Tacrolimus (0.5mg)):

Medical Note: Always consult your doctor before switching medications.

โญ User Reviews

Verified User Jul 10, 2026

Effective and reliable. Worked as expected.

Verified User Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Happy Patient Jul 10, 2026

Effective and reliable. Worked as expected.

Regular Customer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.

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