alagraf 0.5 capsule - Tacrolimus (0.5mg) medicine

Alagraf 0.5 Capsule - Uses, Price, Side Effects

4.6 (14 reviews)
Tacrolimus (0.5mg)
๐Ÿญ Alacris Healthcare Pvt Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 23, 2026
โš ๏ธ Hepatotoxicity Risk โš ๏ธ Nephrotoxicity Risk ๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 23, 2026

What is alagraf 0.5 capsule used for?

Alagraf 0.5 Capsule contains Tacrolimus 0.5mg, an immunosuppressant that prevents organ rejection after transplant by inhibiting calcineurin and T-cell activation. It is used in kidney, liver, and heart transplants to reduce the immune response against the donor organ.

  • Generic Name: Tacrolimus
  • Manufacturer: Alacris Healthcare Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

๐Ÿ’Š alagraf 0.5 capsule Uses & Benefits

Prophylaxis of organ rejection in kidney, liver, and heart transplant recipients.

Off-label uses: Autoimmune hepatitis, Ulcerative colitis, Atopic dermatitis, Nephrotic syndrome

๐Ÿ“‹ Drug Information

Generic Name(s)Tacrolimus
Brand NameAdvagraf
ManufacturerAlacris Healthcare Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI NEOPLASTICS
Action ClassImmunosuppressant- Calcineurin inhibitors
Route of AdministrationOral
StorageStore at 25ยฐC (77ยฐF); excursions permitted to 15-30ยฐC (59-86ยฐF). Protect from light and moisture.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionAbsorbed from the gastrointestinal tract; absorption is variable and incomplete.
DistributionExtensively distributed; high concentration in erythrocytes.
Protein BindingApproximately 99% bound to plasma proteins, mainly albumin and alpha-1-acid glycoprotein.
MetabolismMetabolized primarily in the liver via CYP3A4 and CYP3A5.
Half-LifeApproximately 8.7 hours in healthy volunteers; longer in patients with hepatic impairment.
ExcretionPrimarily excreted in bile and feces; less than 1% excreted unchanged in urine.
BioavailabilityVariable; approximately 17-23% after oral administration.
Onset of ActionRapid; immunosuppressive effects occur within hours.
Peak Plasma Time1-3 hours for immediate-release; prolonged for extended-release (Advagraf).
Duration of Action12-24 hours; dosing interval depends on formulation.

How It Works

Inhibits calcineurin, thereby preventing dephosphorylation and nuclear translocation of nuclear factor of activated T-cells (NF-AT), leading to reduced transcription of interleukin-2 and other cytokines.

Mechanism Steps

1Tacrolimus binds to FKBP12 in T-cells.
2Tacrolimus-FKBP12 complex binds to calcineurin.
3Inhibits calcineurin's phosphatase activity.

๐Ÿ’ก How to Take alagraf 0.5 capsule

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โœ… ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of alagraf 0.5 capsule

โœ… Common Side Effects

  • Tremor
  • Headache
  • Diarrhea
  • Hypertension
  • Nausea
  • Renal impairment
  • Hyperglycemia
  • Hyperkalemia
  • Insomnia
  • Paresthesia

๐Ÿšจ Serious Side Effects

  • Nephrotoxicity
  • Neurotoxicity (e.g., seizures, encephalopathy)
  • Posterior reversible encephalopathy syndrome (PRES)
  • Thrombotic microangiopathy
  • Anaphylaxis
  • Lymphoma
  • Skin malignancies

โš ๏ธ Rare Side Effects

  • Hemolytic uremic syndrome
  • Cardiomyopathy
  • Leukoencephalopathy
  • Pure red cell aplasia
  • Interstitial lung disease

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Cyclosporine Major Increased nephrotoxicity risk
Potassium-sparing diuretics Moderate Hyperkalemia risk
NSAIDs Moderate Increased nephrotoxicity

๐Ÿšจ Major Interactions

  • Ciclosporin
  • Sirolimus
  • Potassium-sparing diuretics
  • ACE inhibitors
  • NSAIDs

โšก Moderate Interactions

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
  • CYP3A4 inducers (e.g., rifampin, phenytoin)
  • Antacids

โ„น๏ธ Minor Interactions

  • Grapefruit juice
  • Magnesium-containing antacids

๐Ÿฝ๏ธ Food Interactions

Grapefruit juice increases tacrolimus levels, High-fat meals decrease absorption

๐Ÿท Alcohol Interaction

Alcohol may increase hepatotoxicity risk; avoid excessive consumption.

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Moderate
Kidney
Moderate
Heart
Low
Pregnancy
Category C

๐Ÿšซ Contraindications

Hypersensitivity to tacrolimus or any excipients; concomitant use with cyclosporine.

๐Ÿ“Š Monitoring Parameters

Tacrolimus trough levels, renal function, liver function, blood pressure, blood glucose, electrolytes (especially potassium), and signs of infection.

๐Ÿคฑ Lactation Safety

Not recommended; excreted in breast milk.

๐Ÿ’Š Overdose Management

Supportive care; no specific antidote. Hemodialysis not effective.

โฐ Missed Dose

Take as soon as remembered unless close to next dose; skip missed dose if near next dose. Do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 23, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for alagraf 0.5 capsule

View All

Alternative brands with exact same active ingredient (Tacrolimus (0.5mg)):

Medical Note: Always consult your doctor before switching medications.

โญ User Reviews

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.

Trusted Reviewer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Trusted Reviewer Jul 10, 2026

Found this to be a helpful product. Good results.

Verified User Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Certified Buyer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

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