cosox syrup - Terbutaline (1.25mg) + Ambroxol (15mg) medicine

Ambocuf Syrup: Complete Medicine Guide

No reviews yet
🏭 Aelida Healthcare 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 22, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate
Reviewed by
SaathiMed Expert Panel | Oct 22, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Irregular heartbeat or palpitations

If experiencing severe symptoms, call emergency services immediately.

What is cosox syrup used for?

This medicine is a combination of terbutaline and ambroxol used to treat respiratory conditions with bronchospasm and thick mucus. It works by relaxing airway muscles and thinning mucus.

  • Generic Name: Terbutaline + Ambroxol
  • Manufacturer: Aelida Healthcare
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 cosox syrup के बारे में (Hindi Summary)

उपयोग: यह दवा टर्ब्यूटलीन और एम्ब्रोक्सोल का संयोजन है, जिसका उपयोग श्वसन संबंधी समस्याओं जैसे ब्रोंकाइटिस, अस्थमा और कफ के इलाज में किया जाता है। यह वायुमार्ग की मांसपेशियों को आराम देकर सांस लेने में मदद करती है और बलगम को पतला करके बाहर निकालने में सहायता करती है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में कंपन, घबराहट, सिरदर्द, चक्कर आना, मतली, उल्टी और पेट खराब होना शामिल हो सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन यदि आपको गंभीर एलर्जी, अनियमित दिल की धड़कन, सीने में दर्द या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक बढ़ाएं या घटाएं नहीं। उपयोग से पहले बोतल को अच्छी तरह हिलाएं। सही मापने वाले कप या चम्मच का उपयोग करें। यदि आपको चक्कर या कंपन महसूस हो तो वाहन चलाने या मशीनरी चलाने से बचें। यदि आप गर्भवती या स्तनपान करा रही हैं तो डॉक्टर से सलाह लें।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 cosox syrup Uses & Benefits

[{"condition":"Bronchitis","description":"Helps relieve bronchospasm and loosen mucus, making breathing easier and reducing cough.","evidence":"Well-established"},{"condition":"Asthma","description":"Used as a bronchodilator to relieve acute bronchospasm and as an adjunct to other asthma treatments.","evidence":"Well-established"},{"condition":"Productive cough","description":"Ambroxol thins mucus, making it easier to expel, while terbutaline helps open airways.","evidence":"Well-established"},{"condition":"Chronic obstructive pulmonary disease (COPD)","description":"May be used to relieve bronchospasm and facilitate mucus clearance in some patients.","evidence":"Limited"}]

Off-label uses: [{"condition":"Premature labor (tocolysis)","description":"Terbutaline has been used off-label to delay premature labor, but this use is not recommended due to safety concerns.","evidence":"Limited"}]

Primary treatment for: Bronchitis

Also treats: Asthma, COPD, Productive cough

📋 Drug Information

Generic Name(s)Terbutaline + Ambroxol
Brand NameAstharid Plus Tablet
ManufacturerAelida Healthcare
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassBronchodilator + Mucolytic
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Do not freeze. Keep the bottle tightly closed.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Stay well hydrated throughout the day to help loosen mucus.
3
Avoid alcohol while taking this medicine as it may increase dizziness.
4
Do not take more than the prescribed dose.
5
Consult your doctor if symptoms persist beyond 7 days.
6
Report any unusual heart palpitations or tremors to your doctor.
7
Use a proper measuring cup to ensure accurate dosing.
8
Shake the bottle well before each use.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic cough with mucus
This medicine is commonly prescribed for this.
Likely Use
✅
Wheezing
Terbutaline helps relieve wheezing.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionTerbutaline is rapidly absorbed from the gastrointestinal tract after oral administration. Ambroxol is also well absorbed orally. However, oral bioavailability of terbutaline is reduced due to first-pass metabolism.
DistributionTerbutaline distributes widely into body tissues, including the lungs. Ambroxol distributes into lung tissue, bronchial secretions, and other tissues. Both agents cross the placenta and are excreted in breast milk.
Protein BindingTerbutaline is approximately 25% bound to plasma proteins. Ambroxol is approximately 90% bound to plasma proteins.
MetabolismTerbutaline undergoes extensive first-pass metabolism in the liver, primarily by conjugation with sulfate. Ambroxol is metabolized in the liver by glucuronidation and some oxidation.
Half-LifeTerbutaline: approximately 3-4 hours; Ambroxol: approximately 7-12 hours.
ExcretionTerbutaline and its metabolites are excreted primarily in the urine. Ambroxol and its metabolites are excreted mainly in the urine.
BioavailabilityTerbutaline oral bioavailability is approximately 15% due to first-pass metabolism. Ambroxol oral bioavailability is approximately 70-80%.
Onset of ActionTerbutaline: bronchodilation occurs within 30 minutes after oral administration. Ambroxol: mucolytic effect may take several hours to become noticeable.
Peak Plasma TimeTerbutaline: 2-4 hours; Ambroxol: 1-3 hours.
Duration of ActionTerbutaline: 4-6 hours; Ambroxol: up to 12 hours.

How It Works

This medicine combines two active ingredients with complementary actions. Terbutaline is a selective beta-2 adrenergic receptor agonist that binds to beta-2 receptors on bronchial smooth muscle, leading to relaxation and bronchodilation. Ambroxol is a mucolytic agent that reduces mucus viscosity by breaking down acidic mucopolysaccharide fibers and stimulating surfactant production, thereby facilitating mucus clearance.

Mechanism Steps

1
Terbutaline binds to beta-2 receptors: Terbutaline selectively binds to beta-2 adrenergic receptors on the surface of bronchial smooth muscle cells.
2
Activation of intracellular signaling: Binding triggers activation of adenylate cyclase, which increases cyclic AMP levels inside the cell.
3
Bronchial smooth muscle relaxation: Elevated cyclic AMP leads to relaxation of bronchial smooth muscle, resulting in bronchodilation and easier breathing.
4
Ambroxol reduces mucus viscosity: Ambroxol breaks down acidic mucopolysaccharide fibers in mucus, reducing its thickness and making it easier to cough out.
5
Enhanced mucociliary clearance: Ambroxol also stimulates surfactant production and ciliary activity, further aiding in the removal of mucus from the airways.

💡 How to Take cosox syrup

Strength: Each 5 mL of syrup contains Terbutaline 1.25 mg and Ambroxol 15 mg.

1Shake the bottle well before each use.
2Use a proper measuring cup or spoon to measure the dose accurately.
3Take the medicine orally with or without food.
4If it upsets your stomach, take it with a meal or snack.
5Follow your doctor's instructions regarding the duration of treatment.
6Do not exceed the prescribed dose.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 10 mL (2 teaspoons) three times a day, or as directed by your doctor. The dose may be adjusted based on your condition and response to treatment. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine, especially cardiovascular effects. Use with caution and adjust dose as needed under medical supervision.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be necessary. Consult your doctor.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose adjustment may be necessary. Consult your doctor.
Maximum Daily DoseThe maximum recommended daily dose is 30 mL (6 teaspoons) in divided doses, or as prescribed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Caffeine
Limit
May increase nervousness and tremors.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of cosox syrup

✅ Common Side Effects

Tremors (Common (5-10%))
Usually resolves with continued use. If bothersome, consult your doctor.
Nervousness (Common (5-10%))
Try to relax and avoid caffeine. Consult doctor if persistent.
Headache (Common (5-10%))
Rest and stay hydrated. Consult doctor if severe.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you feel normal.
Nausea (Common (5-10%))
Take with food to reduce stomach upset.
Vomiting (Common (5-10%))
Take with food and stay hydrated. Consult doctor if persistent.
Stomach upset (Common (5-10%))
Take with meals. Consult doctor if severe.
Increased heart rate (Common (5-10%))
Monitor your pulse. If persistently high, consult doctor.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience rash, itching, swelling of face/lips/throat, or difficulty breathing.
Irregular heartbeat (arrhythmia) (Rare (<0.1%))
Seek immediate medical attention if you feel palpitations, chest pain, or fainting.
Chest pain (Rare (<0.1%))
Seek immediate medical attention.
Severe skin reactions (Stevens-Johnson syndrome) (Very rare (<0.01%))
Seek immediate medical attention if you develop rash, blisters, or peeling skin.

⚠️ Rare Side Effects

Hypokalemia (low potassium)
Report muscle weakness or cramps to your doctor.
Hyperglycemia (high blood sugar)
Monitor blood sugar if diabetic. Consult doctor if levels rise.
Tremors
Usually dose-related. Consult doctor if severe.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Propranolol Major
MAOIs Major
Tricyclic antidepressants Major
Furosemide Moderate
Corticosteroids Moderate
Theophylline Moderate
Ipratropium Minor

🚨 Major Interactions

  • Beta-blockers (e.g., propranolol)
  • Monoamine oxidase inhibitors (MAOIs)
  • Tricyclic antidepressants

⚡ Moderate Interactions

  • Diuretics (e.g., furosemide)
  • Corticosteroids
  • Xanthine derivatives (e.g., theophylline)

🍷 Alcohol Interaction

Alcohol may increase the sedative effects of this medicine and worsen dizziness. Avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to terbutaline, ambroxol, or any component of the formulation","Severe cardiovascular disease","Hyperthyroidism","Diabetes mellitus (uncontrolled)","Severe hepatic or renal impairment"]

⚠️ Warnings & Precautions

["Use with caution in patients with cardiovascular disease, including coronary insufficiency, arrhythmias, and hypertension.","May cause tremors and nervousness; avoid driving or operating machinery if affected.","May cause hypokalemia; monitor potassium levels, especially with concomitant use of diuretics, corticosteroids, or xanthine derivatives.","May increase blood glucose levels; monitor diabetic patients closely.","Use with caution in patients with hyperthyroidism, diabetes, or seizure disorders.","Not recommended for use in children under 2 years of age.","Do not exceed the recommended dose."]

🤱 Lactation Safety

Terbutaline is excreted in breast milk. Ambroxol is also excreted in breast milk. Consult your doctor before breastfeeding while taking this medicine.

💊 Overdose Management

Overdose may cause severe tachycardia, tremors, palpitations, chest pain, and hypokalemia. Seek immediate medical attention. Treatment is supportive and symptomatic. Monitor cardiac function and electrolyte levels.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not increase or decrease the dose without consulting your doctor. Shake the bottle well before each use. Use a proper measuring cup or spoon to measure the dose. Avoid driving or operating heavy machinery if you feel dizzy or shaky after taking this medicine. Inform your doctor if you have heart disease, high blood pressure, diabetes, thyroid problems, or liver or kidney disease. Do not take this medicine with other cough and cold medicines without consulting your doctor. If you are pregnant or breastfeeding, consult your doctor before using this medicine. Keep this medicine out of the reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to cardiovascular effects. Use with caution and monitor closely.

🤰 Pregnancy Planning (TTC)

Consult your doctor before planning pregnancy while on this medicine. Terbutaline is FDA category C; Ambroxol safety not established.

🏥 Post-Surgery Considerations

Consult your doctor before resuming this medicine after surgery, especially if you have heart or lung conditions.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may interact with certain dental anesthetics.

💚 Lifestyle Tips for Better Results

🏃
Avoid smoking and exposure to secondhand smoke.
🥗
Use a humidifier to keep air moist.
😴
Practice deep breathing exercises.
💧
Stay well hydrated.
🧘
Get adequate rest.
🌞
Avoid known allergens.

🏋️ Exercise Considerations

Avoid strenuous exercise if you experience dizziness or tremors. Consult your doctor before starting any exercise program.

🥗 Diet Recommendations

Include warm fluids to help loosen mucus.
Avoid cold drinks and ice cream.
Eat a balanced diet rich in vitamins and minerals.
Limit caffeine intake.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or tremors, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects, seek medical advice immediately.

📅 Long-Term Use Effects

Long-term use of this medicine should be under medical supervision. Regular monitoring of heart rate, blood pressure, and potassium levels may be required. Do not use for prolonged periods without consulting your doctor.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Steam inhalation

Can help loosen mucus and ease breathing.

Evidence: Well-established
Chest physiotherapy

Helps clear mucus from airways.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are established. Consult your doctor for routine vaccinations.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with chronic bronchitis
Started this medicine as prescribed for bronchitis. Within a few days, noticed significant improvement in breathing and cough. Emphasized taking with food to prevent stomach upset.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 60-year-old man with COPD
Used this medicine as part of his COPD management. Experienced mild tremors initially, which subsided after a week. Found that staying hydrated helped loosen mucus.
💡 Lesson: Mild side effects often diminish with continued use, but always report persistent symptoms to your doctor.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Terbutaline starts working within 30 minutes, while Ambroxol's mucolytic effect may take several hours.

Q: Can I take this medicine with other cough medicines?

A: Consult your doctor before combining with other cough medicines to avoid interactions.

Q: Is it safe for children?

A: Pediatric dosing is not established. Consult a pediatrician.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for cosox syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure asthma permanently.
    Fact: This medicine provides symptomatic relief but does not cure asthma. Asthma requires long-term management.
  • Myth: It is safe to take this medicine without a prescription.
    Fact: This medicine should only be taken under medical supervision as it can cause serious side effects.

🔄 Alternative Options

Generic Alternatives

  • Terbutaline + Ambroxol syrup

Brand Alternatives

  • Ambocuf Syrup

📊 Comparison with Similar Medicines

[{"medicine":"Terbutaline + Ambroxol","composition":"Terbutaline 1.25 mg + Ambroxol 15 mg per 5 mL","uses":"Bronchospasm with thick mucus","notes":"Combines bronchodilator and mucolytic."},{"medicine":"Terbutaline + Bromhexine","composition":"Terbutaline 1.25 mg + Bromhexine 4 mg per 5 mL","uses":"Bronchospasm with thick mucus","notes":"Bromhexine is another mucolytic."},{"medicine":"Salbutamol + Ambroxol","composition":"Salbutamol 1 mg + Ambroxol 15 mg per 5 mL","uses":"Bronchospasm with thick mucus","notes":"Salbutamol is a shorter-acting bronchodilator."}]

😊 Was this information helpful?

Browse Medicines A-Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Back to Medicines Directory