cosklot mf 500mg/250mg tablet - Uses, Price, Side Effects & Substitutes
What is cosklot mf 500mg/250mg tablet used for?
Abdotic Plus Tablet (Tranexamic Acid + Mefenamic Acid) is used to treat BLOOD RELATED. It contains Tranexamic Acid (500mg) + Mefenamic Acid (250mg), which Tranexamic acid: inhibits plasminogen activation; Mefenamic acid: inhibits COX-1. Always consult your doctor before use. Take as prescribed.
- Generic Name: Tranexamic Acid + Mefenamic Acid
- Manufacturer: Oaknet Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ cosklot mf 500mg/250mg tablet Uses & Benefits
Menorrhagia, dysmenorrhea, heavy menstrual bleeding
Off-label uses: Epistaxis, dental bleeding, trauma-related bleeding
๐ Drug Information
| Generic Name(s) | Tranexamic Acid + Mefenamic Acid |
| Brand Name | Abdotic Plus Tablet |
| Manufacturer | Oaknet Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | BLOOD RELATED |
| Action Class | Antifibrinolytic + NSAID |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Tranexamic acid: inhibits plasminogen activation; Mefenamic acid: inhibits COX-1/COX-2
Mechanism Steps
๐ก How to Take cosklot mf 500mg/250mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cosklot mf 500mg/250mg tablet
โ Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Dizziness
- Headache
๐จ Serious Side Effects
- Thrombosis
- Anaphylaxis
- GI bleeding
- Renal failure
โ ๏ธ Rare Side Effects
- Color vision disturbance
- Hypotension
- Stevens-Johnson syndrome
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Aspirin | Major | Additive antiplatelet effect |
| Clopidogrel | Major | Increased bleeding risk |
| Heparin | Major | Increased bleeding risk |
| NSAIDs | Major | Additive GI toxicity |
| ACE inhibitors | Moderate | Reduced antihypertensive effect |
| Diuretics | Moderate | Reduced diuretic effect |
| Lithium | Moderate | Increased lithium levels |
| Methotrexate | Moderate | Increased methotrexate toxicity |
| Antacids | Minor | Reduced absorption |
| Corticosteroids | Minor | Increased GI ulcer risk |
๐จ Major Interactions
- Warfarin
- Aspirin
- Clopidogrel
- Heparin
- NSAIDs
โก Moderate Interactions
- ACE inhibitors
- Diuretics
- Lithium
- Methotrexate
โน๏ธ Minor Interactions
- Antacids
- Corticosteroids
๐ฝ๏ธ Food Interactions
Food may delay absorption
๐ท Alcohol Interaction
Increased risk of GI bleeding
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Active peptic ulcer, severe renal impairment, history of hypersensitivity, thromboembolic disease
๐ Monitoring Parameters
Renal function, liver function, CBC, signs of bleeding
๐คฑ Lactation Safety
Use with caution; excreted in milk
๐ Overdose Management
Symptomatic and supportive; gastric lavage, activated charcoal
โฐ Missed Dose
Take as soon as remembered; skip if near next dose