Acolate DS Suspension: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of the eyes or skin, dark urine, or severe abdominal pain, which may indicate liver injury.
- Swelling of the face, lips, tongue, or throat, or difficulty breathing, which may indicate a severe allergic reaction.
- Unusual bruising or bleeding, fever, or sore throat, which may indicate a blood disorder.
- Severe drowsiness, confusion, or difficulty waking up, which may indicate excessive sedation.
- Racing or irregular heartbeat, chest pain, or fainting.
- Difficulty passing urine or severe lower abdominal pain.
- Seizures or unusual body movements.
If experiencing severe symptoms, call emergency services immediately.
What is coriphen plus syrup used for?
This medicine is an oral suspension containing chlorpheniramine maleate 2 mg and paracetamol 250 mg. It is used for short-term relief of cold and allergy symptoms such as runny nose, sneezing, watery eyes, mild pain, and fever. It can cause drowsiness, so avoid driving and alcohol. Do not exceed the recommended dose, and consult a doctor if symptoms persist beyond a few days.
- Generic Name: Chlorpheniramine Maleate + Paracetamol
- Manufacturer: McW Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 coriphen plus syrup के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोरफेनिरामिन मेलिएट और पैरासिटामोल का संयोजन है, जो सर्दी-जुकाम और एलर्जी के लक्षणों जैसे नाक बहना, छींक आना, आंखों में पानी आना, खुजली, हल्का दर्द और बुखार में राहत देती है। यह ओरल सस्पेंशन के रूप में आती है और इसे डॉक्टर की सलाह के अनुसार ही लेना चाहिए। इसमें मौजूद क्लोरफेनिरामिन एलर्जी के कारण होने वाले लक्षणों को कम करता है, जबकि पैरासिटामोल दर्द और बुखार को कम करता है। यह दवा नवजात शिशुओं, गंभीर लिवर रोग वाले लोगों और इसके किसी भी घटक से एलर्जी वाले लोगों के लिए नहीं है। इस दवा से नींद आ सकती है, इसलिए गाड़ी चलाने या मशीन चलाने से बचें। शराब का सेवन बिल्कुल न करें।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में नींद आना, मुंह सूखना, चक्कर आना, धुंधली दृष्टि और हल्का पेट दर्द शामिल हैं। कुछ लोगों को मतली, कब्ज या पेशाब करने में कठिनाई हो सकती है। बच्चों और बुजुर्गों में यह दवा ज्यादा नींद और मुंह सूखने जैसे प्रभाव डाल सकती है। कभी-कभी त्वचा पर दाने, दिल की धड़कन तेज होना, भ्रम या खून से जुड़ी समस्याएं हो सकती हैं। अगर आपको पीलिया, गहरे रंग का पेशाब, त्वचा पर चकत्ते, चेहरे या गले में सूजन या सांस लेने में तकलीफ हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर या फार्मासिस्ट की सलाह के अनुसार ही लें और बताई गई मात्रा से ज्यादा न लें। इसमें पैरासिटामोल होता है, इसलिए अन्य दवाओं में पैरासिटामोल की मात्रा जरूर जांचें ताकि डबल डोज न हो जाए। इस दवा के साथ शराब बिल्कुल न पिएं, क्योंकि इससे लिवर को नुकसान और नींद बढ़ सकती है। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक गाड़ी न चलाएं और मशीन न चलाएं। गर्भवती महिलाएं, स्तनपान कराने वाली महिलाएं और गंभीर लिवर या किडनी रोग वाले लोग बिना डॉक्टर की सलाह के इस दवा का इस्तेमाल न करें। इस दवा को बच्चों की पहुंच से दूर, ठंडी और सूखी जगह पर, मूल डिब्बे में रखें।
💊 coriphen plus syrup Uses & Benefits
[{"condition":"Common cold with allergic symptoms","description":"Relieves runny nose, sneezing, watery eyes, and mild body ache or fever associated with the common cold.","evidence":"Well-established for short-term symptomatic relief"},{"condition":"Allergic rhinitis","description":"Reduces sneezing, nasal itching, and rhinorrhea caused by seasonal or perennial allergies.","evidence":"Well-established for antihistamine component"},{"condition":"Mild pain and fever","description":"Paracetamol provides relief from headache, sore throat, body ache, and lowers elevated temperature.","evidence":"Well-established for paracetamol component"},{"condition":"Allergic skin itching","description":"Chlorpheniramine helps control itching associated with urticaria or other mild allergic skin reactions.","evidence":"Well-established for antihistamine component"}]
Off-label uses: [{"condition":"Insomnia due to allergy","description":"Sometimes used for its sedating effect in people with allergy-related sleep disturbance.","evidence":"Limited"},{"condition":"Motion sickness","description":"First-generation antihistamines may be used off-label for mild motion sickness, but this combination is not a first-choice option.","evidence":"Limited"}]
Primary treatment for: Common cold and allergic rhinitis with mild pain or fever
Also treats: Seasonal allergic rhinitis, Perennial allergic rhinitis, Urticaria with itching, Mild upper respiratory tract infection
📋 Drug Information
| Generic Name(s) | Chlorpheniramine Maleate + Paracetamol |
| Brand Name | Alex P Syrup |
| Manufacturer | McW Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Antihistamine + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C in a dry place, away from direct sunlight and moisture. Keep the bottle tightly closed and out of the reach of children. |
| Shelf Life | Not established from the available information. Refer to the expiry date printed on the pack. |
| WHO Guideline | Not established from the available information. This combination is not specifically listed in WHO guidelines for routine use. |
| ICMR Guideline | Not established from the available information. Follow national or institutional prescribing guidance for cold and allergy symptom relief. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works through two complementary mechanisms. Chlorpheniramine maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors on blood vessels, nerve endings, and smooth muscle, which reduces sneezing, runny nose, itching, and watery eyes. It also crosses the blood-brain barrier and causes sedation by blocking central histamine receptors. Paracetamol acts mainly in the central nervous system by inhibiting prostaglandin synthesis, which lowers fever and reduces pain perception. The combination provides simultaneous relief from allergic symptoms and mild pain or fever.
Mechanism Steps
💡 How to Take coriphen plus syrup
Strength: Oral suspension containing chlorpheniramine maleate 2 mg and paracetamol 250 mg per measured dose.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 5 to 10 mL of the suspension taken orally every 4 to 6 hours as needed for symptoms, not exceeding the maximum daily dose. The exact dose depends on the indication, severity of symptoms, age, weight, liver function, and kidney function. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose, and do not use for more than a few days without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine should not be given to newborns or premature infants. For older children, the dose must be calculated by a pediatrician based on age, weight, and clinical condition. |
| Elderly Dosage | Older adults are more sensitive to the sedative and anticholinergic effects of chlorpheniramine maleate. Use the lowest effective dose and avoid long-term use. Consult a doctor before use, especially if you have prostate enlargement, glaucoma, heart disease, or kidney or liver problems. |
| Renal Impairment | Use with caution in people with kidney disease. The dose may need to be reduced or the dosing interval lengthened. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in people with liver disease. Paracetamol can worsen liver injury, and the dose may need to be reduced or avoided. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | Not established from the available information. Do not exceed the dose recommended by your doctor or the maximum stated on the product label. For paracetamol, the maximum adult daily dose from all sources should not exceed 4 grams per day, and lower limits apply in liver disease, alcohol use, or low body weight. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of coriphen plus syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other paracetamol products | Major | |
| Alcohol | Major | |
| MAOIs | Major | |
| Benzodiazepines | Moderate | |
| Opioid painkillers | Moderate | |
| Tricyclic antidepressants | Moderate | |
| Carbamazepine | Moderate | |
| Rifampicin | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Other paracetamol-containing products
- Alcohol
- Monoamine oxidase inhibitors (MAOIs)
- Warfarin
⚡ Moderate Interactions
- Central nervous system depressants such as benzodiazepines, opioids, and sleeping pills
- Anticholinergic medicines such as tricyclic antidepressants and some bladder medicines
- Carbamazepine, phenytoin, and rifampicin
- Isoniazid
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Alcohol increases the risk of paracetamol-induced liver injury and adds to the sedative and anticholinergic effects of chlorpheniramine maleate. Even moderate drinking can make drowsiness, dizziness, and impaired coordination worse.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy or hypersensitivity to chlorpheniramine maleate or paracetamol","Severe liver disease or active liver failure","Newborn infants and premature babies","Use of monoamine oxidase inhibitors (MAOIs) within the last 14 days","Severe kidney disease without medical supervision","Narrow-angle glaucoma","Urinary retention due to prostate enlargement","Severe heart disease or uncontrolled high blood pressure"]
⚠️ Warnings & Precautions
["This medicine can cause drowsiness. Do not drive or operate machinery until you know how it affects you.","Avoid alcohol completely while taking this medicine.","Do not take other medicines containing paracetamol without checking with your doctor or pharmacist.","Use with caution in older adults because of increased risk of confusion, falls, and urinary retention.","Use with caution in people with asthma, glaucoma, prostate enlargement, or difficulty passing urine.","Consult your doctor before use if you are pregnant, planning pregnancy, or breastfeeding.","Do not use for more than a few days without medical advice if symptoms persist.","Keep out of reach of children and store in the original container."]
🤱 Lactation Safety
Chlorpheniramine maleate may pass into breast milk and can cause drowsiness or irritability in a breastfed infant. Paracetamol passes into breast milk in small amounts and is generally considered compatible with breastfeeding. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause serious liver damage due to paracetamol. Symptoms of paracetamol overdose may not appear immediately and can include nausea, vomiting, abdominal pain, and later yellowing of eyes or skin. If you suspect an overdose, seek emergency medical care immediately, even if you feel well. Do not wait for symptoms to appear. Treatment with activated charcoal or acetylcysteine may be needed, and the decision must be made by a qualified clinician. Chlorpheniramine overdose can cause severe drowsiness, confusion, seizures, and irregular heartbeat, which also require emergency care.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember if less than half the dosing interval has passed. If more than half the dosing interval has passed, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as advised by your doctor or pharmacist, and do not exceed the recommended dose. Because it contains paracetamol, check all other medicines you are using to avoid accidental duplication of paracetamol, which can lead to liver injury. Avoid alcohol completely while taking this medicine, as it increases the risk of liver damage and worsens drowsiness. Do not drive, ride a two-wheeler, or operate heavy machinery until you know how this medicine affects you. If you are pregnant, planning pregnancy, or breastfeeding, speak to your doctor before using this medicine. Keep this medicine out of the reach of children, and store it in its original container at room temperature, away from direct sunlight. Do not use this medicine for more than a few days without medical advice if your symptoms persist or worsen.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults are more sensitive to the sedative, anticholinergic, and urinary effects of chlorpheniramine maleate. This medicine can cause confusion, falls, constipation, dry mouth, and difficulty passing urine in older people. Use the lowest effective dose for the shortest duration, and consult a doctor before use, especially if you have prostate enlargement, glaucoma, heart disease, or kidney or liver problems.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. Paracetamol is generally considered the preferred pain and fever reliever in pregnancy when used at the lowest effective dose for the shortest duration. Chlorpheniramine maleate should be used in pregnancy only if the potential benefit justifies the potential risk. Do not self-medicate during pregnancy.
🏥 Post-Surgery Considerations
After surgery, this medicine should be used only if prescribed by your surgeon or doctor. Chlorpheniramine can add to the sedative effects of anesthesia and pain medicines, increasing drowsiness and breathing difficulty. Paracetamol may be used for mild pain, but the dose must be individualized. Inform your surgical team about all medicines you are taking.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. The sedative and anticholinergic effects may interact with dental anesthetics or sedatives. Paracetamol in this medicine may help with mild dental pain, but do not take extra paracetamol without checking with your dentist or doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness, dizziness, and blurred vision, which may affect your coordination. Avoid strenuous exercise, swimming, cycling, or using heavy gym equipment until you know how this medicine affects you. Light activity is fine if you feel alert and steady.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, dizziness, and blurred vision, which may affect your ability to drive, operate machinery, or perform tasks that require alertness. It is best to avoid driving or risky work until you know how the medicine affects you. If your job requires mental alertness, discuss with your doctor about timing the dose after work hours or choosing a less sedating alternative.
🛑 When to Stop This Medicine
Stop this medicine when your symptoms improve or as advised by your doctor. Do not stop suddenly if you have been taking it regularly for a long time without consulting your doctor. Seek medical advice before stopping if you have liver or kidney disease or if you are taking other medicines. If you notice any serious side effects, stop the medicine and seek medical help immediately.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended without medical supervision. Prolonged use of chlorpheniramine maleate can cause persistent drowsiness, dry mouth, constipation, and urinary problems, especially in older adults. Long-term high-dose paracetamol can increase the risk of liver and kidney problems. Regular monitoring of liver and kidney function may be needed if long-term use is unavoidable. Consult your doctor for a review if you need this medicine for more than a few days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps clear nasal passages and reduce congestion without medicine.
Evidence: Well-established for cold symptomsCan temporarily relieve nasal stuffiness and throat irritation.
Evidence: Traditionally used, limited clinical evidenceReducing exposure to dust, pollen, and pet dander can decrease allergy symptoms.
Evidence: Well-established for allergic rhinitisMedicines such as cetirizine or loratadine cause less drowsiness and may be preferred for daytime use.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you have a fever or are unwell, your doctor may advise postponing vaccination until you recover. Follow your doctor's advice regarding vaccination timing.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C.
❌ DON'T
Do not refrigerate unless specified on the label.
✅ DO
Keep the bottle tightly closed in its original container.
❌ DON'T
Do not transfer the medicine to an unmarked container.
✅ DO
Keep away from direct sunlight and moisture.
❌ DON'T
Do not store in the bathroom cabinet.
✅ DO
Keep out of the reach of children.
❌ DON'T
Do not use after the expiry date printed on the pack.
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription or a copy of the prescription. Keep it in your hand luggage if you are flying, and store it at room temperature away from direct sunlight and moisture. If you are traveling across time zones, continue your doses at the usual intervals as advised by your doctor, but do not double up. Check the customs rules of your destination country for carrying prescription medicines. Avoid alcohol during travel while taking this medicine, and do not drive if you feel drowsy.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving symptoms within 30 to 60 minutes after taking a dose. The antihistamine effect may last 4 to 6 hours, and paracetamol also works for about 4 to 6 hours.
A: Yes, this medicine can be taken with or without food. However, taking it with food or milk may reduce stomach discomfort.
A: Drowsiness is a common side effect because of the chlorpheniramine maleate in this medicine. Avoid driving or operating machinery until you know how it affects you.
A: No, you should not take additional paracetamol-containing medicines without consulting your doctor, because this medicine already contains paracetamol and doubling the dose can harm your liver.
A: Paracetamol is generally considered the preferred pain and fever reliever in pregnancy when used at the lowest effective dose for the shortest time. Chlorpheniramine should be used in pregnancy only after consulting your doctor. Do not use this medicine without medical advice if you are pregnant.
A: This medicine is meant for short-term relief. If your symptoms do not improve within a few days or get worse, consult your doctor. Do not use it for longer than advised.
🤔 Common Patient Concerns
🔄 Substitutes for coriphen plus syrup
View AllAlternative brands with exact same active ingredient:
-
acuflu plus syrupAcuition Pharmaceutical ₹28.13 51.5% CHEAPER
-
ritz p syrupStandard Remedies Pvt Ltd ₹28.13 51.5% CHEAPER
-
dvcold tabletFlagship Biotech International ₹30.00 48.3% CHEAPER
-
coldrid syrupMedley Pharmaceuticals ₹30.68 47.1% CHEAPER
-
coldciz plus suspensionIntellect Lifescience ₹36.18 37.6% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure the common cold.
Fact: This medicine only relieves symptoms such as runny nose, sneezing, and mild fever. It does not cure the underlying viral infection. - Myth: More medicine means faster relief.
Fact: Taking more than the recommended dose does not speed up relief and can cause serious liver injury due to paracetamol. - Myth: It is safe to take with alcohol.
Fact: Alcohol increases the risk of liver damage and worsens drowsiness. It should be avoided completely. - Myth: This medicine is safe for newborns.
Fact: This medicine is not recommended for newborns or premature infants. Consult a pediatrician for young children. - Myth: It can be taken for weeks without any problem.
Fact: This medicine is meant for short-term use. Prolonged use without medical advice can increase the risk of side effects.
🔄 Alternative Options
Generic Alternatives
- Chlorpheniramine maleate and paracetamol oral suspension
Brand Alternatives
- Acolate DS Suspension