comptil 12.5mg injection

4.4 (16 reviews)

Prochlorperazine (12.5mg)

🏭 Trends Pharma Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is comptil 12.5mg injection used for?

Acuvert Tablet (Prochlorperazine) is used to treat GASTRO INTESTINAL. It contains Prochlorperazine (12.5mg), which Blocks dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) and gastroi. Always consult your doctor before use. Take as prescribed.

Generic Name: Prochlorperazine
Manufacturer: Trends Pharma Pvt Ltd
Form: Allopathy
Pregnancy Category: C
Prescription Required: Yes

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 comptil 12.5mg injection Uses & Benefits

Nausea and vomiting, vertigo, migraine, psychotic disorders.

Off-label uses: Hiccups, anxiety, pruritus.

📋 Drug Information

Generic Name(s)	Prochlorperazine
Brand Name	Acuvert Tablet
Manufacturer	Trends Pharma Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	GASTRO INTESTINAL
Action Class	Dopamine (D2) receptor antagonist- Prochlorperazine
Route of Administration	Oral
Storage	Store at room temperature (20-25°C), protect from light and moisture.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed orally; peak plasma concentrations achieved within 1-2 hours.

DistributionWidely distributed throughout the body; crosses the blood-brain barrier.

Protein BindingApproximately 90-95% bound to plasma proteins.

MetabolismExtensively metabolized in the liver via CYP2D6 and other pathways.

Half-LifeApproximately 6-8 hours.

ExcretionPrimarily excreted in urine as metabolites; small amount in feces.

BioavailabilityOral bioavailability is about 30-40% due to first-pass metabolism.

Onset of Action30-60 minutes after oral administration.

Peak Plasma Time1-2 hours.

Duration of Action4-6 hours.

How It Works

Blocks dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) and gastrointestinal tract.

Mechanism Steps

1Prochlorperazine binds to dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) of the medulla oblongata.

2Blockade of D2 receptors inhibits the emetic signal transmission to the vomiting center.

3Additionally, it may block D2 receptors in the gastrointestinal tract, reducing local emetic stimuli.

💡 How to Take comptil 12.5mg injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of comptil 12.5mg injection

✅ Common Side Effects

Drowsiness
Dizziness
Dry mouth
Constipation
Blurred vision

🚨 Serious Side Effects

Extrapyramidal symptoms
Tardive dyskinesia
Neuroleptic malignant syndrome
Seizures
QT prolongation

⚠️ Rare Side Effects

Agranulocytosis
Cholestatic jaundice
Photosensitivity
Hypotension

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased bleeding risk
Alcohol	Major	Enhanced CNS depression
Levodopa	Major	Antagonism of levodopa effects
Lithium	Major	Increased risk of neurotoxicity
Anticholinergics	Major	Additive anticholinergic effects
CNS depressants	Major	Additive sedation
Antihypertensives	Moderate	Enhanced hypotensive effect
Metoclopramide	Moderate	Increased risk of extrapyramidal symptoms
SSRIs	Moderate	Increased risk of serotonin syndrome
Antacids	Minor	Reduced absorption of prochlorperazine
Cimetidine	Minor	Increased prochlorperazine levels

🚨 Major Interactions

Anticholinergics
CNS depressants
Levodopa
Lithium

⚡ Moderate Interactions

Antihypertensives
Metoclopramide
SSRIs

ℹ️ Minor Interactions

Antacids
Cimetidine

🍽️ Food Interactions

Food may delay absorption but does not significantly affect bioavailability.

🍷 Alcohol Interaction

Increased CNS depression; avoid concurrent use.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity, coma, CNS depression, bone marrow suppression, pheochromocytoma.

📊 Monitoring Parameters

Blood pressure, heart rate, extrapyramidal symptoms, liver function tests.

🤱 Lactation Safety

Excreted in breast milk; use with caution.

💊 Overdose Management

Supportive care; activated charcoal, benzodiazepines for seizures, anticholinergics for extrapyramidal symptoms.

⏰ Missed Dose

Take as soon as remembered; skip if near next dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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Alternative brands with exact same active ingredient (Prochlorperazine (12.5mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Regular Customer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Happy Patient Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Trusted Reviewer Jul 10, 2026

Found this to be a helpful product. Good results.