comelt a 300mg/30mg tablet - Acetylcysteine (300mg) + Ambroxol (30mg) medicine

comelt a 300mg/30mg tablet

4.6 (15 reviews)
๐Ÿญ Jabs Biotech Pvt Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 23, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 23, 2026

What is comelt a 300mg/30mg tablet used for?

Comelt A (Acetylcysteine + Ambroxol) is used to treat RESPIRATORY. It contains Acetylcysteine (300mg) + Ambroxol (30mg), which Acetylcysteine reduces mucus viscosity by breaking disulfide bonds; Ambroxol inc. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Acetylcysteine + Ambroxol
  • Manufacturer: Jabs Biotech Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

๐Ÿ’Š comelt a 300mg/30mg tablet Uses & Benefits

Acute and chronic respiratory diseases with thick mucus (e.g., COPD, bronchitis, asthma, sinusitis).

Off-label uses: Acetylcysteine for acetaminophen overdose; ambroxol for sore throat (lozenges).

๐Ÿ“‹ Drug Information

Generic Name(s)Acetylcysteine + Ambroxol
Brand NameComelt A
ManufacturerJabs Biotech Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassMucolytic and Expectorant
Route of AdministrationOral
StorageStore at room temperature (20-25ยฐC), protect from moisture.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionAcetylcysteine is well absorbed orally; Ambroxol is rapidly and completely absorbed from the gastrointestinal tract.
DistributionAcetylcysteine distributes widely; Ambroxol has high tissue distribution, especially in lungs.
Protein BindingAcetylcysteine: 50-83%; Ambroxol: 90%
MetabolismAcetylcysteine undergoes hepatic metabolism; Ambroxol is metabolized in the liver via glucuronidation.
Half-LifeAcetylcysteine: 5.6 hours; Ambroxol: 7-12 hours
ExcretionAcetylcysteine: renal; Ambroxol: renal (90%)
BioavailabilityAcetylcysteine: 6-10% (oral); Ambroxol: 70-80%
Onset of ActionAcetylcysteine: 30-60 minutes; Ambroxol: 30 minutes
Peak Plasma TimeAcetylcysteine: 1-3 hours; Ambroxol: 1-3 hours
Duration of ActionAcetylcysteine: 4-6 hours; Ambroxol: 6-12 hours

How It Works

Acetylcysteine reduces mucus viscosity by breaking disulfide bonds; Ambroxol increases secretion of respiratory tract fluid and enhances surfactant production.

Mechanism Steps

1Acetylcysteine: Breaks disulfide bonds in mucus glycoproteins, reducing viscosity.
2Ambroxol: Stimulates type II pneumocytes to increase surfactant production.
3Ambroxol: Increases ciliary beat frequency, enhancing mucociliary clearance.

๐Ÿ’ก How to Take comelt a 300mg/30mg tablet

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of comelt a 300mg/30mg tablet

โœ… Common Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Heartburn
  • Rash

๐Ÿšจ Serious Side Effects

  • Bronchospasm
  • Anaphylaxis
  • Stevens-Johnson syndrome
  • Hepatotoxicity

โš ๏ธ Rare Side Effects

  • Tinnitus
  • Hypotension
  • Angioedema

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk
Nitroglycerin Major Hypotension and headache
Activated charcoal Major Reduced absorption of acetylcysteine
Antibiotics (tetracyclines) Moderate Reduced antibiotic absorption
Cough suppressants Moderate Impaired expectoration
Paracetamol Minor Possible additive hepatotoxicity

๐Ÿšจ Major Interactions

  • Warfarin
  • Nitroglycerin
  • Activated charcoal

โšก Moderate Interactions

  • Antibiotics (e.g., tetracyclines)
  • Cough suppressants

โ„น๏ธ Minor Interactions

  • Paracetamol

๐Ÿฝ๏ธ Food Interactions

No significant food interactions.

๐Ÿท Alcohol Interaction

Avoid alcohol; may increase risk of hepatotoxicity with acetylcysteine.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to acetylcysteine or ambroxol; peptic ulcer (acetylcysteine); severe hepatic impairment.

๐Ÿ“Š Monitoring Parameters

Respiratory symptoms, liver function tests (if high doses), renal function.

๐Ÿคฑ Lactation Safety

Use with caution; limited data.

๐Ÿ’Š Overdose Management

Gastric lavage, supportive care; acetylcysteine overdose may cause nausea, vomiting, hypotension.

โฐ Missed Dose

Take as soon as remembered; skip if almost time for next dose; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 23, 2026

๐Ÿ”— View Profile

โญ User Reviews

Certified Buyer Jul 10, 2026

Found this to be a helpful product. Good results.

Verified User Jul 10, 2026

Effective and reliable. Worked as expected.

Happy Patient Jul 10, 2026

Effective and reliable. Worked as expected.

Happy Patient Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Trusted Reviewer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

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