combicold syrup - Ambroxol (5mg) + Guaifenesin (50mg) medicine

combicold syrup

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🏭 Biomiicron Pharmaceuticals 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 19, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Oct 19, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

What is combicold syrup used for?

This medicine contains Ambroxol (5mg) + Guaifenesin (50mg) and is used to treat RESPIRATORY. Ambroxol increases secretion of respiratory tract fluid and reduces mucus viscosity; Guaifenesin inc. Always consult your doctor before use.

  • Generic Name: Ambroxol + Guaifenesin
  • Manufacturer: Biomiicron Pharmaceuticals
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 combicold syrup Uses & Benefits

Productive cough, acute/chronic bronchitis, COPD, bronchiectasis

Off-label uses: None well-established

📋 Drug Information

Generic Name(s)Ambroxol + Guaifenesin
Brand NameAmbrolite-S Expectorant
ManufacturerBiomiicron Pharmaceuticals
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassMucolytic and Expectorant
Route of AdministrationOral
StorageStore at room temperature (20-25°C), protect from light
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionWell absorbed orally
DistributionDistributes widely in body tissues
Protein BindingAmbroxol: ~90%; Guaifenesin: ~50%
MetabolismAmbroxol: Hepatic; Guaifenesin: Hepatic
Half-LifeAmbroxol: 7-12 hours; Guaifenesin: 1 hour
ExcretionAmbroxol: Renal; Guaifenesin: Renal
BioavailabilityAmbroxol: ~70%; Guaifenesin: ~95%
Onset of Action30-60 minutes
Peak Plasma TimeAmbroxol: 1-3 hours; Guaifenesin: 0.5-1 hour
Duration of Action6-12 hours

How It Works

Ambroxol increases secretion of respiratory tract fluid and reduces mucus viscosity; Guaifenesin increases respiratory tract fluid to thin bronchial secretions.

Mechanism Steps

1Ambroxol stimulates serous cells in bronchial glands to increase thin secretions
2Ambroxol depolymerizes mucopolysaccharides, reducing mucus viscosity
3Guaifenesin increases respiratory tract fluid volume, thinning mucus
4Enhanced mucociliary clearance and expectoration

💡 How to Take combicold syrup

Follow your doctor's prescription exactly.

⚠️ Side Effects of combicold syrup

✅ Common Side Effects

Nausea
Vomiting
Diarrhea
Dizziness
Headache

🚨 Serious Side Effects

Severe allergic reaction
Stevens-Johnson syndrome
Bronchospasm

⚠️ Rare Side Effects

Anaphylaxis
Angioedema
Renal calculi

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Codeine Major Reduced cough clearance
Atropine Major Increased mucus viscosity
MAOIs Moderate Possible hypertensive crisis
Antacids Minor Reduced absorption

🚨 Major Interactions

  • Cough suppressants (e.g., codeine)
  • Anticholinergics

⚡ Moderate Interactions

  • MAOIs
  • Antihypertensives

🍷 Alcohol Interaction

Avoid alcohol; may increase sedation

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to any component, peptic ulcer, severe hepatic/renal impairment

🤱 Lactation Safety

Use with caution; not recommended

💊 Overdose Management

Gastric lavage, supportive care, monitor for CNS depression

⏰ Missed Dose

Take as soon as remembered; skip if near next dose

🔄 Substitutes for combicold syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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