coly monas 4.5 injection - Uses, Price, Side Effects & Substitutes
What is coly monas 4.5 injection used for?
Acostin 1 Million IU Injection (Colistimethate Sodium) is used to treat GASTRO INTESTINAL. It contains Colistimethate Sodium (4.5Million IU), which Disrupts bacterial cell membrane integrity by binding to lipopolysaccharides and. Always consult your doctor before use. Take as prescribed.
- Generic Name: Colistimethate Sodium
- Manufacturer: Glenmark Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ coly monas 4.5 injection Uses & Benefits
Treatment of multidrug-resistant Gram-negative infections (e.g., Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae); used in cystic fibrosis exacerbations.
Off-label uses: Nebulized therapy for ventilator-associated pneumonia; topical use for wound infections.
๐ Drug Information
| Generic Name(s) | Colistimethate Sodium |
| Brand Name | Acostin 1 Million IU Injection |
| Manufacturer | Glenmark Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Cell membrane active agent |
| Route of Administration | Intravenous (IV) or intramuscular (IM); also via nebulization for respiratory infections. |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light; reconstituted solution stable for 24 hours at room temperature. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Disrupts bacterial cell membrane integrity by binding to lipopolysaccharides and phospholipids, leading to increased permeability and cell death.
Mechanism Steps
๐ก How to Take coly monas 4.5 injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of coly monas 4.5 injection
โ Common Side Effects
- Nephrotoxicity (increased creatinine)
- Neurotoxicity (paresthesias, dizziness, vertigo)
- Gastrointestinal disturbances (nausea, vomiting)
๐จ Serious Side Effects
- Acute kidney injury
- Neuromuscular blockade leading to respiratory depression
- Seizures
- Anaphylaxis
โ ๏ธ Rare Side Effects
- Hepatotoxicity
- Cardiotoxicity (arrhythmias)
- Pseudomembranous colitis
- Superinfection
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Neuromuscular blocking agents | Major | Enhanced neuromuscular blockade, respiratory depression |
| Aminoglycosides | Major | Increased nephrotoxicity and ototoxicity |
| Vancomycin | Major | Increased nephrotoxicity |
| Cyclosporine | Major | Increased nephrotoxicity |
| Tacrolimus | Major | Increased nephrotoxicity |
| Amphotericin B | Major | Increased nephrotoxicity |
| Cisplatin | Major | Increased nephrotoxicity and ototoxicity |
| Loop diuretics | Major | Increased nephrotoxicity and ototoxicity |
| Cephalosporins | Moderate | Increased nephrotoxicity |
| Penicillins | Moderate | Possible additive nephrotoxicity |
| NSAIDs | Moderate | Increased risk of renal impairment |
| ACE inhibitors | Moderate | Increased risk of renal impairment |
| Antacids | Minor | No significant interaction |
| Probenecid | Minor | May reduce renal excretion of colistin |
๐จ Major Interactions
- Neuromuscular blocking agents
- Aminoglycosides
- Vancomycin
- Cyclosporine
- Tacrolimus
- Amphotericin B
- Cisplatin
- Loop diuretics
โก Moderate Interactions
- Cephalosporins
- Penicillins
- NSAIDs
- ACE inhibitors
โน๏ธ Minor Interactions
- Antacids
- Probenecid
๐ฝ๏ธ Food Interactions
No significant food interactions (parenteral).
๐ท Alcohol Interaction
No known interaction.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to colistimethate or colistin; myasthenia gravis (relative).
๐ Monitoring Parameters
Renal function (serum creatinine, BUN, urine output), electrolytes, neuromuscular function, signs of neurotoxicity (paresthesias, dizziness, seizures).
๐คฑ Lactation Safety
Excreted in breast milk; caution advised.
๐ Overdose Management
Supportive care; hemodialysis may remove colistin; monitor renal function and neuromuscular status.
โฐ Missed Dose
Administer as soon as remembered; if close to next dose, skip missed dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for coly monas 4.5 injection
View AllAlternative brands with exact same active ingredient (Colistimethate Sodium (4.5Million IU)):
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hicoly 4.5miu injectionIntas Pharmaceuticals Ltd โน1,999.00 68.7% CHEAPER
-
coly-suz 4.5 miu injectionSuzan Pharma โน2,559.00 59.9% CHEAPER
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colis 4.5miu injectionServo Healthcare โน3,093.75 51.5% CHEAPER
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colisig 4.5 injectionSignity Pharmaceuticals Pvt Ltd โน3,635.91 43% CHEAPER
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kabimethate 4.5million iu injectionFresenius Kabi India Pvt Ltd โน3,875.00 39.3% CHEAPER
-
colistin 4.5million iu injectionTaj Pharma India Ltd โน3,880.31 39.2% CHEAPER
-
zombistin 4.5miu injectionAbbott โน3,884.55 39.1% CHEAPER
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koolistin 4.5million iu injectionBiocon โน3,928.57 38.4% CHEAPER
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colbestin 4.5miu injectionMedic Biologicals And Pharmaceuticals Pvt Ltd โน3,990.00 37.5% CHEAPER
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guficol plus 4.5miu injectionGufic Bioscience Ltd โน3,999.00 37.3% CHEAPER
Medical Note: Always consult your doctor before switching medications.