colep tablet - Caffeine (15mg) + Paracetamol (325mg) medicine

Colep Tablet

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🏭 Biomax Biotechnics Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 30, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Oct 30, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

What is colep tablet used for?

This medicine contains Caffeine (15mg) + Paracetamol (325mg) and is used to treat RESPIRATORY. Paracetamol: Inhibits COX enzymes in CNS, reducing prostaglandin synthesis; Caffeine: Adenosine rece. Always consult your doctor before use.

  • Generic Name: Caffeine + Paracetamol
  • Manufacturer: Biomax Biotechnics Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 colep tablet Uses & Benefits

Mild to moderate pain, fever

Off-label uses: Migraine (combination with other agents)

📋 Drug Information

Generic Name(s)Caffeine + Paracetamol
Brand NameAcolate Tablet
ManufacturerBiomax Biotechnics Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassAnalgesic and Antipyretic Combination
Route of AdministrationOral
StorageStore at room temperature (20-25°C), protect from moisture
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionRapidly absorbed from the gastrointestinal tract
DistributionWidely distributed throughout body fluids
Protein BindingParacetamol: 10-25%; Caffeine: 35%
MetabolismParacetamol: Hepatic via conjugation; Caffeine: Hepatic via CYP1A2
Half-LifeParacetamol: 1.5-3 hours; Caffeine: 3-6 hours
ExcretionRenal (primarily as metabolites)
BioavailabilityParacetamol: 70-90%; Caffeine: 100%
Onset of Action30-60 minutes
Peak Plasma TimeParacetamol: 30-60 minutes; Caffeine: 30-60 minutes
Duration of Action4-6 hours

How It Works

Paracetamol: Inhibits COX enzymes in CNS, reducing prostaglandin synthesis; Caffeine: Adenosine receptor antagonist, enhances analgesic effect

Mechanism Steps

1Paracetamol inhibits cyclooxygenase (COX) enzymes in the central nervous system, reducing prostaglandin synthesis.
2Decreased prostaglandins lead to reduced pain perception and fever.
3Caffeine blocks adenosine receptors (A1 and A2A), reducing pain signal transmission and enhancing the analgesic effect of paracetamol.
4Caffeine also causes mild CNS stimulation, improving alertness.

💡 How to Take colep tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of colep tablet

✅ Common Side Effects

Nausea
Vomiting
Insomnia
Nervousness

🚨 Serious Side Effects

Hepatotoxicity
Stevens-Johnson syndrome
Anaphylaxis

⚠️ Rare Side Effects

Blood dyscrasias
Pancreatitis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major Increased bleeding risk
Alcohol (chronic) Major Increased hepatotoxicity
Isoniazid Major Increased hepatotoxicity risk
Rifampin Major Reduced paracetamol efficacy
Carbamazepine Moderate Reduced paracetamol efficacy
Phenytoin Moderate Reduced paracetamol efficacy
Oral contraceptives Moderate Increased caffeine half-life
Cimetidine Minor Increased caffeine levels
Disulfiram Minor Reduced caffeine clearance
Quinolones Minor Increased caffeine levels

🚨 Major Interactions

  • Warfarin
  • Alcohol (chronic use)
  • Isoniazid
  • Rifampin

⚡ Moderate Interactions

  • Carbamazepine
  • Phenytoin
  • Barbiturates
  • Oral contraceptives

🍷 Alcohol Interaction

Chronic alcohol use increases hepatotoxicity risk of paracetamol

🛡️ Safety & Warnings

🚫 Contraindications

Severe hepatic impairment, hypersensitivity to components

🤱 Lactation Safety

Paracetamol: Safe; Caffeine: Excreted in milk, use caution

💊 Overdose Management

Activated charcoal, N-acetylcysteine for paracetamol; supportive care for caffeine

⏰ Missed Dose

Take as soon as remembered; skip if near next dose

🔄 Substitutes for colep tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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