cetriliv ac tablet - Caffeine (15mg) + Paracetamol (325mg) medicine

cetriliv ac tablet - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Geno Pharmaceuticals Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 26, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 26, 2026

What is cetriliv ac tablet used for?

Acolate Tablet (Caffeine + Paracetamol) is used to treat RESPIRATORY. It contains Caffeine (15mg) + Paracetamol (325mg), which Paracetamol: Inhibits COX enzymes in CNS, reducing prostaglandin synthesis; Caff. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Caffeine + Paracetamol
  • Manufacturer: Geno Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š cetriliv ac tablet Uses & Benefits

Mild to moderate pain, fever

Off-label uses: Migraine (combination with other agents)

๐Ÿ“‹ Drug Information

Generic Name(s)Caffeine + Paracetamol
Brand NameAcolate Tablet
ManufacturerGeno Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassAnalgesic and Antipyretic Combination
Route of AdministrationOral
StorageStore at room temperature (20-25ยฐC), protect from moisture
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed from the gastrointestinal tract
DistributionWidely distributed throughout body fluids
Protein BindingParacetamol: 10-25%; Caffeine: 35%
MetabolismParacetamol: Hepatic via conjugation; Caffeine: Hepatic via CYP1A2
Half-LifeParacetamol: 1.5-3 hours; Caffeine: 3-6 hours
ExcretionRenal (primarily as metabolites)
BioavailabilityParacetamol: 70-90%; Caffeine: 100%
Onset of Action30-60 minutes
Peak Plasma TimeParacetamol: 30-60 minutes; Caffeine: 30-60 minutes
Duration of Action4-6 hours

How It Works

Paracetamol: Inhibits COX enzymes in CNS, reducing prostaglandin synthesis; Caffeine: Adenosine receptor antagonist, enhances analgesic effect

Mechanism Steps

1Paracetamol inhibits cyclooxygenase (COX) enzymes in the central nervous system, reducing prostaglandin synthesis.
2Decreased prostaglandins lead to reduced pain perception and fever.
3Caffeine blocks adenosine receptors (A1 and A2A), reducing pain signal transmission and enhancing the analgesic effect of paracetamol.

๐Ÿ’ก How to Take cetriliv ac tablet

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of cetriliv ac tablet

โœ… Common Side Effects

  • Nausea
  • Vomiting
  • Insomnia
  • Nervousness

๐Ÿšจ Serious Side Effects

  • Hepatotoxicity
  • Stevens-Johnson syndrome
  • Anaphylaxis

โš ๏ธ Rare Side Effects

  • Blood dyscrasias
  • Pancreatitis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk
Alcohol (chronic) Major Increased hepatotoxicity
Isoniazid Major Increased hepatotoxicity risk
Rifampin Major Reduced paracetamol efficacy
Carbamazepine Moderate Reduced paracetamol efficacy
Phenytoin Moderate Reduced paracetamol efficacy
Oral contraceptives Moderate Increased caffeine half-life
Cimetidine Minor Increased caffeine levels
Disulfiram Minor Reduced caffeine clearance
Quinolones Minor Increased caffeine levels

๐Ÿšจ Major Interactions

  • Warfarin
  • Alcohol (chronic use)
  • Isoniazid
  • Rifampin

โšก Moderate Interactions

  • Carbamazepine
  • Phenytoin
  • Barbiturates
  • Oral contraceptives

โ„น๏ธ Minor Interactions

  • Cimetidine
  • Disulfiram
  • Quinolones

๐Ÿฝ๏ธ Food Interactions

Caffeine-containing foods/beverages may increase CNS stimulation

๐Ÿท Alcohol Interaction

Chronic alcohol use increases hepatotoxicity risk of paracetamol

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Severe hepatic impairment, hypersensitivity to components

๐Ÿ“Š Monitoring Parameters

Liver function tests (with chronic use), renal function

๐Ÿคฑ Lactation Safety

Paracetamol: Safe; Caffeine: Excreted in milk, use caution

๐Ÿ’Š Overdose Management

Activated charcoal, N-acetylcysteine for paracetamol; supportive care for caffeine

โฐ Missed Dose

Take as soon as remembered; skip if near next dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 26, 2026

๐Ÿ”— View Profile

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