cobimep-g 300mg/500mcg capsule
What is cobimep-g 300mg/500mcg capsule used for?
Alfagaba 100 Tablet (Gabapentin + Methylcobalamin) is used to treat NEURO CNS. It contains Gabapentin (300mg) + Methylcobalamin (500mcg), which Gabapentin binds to ฮฑ2ฮด subunit of voltage-gated calcium channels, reducing ca. Always consult your doctor before use. Take as prescribed.
- Generic Name: Gabapentin + Methylcobalamin
- Manufacturer: Mepfarma India Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ cobimep-g 300mg/500mcg capsule Uses & Benefits
Neuropathic pain, epilepsy (adjunctive), peripheral neuropathy, restless legs syndrome
Off-label uses: Anxiety, bipolar disorder, hot flashes, fibromyalgia
๐ Drug Information
| Generic Name(s) | Gabapentin + Methylcobalamin |
| Brand Name | Alfagaba 100 Tablet |
| Manufacturer | Mepfarma India Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Anticonvulsant, Neurotropic agent |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Gabapentin binds to ฮฑ2ฮด subunit of voltage-gated calcium channels, reducing calcium influx and neurotransmitter release. Methylcobalamin acts as a cofactor for methionine synthase and methylmalonyl-CoA mutase, promoting myelin synthesis and nerve regeneration.
Mechanism Steps
๐ก How to Take cobimep-g 300mg/500mcg capsule
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cobimep-g 300mg/500mcg capsule
โ Common Side Effects
- Dizziness
- Somnolence
- Peripheral edema
- Ataxia
- Fatigue
- Nausea
๐จ Serious Side Effects
- Angioedema
- Suicidal ideation
- Respiratory depression
- Stevens-Johnson syndrome
- Drug reaction with eosinophilia and systemic symptoms (DRESS)
โ ๏ธ Rare Side Effects
- Pancreatitis
- Rhabdomyolysis
- Hepatotoxicity
- Myoclonus
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Opioids | Major | Increased risk of respiratory depression and sedation |
| Antacids | Major | Reduced gabapentin absorption |
| Cimetidine | Major | Decreased renal clearance of gabapentin |
| NSAIDs | Moderate | Increased risk of gastrointestinal bleeding |
| Alcohol | Moderate | Additive CNS depression |
๐จ Major Interactions
- Opioids
- Antacids
- Cimetidine
- Hydrocodone
- Morphine
โก Moderate Interactions
- NSAIDs
- Antidiabetic agents
- Losartan
- Ethanol
โน๏ธ Minor Interactions
- Oral contraceptives
- Antacids (aluminum/magnesium)
๐ฝ๏ธ Food Interactions
High-fat meals may decrease gabapentin absorption, Avoid excessive alcohol
๐ท Alcohol Interaction
Increased CNS depression; avoid concurrent use.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to gabapentin or methylcobalamin, severe renal impairment (CrCl <30 mL/min for gabapentin)
๐ Monitoring Parameters
Renal function, CNS effects (dizziness, sedation), therapeutic response (pain, seizure control)
๐คฑ Lactation Safety
Gabapentin excreted in breast milk; caution advised. Methylcobalamin is safe.
๐ Overdose Management
Supportive care; hemodialysis may remove gabapentin. Monitor CNS depression.
โฐ Missed Dose
Take as soon as remembered unless near next dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
Found this to be a helpful product. Good results.
Helpful and effective medicine as per my experience. Always consult a doctor.
Good quality medicine. Satisfied with the outcome.
Good quality medicine. Satisfied with the outcome.
Good quality medicine. Satisfied with the outcome.