Axogurd Capsule: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Chest pain or irregular heartbeat
- Suicidal thoughts or self-harm urges
- Severe dizziness or fainting
- Unexplained muscle pain with dark urine
- Yellowing of skin or eyes
- Decreased urine output or swelling in legs
If experiencing severe symptoms, call emergency services immediately.
What is coba pg tablet used for?
This medicine is a combination of methylcobalamin (vitamin B12) and pregabalin used to treat nerve pain, especially diabetic neuropathy. It works by reducing pain signals and supporting nerve health. Take it exactly as prescribed, and avoid alcohol and driving until you know how it affects you.
- Generic Name: Methylcobalamin + Pregabalin
- Manufacturer: Triton Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 coba pg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मेथिलकोबालामिन और प्रीगाबालिन का संयोजन है, जिसका उपयोग नसों के दर्द, विशेष रूप से डायबिटिक न्यूरोपैथी के इलाज के लिए किया जाता है। यह नसों को आराम देने और विटामिन बी12 की कमी को पूरा करने में मदद करती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में चक्कर आना, नींद आना, हाथ-पैरों में सूजन, वजन बढ़ना और मुँह सूखना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर आपको सांस लेने में कठिनाई, दिल की धड़कन तेज होना, या मन में आत्मघाती विचार आएं तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अचानक बंद न करें, इससे withdrawal के लक्षण हो सकते हैं। शराब न पिएं। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन न चलाएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।
💊 coba pg tablet Uses & Benefits
[{"condition":"Diabetic peripheral neuropathy","description":"Reduces nerve pain, burning, and tingling in the feet and hands caused by diabetes.","evidence":"Well-established"},{"condition":"Postherpetic neuralgia","description":"Helps relieve persistent nerve pain after a shingles infection.","evidence":"Well-established"},{"condition":"Vitamin B12 deficiency with neurological symptoms","description":"Methylcobalamin helps repair nerves and improve symptoms like numbness and tingling.","evidence":"Well-established"},{"condition":"Fibromyalgia","description":"Pregabalin is approved for fibromyalgia in some regions and may reduce pain and improve sleep.","evidence":"Moderate"},{"condition":"Partial-onset seizures","description":"Pregabalin is used as an add-on treatment for certain types of epilepsy.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Generalized anxiety disorder","description":"Sometimes prescribed off-label for anxiety when other treatments are not effective.","evidence":"Limited"},{"condition":"Chronic low back pain with neuropathic features","description":"May be used off-label when nerve involvement is suspected.","evidence":"Limited"},{"condition":"Restless legs syndrome","description":"Occasionally used off-label, but not first-line.","evidence":"Limited"}]
Primary treatment for: Diabetic peripheral neuropathy
Also treats: Postherpetic neuralgia, Fibromyalgia, Vitamin B12 deficiency with neurological symptoms, Partial-onset seizures
📋 Drug Information
| Generic Name(s) | Methylcobalamin + Pregabalin |
| Brand Name | Axogurd-SR Tablet |
| Manufacturer | Triton Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Neurotropic vitamin + Gabapentinoid |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This reduces the release of excitatory neurotransmitters such as glutamate, substance P, and noradrenaline, which decreases nerve pain signals. Methylcobalamin is a coenzyme form of vitamin B12 that supports methylation reactions needed for myelin formation and nerve cell maintenance. Together, they help reduce neuropathic pain and support nerve health.
Mechanism Steps
💡 How to Take coba pg tablet
Strength: Capsule containing Methylcobalamin 750 mcg and Pregabalin 75 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one capsule taken orally once or twice daily, or as directed by your doctor. The dose depends on your condition, kidney function, and response to treatment. Do not change your dose without consulting your doctor. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may need a lower dose because kidney function declines with age. Your doctor will adjust the dose based on your kidney function. Use with caution due to increased risk of dizziness, drowsiness, and falls. |
| Renal Impairment | Dose adjustment is required in patients with kidney disease. For creatinine clearance 30-60 mL/min, the dose may be reduced. For creatinine clearance 15-30 mL/min, further reduction is needed. For creatinine clearance less than 15 mL/min, use is not recommended. Consult your doctor for personalized dosing. |
| Hepatic Impairment | No dose adjustment is needed for mild to moderate liver impairment. Pregabalin is not metabolized by the liver. However, caution is advised in severe liver disease. |
| Maximum Daily Dose | The maximum recommended daily dose of pregabalin is 600 mg, but for neuropathic pain, doses above 300 mg per day rarely provide additional benefit. The maximum daily dose of methylcobalamin is not established, but 1500 mcg per day is commonly used. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of coba pg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Morphine | Major | |
| Diazepam | Major | |
| Alcohol | Major | |
| Lisinopril | Moderate | |
| Metformin | Moderate | |
| Omeprazole | Minor | |
| Chloramphenicol | Minor |
🚨 Major Interactions
- Opioid pain medicines (e.g., morphine, oxycodone)
- Benzodiazepines (e.g., diazepam, alprazolam)
- Alcohol
⚡ Moderate Interactions
- Antihypertensives
- Antidiabetics
- CNS depressants (e.g., sleeping pills, antipsychotics)
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase the sedative effects of pregabalin, leading to excessive drowsiness, dizziness, and increased risk of falls or accidents. It may also worsen nerve damage associated with vitamin B12 deficiency.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to pregabalin, methylcobalamin, or any component of the formulation.","Severe renal impairment (creatinine clearance less than 30 mL/min) without dose adjustment.","Pregnancy and breastfeeding unless clearly necessary.","Children under 18 years of age (safety and efficacy not established)."]
⚠️ Warnings & Precautions
["May cause dizziness and drowsiness; avoid driving or operating machinery until you know how it affects you.","Do not stop this medicine suddenly; withdrawal symptoms may occur. Taper gradually under medical supervision.","May increase suicidal thoughts or behavior; monitor mood closely.","May cause swelling of hands and feet; report persistent swelling to your doctor.","Use with caution in elderly patients due to increased risk of falls and confusion.","May impair fertility in some men; discuss with your doctor if planning a family.","Avoid alcohol while taking this medicine."]
🤱 Lactation Safety
Pregabalin is excreted in breast milk. Breastfeeding is not recommended while taking this medicine unless the benefit outweighs the risk. Consult your doctor.
💊 Overdose Management
Overdose may cause excessive drowsiness, confusion, agitation, and rapid heartbeat. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Hemodialysis may be considered in severe cases.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time.
Additional Safety Advice
Take this medicine exactly as prescribed. Do not stop suddenly, as this can cause withdrawal symptoms such as anxiety, trouble sleeping, and sweating. Avoid alcohol because it can increase dizziness and drowsiness. Do not drive or use heavy machines until you know how this medicine affects you. Tell your doctor about all other medicines you take, especially pain relievers, anxiety medicines, and sleeping pills. If you are pregnant, planning pregnancy, or breastfeeding, talk to your doctor before using this medicine. Keep this medicine out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the side effects of pregabalin, especially drowsiness, dizziness, and confusion. They also have reduced kidney function, so dose adjustment is often needed. Regular monitoring for falls and kidney function is advised.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. Pregabalin may harm the unborn baby. Effective contraception should be used during treatment. Methylcobalamin is safe, but the combination should be used only if clearly needed.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthesia and pain medications used during and after surgery. Your doctor may adjust the dose temporarily.
🦷 Dental Procedures
Tell your dentist that you are taking this medicine. It may interact with local anesthetics or sedatives used during dental procedures. Your dentist may need to adjust the medications used.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid high-impact exercises that may worsen nerve pain. Start slowly and stop if you feel dizzy or unsteady. Balance exercises can help prevent falls, especially in elderly patients.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive or operate machinery. Avoid these activities until you know how it affects you. It may also cause difficulty concentrating. Inform your employer if your job requires alertness.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects or your doctor decides to discontinue, the dose should be tapered gradually to avoid withdrawal symptoms.
📅 Long-Term Use Effects
Long-term use of pregabalin may lead to tolerance, dependence, and withdrawal symptoms if stopped abruptly. Regular monitoring of kidney function, mood, and weight is recommended. Methylcobalamin is generally safe for long-term use. Your doctor may periodically reassess the need for continued therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help improve strength and reduce nerve pain.
Evidence: Well-establishedMay provide some relief for neuropathic pain.
Evidence: LimitedMay help reduce pain in some patients.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, if you are scheduled for any vaccine, inform your doctor that you are taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. If traveling across time zones, adjust the timing of doses gradually. Store at room temperature and protect from extreme heat or moisture. Check customs regulations for controlled substances, as pregabalin may be regulated in some countries.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling some pain relief within 1-2 hours after a dose, but full benefits for nerve pain may take several days to weeks. Methylcobalamin's effect on nerve health takes longer.
A: It depends on the other painkiller. Some combinations can increase drowsiness. Always consult your doctor before taking any other medicine.
A: Pregabalin should be used during pregnancy only if clearly needed. Methylcobalamin is generally safe. Consult your doctor.
A: No, stopping suddenly can cause withdrawal symptoms like anxiety, insomnia, and sweating. Always taper gradually under medical supervision.
A: Weight gain is a common side effect of pregabalin. Monitor your weight and follow a healthy diet.
🤔 Common Patient Concerns
🔄 Substitutes for coba pg tablet
View AllAlternative brands with exact same active ingredient:
-
lineuron plus 750mcg/75mg injectionLee Benz Life Science ₹20.00 87% CHEAPER
-
nervzone-m capsuleZeelab Pharmacy Pvt Ltd ₹30.00 80.5% CHEAPER
-
ranprega m capsuleSun Pharmaceutical Industries Ltd ₹35.56 76.9% CHEAPER
-
midlin 75 tabletMidas Healthcare Ltd ₹40.00 74% CHEAPER
-
davaindia methylcobalamin+pregabalin 750mcg/75mg capsuleDavaindia Generic Pharmacy ₹45.00 70.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a painkiller like paracetamol.
Fact: This medicine is not a simple painkiller. It works specifically on nerve pain and also provides vitamin B12. - Myth: It can be taken for any type of pain.
Fact: It is mainly for neuropathic pain. It is not effective for ordinary muscle or joint pain. - Myth: You can stop it as soon as you feel better.
Fact: Stopping suddenly can cause withdrawal symptoms. Always taper under medical supervision. - Myth: It is safe to drive while taking this medicine.
Fact: It can cause drowsiness and dizziness. Avoid driving until you know how it affects you.
🔄 Alternative Options
Generic Alternatives
- Methylcobalamin + Pregabalin capsules (various manufacturers)
Brand Alternatives
- Axogurd Capsule
- Pregabid M Capsule
- Nurokind-G Capsule
- Maxgalin M Capsule