cmvir 450mg tablet

4.3 (12 reviews)

Valganciclovir (450mg)

🏭 Rene Lifescience 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is cmvir 450mg tablet used for?

Cymgal (Valganciclovir) is used to treat ANTI INFECTIVES. It contains Valganciclovir (450mg), which Valganciclovir is a prodrug of ganciclovir; ganciclovir is phosphorylated to gan. Always consult your doctor before use. Take as prescribed.

Generic Name: Valganciclovir
Manufacturer: Rene Lifescience
Form: Allopathy
Pregnancy Category: C
Prescription Required: Yes

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 cmvir 450mg tablet Uses & Benefits

Treatment of cytomegalovirus (CMV) retinitis in immunocompromised patients; prevention of CMV disease in solid organ transplant recipients.

Off-label uses: CMV prophylaxis in hematopoietic stem cell transplant recipients, Treatment of CMV infection in HIV patients

📋 Drug Information

Generic Name(s)	Valganciclovir
Brand Name	Cymgal
Manufacturer	Rene Lifescience
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI INFECTIVES
Action Class	Antiviral (Non-HIV) drugs
Route of Administration	Oral
Storage	Store at 20-25°C (68-77°F); protect from moisture.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed after oral administration; prodrug rapidly hydrolyzed to ganciclovir.

DistributionWidely distributed; crosses blood-brain barrier and placenta.

Protein Binding1-2% (ganciclovir)

MetabolismHydrolyzed by esterases in intestinal wall and liver to ganciclovir; ganciclovir undergoes minimal hepatic metabolism.

Half-Life4-6 hours (ganciclovir); prolonged in renal impairment.

ExcretionPrimarily renal (90% as ganciclovir) via glomerular filtration and tubular secretion.

BioavailabilityApproximately 60% (valganciclovir); ganciclovir bioavailability ~6%.

Onset of ActionNot specified; antiviral effect occurs within days.

Peak Plasma Time1-3 hours (valganciclovir); 2-4 hours (ganciclovir).

Duration of ActionDosing interval typically 12-24 hours.

How It Works

Valganciclovir is a prodrug of ganciclovir; ganciclovir is phosphorylated to ganciclovir triphosphate, which competitively inhibits viral DNA polymerase and incorporates into viral DNA, causing chain termination.

Mechanism Steps

1Valganciclovir is absorbed and rapidly hydrolyzed to ganciclovir by intestinal and hepatic esterases.

2Ganciclovir is phosphorylated to ganciclovir monophosphate by viral thymidine kinase (UL97) in CMV-infected cells.

3Cellular kinases convert ganciclovir monophosphate to ganciclovir triphosphate.

💡 How to Take cmvir 450mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of cmvir 450mg tablet

✅ Common Side Effects

Diarrhea
Nausea
Vomiting
Neutropenia
Anemia
Headache
Insomnia

🚨 Serious Side Effects

Severe neutropenia
Thrombocytopenia
Pancreatitis
Renal impairment
Seizures
Retinal detachment

⚠️ Rare Side Effects

Hepatic failure
Stevens-Johnson syndrome
Anaphylaxis
Hemolytic uremic syndrome

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Mycophenolate mofetil	Major	Increased risk of hematologic toxicity (neutropenia, anemia)
Didanosine	Major	Increased didanosine exposure and toxicity
Zidovudine	Major	Increased risk of severe neutropenia and anemia
Probenecid	Major	Reduced renal clearance of ganciclovir, increased toxicity
Tenofovir	Moderate	Increased risk of nephrotoxicity
Cidofovir	Moderate	Additive nephrotoxicity
Acyclovir	Moderate	Additive nephrotoxicity
Foscarnet	Moderate	Additive nephrotoxicity
Trimethoprim-sulfamethoxazole	Minor	Possible additive bone marrow suppression
Cyclosporine	Minor	Possible additive nephrotoxicity

🚨 Major Interactions

Mycophenolate mofetil
Didanosine
Zidovudine
Probenecid

⚡ Moderate Interactions

Tenofovir
Cidofovir
Acyclovir
Foscarnet

ℹ️ Minor Interactions

Trimethoprim-sulfamethoxazole
Cyclosporine

🍽️ Food Interactions

Take with food to reduce gastrointestinal side effects and improve absorption.

🍷 Alcohol Interaction

No known interaction; but alcohol may worsen gastrointestinal side effects.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to valganciclovir, ganciclovir, or acyclovir; absolute neutrophil count <500 cells/µL; platelet count <25,000/µL; hemoglobin <8 g/dL.

📊 Monitoring Parameters

Complete blood count (CBC) with differential, renal function, liver function tests.

🤱 Lactation Safety

Not recommended; ganciclovir is excreted in breast milk.

💊 Overdose Management

Supportive care; hemodialysis may reduce ganciclovir levels.

⏰ Missed Dose

Take as soon as remembered; if close to next dose, skip missed dose. Do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

🔗 View Profile

🔄 Substitutes for cmvir 450mg tablet

View All

Alternative brands with exact same active ingredient (Valganciclovir (450mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Trusted Reviewer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Certified Buyer Jul 10, 2026

Found this to be a helpful product. Good results.