Acmprol C 50mg/6.25mg Tablet ER: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Severe dizziness or fainting
- Heart rate below 50 beats per minute with symptoms
- Chest pain or difficulty breathing
- Sudden swelling of face, lips, or throat
- Decreased urine output or swelling in legs
- Severe abdominal pain or vomiting
- Yellowing of skin or eyes
- Irregular heartbeat or palpitations
If experiencing severe symptoms, call emergency services immediately.
What is clovet m 50mg/6.25mg tablet used for?
This medicine is a combination of metoprolol succinate and chlorthalidone used to treat high blood pressure. It works by slowing the heart rate and removing excess fluid from the body. It is taken once daily, usually in the morning, and should not be stopped suddenly.
- Generic Name: Metoprolol Succinate + Chlorthalidone
- Manufacturer: Ajanta Pharma Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 clovet m 50mg/6.25mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा उच्च रक्तचाप (हाई ब्लड प्रेशर) के इलाज के लिए इस्तेमाल की जाती है। इसमें मेटोप्रोलोल सक्सिनेट और क्लोर्थालिडोन दो सक्रिय तत्व हैं। मेटोप्रोलोल दिल की धड़कन को धीमा करता है और रक्तचाप को कम करता है, जबकि क्लोर्थालिडोन शरीर से अतिरिक्त पानी और नमक को बाहर निकालता है। यह दवा दिल के दौरे और स्ट्रोक के खतरे को कम करने में मदद करती है। इसे रोजाना एक बार सुबह लेना चाहिए। डॉक्टर की सलाह के बिना इसे अचानक बंद न करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में थकान, चक्कर आना, सिरदर्द, धीमी हृदय गति, ठंडे हाथ-पैर, बार-बार पेशाब आना और प्यास लगना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें बहुत धीमी हृदय गति, हृदय रुकावट, गंभीर निम्न रक्तचाप, इलेक्ट्रोलाइट असंतुलन, गुर्दे की समस्या और एलर्जी प्रतिक्रिया शामिल हो सकते हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे चबाएं या तोड़ें नहीं, पूरा निगल लें। इसे अचानक बंद न करें, क्योंकि इससे सीने में दर्द या अनियमित धड़कन हो सकती है। अपना रक्तचाप और हृदय गति नियमित रूप से जांचते रहें। पर्याप्त पानी पिएं। शराब से बचें। डॉक्टर को अपनी सभी दवाओं और बीमारियों के बारे में बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।
💊 clovet m 50mg/6.25mg tablet Uses & Benefits
- [{"condition":"Essential hypertension","description":"This medicine is used to lower high blood pressure in adults when a single agent is insufficient.
- It reduces cardiovascular risk and helps prevent stroke, heart attack, and kidney damage.","evidence":"Well-established"},{"condition":"Heart failure with reduced ejection fraction","description":"Metoprolol succinate component is indicated to reduce mortality and hospitalization in stable heart failure patients.
- The chlorthalidone component may be added for blood pressure control or fluid management.","evidence":"Well-established for metoprolol component"},{"condition":"Post-myocardial infarction","description":"Beta-blockers like metoprolol are used after a heart attack to reduce the risk of reinfarction and death.
- The diuretic component may be used for concurrent hypertension.","evidence":"Well-established for metoprolol component"}]
Off-label uses: [{"condition":"Migraine prophylaxis","description":"Metoprolol is sometimes used off-label to prevent migraines, though evidence is limited compared to other beta-blockers.","evidence":"Limited"},{"condition":"Performance anxiety","description":"Beta-blockers may be used off-label to reduce physical symptoms of anxiety, but combination with a diuretic is not standard for this purpose.","evidence":"Limited"}]
Primary treatment for: Hypertension
Also treats: Heart failure with reduced ejection fraction, Post-myocardial infarction, Angina pectoris
📋 Drug Information
| Generic Name(s) | Metoprolol Succinate + Chlorthalidone |
| Brand Name | Acmprol C 50mg/6.25mg Tablet ER |
| Manufacturer | Ajanta Pharma Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Beta-blocker + Thiazide diuretic |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and light. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Metoprolol succinate is a cardioselective beta-1 adrenergic receptor blocker. It reduces heart rate, myocardial contractility, and cardiac output, thereby lowering blood pressure and myocardial oxygen demand. It also suppresses renin release from the kidneys. Chlorthalidone is a thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule of the kidney, increasing excretion of sodium, water, and potassium. This reduces plasma volume and peripheral vascular resistance, leading to lower blood pressure. The combination provides additive antihypertensive effects.
Mechanism Steps
💡 How to Take clovet m 50mg/6.25mg tablet
Strength: Extended-release tablet containing metoprolol succinate 50 mg and chlorthalidone 6.25 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet of metoprolol succinate 50 mg and chlorthalidone 6.25 mg taken orally once daily, preferably in the morning. The dose may be adjusted by your doctor based on blood pressure response and tolerability. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially dizziness, hypotension, and electrolyte imbalances. Start with a low dose and titrate slowly under medical supervision. Regular monitoring of renal function and electrolytes is recommended. |
| Renal Impairment | Use with caution in patients with renal impairment. Chlorthalidone may accumulate and cause electrolyte disturbances. Dose adjustment may be necessary based on creatinine clearance. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Metoprolol is metabolized in the liver; hepatic impairment can increase its levels. Use with caution and consider dose reduction. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet of metoprolol succinate 50 mg and chlorthalidone 6.25 mg, unless otherwise directed by your doctor. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of clovet m 50mg/6.25mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Verapamil | Major | |
| Digoxin | Major | |
| Lithium | Major | |
| NSAIDs | Major | |
| Clonidine | Major | |
| Fluoxetine | Moderate | |
| Corticosteroids | Moderate | |
| Antidiabetic drugs | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor |
🚨 Major Interactions
- Verapamil or diltiazem
- Digoxin
- Clonidine
- Lithium
- NSAIDs
⚡ Moderate Interactions
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
- Corticosteroids
- Antidiabetic drugs
- Other antihypertensives
🍷 Alcohol Interaction
Alcohol can enhance the blood pressure-lowering and central nervous system effects of this medicine, leading to dizziness, fainting, and increased risk of falls. It is advisable to avoid alcohol or limit intake significantly while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe bradycardia","Second or third-degree heart block","Cardiogenic shock","Decompensated heart failure","Severe asthma or COPD with bronchospasm","Anuria","Severe renal impairment","Hypersensitivity to metoprolol, chlorthalidone, or sulfonamide-derived drugs"]
⚠️ Warnings & Precautions
["Do not stop this medicine abruptly; taper gradually under medical supervision.","Use with caution in patients with diabetes, as it may mask hypoglycemia symptoms.","May worsen symptoms of peripheral vascular disease.","Can cause electrolyte disturbances; monitor potassium and sodium levels.","May increase blood uric acid levels and precipitate gout.","Use with caution in patients with a history of severe allergic reactions.","May cause photosensitivity; use sun protection.","Avoid in patients with untreated pheochromocytoma unless alpha-blockade is established."]
🤱 Lactation Safety
Metoprolol and chlorthalidone are excreted in breast milk. Chlorthalidone may reduce milk production. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose can cause severe bradycardia, hypotension, heart failure, bronchospasm, and electrolyte imbalances. Seek emergency medical attention immediately. Treatment is supportive and may include activated charcoal, atropine, glucagon, vasopressors, and electrolyte replacement. Hemodialysis may be considered for chlorthalidone overdose.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, usually once daily in the morning with or without food. Do not crush or chew the extended-release tablet; swallow it whole. Do not stop this medicine suddenly, as abrupt discontinuation can cause chest pain, irregular heartbeat, or worsening hypertension. Monitor your blood pressure and heart rate regularly as advised. Stay well hydrated, especially during hot weather or exercise, because chlorthalidone can cause fluid and electrolyte loss. Avoid alcohol, as it can worsen dizziness and low blood pressure. Inform your doctor if you have diabetes, asthma, kidney or liver disease, gout, or lupus. Tell your doctor about all other medicines, especially those for blood pressure, diabetes, pain, or depression. Do not take potassium supplements or salt substitutes without consulting your doctor. If you become pregnant or plan to become pregnant, contact your doctor immediately. Keep all follow-up appointments for blood tests to check kidney function, electrolytes, and blood sugar.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the blood pressure-lowering and diuretic effects of this medicine. They are at higher risk of dizziness, falls, electrolyte imbalances, and kidney problems. Start with a low dose and monitor closely. Regular blood tests and blood pressure checks are essential.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before conception. This medicine may not be suitable during pregnancy. Your doctor may switch you to a safer alternative. Use effective contraception while taking this medicine unless otherwise advised.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and affect heart rate and blood pressure during surgery. Your doctor may advise temporary dose adjustments or monitoring.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It can cause dry mouth and may interact with certain dental anesthetics containing epinephrine. Your dentist may take precautions to monitor your blood pressure and heart rate during procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause dizziness and low blood pressure, especially when starting treatment or changing doses. Avoid strenuous exercise until you know how the medicine affects you. Stay hydrated during exercise. If you experience dizziness, chest pain, or shortness of breath during exercise, stop and seek medical attention.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal work activities with dose adjustment. Inform your employer if your job involves operating machinery or working at heights.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects or your doctor decides to discontinue, the dose will be tapered gradually to avoid rebound hypertension, chest pain, or heart attack. If you need to stop for surgery or other reasons, your doctor will provide specific instructions.
📅 Long-Term Use Effects
Long-term use of this medicine requires regular monitoring of blood pressure, heart rate, kidney function, and electrolyte levels. It can cause electrolyte imbalances, increased blood sugar, and increased uric acid levels. Periodic blood tests are essential. Do not stop the medicine without medical advice, as abrupt withdrawal can worsen heart conditions. Lifestyle modifications, including a low-sodium diet and regular exercise, enhance the benefits.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, weight loss, and stress reduction can help lower blood pressure and may reduce the need for medication.
Evidence: Well-establishedACE inhibitors, ARBs, calcium channel blockers, or other beta-blockers may be alternatives if this medicine is not suitable.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. However, maintain routine vaccinations as recommended by your doctor. Inform your healthcare provider about this medicine before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, consult your doctor about adjusting the dosing schedule. Carry enough supply for the entire trip plus extra in case of delays. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood pressure within a few hours, but the full effect may take 1-2 weeks. It may take up to 4 weeks to achieve optimal blood pressure control.
A: No, you should not stop without consulting your doctor. Blood pressure will rise again if the medicine is stopped. Your doctor may adjust the dose or switch medicines if needed.
A: If you remember within 12 hours, take the missed dose. If more than 12 hours have passed, skip it and take your next dose at the regular time. Do not double dose.
A: Only if prescribed by your doctor. Combining with other blood pressure medicines can increase the risk of low blood pressure. Always inform your doctor about all medicines you take.
🤔 Common Patient Concerns
🔄 Substitutes for clovet m 50mg/6.25mg tablet
View AllAlternative brands with exact same active ingredient:
-
acmprol c 50mg/6.25mg tablet erAccilex Diacardo ₹59.00 5.2% CHEAPER
-
Topme-C 50mg/6.25mg TabletJohnlee Pharmaceuticals Pvt Ltd ₹75.00 20.5% COSTLIER
-
bitatel m 3d 6.25mg/50mg/40mg tablet4Care Lifescience Pvt Ltd ₹112.50 80.7% COSTLIER
-
starpress 3d 6.25mg/50mg/40mg tabletLupin Ltd ₹121.07 94.5% COSTLIER
-
telma-mct 50/6.25 tablet erGlenmark Pharmaceuticals Ltd ₹135.94 118.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure high blood pressure permanently.
Fact: This medicine controls blood pressure but does not cure hypertension. Lifestyle changes and ongoing medication are usually needed. - Myth: You can stop taking this medicine once your blood pressure is normal.
Fact: Blood pressure returns to high levels if you stop. Always consult your doctor before stopping. - Myth: This medicine causes kidney damage in everyone.
Fact: When used appropriately and monitored, this medicine is safe for most people. Regular blood tests help prevent kidney problems.
🔄 Alternative Options
Generic Alternatives
- Metoprolol succinate + chlorthalidone generic tablets