closum 10mg tablet md

4.7 (10 reviews)

Clobazam (10mg)

🏭 Lifecare Innovations Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 21, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 21, 2026

What is closum 10mg tablet md used for?

Adobe 10mg Tablet (Clobazam) is used to treat NEURO CNS. It contains Clobazam (10mg), which Binds to benzodiazepine site on GABA-A receptors, enhancing GABAergic inhibition. Always consult your doctor before use. Take as prescribed.

Generic Name: Clobazam
Manufacturer: Lifecare Innovations Pvt Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 closum 10mg tablet md Uses & Benefits

Adjunctive therapy for epilepsy (Lennox-Gastaut syndrome), anxiety disorders.

Off-label uses: Status epilepticus (IV formulation), catamenial epilepsy, panic disorder.

📋 Drug Information

Generic Name(s)	Clobazam
Brand Name	Adobe 10mg Tablet
Manufacturer	Lifecare Innovations Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	NEURO CNS
Action Class	Benzodiazepines
Route of Administration	Oral.
Storage	Store at 20-25°C (68-77°F), protect from light and moisture.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after oral administration; peak plasma concentrations achieved within 1-4 hours.

DistributionWidely distributed; crosses blood-brain barrier; volume of distribution approximately 1 L/kg.

Protein BindingApproximately 80-90% bound to plasma proteins.

MetabolismExtensively metabolized in the liver via CYP3A4 to active metabolite N-desmethylclobazam.

Half-LifeClobazam: 36-42 hours; N-desmethylclobazam: 71-82 hours.

ExcretionPrimarily renal (87% as metabolites, 2% unchanged); fecal (11%).

BioavailabilityApproximately 90%.

Onset of Action30-60 minutes.

Peak Plasma Time1-4 hours.

Duration of Action12-24 hours.

How It Works

Binds to benzodiazepine site on GABA-A receptors, enhancing GABAergic inhibition.

Mechanism Steps

1Clobazam binds to benzodiazepine site on GABA-A receptor.

2Enhances affinity of GABA for receptor.

3Increases frequency of chloride channel opening.

💡 How to Take closum 10mg tablet md

Follow your doctor's prescription exactly.

⚠️ Side Effects of closum 10mg tablet md

✅ Common Side Effects

Drowsiness
Sedation
Dizziness
Ataxia
Fatigue

🚨 Serious Side Effects

Respiratory depression
Paradoxical reactions (agitation, aggression)
Stevens-Johnson syndrome
Dependence/withdrawal seizures

⚠️ Rare Side Effects

Blood dyscrasias
Hepatic failure
Angioedema

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Alcohol	Major	Increased sedation and respiratory depression
Opioids	Major	Additive CNS depression, risk of respiratory depression
Ketoconazole	Major	Increased clobazam levels due to CYP3A4 inhibition
Carbamazepine	Major	Decreased clobazam levels due to CYP3A4 induction

🚨 Major Interactions

CNS depressants (e.g., alcohol, opioids)
CYP3A4 inhibitors (e.g., ketoconazole)
CYP3A4 inducers (e.g., carbamazepine)

⚡ Moderate Interactions

Antihistamines
Antipsychotics
MAOIs

ℹ️ Minor Interactions

Caffeine
Oral contraceptives

🍽️ Food Interactions

Grapefruit juice may increase clobazam levels.

🍷 Alcohol Interaction

Additive CNS depression; avoid concurrent use.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to benzodiazepines, severe hepatic impairment, narrow-angle glaucoma, myasthenia gravis, respiratory insufficiency.

📊 Monitoring Parameters

Liver function tests, CBC, renal function, signs of CNS depression, tolerance/dependence.

🤱 Lactation Safety

Excreted in breast milk; use with caution; monitor infant for sedation.

💊 Overdose Management

Supportive care; flumazenil as antidote (caution in mixed overdoses).

⏰ Missed Dose

Take as soon as remembered; if near next dose, skip missed dose; do not double.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

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🔄 Substitutes for closum 10mg tablet md

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Alternative brands with exact same active ingredient (Clobazam (10mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Happy Patient Jul 10, 2026

Good quality medicine. Satisfied with the outcome.