Algeline 50mg Injection (Tigecycline): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe, persistent diarrhea or bloody stools
- Severe abdominal pain radiating to the back
- Yellowing of the skin or eyes (jaundice)
- Dark urine or pale stools
- Chest pain or difficulty breathing
- Swelling of the face, lips, or throat
- Severe headache with vision changes
- Decreased urine output
- Unusual bleeding or bruising
- High fever with chills
If experiencing severe symptoms, call emergency services immediately.
What is bactigelin 50mg injection used for?
This medicine is an intravenous antibiotic containing tigecycline 50 mg. It is used to treat serious bacterial infections such as complicated skin infections, intra-abdominal infections, and community-acquired pneumonia when other antibiotics are not suitable. It works by stopping bacterial protein synthesis.
- Generic Name: Tigecycline
- Manufacturer: Lifecare Innovations Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 bactigelin 50mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा टाइजेसाइक्लिन 50 मिलीग्राम इंजेक्शन है, जिसे अस्पताल में नस के माध्यम से दिया जाता है। यह गंभीर बैक्टीरियल संक्रमणों के इलाज के लिए उपयोग की जाती है, जैसे कि त्वचा और त्वचा संरचना के जटिल संक्रमण, पेट के अंदर के संक्रमण, और निमोनिया। यह दवा बैक्टीरिया के प्रोटीन संश्लेषण को रोककर उनके विकास को रोकती है। यह उन रोगियों के लिए है जिन्हें अन्य एंटीबायोटिक्स से लाभ नहीं हुआ है। यह दवा 8 साल से छोटे बच्चों, गर्भवती महिलाओं और स्तनपान कराने वाली महिलाओं के लिए अनुशंसित नहीं है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट दर्द, सिरदर्द और इंजेक्शन स्थल पर दर्द या सूजन शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें क्लोस्ट्रीडियम डिफिसाइल के कारण गंभीर दस्त, अग्नाशयशोथ, यकृत की समस्या और एलर्जी प्रतिक्रियाएं शामिल हो सकती हैं। यदि आपको गंभीर दस्त, पेट में तेज दर्द, त्वचा या आंखों का पीलापन, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल अस्पताल या क्लिनिक में स्वास्थ्य पेशेवर द्वारा दी जानी चाहिए। इसे स्वयं न लगाएं। अपने डॉक्टर को बताएं यदि आपको टाइजेसाइक्लिन या किसी अन्य टेट्रासाइक्लिन से एलर्जी है। यदि आप गर्भवती हैं, गर्भधारण की योजना बना रही हैं, या स्तनपान करा रही हैं, तो अपने डॉक्टर को बताएं। एंटासिड, आयरन या कैल्शियम सप्लीमेंट लेने से बचें क्योंकि वे इस दवा के प्रभाव को कम कर सकते हैं। पर्याप्त मात्रा में तरल पदार्थ पिएं। गंभीर दस्त, पेट दर्द, या यकृत की समस्या के लक्षणों की रिपोर्ट करें। उपचार जल्दी बंद न करें, भले ही आप बेहतर महसूस करें।
💊 bactigelin 50mg injection Uses & Benefits
[{"condition":"Complicated skin and skin structure infections","description":"This medicine is used to treat serious skin infections, including those caused by resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis.","evidence":"Well-established"},{"condition":"Complicated intra-abdominal infections","description":"It is effective against a range of bacteria that cause infections within the abdominal cavity, such as perforated appendicitis or peritonitis.","evidence":"Well-established"},{"condition":"Community-acquired bacterial pneumonia","description":"This medicine is indicated for pneumonia acquired outside of hospitals, particularly when caused by Streptococcus pneumoniae, Haemophilus influenzae, or atypical pathogens.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Multidrug-resistant Acinetobacter infections","description":"Sometimes used off-label for infections caused by multidrug-resistant Acinetobacter baumannii when other options are limited.","evidence":"Limited"},{"condition":"Infections caused by Stenotrophomonas maltophilia","description":"Occasionally used off-label for Stenotrophomonas maltophilia infections, though evidence is limited.","evidence":"Limited"}]
Primary treatment for: Complicated skin and skin structure infections
Also treats: Complicated intra-abdominal infections, Community-acquired bacterial pneumonia
📋 Drug Information
| Generic Name(s) | Tigecycline |
| Brand Name | Algeline 50mg Injection |
| Manufacturer | Lifecare Innovations Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Tetracyclines |
| Route of Administration | Intravenous (IV) infusion over 30 to 60 minutes |
| Storage | This medicine should be stored at room temperature, between 20°C and 25°C (68°F to 77°F). It should be kept in its original packaging, protected from light and moisture. Do not freeze. Once reconstituted, the solution should be used immediately or stored as directed by the pharmacist. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture. Check the expiration date on the packaging before use. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by binding to the 30S ribosomal subunit of susceptible bacteria, blocking the entry of aminoacyl-tRNA molecules into the ribosomal A site. This action prevents the addition of amino acids to the growing peptide chain, thereby inhibiting bacterial protein synthesis. Because protein synthesis is essential for bacterial growth and replication, this medicine effectively stops the bacteria from multiplying, allowing the body's immune system to clear the infection. Unlike older tetracyclines, tigecycline is less affected by common resistance mechanisms such as ribosomal protection and efflux pumps, which gives it activity against many multidrug-resistant bacteria.
Mechanism Steps
💡 How to Take bactigelin 50mg injection
Strength: 50 mg lyophilized powder for intravenous infusion
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 100 mg administered intravenously as a loading dose, followed by 50 mg every 12 hours. Each dose is infused over 30 to 60 minutes. The duration of treatment depends on the type and severity of the infection, typically 5 to 14 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. For complicated skin infections, the recommended duration is 5 to 14 days. For complicated intra-abdominal infections, 5 to 14 days. For community-acquired pneumonia, 7 to 14 days. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine is not recommended for children under 8 years of age due to the risk of permanent tooth discoloration and effects on bone growth. |
| Elderly Dosage | No dose adjustment is required based on age alone. However, elderly patients may be more susceptible to certain side effects and should be monitored closely. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | No dose adjustment is necessary for patients with renal impairment, including those on hemodialysis. This medicine is primarily eliminated via the biliary route. |
| Hepatic Impairment | For patients with mild to moderate hepatic impairment (Child-Pugh Class A and B), no dose adjustment is needed. For severe hepatic impairment (Child-Pugh Class C), the maintenance dose should be reduced to 25 mg every 12 hours after the initial 100 mg loading dose. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is 100 mg (50 mg every 12 hours) for patients with normal hepatic function. For severe hepatic impairment, the maximum daily dose is 50 mg (25 mg every 12 hours). |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of bactigelin 50mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Oral contraceptives | Major | |
| Isotretinoin | Major | |
| Digoxin | Minor | |
| Antacids | Minor | |
| Iron supplements | Minor | |
| Calcium supplements | Minor | |
| Methotrexate | Moderate | |
| Live vaccines | Moderate | |
| Cyclosporine | Moderate |
🚨 Major Interactions
- Warfarin
- Oral contraceptives
- Retinoids (e.g., isotretinoin)
⚡ Moderate Interactions
- Antacids containing aluminum, calcium, or magnesium
- Iron supplements
🍷 Alcohol Interaction
Alcohol may worsen nausea, vomiting, and dizziness caused by this medicine. It is advisable to avoid alcohol during treatment to reduce the risk of these side effects and to support recovery from infection.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to tigecycline or any tetracycline antibiotic","Children under 8 years of age (risk of tooth discoloration and bone growth inhibition)","Pregnancy (unless benefit outweighs risk)","Breastfeeding (unless benefit outweighs risk)"]
⚠️ Warnings & Precautions
["This medicine should be used with caution in patients with severe hepatic impairment. Dose adjustment may be necessary.","It may cause fetal harm. Women of childbearing potential should use effective contraception.","It can cause Clostridium difficile-associated diarrhea. Monitor for severe diarrhea.","It may increase the risk of mortality in critically ill patients. Use with caution.","It can cause pancreatitis. Monitor for symptoms.","It may cause photosensitivity. Avoid prolonged sun exposure.","It can reduce the efficacy of oral contraceptives. Use backup contraception.","It may cause tooth discoloration and bone growth inhibition in children under 8 years.","It should be administered only by intravenous infusion over 30 to 60 minutes.","It is not effective against Pseudomonas aeruginosa or Proteus species."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. In case of overdose, treatment should be symptomatic and supportive. Hemodialysis does not significantly remove tigecycline from the blood. Patients should be monitored closely for signs of toxicity, and appropriate supportive care should be provided.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional in a hospital or clinic, missed doses are unlikely. If a dose is missed, it should be given as soon as possible. However, if it is almost time for the next dose, the missed dose should be skipped, and the regular dosing schedule should be resumed. Do not double the dose to catch up.
Additional Safety Advice
This medicine must only be given by a healthcare professional in a hospital or clinic setting. Do not attempt to administer it yourself. Inform your doctor if you are allergic to tigecycline, other tetracyclines, or any other medicines. Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as this medicine may harm the developing baby. Avoid taking antacids, iron supplements, or calcium supplements within two hours before or after your infusion, as they can reduce the effectiveness of this medicine. Drink plenty of fluids unless your doctor advises otherwise. Report any severe diarrhea, stomach pain, or signs of liver problems such as yellowing of the skin or eyes. Do not skip doses or stop treatment early, even if you feel better, because doing so can allow the infection to return and may lead to antibiotic resistance. Keep all follow-up appointments and blood tests as scheduled by your doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to the side effects of this medicine, particularly nausea, vomiting, and diarrhea. They should be monitored closely for signs of dehydration and electrolyte imbalance. No dose adjustment is required based on age alone, but hepatic and renal function should be considered.
🤰 Pregnancy Planning (TTC)
This medicine may harm the developing baby. Women who are planning to become pregnant should discuss alternative antibiotics with their doctor. Effective contraception should be used during treatment and for at least one week after the last dose.
🏥 Post-Surgery Considerations
This medicine may be used to treat surgical site infections. It is important to monitor the surgical wound for signs of infection and to follow your surgeon's instructions for wound care. Inform your surgeon if you are taking this medicine.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. This medicine may increase the risk of bleeding, especially if you are also taking blood thinners. Your dentist may recommend postponing elective dental work until you have completed treatment.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise during treatment, especially if you experience dizziness or fatigue. Light activity such as walking may be beneficial, but consult your doctor before resuming your normal exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital setting, so you will likely need to take time off work during treatment. You may experience fatigue, dizziness, or nausea, which can affect your ability to drive or operate machinery. It is advisable to rest and avoid driving until you feel fully recovered.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping early can allow the infection to return and may lead to antibiotic resistance. Your doctor will determine the appropriate duration of treatment based on your infection and clinical response.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance and superinfections. It can also cause persistent liver enzyme abnormalities. Regular monitoring of liver function is recommended if prolonged treatment is necessary. The risk of serious side effects increases with duration of use.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the infection, other antibiotics such as beta-lactams, fluoroquinolones, or aminoglycosides may be used.
Evidence: Well-establishedFor intra-abdominal infections, surgical drainage of abscesses may be necessary in addition to antibiotics.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with this medicine because it may reduce the immune response. Inactivated vaccines are generally safe, but consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
This medicine is administered in a hospital or clinic setting, so travel is not typically applicable. If you are traveling after treatment, carry a copy of your prescription and medical records. Store any remaining medication as directed, and keep it in its original packaging. Check customs regulations for carrying prescription medications across borders.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine typically starts working within 24 to 48 hours after the first dose. However, full recovery may take several days to weeks depending on the infection.
A: No, this medicine is only available as an intravenous infusion and must be given by a healthcare professional.
A: This medicine may harm the developing baby. It should only be used during pregnancy if the potential benefit justifies the risk. Consult your doctor.
A: Report any side effects to your doctor or nurse immediately. Mild side effects like nausea may be managed with supportive care, but severe effects require prompt medical attention.
🤔 Common Patient Concerns
🔄 Substitutes for bactigelin 50mg injection
View AllAlternative brands with exact same active ingredient:
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tigeguard 50mg injectionChandra Bhagat Pharma Pvt Ltd ₹1,124.06 61.4% CHEAPER
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zutig 50 injectionZuventus Healthcare Ltd ₹1,242.70 57.4% CHEAPER
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tigi-bac injectionSuzan Pharma ₹1,259.00 56.8% CHEAPER
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Tigcyn 50mg InjectionFantabulous Pharma ₹1,299.00 55.4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken orally.
Fact: This medicine is only available as an intravenous infusion and must be given by a healthcare professional. - Myth: This medicine is safe for children.
Fact: This medicine is not recommended for children under 8 years due to the risk of tooth discoloration and bone growth inhibition. - Myth: This medicine is a first-line antibiotic for all infections.
Fact: This medicine is reserved for serious infections when other antibiotics are not suitable, due to its risk profile.
🔄 Alternative Options
Generic Alternatives
- Tigecycline
Brand Alternatives
- Tygacil