clopitab-a 150 capsule - Uses, Price, Side Effects & Substitutes
What is clopitab-a 150 capsule used for?
Aspidol Tablet (Aspirin + Clopidogrel) is used to treat BLOOD RELATED. It contains Aspirin (150mg) + Clopidogrel (75mg), which Aspirin: Irreversibly acetylates cyclooxygenase-1 (COX-1), inhibiting thromboxan. Always consult your doctor before use. Take as prescribed.
- Generic Name: Aspirin + Clopidogrel
- Manufacturer: Lupin Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ clopitab-a 150 capsule Uses & Benefits
Prevention of thrombotic events in patients with acute coronary syndrome, recent MI, stroke, or peripheral arterial disease.
Off-label uses: Prevention of preeclampsia (low-dose aspirin), prevention of colorectal cancer (aspirin).
๐ Drug Information
| Generic Name(s) | Aspirin + Clopidogrel |
| Brand Name | Aspidol Tablet |
| Manufacturer | Lupin Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | BLOOD RELATED |
| Action Class | Antiplatelet Agent |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture and light. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Aspirin: Irreversibly acetylates cyclooxygenase-1 (COX-1), inhibiting thromboxane A2 synthesis and platelet aggregation. Clopidogrel: Irreversibly blocks P2Y12 receptor on platelets, inhibiting ADP-induced platelet aggregation.
Mechanism Steps
๐ก How to Take clopitab-a 150 capsule
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of clopitab-a 150 capsule
โ Common Side Effects
- Dyspepsia
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Bruising
- Epistaxis
๐จ Serious Side Effects
- GI bleeding
- Intracranial hemorrhage
- Stevens-Johnson syndrome
- Thrombotic thrombocytopenic purpura
- Aplastic anemia
โ ๏ธ Rare Side Effects
- Reye's syndrome (aspirin in children)
- Hepatitis
- Interstitial nephritis
- Pancreatitis
- Anaphylaxis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| NSAIDs | Major | Increased GI bleeding risk |
| Methotrexate | Major | Increased methotrexate toxicity |
| SSRIs | Major | Increased bleeding risk |
| ACE inhibitors | Moderate | Reduced antihypertensive effect |
| Diuretics | Moderate | Reduced diuretic effect |
| Antacids | Minor | Reduced aspirin absorption |
๐จ Major Interactions
- Warfarin
- NSAIDs
- Methotrexate
- Anticoagulants (heparin, LMWH)
- Thrombolytics
- SSRIs
- Valproic acid
โก Moderate Interactions
- ACE inhibitors
- Diuretics
- Phenytoin
- Sulfonylureas
- Probenecid
- Corticosteroids
โน๏ธ Minor Interactions
- Antacids
- Alcohol
- Beta-blockers
- Calcium channel blockers
๐ฝ๏ธ Food Interactions
Food may delay absorption of aspirin; avoid grapefruit juice (may affect clopidogrel metabolism).
๐ท Alcohol Interaction
Increased risk of GI bleeding; avoid or limit alcohol.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Active bleeding, peptic ulcer, severe liver disease, hypersensitivity to aspirin or clopidogrel, history of asthma with aspirin, third trimester of pregnancy.
๐ Monitoring Parameters
Platelet function tests, bleeding time, CBC, renal function, liver function, signs of bleeding.
๐คฑ Lactation Safety
Aspirin excreted in breast milk; avoid high doses. Clopidogrel: Unknown; caution advised.
๐ Overdose Management
Gastric lavage, activated charcoal, supportive care; for aspirin overdose: alkalinization, hemodialysis in severe cases.
โฐ Missed Dose
Take as soon as remembered; if close to next dose, skip missed dose. Do not double dose.