Clomipramine 50 mg Tablet: Complete Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Thoughts of harming yourself or others
- Irregular heartbeat or palpitations
- Severe allergic reaction (swelling of face, lips, throat, difficulty breathing)
- Seizures
- Yellowing of skin or eyes
- Severe abdominal pain or vomiting blood
- Confusion, high fever, muscle rigidity (possible neuroleptic malignant syndrome)
If experiencing severe symptoms, call emergency services immediately.
What is clomijet 50mg tablet used for?
Clomipramine 50 mg is a tricyclic antidepressant used to treat obsessive-compulsive disorder (OCD) and depression. It works by increasing serotonin and norepinephrine in the brain. It is taken orally, usually 1-3 times daily, and may cause dry mouth, drowsiness, and dizziness. Regular monitoring is important.
- Generic Name: Clomipramine
- Manufacturer: Dagon Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 clomijet 50mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोमिप्रामाइन 50 मिलीग्राम की गोली है, जिसका उपयोग मुख्य रूप से ऑब्सेसिव-कंपल्सिव डिसऑर्डर (ओसीडी) और अवसाद (डिप्रेशन) के इलाज के लिए किया जाता है। यह मस्तिष्क में सेरोटोनिन और नॉरएपिनेफ्रिन के स्तर को बढ़ाकर काम करती है, जिससे मूड बेहतर होता है और बार-बार आने वाले विचारों और व्यवहारों को नियंत्रित करने में मदद मिलती है। यह दवा डॉक्टर के परामर्श से ही लेनी चाहिए और अचानक बंद नहीं करनी चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में मुँह सूखना, नींद आना, चक्कर आना, कब्ज, धुंधली दृष्टि और वजन बढ़ना शामिल हैं। गंभीर दुष्प्रभावों में अनियमित दिल की धड़कन, दौरे, गंभीर एलर्जी और आत्महत्या के विचार हो सकते हैं। यदि आपको कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अचानक बंद न करें। शराब और अन्य नींद लाने वाली दवाओं से बचें। जब तक आपको इसका असर पता न चल जाए, तब तक वाहन न चलाएँ। अपने डॉक्टर को सभी दवाओं के बारे में बताएं, खासकर एमएओ इनहिबिटर, एसएसआरआई और खून पतला करने वाली दवाएं। नियमित जांच कराते रहें।
💊 clomijet 50mg tablet Uses & Benefits
[{"condition":"Obsessive-compulsive disorder (OCD)","description":"This medicine is FDA-approved for OCD and helps reduce the frequency and intensity of obsessions and compulsions.","evidence":"Well-established"},{"condition":"Major depressive disorder","description":"It is effective in treating depression, especially when other antidepressants have failed.","evidence":"Well-established"},{"condition":"Panic disorder","description":"May be used to reduce the frequency and severity of panic attacks.","evidence":"Moderate"},{"condition":"Chronic pain syndromes","description":"Sometimes prescribed for neuropathic pain or fibromyalgia, though not first-line.","evidence":"Limited"}]
Off-label uses: [{"condition":"Premature ejaculation","description":"Clomipramine can delay ejaculation and is sometimes used off-label for this condition.","evidence":"Moderate"},{"condition":"Cataplexy in narcolepsy","description":"May help reduce cataplectic attacks, but other treatments are preferred.","evidence":"Limited"}]
Primary treatment for: Obsessive-compulsive disorder (OCD)
Also treats: Major depressive disorder, Panic disorder, Chronic pain syndromes
📋 Drug Information
| Generic Name(s) | Clomipramine |
| Brand Name | Anafranil |
| Manufacturer | Dagon Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Tricyclic antidepressants |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Clomipramine is a tricyclic antidepressant that inhibits the reuptake of serotonin and norepinephrine in the brain. Its active metabolite, desmethylclomipramine, primarily inhibits norepinephrine reuptake. This increases the availability of these neurotransmitters in the synaptic cleft, which helps regulate mood and anxiety. It also has anticholinergic, antihistaminic, and alpha-adrenergic blocking effects, contributing to its side effect profile.
Mechanism Steps
💡 How to Take clomijet 50mg tablet
Strength: 50 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual starting dose for adults is 25 mg once daily, gradually increased to a target dose of 100-150 mg per day for OCD, or 75-150 mg per day for depression, in divided doses. The maximum recommended daily dose is 250 mg. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients should start at a lower dose (e.g., 10-25 mg daily) and titrate slowly due to increased sensitivity to side effects. Close monitoring is required. |
| Renal Impairment | Use with caution in renal impairment. Dose adjustment may be necessary. Consult your doctor. |
| Hepatic Impairment | Use with caution in hepatic impairment. Dose reduction may be required. Monitor liver function. |
| Maximum Daily Dose | 250 mg per day (in divided doses) for adults; lower maximum for elderly or those with comorbidities. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of clomijet 50mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| SSRIs | Major | |
| QT-prolonging drugs | Major | |
| CYP2D6 inhibitors | Moderate | |
| CNS depressants | Moderate | |
| Anticholinergics | Moderate | |
| Cimetidine | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- MAO inhibitors (e.g., phenelzine, tranylcypromine)
- SSRIs (e.g., fluoxetine, paroxetine)
- QT-prolonging drugs (e.g., amiodarone, sotalol)
⚡ Moderate Interactions
- CYP2D6 inhibitors (e.g., quinidine, terbinafine)
- CNS depressants (e.g., alcohol, benzodiazepines)
- Anticholinergic drugs (e.g., benztropine, diphenhydramine)
🍷 Alcohol Interaction
Alcohol increases the sedative effects of this medicine and can impair motor skills and judgment. It is best to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to clomipramine or other tricyclic antidepressants","Concurrent use with MAO inhibitors","Acute recovery phase after myocardial infarction","Uncontrolled glaucoma","Severe liver disease","Urinary retention","Use in children under 10 years for OCD (safety not established)"]
⚠️ Warnings & Precautions
["May increase risk of suicidal thoughts and behaviors, especially in children, adolescents, and young adults.","Can cause sedation; avoid driving or operating machinery until effects are known.","May cause orthostatic hypotension; rise slowly from sitting or lying positions.","Use with caution in patients with seizures, thyroid disease, or narrow-angle glaucoma.","Do not stop abruptly; taper gradually to avoid withdrawal symptoms.","May impair cognitive and motor performance.","Avoid alcohol and other CNS depressants."]
🤱 Lactation Safety
Clomipramine is excreted in breast milk. There is limited information on its effects on the breastfed infant. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose of clomipramine can be life-threatening. Symptoms include irregular heartbeat, seizures, coma, and respiratory depression. Seek immediate emergency medical attention. Treatment is supportive and may include activated charcoal, sodium bicarbonate for cardiac toxicity, and management of seizures.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
Additional Safety Advice
Take this medicine exactly as prescribed. Do not stop suddenly. Avoid alcohol and other central nervous system depressants. Use caution when driving or operating machinery until you know how it affects you. Inform your doctor about all other medicines, especially MAO inhibitors, SSRIs, and blood thinners. Tell your doctor if you have heart disease, glaucoma, thyroid problems, or liver/kidney disease. Regular monitoring of heart rhythm, blood counts, and mood is recommended. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to side effects such as confusion, constipation, and cardiac effects. Start at a lower dose and monitor closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor to discuss the risks and benefits of continuing this medicine. It may be necessary to switch to a safer alternative.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine, as it can interact with anesthetic agents and affect heart rhythm.
🦷 Dental Procedures
Tell your dentist you are taking this medicine, as it can cause dry mouth and may interact with certain anesthetics or sedatives.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness and dizziness. Avoid strenuous exercise until you know how it affects you. Stay hydrated during exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and difficulty concentrating, especially when starting treatment. Avoid driving or operating heavy machinery until you know how it affects you. It may affect your ability to perform complex tasks.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects or need to discontinue, your doctor will guide you through a gradual taper to avoid withdrawal symptoms.
📅 Long-Term Use Effects
Long-term use may require periodic monitoring of heart function, blood counts, and liver enzymes. Weight gain and metabolic changes can occur. Do not stop without medical advice. Regular follow-up is essential to adjust dose and manage side effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
First-line therapy for OCD and depression; can be used alone or with medication.
Evidence: Well-establishedOften preferred due to better safety profile; examples include fluoxetine, sertraline.
Evidence: Well-establishedCan help manage anxiety and stress.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, consult your doctor before any vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. If traveling across time zones, adjust dosing times gradually to avoid missing doses. Store at room temperature and protect from moisture. Check customs regulations for controlled substances before traveling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: It may take 2-4 weeks to notice improvement, and up to 8-12 weeks for full benefits.
A: Take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose. Do not double dose.
A: No, stopping suddenly can cause withdrawal symptoms. Always taper gradually under medical supervision.
A: Consult your doctor. Use only if clearly needed, as risks and benefits must be weighed.
🤔 Common Patient Concerns
🔄 Substitutes for clomijet 50mg tablet
View AllAlternative brands with exact same active ingredient:
-
omifram 50mg tabletZeelab Pharmacy Pvt Ltd ₹30.00 48.3% CHEAPER
-
clominex 50 tabletNext Labs Pvt Ltd ₹42.19 27.3% CHEAPER
-
imi-ci 50mg tabletSunrise Remedies Pvt Ltd ₹51.56 11.1% CHEAPER
-
ecmin 50mg tabletElite Pharma Pvt Ltd ₹56.25 3% CHEAPER
-
lodep 50mg tabletExcare Laboratories ₹56.25 3% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Clomipramine is addictive.
Fact: Clomipramine is not addictive in the traditional sense, but it can cause dependence and withdrawal symptoms if stopped abruptly. It should be tapered gradually. - Myth: You can stop taking clomipramine once you feel better.
Fact: You should continue taking it as prescribed, even if you feel better, to prevent relapse. Stopping suddenly can cause withdrawal symptoms. - Myth: Clomipramine works immediately.
Fact: It may take 2-4 weeks to notice improvement, and up to 8-12 weeks for full benefits.
🔄 Alternative Options
Generic Alternatives
- Clomipramine hydrochloride
Brand Alternatives
- Anafranil
- Clomipramine 50 mg tablets (various manufacturers)